ATE340173T1 - Piperazin- und piperidin- derivate - Google Patents

Piperazin- und piperidin- derivate

Info

Publication number: ATE340173T1
Authority: AT; Austria
Prior art keywords: group; alkyl; alkoxy; halogen; nitrogen
Prior art date: 1996-03-29

Application number

AT97908288T

Other languages

English (en)

Inventor

Roelof Willem Feenstra

Cornelis Gerrit Kruse

Martinus Theodorus Maria Tulp

Wilma Kuipers

Stephen Kenneth Long

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-29

Filing date

1997-03-20

Publication date

2006-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8223832&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE340173(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-03-20 Application filed by Duphar Int Res filed Critical Duphar Int Res

2006-10-15 Application granted granted Critical

2006-10-15 Publication of ATE340173T1 publication Critical patent/ATE340173T1/de

Links

GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 4
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
229910052757 nitrogen Inorganic materials 0.000 abstract 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
102000017911 HTR1A Human genes 0.000 abstract 1
101150015707 HTR1A gene Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 cyano, aminocarbonyl Chemical group 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003053 piperidines Chemical class 0.000 abstract 1
125000006413 ring segment Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Indole Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Quinoline Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT97908288T 1996-03-29 1997-03-20 Piperazin- und piperidin- derivate ATE340173T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP96200864		1996-03-29

Publications (1)

Publication Number	Publication Date
ATE340173T1 true ATE340173T1 (de)	2006-10-15

Family

ID=8223832

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97908288T ATE340173T1 (de)	1996-03-29	1997-03-20	Piperazin- und piperidin- derivate

Country Status (25)

Country	Link
US (1)	US6225312B1 (de)
EP (1)	EP0889889B1 (de)
JP (1)	JP3989554B2 (de)
CN (1)	CN1100055C (de)
AT (1)	ATE340173T1 (de)
AU (1)	AU708053B2 (de)
BR (1)	BRPI9708389B8 (de)
CA (1)	CA2250347C (de)
CZ (1)	CZ294413B6 (de)
DE (1)	DE69736704T2 (de)
DK (1)	DK0889889T3 (de)
ES (1)	ES2271967T3 (de)
HU (1)	HU227454B1 (de)
IL (1)	IL126187A0 (de)
NO (1)	NO320970B1 (de)
NZ (1)	NZ331860A (de)
PL (1)	PL189256B1 (de)
PT (1)	PT889889E (de)
RU (1)	RU2178414C2 (de)
SK (1)	SK285119B6 (de)
TR (1)	TR199801942T2 (de)
TW (1)	TW422846B (de)
UA (1)	UA52656C2 (de)
WO (1)	WO1997036893A1 (de)
ZA (1)	ZA972639B (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0900792B1 (de) *	1997-09-02	2003-10-29	Duphar International Research B.V	Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
TW530054B (en)	1997-09-24	2003-05-01	Duphar Int Res	New piperazine and piperidine compounds
EP1146045A1 (de) *	1998-06-30	2001-10-17	Eli Lilly And Company	Auf Serotonin-verwandte Systeme wirkende Piperidin-Derivate
WO2000000198A1 (en) *	1998-06-30	2000-01-06	Eli Lilly And Company	Piperidine derivatives having effects on serotonin related systems
UA71590C2 (en) *	1998-11-13	2004-12-15	Duphar Int Res	Piperazine and piperidine derivatives
BR0012752A (pt)	1999-07-29	2002-04-02	Lilly Co Eli	Benzofuril piperazinas e benzofuril homopiperazinas: agonistas de serotonina
CA2380531A1 (en) *	1999-07-29	2001-02-08	Mark Louis Heiman	Benzofurylpiperazine serotonin agonists
EP1284731A1 (de) *	2000-05-12	2003-02-26	Solvay Pharmaceuticals B.V.	Verwendung von verbindungen mit kombinierter d2, 5-ht1a und alpha adrenoceptor agonistischer wirkung zur behandlung von zns-erkrankungen
ES2211809T3 (es)	2000-05-12	2004-07-16	Solvay Pharmaceuticals B.V.	Compuesto de piperazina y piperidina.
KR100791799B1 (ko)	2000-05-12	2008-01-04	솔베이 파마슈티칼스 비. 브이	피페라진 및 피페리딘 화합물 및 이의 제조방법
AR034206A1 (es) *	2001-02-16	2004-02-04	Solvay Pharm Bv	Un procedimiento para la preparacion de mesilatos de derivados de piperazina y dichos mesilatos
ATE424825T1 (de)	2001-07-20	2009-03-15	Psychogenics Inc	Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
MXPA05004758A (es)	2002-11-08	2005-08-02	Hoffmann La Roche	Benzoxazinonas sustituidas y uso de las mismas.
CN1326852C (zh) *	2003-03-07	2007-07-18	兴和株式会社	苯并呋喃衍生物
GB0316915D0 (en) *	2003-07-18	2003-08-20	Glaxo Group Ltd	Compounds
ES2232292B1 (es) *	2003-07-30	2006-11-01	Laboratorios Del Dr. Esteve, S.A.	Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos.
US7435738B2 (en)	2003-08-18	2008-10-14	Solvay Pharmaceuticals, Inc.	Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
AR045362A1 (es) *	2003-08-18	2005-10-26	Solvay Pharm Bv	Forma cristalina estable de mesilato de bifeprunox (monometansulfonato de 7-[4-([1,1- bifenil] -3- ilmetil) -1- piperazinil] - 2-(3h) -benzoxazolona
AR049478A1 (es)	2004-03-25	2006-08-09	Solvay Pharm Bv	Un procedimiento para la preparacion de 3-amino-8-(1-piperazinil)-2h-1-benzopiran-2-ona. sales e hidratos y composiciones farmaceuticas.
AR048112A1 (es) *	2004-03-25	2006-03-29	Solvay Pharm Bv	Derivados de 1-(2h-1-benzopiran-2-on-8-il)-piperazina para el tratamiento de dolor
US20050215551A1 (en) *	2004-03-25	2005-09-29	Solvay Pharmaceuticals B.V.	1-[2H-1-benzopyran-2-one-8-yl]- piperazine derivatives for the treatment of movement disorders
US7405216B2 (en)	2004-08-18	2008-07-29	Solvay Pharmaceuticals, B.V.	Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7371769B2 (en)	2004-12-07	2008-05-13	Solvay Pharmaceuticals B.V.	Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20070072870A2 (en)	2004-12-08	2007-03-29	Solvay Pharmeceuticals B.V.	Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
US7964604B2 (en)	2005-02-18	2011-06-21	Solvay Pharmaceuticals B.V.	Bifeprunox mesylate maintenance dose compositions and methods for using the same
US7423040B2 (en)	2005-02-18	2008-09-09	Irene Eijgendaal	Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
TWI320783B (en)	2005-04-14	2010-02-21	Otsuka Pharma Co Ltd	Heterocyclic compound
AR058022A1 (es) *	2005-08-22	2008-01-23	Solvay Pharm Bv	Derivados de benzooxazoles, composiciones farmaceuticas y su uso para el tratamiento de desordenes del sistema nervioso.
US7750013B2 (en)	2005-08-22	2010-07-06	Solvay Pharmaceuticals, B.V.	N-oxides as prodrugs of piperazine and piperidine derivatives
KR20080046205A (ko) *	2005-08-22	2008-05-26	솔베이 파마슈티칼스 비. 브이	프로드럭으로서 피페라진 및 피페리딘 유도체의 ｎ-산화물
US8106056B2 (en)	2006-06-16	2012-01-31	Solvay Pharmaceuticals B.V.	Combination preparations comprising bifeprunox and a dopamine agonist
US7786126B2 (en)	2006-06-16	2010-08-31	Solvay Pharmaceuticals B.V.	Combination preparations comprising SLV308 and a dopamine agonist
AU2007291234A1 (en)	2006-08-31	2008-03-06	Solvay Pharmaceuticals B.V.	Titration schedule for bifeprunox for treating schizophrenia and kits for use therein
TW200840566A (en) *	2006-12-22	2008-10-16	Esteve Labor Dr	Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
US20080299217A1 (en) *	2007-06-01	2008-12-04	Protia, Llc	Deuterium-enriched bifeprunox
KR20100098653A (ko) *	2007-11-21	2010-09-08	디코드 제네틱스 이에이치에프	염증의 치료를 위한 바이아릴 ｐｄｅ４ 억제제
US20110105523A1 (en) *	2008-01-15	2011-05-05	Van Stuivenberg Herman H	Bifeprunox derivatives
EA018974B9 (ru)	2008-02-05	2014-04-30	Харбор Терапьютикс, Инк.	Твердые лекарственные формы
US8853202B2 (en) *	2008-11-04	2014-10-07	Chemocentryx, Inc.	Modulators of CXCR7
US20110014121A1 (en) *	2008-11-04	2011-01-20	Chemocentryx, Inc.	Modulators of cxcr7
MX2011004490A (es) *	2008-11-04	2011-07-20	Chemocentryx Inc	Moduladores de cxcr7.
LT2445502T (lt)	2009-06-25	2017-09-25	Alkermes Pharma Ireland Limited	Heterocikliniai junginiai, skirti neurologinių ir fiziologinių susirgimų gydymui
CA2937222C (en) *	2009-06-25	2019-06-04	Alkermes Pharma Ireland Limited	Prodrugs of nh-acidic compounds
WO2011023796A1 (en)	2009-08-31	2011-03-03	Abbott Healthcare Products B.V.	Bifeprunox for treating addiction
PL395469A1 (pl)	2011-06-29	2013-01-07	Adamed Spólka Z Ograniczona Odpowiedzialnoscia	Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego
JP6272897B2 (ja)	2012-11-29	2018-01-31	ケモセントリックス，インコーポレイティド	Ｃｘｃｒ７アンタゴニスト
US11103499B2 (en)	2016-08-26	2021-08-31	EXCIVA (UG) (haftungsbeschränkt)	Compositions and methods thereof
EP3761983A1 (de)	2018-03-05	2021-01-13	Alkermes Pharma Ireland Limited	Dosierstrategie für aripiprazol
MX2021006915A (es)	2018-12-12	2021-08-24	Chemocentryx Inc	Inhibidores de cxcr7 para el tratamiento de cancer.
CN114246869A (zh) *	2022-01-18	2022-03-29	万宜合药业(海南)有限责任公司	联苯芦诺及其衍生物的抗肿瘤活性和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2263211A1 (de) *	1972-12-23	1974-07-04	Boehringer Sohn Ingelheim	Neue arylpiperazine und verfahren zu ihrer herstellung
JPS5777676A (en)	1980-10-31	1982-05-15	Otsuka Pharmaceut Co Ltd	Carbostyril derivative
EP0185429A1 (de) *	1984-12-21	1986-06-25	Duphar International Research B.V	Bizyklische Piperazine
DE3586794T2 (de) *	1984-12-21	1993-05-27	Duphar Int Res	Arzneimittel mit psychotroper wirkung.
EP0241053B1 (de) *	1986-02-27	1992-11-11	Duphar International Research B.V	Aryl-substituierte(N-piperidinyl)methyl und (N-piperazinyl)methylazole mit antipsychotischer Wirkung
FR2602771B1 (fr) *	1986-08-12	1988-11-04	Rhone Poulenc Sante	Nouveaux derives de la benzyl-4 piperazine, leur preparation et les compositions pharmaceutiques qui les contiennent
WO1990006303A1 (en)	1988-12-02	1990-06-14	Pfizer Inc.	Arylpiperidine derivatives
US5240942A (en)	1990-07-10	1993-08-31	Adir Et Compagnie	Piperidine, tetrahydropyridine and pyrrolidine compounds
US5242933A (en)	1990-07-10	1993-09-07	Adir Et Compagnie	Piperidine, tetrahydropyridine and pyrrolidine compounds
US5260317A (en)	1990-07-10	1993-11-09	Adir Et Compagnie	Piperidine, tetrahydropyridine and pyrrolidine compounds
FR2664592B1 (fr)	1990-07-10	1994-09-02	Adir	Nouveaux derives de la piperidine, de la tetrahydropyridine et de la pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4127849A1 (de) *	1991-08-22	1993-02-25	Merck Patent Gmbh	Benzodioxanderivate
NZ240863A (en) *	1991-09-11	1995-04-27	Mcneilab Inc	Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
US5569659A (en)	1991-09-11	1996-10-29	Mcneilab, Inc.	4-arylpiperazines and 4-arylpiperidines
US5436246A (en)	1992-09-17	1995-07-25	Merrell Dow Pharmaceuticals Inc.	Serotonin receptor agents
DK148392D0 (da) *	1992-12-09	1992-12-09	Lundbeck & Co As H	Heterocykliske forbindelser
GB9314758D0 (en)	1993-07-16	1993-08-25	Wyeth John & Brother Ltd	Heterocyclic derivatives
EP0650964A1 (de)	1993-11-02	1995-05-03	Duphar International Research B.V	1- 2H-1-Benzopyran-2-on-8-yl -Piperazin Derivate

1997
- 1997-03-20 DE DE69736704T patent/DE69736704T2/de not_active Expired - Lifetime
- 1997-03-20 RU RU98119523/04A patent/RU2178414C2/ru not_active IP Right Cessation
- 1997-03-20 US US09/155,608 patent/US6225312B1/en not_active Expired - Lifetime
- 1997-03-20 CN CN97193520A patent/CN1100055C/zh not_active Expired - Fee Related
- 1997-03-20 AT AT97908288T patent/ATE340173T1/de active
- 1997-03-20 UA UA98105745A patent/UA52656C2/uk unknown
- 1997-03-20 AU AU20294/97A patent/AU708053B2/en not_active Ceased
- 1997-03-20 DK DK97908288T patent/DK0889889T3/da active
- 1997-03-20 PL PL97329123A patent/PL189256B1/pl not_active IP Right Cessation
- 1997-03-20 WO PCT/EP1997/001461 patent/WO1997036893A1/en not_active Ceased
- 1997-03-20 TR TR1998/01942T patent/TR199801942T2/xx unknown
- 1997-03-20 EP EP97908288A patent/EP0889889B1/de not_active Expired - Lifetime
- 1997-03-20 CZ CZ19983068A patent/CZ294413B6/cs not_active IP Right Cessation
- 1997-03-20 JP JP53488697A patent/JP3989554B2/ja not_active Expired - Fee Related
- 1997-03-20 PT PT97908288T patent/PT889889E/pt unknown
- 1997-03-20 SK SK1331-98A patent/SK285119B6/sk not_active IP Right Cessation
- 1997-03-20 ES ES97908288T patent/ES2271967T3/es not_active Expired - Lifetime
- 1997-03-20 HU HU9902471A patent/HU227454B1/hu not_active IP Right Cessation
- 1997-03-20 BR BRPI9708389A patent/BRPI9708389B8/pt not_active IP Right Cessation
- 1997-03-20 IL IL12618797A patent/IL126187A0/xx not_active IP Right Cessation
- 1997-03-20 NZ NZ331860A patent/NZ331860A/xx not_active IP Right Cessation
- 1997-03-20 CA CA002250347A patent/CA2250347C/en not_active Expired - Fee Related
- 1997-03-26 ZA ZA9702639A patent/ZA972639B/xx unknown
- 1997-03-28 TW TW086104056A patent/TW422846B/zh not_active IP Right Cessation
1998
- 1998-09-28 NO NO19984533A patent/NO320970B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO320970B1 (no)	2006-02-20
HUP9902471A2 (hu)	2000-03-28
HU227454B1 (en)	2011-06-28
CA2250347C (en)	2006-02-21
SK133198A3 (en)	1999-02-11
NO984533D0 (no)	1998-09-28
JP3989554B2 (ja)	2007-10-10
AU708053B2 (en)	1999-07-29
JP2000507949A (ja)	2000-06-27
DK0889889T3 (da)	2007-01-29
CN1215400A (zh)	1999-04-28
DE69736704D1 (de)	2006-11-02
IL126187A0 (en)	1999-05-09
PT889889E (pt)	2007-01-31
AU2029497A (en)	1997-10-22
DE69736704T2 (de)	2007-09-13
WO1997036893A1 (en)	1997-10-09
CZ294413B6 (cs)	2004-12-15
PL329123A1 (en)	1999-03-15
CA2250347A1 (en)	1997-10-09
PL189256B1 (pl)	2005-07-29
RU2178414C2 (ru)	2002-01-20
ES2271967T3 (es)	2007-04-16
CZ306898A3 (cs)	1999-01-13
NZ331860A (en)	2000-04-28
HUP9902471A3 (en)	2000-04-28
SK285119B6 (sk)	2006-06-01
BR9708389B1 (pt)	2009-12-01
EP0889889A1 (de)	1999-01-13
EP0889889B1 (de)	2006-09-20
NO984533L (no)	1998-11-02
TR199801942T2 (xx)	2000-08-21
ZA972639B (en)	1997-10-02
US6225312B1 (en)	2001-05-01
UA52656C2 (uk)	2003-01-15
CN1100055C (zh)	2003-01-29
TW422846B (en)	2001-02-21
BRPI9708389B8 (pt)	2015-12-08
BR9708389A (pt)	2000-01-04

Legal Events

Date

Code

Title

Description

2007-03-15

UEP

Publication of translation of european patent specification

Ref document number: 0889889

Country of ref document: EP

Publication	Publication Date	Title
ATE340173T1 (de)	2006-10-15	Piperazin- und piperidin- derivate
ATE317378T1 (de)	2006-02-15	Triphenylalkenderivate und ihre anwendung als selektive modulatoren des östrogenrezeptors
TNSN07255A1 (en)	2008-12-31	Cyclohexylamides as dopamine d3, d2 and 5ht 1a antagonists
ECSP941146A (es)	1995-01-16	Derivados de benzofurano
MY110142A (en)	1998-02-28	Thiazolidinedione derivatives, their production and use
UA66756C2 (uk)	2004-06-15	Сполуки піперазину та піперидину, спосіб одержання сполук та спосіб лікування розладів центральної нервової системи
BG106961A (en)	2003-04-30	Phenylpiperazinyl derivatives
HUP0001165A2 (hu)	2000-11-28	NK1 és NK2 antagonista hatású acil-amino-alkil-amid-származékok, a vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra
SG152900A1 (en)	2009-06-29	4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives
DE69819266D1 (de)	2003-12-04	Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
DK1559714T3 (da)	2008-03-25	Fremgangsmåde til fremstilling af 2-alkyl-3-aminothiophenderivater og 3-aminothiophenderivater
MA24197A1 (fr)	1997-12-31	Nouvelles fungarrestines
HUP0300786A2 (hu)	2003-07-28	A központi idegrendszer megbetegedéseinek kezelésére alkalmas indolszármazékok és ezeket tartalmazó gyógyszerkészítmények
ATE259800T1 (de)	2004-03-15	Substituierte 5-(2,2difluor-1,3-benzodioxol-5-yl) cyclopentenopyridinderivate
UY28163A1 (es)	2005-04-29	Compuestos de piperazina y piperidina
ECSP972301A (es)	1998-12-14	Triciclicos sustituidos