ATE335823T1 - Verfahren zur biologischen herstellung von 1,3- propandiol - Google Patents

Verfahren zur biologischen herstellung von 1,3- propandiol

Info

Publication number
ATE335823T1
ATE335823T1 AT00955772T AT00955772T ATE335823T1 AT E335823 T1 ATE335823 T1 AT E335823T1 AT 00955772 T AT00955772 T AT 00955772T AT 00955772 T AT00955772 T AT 00955772T AT E335823 T1 ATE335823 T1 AT E335823T1
Authority
AT
Austria
Prior art keywords
propanediol
dehydratase
coli
present
improved process
Prior art date
Application number
AT00955772T
Other languages
English (en)
Inventor
Mark Emptage
Sharon Haynie
Lisa Laffend
Jeff Pucci
Greg Whited
Original Assignee
Du Pont
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont, Genencor Int filed Critical Du Pont
Application granted granted Critical
Publication of ATE335823T1 publication Critical patent/ATE335823T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT00955772T 1999-08-18 2000-08-18 Verfahren zur biologischen herstellung von 1,3- propandiol ATE335823T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14953499P 1999-08-18 1999-08-18

Publications (1)

Publication Number Publication Date
ATE335823T1 true ATE335823T1 (de) 2006-09-15

Family

ID=22530731

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00955772T ATE335823T1 (de) 1999-08-18 2000-08-18 Verfahren zur biologischen herstellung von 1,3- propandiol

Country Status (13)

Country Link
US (5) US6514733B1 (de)
EP (1) EP1204755B1 (de)
JP (1) JP4716634B2 (de)
KR (1) KR100785997B1 (de)
CN (2) CN101024843A (de)
AT (1) ATE335823T1 (de)
BR (2) BRPI0013315B8 (de)
CA (2) CA2733616C (de)
DE (1) DE60029971T2 (de)
DK (1) DK1204755T3 (de)
HK (1) HK1044963B (de)
PT (1) PT1204755E (de)
WO (1) WO2001012833A2 (de)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2311601C (en) 1997-12-02 2008-07-08 E.I. Du Pont De Nemours And Company Method for the production of glycerol by recombinant organisms
DE60229050D1 (de) 2001-04-04 2008-11-06 Genencor Int Verfahren zur herstellung von ascorbinsäurezwischenprodukten in wirtszellen
ATE513036T1 (de) 2001-04-04 2011-07-15 Danisco Us Inc Entkoppelte anabole und katabole stoffwechselwege in wirtszellen
JP2002330763A (ja) 2001-05-02 2002-11-19 Ajinomoto Co Inc 発酵法による目的物質の製造法
EP1499709B1 (de) * 2002-04-22 2012-01-04 E.I. Du Pont De Nemours And Company Promotor und plasmidsystem für die gentechnik
EP1546304B1 (de) 2002-10-04 2013-05-08 Danisco US Inc. VERBESSERTE PRODUKTION VON BAKTERIENSTûMMEN
US20050079617A1 (en) 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
AU2003287028B2 (en) 2002-10-04 2008-09-04 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
BR0316897A (pt) 2002-12-16 2005-11-08 Du Pont Método de seleção para desidratases dependentes de b12, sequências de ácido nucléico, desidratase mutante dependente de b12, método para a criação de mutantes de desidratase dependente de b12 e métodos para a identificação de desidratase dependente de b12
KR100864672B1 (ko) * 2003-04-02 2008-10-23 씨제이제일제당 (주) 클렙시엘라 뉴모니아를 이용한 1,2-프로판디올의 생산방법
US7056439B2 (en) * 2003-05-06 2006-06-06 Tate & Lyle Ingredidents Americas, Inc. Process for producing 1, 3-propanediol
US7323539B2 (en) 2003-05-06 2008-01-29 E. I. Du Pont De Nemours And Company Polytrimethylene ether glycol and polytrimethylene ether ester with excellent quality
FR2864967B1 (fr) * 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
WO2005093060A1 (ja) * 2004-03-26 2005-10-06 Nippon Shokubai Co., Ltd. 1,3−プロパンジオール及び/又は3−ヒドロキシプロピオン酸を製造する方法
WO2005103262A1 (en) * 2004-04-20 2005-11-03 Cj Corp. A novel diol dehydratase gene cluster in listeria genus
US20070029252A1 (en) * 2005-04-12 2007-02-08 Dunson James B Jr System and process for biomass treatment
BRPI0612944B1 (pt) * 2005-04-12 2017-11-28 E.I.Du Pont De Nemours And Company Method of production of target substance
US7781191B2 (en) * 2005-04-12 2010-08-24 E. I. Du Pont De Nemours And Company Treatment of biomass to obtain a target chemical
EP3919543A3 (de) 2005-04-22 2022-03-16 Mitsubishi Chemical Corporation Aus einer biomassenressource gewonnenes polyester und herstellungsverfahren dafür
US7524660B2 (en) 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
CN100427605C (zh) * 2005-06-17 2008-10-22 清华大学 一种由粗淀粉原料生产1,3-丙二醇和2,3-丁二醇的方法
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
US20080274526A1 (en) * 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of isobutanol
US8956850B2 (en) 2008-06-05 2015-02-17 Butamax Advanced Biofuels Llc Enhanced pyruvate to acetolactate conversion in yeast
EP1948814B1 (de) 2005-10-26 2018-11-21 Butamax (TM) Advanced Biofuels LLC Fermentive herstellung von alkoholen mit vier kohlenstoffatomen
CN100392071C (zh) * 2005-12-05 2008-06-04 中国农业大学 产乳酸途径缺失的工程菌及其构建方法与应用
CN105175257A (zh) 2006-02-10 2015-12-23 杜邦塔特和莱尔生物产品有限责任公司 包括生物学基1,3-丙二醇的单酯和二酯的组合物
US20070275139A1 (en) * 2006-02-10 2007-11-29 Melissa Joerger Food compositions comprising renewably-based, biodegradable1,3-propanediol
US8962298B2 (en) 2006-05-02 2015-02-24 Butamax Advanced Biofuels Llc Recombinant host cell comprising a diol dehydratase
US8828704B2 (en) 2006-05-02 2014-09-09 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US20080003653A1 (en) * 2006-06-29 2008-01-03 Wenzel J Douglas Supplementation of ethanol fermentations and processes including supplemental components
JP2010508013A (ja) * 2006-10-31 2010-03-18 メタボリック エクスプローラー グリセロールから1,3−プロパンジオールを高収量で生物学的に製造する方法
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
WO2008061187A1 (en) * 2006-11-15 2008-05-22 Dupont Tate & Lyle Bio Products Company, Llc Preservative compositions comprising renewably-based, biodegradable 1,3-propanediol
TWI568847B (zh) 2007-03-16 2017-02-01 奇諾麥提卡公司 用於1,4-丁二醇及其前驅物之生物合成的組合物及方法
NZ579780A (en) * 2007-04-18 2012-07-27 Butamax Advanced Biofuels Llc Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes
US8426174B2 (en) * 2007-05-02 2013-04-23 Butamax(Tm) Advanced Biofuels Llc Method for the production of 2-butanol
DE102007027006A1 (de) * 2007-06-08 2008-12-11 Evonik Degussa Gmbh Mikrobiologische Herstellung von Aldehyden, insbesondere von 3-Hydroxypropionaldehyd
CN101130782B (zh) * 2007-07-23 2011-01-26 江南大学 以葡萄糖为底物产1,3-丙二醇重组酿酒酵母的构建方法
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
US7807419B2 (en) * 2007-08-22 2010-10-05 E. I. Du Pont De Nemours And Company Process for concentrated biomass saccharification
US7819976B2 (en) * 2007-08-22 2010-10-26 E. I. Du Pont De Nemours And Company Biomass treatment method
US20090053800A1 (en) * 2007-08-22 2009-02-26 Julie Friend Biomass Treatment Apparatus
US8445236B2 (en) * 2007-08-22 2013-05-21 Alliance For Sustainable Energy Llc Biomass pretreatment
EP2594645A3 (de) 2007-09-21 2013-11-06 BASF Plant Science GmbH Pflanzen mit erhöhtem Ertrag
CA2735883C (en) * 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
CA2735948A1 (en) * 2008-09-29 2011-04-01 Butamaxtm Advanced Biofuels Llc Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria
DE102009029567A1 (de) 2008-10-02 2010-04-08 Basf Se Verfahren zur Abreicherung von Schwefel und/oder schwefelhaltigen Verbindungen aus einer biochemisch hergestellten organischen Verbindung
CN101633928B (zh) * 2008-10-22 2011-09-14 大连理工大学 一种醛还原酶的重组表达及其在甘油生物转化为1,3-丙二醇中的应用
CN102395671B (zh) * 2008-12-03 2014-06-25 韩国生命工学研究院 用于制造1,3-丙二醇的丙三醇氧化途径中阻隔的突变体
US20100159521A1 (en) * 2008-12-19 2010-06-24 E. I. Du Pont De Nemours And Company Ozone treatment of biomass to enhance enzymatic saccharification
EP2379730B1 (de) 2008-12-31 2015-07-22 Metabolic Explorer Verfahren zur herstellung von diolen
KR101189187B1 (ko) * 2009-03-12 2012-10-10 한국생명공학연구원 글리세롤 산화대사경로를 차단시킨 재조합 균주를 이용한 1、3―프로판디올의 제조방법
EP2407544A4 (de) * 2009-03-12 2014-01-22 Korea Res Inst Of Bioscience Herstellungsverfahren für 1,3-propandiol unter verwendung eines rekombinanten mikrobiellen stamms mit blockiertem glycerinoxidationsstoffwechselweg
KR20180042467A (ko) * 2009-06-04 2018-04-25 게노마티카 인코포레이티드 발효액 성분들의 분리 방법
US8129169B2 (en) 2009-06-04 2012-03-06 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol and related methods
US8969053B2 (en) 2009-07-30 2015-03-03 Metabolic Explorer Mutant YqhD enzyme for the production of a biochemical by fermentation
KR101048485B1 (ko) * 2009-08-17 2011-07-12 부산대학교 산학협력단 재조합 대장균을 배양하여 글리세롤로부터 3-히드록시프로피온산 및 1,3-프로판디올을 동시 생산하는 방법
WO2011029166A1 (en) 2009-09-09 2011-03-17 Braskem S.A. Microorganisms and process for producing n-propanol
WO2011047101A1 (en) * 2009-10-13 2011-04-21 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
US8852903B2 (en) 2009-10-23 2014-10-07 E I Du Pont De Nemours And Company Co-metabolism of fructose and glucose in microbial production strains
US9090919B2 (en) * 2009-10-29 2015-07-28 Korea Research Institute Of Bioscience And Biotechnology Method of producing 3-hydroxypropionic acid from glycerol
WO2011066076A1 (en) 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
US20110136190A1 (en) 2009-12-04 2011-06-09 E. I. Du Pont De Nemours And Company Recombinant bacteria for producing glycerol and glycerol-derived products from sucrose
CN102781901B (zh) 2010-02-11 2016-08-03 梅塔玻利克斯公司 用于从经遗传修饰的聚羟基链烷酸酯生物质制备单体组分的方法
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US8721794B2 (en) 2010-04-28 2014-05-13 E I Du Pont De Nemours And Company Production of high solids syrup from lignocellulosic biomass hydrolysate fermentation broth
US8906235B2 (en) 2010-04-28 2014-12-09 E I Du Pont De Nemours And Company Process for liquid/solid separation of lignocellulosic biomass hydrolysate fermentation broth
KR101220499B1 (ko) * 2010-05-25 2013-01-10 한국생명공학연구원 글리세롤로부터 3-하이드록시프로피온산을 고수율로 제조하는 방법
TWI500768B (zh) * 2010-07-05 2015-09-21 代謝探索公司 由蔗糖製備1,3-丙二醇之方法
US8651403B2 (en) 2010-07-21 2014-02-18 E I Du Pont De Nemours And Company Anhydrous ammonia treatment for improved milling of biomass
US20120125548A1 (en) 2010-11-23 2012-05-24 E. I. Du Pont De Nemours And Company Continuously fed biomass pretreatment process for a packed bed reactor
US20120125551A1 (en) 2010-11-23 2012-05-24 E. I. Du Pont De Nemours And Company Biomass pretreatment process for a packed bed reactor
US8129170B1 (en) 2010-12-06 2012-03-06 E.I. Du Pont De Nemours And Company Recombinant bacteria having the ability to metabolize sucrose
EP2652122B1 (de) 2010-12-13 2018-08-22 Myriant Corporation Verfahren zur herstellung von bernsteinsäure und anderen chemikalien aus einem sucrosehaltigen rohmaterial
EP2689014B1 (de) 2011-03-24 2019-04-24 Butamax (TM) Advanced Biofuels LLC Wirtszellen und verfahren zur herstellung von isobutanol
EP2697349A4 (de) 2011-04-13 2015-01-07 Elc Man Llc Milde anionische tenside für körperpflegezusammensetzungen
JP5852732B2 (ja) 2011-04-13 2016-02-03 イーエルシー マネージメント エルエルシー パーソナルケア組成物用コンディショニング剤
WO2012170793A1 (en) 2011-06-08 2012-12-13 Metabolix, Inc. Biorefinery process for thf production
EP2540834A1 (de) * 2011-06-29 2013-01-02 Metabolic Explorer Verfahren zur Herstellung von 1,3-Propandiol
JP2013013353A (ja) * 2011-07-01 2013-01-24 Daicel Corp 1,3−プロパンジオールの製造方法
US20140170714A1 (en) 2011-08-10 2014-06-19 Metabolix, Inc. Post process purification for gamma-butyrolactone production
JP2013070675A (ja) * 2011-09-28 2013-04-22 Daicel Corp アルキルジオールを産生する組換え菌の培養方法
WO2013126855A1 (en) * 2012-02-23 2013-08-29 The Regents Of The University Of California Atp driven direct photosynthetic production of fuels and chemicals
US9017961B2 (en) 2012-03-05 2015-04-28 E.I. Du Pont De Nemours And Company Recombinant bacteria comprising novel sucrose transporters
US8686114B2 (en) 2012-03-05 2014-04-01 E I Du Pont De Nemours And Company Variant sucrose transporter polypeptides
MX2014013446A (es) 2012-05-11 2014-12-08 Butamax Advanced Biofuels Llc Enzimas de cetol-acido reductoisomerasa y metodos de uso.
SI2855687T1 (sl) 2012-06-04 2020-09-30 Genomatica, Inc. Mikroorganizmi in metode za proizvodnjo 4-hidroksibutirat, 1,4-butandiola in sorodne spojine
US9605283B2 (en) 2012-07-11 2017-03-28 Institut National Des Sciences Appliquées Microorganism modified for the production of 1,3-propanediol
AU2013323427A1 (en) 2012-09-26 2015-03-05 Butamax (Tm) Advanced Biofuels Llc Polypeptides with ketol-acid reductoisomerase activity
WO2014062993A1 (en) * 2012-10-18 2014-04-24 Algenol Biofuels Inc. Production of 1,2-propanediol in cyanobacteria
CN104919039A (zh) * 2012-10-18 2015-09-16 阿尔吉诺生物技术有限责任公司 在蓝藻中生产1,3-丙二醇
US9845474B2 (en) 2012-10-24 2017-12-19 Calysta, Inc. Engineering of multi-carbon substrate utilization pathways in methanotrophic bacteria
US20140178954A1 (en) 2012-12-20 2014-06-26 E I Du Pont De Nemours And Company Expression of xylose isomerase activity in yeast
US8669076B1 (en) 2013-03-11 2014-03-11 E I Du Pont De Nemours And Company Cow rumen xylose isomerases active in yeast cells
US9187743B2 (en) 2013-03-11 2015-11-17 E I Du Pont De Nemours And Company Bacterial xylose isomerases active in yeast cells
US20140273105A1 (en) 2013-03-12 2014-09-18 E I Du Pont De Nemours And Company Gradient pretreatment of lignocellulosic biomass
WO2014160262A1 (en) 2013-03-14 2014-10-02 Abengoa Bioenergy New Technologies, Llc Methods for converting cellulosic waste to bioproducts
US10035749B2 (en) 2013-09-03 2018-07-31 Myriant Corporation Process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol
US10227623B2 (en) 2013-11-24 2019-03-12 E I Du Pont De Nemours And Company High force and high stress destructuring of cellulosic biomass
KR101577503B1 (ko) 2013-12-16 2015-12-14 지에스칼텍스 주식회사 1,3-프로판디올 생성능이 개선된 재조합 미생물 및 이를 이용한 1,3-프로판디올의 생산 방법
CN103789248B (zh) * 2014-02-14 2016-03-02 江苏大学 一种1,3-丙二醇基因工程菌及转化生产1,3-丙二醇的方法
WO2016007350A1 (en) 2014-07-09 2016-01-14 Danisco Us Inc. Preconditioning of lignocellulosic biomass
CN104726505A (zh) * 2015-03-31 2015-06-24 上海交通大学 一种利用基因工程蓝藻生产三碳化合物的方法
CN104774879B (zh) * 2015-04-29 2017-10-20 大连理工大学 一种混菌发酵甘油生产1,3‑丙二醇的方法
WO2017017292A1 (es) 2015-07-29 2017-02-02 Abengoa Bioenergía Nuevas Tecnologías, S. A. Expresión de enzimas beta-xilosidasas recombinantes
US9968531B2 (en) 2015-08-05 2018-05-15 Dupont Tate & Lyle Bio Products Company, Llc Deodorants containing 1,3-propanediol
BR112018070645A2 (pt) 2016-04-08 2019-02-05 Du Pont células de levedura recombinante, métodos para produzir uma célula de levedura e método para produzir um composto alvo
CN106906248A (zh) * 2017-03-28 2017-06-30 清华大学 一种利用重组微生物发酵生产1,3‑丙二醇的方法
CN107119003B (zh) * 2017-04-28 2020-04-24 中国科学院青岛生物能源与过程研究所 一种利用葡聚糖合成3-羟基丙酸的重组菌及其构建方法和应用
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CN114107145B (zh) * 2021-11-04 2024-05-07 清华大学 一种重组微生物及其在生产1,3-丙二醇中的应用
CN117050924B (zh) * 2022-05-06 2025-12-12 中国科学院天津工业生物技术研究所 生产1,3-丙二醇的重组密歇根克雷伯氏菌及其构建方法与应用
WO2024117834A1 (ko) * 2022-11-30 2024-06-06 주식회사 엘지화학 1,3-propanediol과 3-hydroxypropionic acid를 동시 생산하는 미생물 및 이의 용도
CN119954960B (zh) * 2023-10-30 2026-02-13 中国科学院天津工业生物技术研究所 促进1,3-丙二醇合成的融合蛋白及其应用
CN119979503B (zh) * 2023-12-14 2026-02-27 中国科学院天津工业生物技术研究所 磷酸二羟基丙酮磷酸酶的突变体蛋白及应用
KR102835046B1 (ko) * 2024-05-09 2025-07-18 주식회사 엑티브온 1,3-프로판디올을 생산하는 변이 미생물 및 이를 이용한 1,3-프로판디올의 생산방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3734764A1 (de) 1987-10-14 1989-05-03 Huels Chemische Werke Ag Verfahren zur herstellung von propandiol-(1,3)
DE3878564T2 (de) 1988-12-12 1993-08-19 Unilever Nv Verfahren zur mikrobiologischen herstellung von 1,3-propandiol aus glycerin.
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
ID21487A (id) 1996-11-13 1999-06-17 Du Pont Metoda pembuatan 1,3 - propandiol dengan organisme rekombinan
CA2311601C (en) * 1997-12-02 2008-07-08 E.I. Du Pont De Nemours And Company Method for the production of glycerol by recombinant organisms

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