ATE335823T1 - Verfahren zur biologischen herstellung von 1,3- propandiol - Google Patents

Verfahren zur biologischen herstellung von 1,3- propandiol

Info

Publication number
ATE335823T1
ATE335823T1 AT00955772T AT00955772T ATE335823T1 AT E335823 T1 ATE335823 T1 AT E335823T1 AT 00955772 T AT00955772 T AT 00955772T AT 00955772 T AT00955772 T AT 00955772T AT E335823 T1 ATE335823 T1 AT E335823T1
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AT
Austria
Prior art keywords
propanediol
dehydratase
coli
present
improved process
Prior art date
Application number
AT00955772T
Other languages
English (en)
Inventor
Mark Emptage
Sharon Haynie
Lisa Laffend
Jeff Pucci
Greg Whited
Original Assignee
Du Pont
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont, Genencor Int filed Critical Du Pont
Application granted granted Critical
Publication of ATE335823T1 publication Critical patent/ATE335823T1/de

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT00955772T 1999-08-18 2000-08-18 Verfahren zur biologischen herstellung von 1,3- propandiol ATE335823T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14953499P 1999-08-18 1999-08-18

Publications (1)

Publication Number Publication Date
ATE335823T1 true ATE335823T1 (de) 2006-09-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AT00955772T ATE335823T1 (de) 1999-08-18 2000-08-18 Verfahren zur biologischen herstellung von 1,3- propandiol

Country Status (13)

Country Link
US (5) US6514733B1 (de)
EP (1) EP1204755B1 (de)
JP (1) JP4716634B2 (de)
KR (1) KR100785997B1 (de)
CN (2) CN1298852C (de)
AT (1) ATE335823T1 (de)
BR (2) BR0013315B1 (de)
CA (2) CA2733616C (de)
DE (1) DE60029971T2 (de)
DK (1) DK1204755T3 (de)
HK (1) HK1044963B (de)
PT (1) PT1204755E (de)
WO (1) WO2001012833A2 (de)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2311601C (en) * 1997-12-02 2008-07-08 E.I. Du Pont De Nemours And Company Method for the production of glycerol by recombinant organisms
DK1383903T3 (da) 2001-04-04 2009-03-23 Genencor Int Fremgangsmåder til fremstilling af askorbinsyre-intermediater i vært-celler
DK1373480T3 (da) 2001-04-04 2009-05-11 Genencor Int Ukoblede produktive og katabolske værtscellebaner
JP2002330763A (ja) 2001-05-02 2002-11-19 Ajinomoto Co Inc 発酵法による目的物質の製造法
EP2374879A3 (de) * 2002-04-22 2012-01-11 E. I. du Pont de Nemours and Company Promoter und Plasmidsystem für Gentechnologie
WO2004033421A2 (en) 2002-10-04 2004-04-22 Genencor International, Inc. Improved production of bacterial strains
US20050079617A1 (en) 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
CA2501574C (en) 2002-10-04 2013-12-03 E. I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
CN102031265A (zh) 2002-12-16 2011-04-27 纳幕尔杜邦公司 具有改善了的反应动力学的b12-依赖型脱水酶
KR100864672B1 (ko) * 2003-04-02 2008-10-23 씨제이제일제당 (주) 클렙시엘라 뉴모니아를 이용한 1,2-프로판디올의 생산방법
US7323539B2 (en) * 2003-05-06 2008-01-29 E. I. Du Pont De Nemours And Company Polytrimethylene ether glycol and polytrimethylene ether ester with excellent quality
US7056439B2 (en) * 2003-05-06 2006-06-06 Tate & Lyle Ingredidents Americas, Inc. Process for producing 1, 3-propanediol
FR2864967B1 (fr) * 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
EP1731604A4 (de) * 2004-03-26 2007-04-04 Nippon Catalytic Chem Ind Verfahren zur herstellung von 1,3-propandiol und/oder 3-hydroxypropionsäure
WO2005103262A1 (en) * 2004-04-20 2005-11-03 Cj Corp. A novel diol dehydratase gene cluster in listeria genus
US7998713B2 (en) * 2005-04-12 2011-08-16 E. I. Du Pont De Nemours And Company Treatment of biomass to obtain ethanol
US7781191B2 (en) * 2005-04-12 2010-08-24 E. I. Du Pont De Nemours And Company Treatment of biomass to obtain a target chemical
US20070029252A1 (en) * 2005-04-12 2007-02-08 Dunson James B Jr System and process for biomass treatment
CN103183812B (zh) 2005-04-22 2016-03-02 三菱化学株式会社 来自生物质资源的聚酯及其制造方法
US7524660B2 (en) 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
CN100427605C (zh) * 2005-06-17 2008-10-22 清华大学 一种由粗淀粉原料生产1,3-丙二醇和2,3-丁二醇的方法
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
US20080274526A1 (en) * 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of isobutanol
US8956850B2 (en) * 2008-06-05 2015-02-17 Butamax Advanced Biofuels Llc Enhanced pyruvate to acetolactate conversion in yeast
RU2394913C2 (ru) 2005-10-26 2010-07-20 Е.И.Дюпон Де Немур Энд Компани Ферментативное получение четырехуглеродных спиртов
CN100392071C (zh) * 2005-12-05 2008-06-04 中国农业大学 产乳酸途径缺失的工程菌及其构建方法与应用
US20070275139A1 (en) * 2006-02-10 2007-11-29 Melissa Joerger Food compositions comprising renewably-based, biodegradable1,3-propanediol
US20070203276A1 (en) * 2006-02-10 2007-08-30 Gyorgyi Fenyvesi Plasticizers comprising biologically-based mono and di esters
US8962298B2 (en) 2006-05-02 2015-02-24 Butamax Advanced Biofuels Llc Recombinant host cell comprising a diol dehydratase
US8828704B2 (en) 2006-05-02 2014-09-09 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US20080003653A1 (en) * 2006-06-29 2008-01-03 Wenzel J Douglas Supplementation of ethanol fermentations and processes including supplemental components
US8236994B2 (en) * 2006-10-31 2012-08-07 Metabolic Explorer Process for the biological production of 1,3-propanediol from glycerol with high yield
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
WO2008061187A1 (en) * 2006-11-15 2008-05-22 Dupont Tate & Lyle Bio Products Company, Llc Preservative compositions comprising renewably-based, biodegradable 1,3-propanediol
JP5551448B2 (ja) 2007-03-16 2014-07-16 ジェノマティカ・インコーポレイテッド 1,4−ブタンジオールおよびその前駆体の生合成のための組成物および方法
NZ579780A (en) * 2007-04-18 2012-07-27 Butamax Advanced Biofuels Llc Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes
US8426174B2 (en) * 2007-05-02 2013-04-23 Butamax(Tm) Advanced Biofuels Llc Method for the production of 2-butanol
DE102007027006A1 (de) * 2007-06-08 2008-12-11 Evonik Degussa Gmbh Mikrobiologische Herstellung von Aldehyden, insbesondere von 3-Hydroxypropionaldehyd
CN101130782B (zh) * 2007-07-23 2011-01-26 江南大学 以葡萄糖为底物产1,3-丙二醇重组酿酒酵母的构建方法
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
US7807419B2 (en) * 2007-08-22 2010-10-05 E. I. Du Pont De Nemours And Company Process for concentrated biomass saccharification
US7819976B2 (en) * 2007-08-22 2010-10-26 E. I. Du Pont De Nemours And Company Biomass treatment method
US8445236B2 (en) * 2007-08-22 2013-05-21 Alliance For Sustainable Energy Llc Biomass pretreatment
US20090053800A1 (en) * 2007-08-22 2009-02-26 Julie Friend Biomass Treatment Apparatus
CA2712326A1 (en) 2007-09-21 2009-03-26 Basf Plant Science Gmbh Plants with increased yield comprising increased glutamine synthetase activity
AU2009291825B2 (en) 2008-09-10 2016-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
AU2009296227A1 (en) 2008-09-29 2010-04-01 Butamax(Tm) Advanced Biofuels Llc Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria
DE102009029567A1 (de) 2008-10-02 2010-04-08 Basf Se Verfahren zur Abreicherung von Schwefel und/oder schwefelhaltigen Verbindungen aus einer biochemisch hergestellten organischen Verbindung
CN101633928B (zh) * 2008-10-22 2011-09-14 大连理工大学 一种醛还原酶的重组表达及其在甘油生物转化为1,3-丙二醇中的应用
CN102395671B (zh) * 2008-12-03 2014-06-25 韩国生命工学研究院 用于制造1,3-丙二醇的丙三醇氧化途径中阻隔的突变体
WO2010080489A1 (en) * 2008-12-19 2010-07-15 E. I. Du Pont De Nemours And Company Ozone treatment of biomass to enhance enzymatic saccharification
WO2010076324A1 (en) 2008-12-31 2010-07-08 Metabolic Explorer Method for the preparation of diols
KR101189187B1 (ko) * 2009-03-12 2012-10-10 한국생명공학연구원 글리세롤 산화대사경로를 차단시킨 재조합 균주를 이용한 1、3―프로판디올의 제조방법
US8338148B2 (en) * 2009-03-12 2012-12-25 Korea Research Institute Of Bioscience And Biotechnology Method of producing 1,3-propanediol using recombinant Klebsiella strain in which glycerol oxidative pathway has been blocked
ES2625623T3 (es) * 2009-06-04 2017-07-20 Genomatica, Inc. Procedimiento de separación de componentes de un caldo de fermentación
EP4056706A1 (de) 2009-06-04 2022-09-14 Genomatica, Inc. Mikroorganismen zur herstellung von 1,4-butandiol und entsprechende verfahren
US8969053B2 (en) 2009-07-30 2015-03-03 Metabolic Explorer Mutant YqhD enzyme for the production of a biochemical by fermentation
KR101048485B1 (ko) * 2009-08-17 2011-07-12 부산대학교 산학협력단 재조합 대장균을 배양하여 글리세롤로부터 3-히드록시프로피온산 및 1,3-프로판디올을 동시 생산하는 방법
US20130095542A1 (en) 2009-09-09 2013-04-18 Gonçalo Amarante Guimarães Pereira Engineered microorganisms and integrated process for producing n-propanol, propylene and polypropylene
CN105441374A (zh) * 2009-10-13 2016-03-30 基因组股份公司 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法
US8852903B2 (en) 2009-10-23 2014-10-07 E I Du Pont De Nemours And Company Co-metabolism of fructose and glucose in microbial production strains
EP2495328B1 (de) * 2009-10-29 2016-03-30 Korea Research Institute of Bioscience and Biotechnology Neues verfahren zur herstellung von 3-hydroxypropionsäure aus glycerin
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
US20110136190A1 (en) 2009-12-04 2011-06-09 E. I. Du Pont De Nemours And Company Recombinant bacteria for producing glycerol and glycerol-derived products from sucrose
CN102781901B (zh) 2010-02-11 2016-08-03 梅塔玻利克斯公司 用于从经遗传修饰的聚羟基链烷酸酯生物质制备单体组分的方法
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US8906235B2 (en) 2010-04-28 2014-12-09 E I Du Pont De Nemours And Company Process for liquid/solid separation of lignocellulosic biomass hydrolysate fermentation broth
US8721794B2 (en) 2010-04-28 2014-05-13 E I Du Pont De Nemours And Company Production of high solids syrup from lignocellulosic biomass hydrolysate fermentation broth
KR101220499B1 (ko) * 2010-05-25 2013-01-10 한국생명공학연구원 글리세롤로부터 3-하이드록시프로피온산을 고수율로 제조하는 방법
TWI500768B (zh) * 2010-07-05 2015-09-21 Metabolic Explorer Sa 由蔗糖製備1,3-丙二醇之方法
US8651403B2 (en) 2010-07-21 2014-02-18 E I Du Pont De Nemours And Company Anhydrous ammonia treatment for improved milling of biomass
US20120125548A1 (en) 2010-11-23 2012-05-24 E. I. Du Pont De Nemours And Company Continuously fed biomass pretreatment process for a packed bed reactor
US20120125551A1 (en) 2010-11-23 2012-05-24 E. I. Du Pont De Nemours And Company Biomass pretreatment process for a packed bed reactor
US8129170B1 (en) 2010-12-06 2012-03-06 E.I. Du Pont De Nemours And Company Recombinant bacteria having the ability to metabolize sucrose
CN103347999B (zh) 2010-12-13 2016-02-10 麦兰特公司 使用含有蔗糖的原料生产琥珀酸和其他化学品的方法
BR112013024328A2 (pt) 2011-03-24 2020-08-25 Butamax (Tm) Advanced Biofuels Llc. Células hospedeiras recombinantes, métodos para produzir isobutanol, composiçãofermentativa, métodos para produzir uma célula hospedeira recombinante, para reduzir oueliminar a conversão de isobutiraldeído, polipeptídeos, polinucleqtídeo, método paraconverter acetolactato, leveduras recombinantes, métodos para produzir butanol, paraaumentar a atividade e para aumentar a produtividade da enzima karl
CA2830975C (en) 2011-04-13 2016-06-21 Elc Management Llc Mild anionic surfactants suitable for personal care compositions
CN103476914A (zh) 2011-04-13 2013-12-25 Elc管理公司 用于个人护理组合物的调节剂
US20140114082A1 (en) 2011-06-08 2014-04-24 Metabolix, Inc. Biorefinery Process For THF Production
EP2540834A1 (de) * 2011-06-29 2013-01-02 Metabolic Explorer Verfahren zur Herstellung von 1,3-Propandiol
JP2013013353A (ja) * 2011-07-01 2013-01-24 Daicel Corp 1,3−プロパンジオールの製造方法
EP2742143A1 (de) 2011-08-10 2014-06-18 Metabolix, Inc. Postprozessreinigung zur herstellung von gamma-butyrolacton
JP2013070675A (ja) * 2011-09-28 2013-04-22 Daicel Corp アルキルジオールを産生する組換え菌の培養方法
US20160024532A1 (en) * 2012-02-23 2016-01-28 The Regents Of The University Of California Atp driven direct photosynthetic production of fuels and chemicals
US9017961B2 (en) 2012-03-05 2015-04-28 E.I. Du Pont De Nemours And Company Recombinant bacteria comprising novel sucrose transporters
US8686114B2 (en) 2012-03-05 2014-04-01 E I Du Pont De Nemours And Company Variant sucrose transporter polypeptides
AU2013266727A1 (en) 2012-05-11 2014-11-06 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase enzymes and methods of use
US11932845B2 (en) 2012-06-04 2024-03-19 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
KR20150045432A (ko) * 2012-07-11 2015-04-28 엥스티튀 나쇼날 데 샹스 아플리케 드 툴루즈 변형된 1,3-프로판올 생산 미생물
CA2886157A1 (en) 2012-09-26 2014-04-03 Butamax Advanced Biofuels Llc Polypeptides with ketol-acid reductoisomerase activity
CN104919039A (zh) * 2012-10-18 2015-09-16 阿尔吉诺生物技术有限责任公司 在蓝藻中生产1,3-丙二醇
WO2014062993A1 (en) * 2012-10-18 2014-04-24 Algenol Biofuels Inc. Production of 1,2-propanediol in cyanobacteria
WO2014066670A1 (en) * 2012-10-24 2014-05-01 Calysta Energy, Inc. Engineering of multi-carbon substrate utilization pathways in methanotrophic bacteria
US20140178954A1 (en) 2012-12-20 2014-06-26 E I Du Pont De Nemours And Company Expression of xylose isomerase activity in yeast
US8669076B1 (en) 2013-03-11 2014-03-11 E I Du Pont De Nemours And Company Cow rumen xylose isomerases active in yeast cells
US9187743B2 (en) 2013-03-11 2015-11-17 E I Du Pont De Nemours And Company Bacterial xylose isomerases active in yeast cells
US20140273105A1 (en) 2013-03-12 2014-09-18 E I Du Pont De Nemours And Company Gradient pretreatment of lignocellulosic biomass
US20140315258A1 (en) 2013-03-14 2014-10-23 Abengoa Bioenergy New Technologies, Llc Methods for converting cellulosic waste to bioproducts
CN105705647B (zh) 2013-09-03 2020-03-27 Ptt全球化学公众有限公司 从1,3-丙二醇制造丙烯酸、丙烯腈和1,4-丁二醇的方法
US10227623B2 (en) 2013-11-24 2019-03-12 E I Du Pont De Nemours And Company High force and high stress destructuring of cellulosic biomass
KR101577503B1 (ko) 2013-12-16 2015-12-14 지에스칼텍스 주식회사 1,3-프로판디올 생성능이 개선된 재조합 미생물 및 이를 이용한 1,3-프로판디올의 생산 방법
CN103789248B (zh) * 2014-02-14 2016-03-02 江苏大学 一种1,3-丙二醇基因工程菌及转化生产1,3-丙二醇的方法
WO2016007350A1 (en) 2014-07-09 2016-01-14 Danisco Us Inc. Preconditioning of lignocellulosic biomass
CN104726505A (zh) * 2015-03-31 2015-06-24 上海交通大学 一种利用基因工程蓝藻生产三碳化合物的方法
CN104774879B (zh) * 2015-04-29 2017-10-20 大连理工大学 一种混菌发酵甘油生产1,3‑丙二醇的方法
BR112018001855A2 (pt) 2015-07-29 2018-09-25 Abengoa Bioenergia Nuevas Tecnologias Sa expressão de enzimas beta-xilosidase recombinantes
US9968531B2 (en) 2015-08-05 2018-05-15 Dupont Tate & Lyle Bio Products Company, Llc Deodorants containing 1,3-propanediol
US20190112590A1 (en) 2016-04-08 2019-04-18 Ei Du Pont De Nemours And Company Arabinose isomerases for yeast
CN106906248A (zh) * 2017-03-28 2017-06-30 清华大学 一种利用重组微生物发酵生产1,3‑丙二醇的方法
CN107119003B (zh) * 2017-04-28 2020-04-24 中国科学院青岛生物能源与过程研究所 一种利用葡聚糖合成3-羟基丙酸的重组菌及其构建方法和应用
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CN114107145B (zh) * 2021-11-04 2024-05-07 清华大学 一种重组微生物及其在生产1,3-丙二醇中的应用
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CN119954960B (zh) * 2023-10-30 2026-02-13 中国科学院天津工业生物技术研究所 促进1,3-丙二醇合成的融合蛋白及其应用
CN119979503B (zh) * 2023-12-14 2026-02-27 中国科学院天津工业生物技术研究所 磷酸二羟基丙酮磷酸酶的突变体蛋白及应用
KR102835046B1 (ko) * 2024-05-09 2025-07-18 주식회사 엑티브온 1,3-프로판디올을 생산하는 변이 미생물 및 이를 이용한 1,3-프로판디올의 생산방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3734764A1 (de) 1987-10-14 1989-05-03 Huels Chemische Werke Ag Verfahren zur herstellung von propandiol-(1,3)
EP0373230B1 (de) 1988-12-12 1993-02-17 Unilever N.V. Verfahren zur mikrobiologischen Herstellung von 1,3-Propandiol aus Glycerin
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
DE69739715D1 (de) 1996-11-13 2010-02-04 Du Pont Herstellungsverfahren von 1,3-propandiol durch rekombinante organismen
CA2311601C (en) * 1997-12-02 2008-07-08 E.I. Du Pont De Nemours And Company Method for the production of glycerol by recombinant organisms

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