ATE340173T1 - Piperazin- und piperidin- derivate - Google Patents

Piperazin- und piperidin- derivate

Info

Publication number: ATE340173T1
Authority: AT; Austria
Prior art keywords: group; alkyl; alkoxy; halogen; nitrogen
Prior art date: 1996-03-29

Application number

AT97908288T

Other languages

English (en)

Inventor

Roelof Willem Feenstra

Cornelis Gerrit Kruse

Martinus Theodorus Maria Tulp

Wilma Kuipers

Stephen Kenneth Long

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-29

Filing date

1997-03-20

Publication date

2006-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8223832&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE340173(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-03-20 Application filed by Duphar Int Res filed Critical Duphar Int Res

2006-10-15 Application granted granted Critical

2006-10-15 Publication of ATE340173T1 publication Critical patent/ATE340173T1/de

Links

GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 4
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
229910052757 nitrogen Inorganic materials 0.000 abstract 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
102000017911 HTR1A Human genes 0.000 abstract 1
101150015707 HTR1A gene Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 cyano, aminocarbonyl Chemical group 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003053 piperidines Chemical class 0.000 abstract 1
125000006413 ring segment Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Indole Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Quinoline Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT97908288T 1996-03-29 1997-03-20 Piperazin- und piperidin- derivate ATE340173T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP96200864		1996-03-29

Publications (1)

Publication Number	Publication Date
ATE340173T1 true ATE340173T1 (de)	2006-10-15

Family

ID=8223832

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97908288T ATE340173T1 (de)	1996-03-29	1997-03-20	Piperazin- und piperidin- derivate

Country Status (25)

Country	Link
US (1)	US6225312B1 (de)
EP (1)	EP0889889B1 (de)
JP (1)	JP3989554B2 (de)
CN (1)	CN1100055C (de)
AT (1)	ATE340173T1 (de)
AU (1)	AU708053B2 (de)
BR (1)	BRPI9708389B8 (de)
CA (1)	CA2250347C (de)
CZ (1)	CZ294413B6 (de)
DE (1)	DE69736704T2 (de)
DK (1)	DK0889889T3 (de)
ES (1)	ES2271967T3 (de)
HU (1)	HU227454B1 (de)
IL (1)	IL126187A0 (de)
NO (1)	NO320970B1 (de)
NZ (1)	NZ331860A (de)
PL (1)	PL189256B1 (de)
PT (1)	PT889889E (de)
RU (1)	RU2178414C2 (de)
SK (1)	SK285119B6 (de)
TR (1)	TR199801942T2 (de)
TW (1)	TW422846B (de)
UA (1)	UA52656C2 (de)
WO (1)	WO1997036893A1 (de)
ZA (1)	ZA972639B (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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TW530054B (en)	1997-09-24	2003-05-01	Duphar Int Res	New piperazine and piperidine compounds
JP2002519323A (ja) *	1998-06-30	2002-07-02	イーライ・リリー・アンド・カンパニー	セロトニン関連系に効果を及ぼすピペリジン誘導体
EP1146045A1 (de) *	1998-06-30	2001-10-17	Eli Lilly And Company	Auf Serotonin-verwandte Systeme wirkende Piperidin-Derivate
UA71590C2 (en) *	1998-11-13	2004-12-15	Duphar Int Res	Piperazine and piperidine derivatives
WO2001009123A1 (en) *	1999-07-29	2001-02-08	Eli Lilly And Company	Benzofurylpiperazine serotonin agonists
DK1204654T3 (da)	1999-07-29	2003-11-17	Lilly Co Eli	Benzofurylpiperaziner og benzofurylhomopiperaziner: Serotonin agonister
US6911448B2 (en)	2000-05-12	2005-06-28	Solvay Pharmaceuticals B.V.	Piperazine and piperidine compounds
WO2001085168A1 (en) *	2000-05-12	2001-11-15	Solvay Pharmaceuticals B.V.	Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders
KR100791799B1 (ko)	2000-05-12	2008-01-04	솔베이 파마슈티칼스 비. 브이	피페라진 및 피페리딘 화합물 및 이의 제조방법
AR034206A1 (es) *	2001-02-16	2004-02-04	Solvay Pharm Bv	Un procedimiento para la preparacion de mesilatos de derivados de piperazina y dichos mesilatos
US7504395B2 (en) *	2001-07-20	2009-03-17	Psychogenics, Inc.	Treatment for attention-deficit hyperactivity disorder
EP1562918B1 (de) *	2002-11-08	2008-01-16	F. Hoffmann-La Roche Ag	Substituierte benzoxazinones und ihre verwendung
EP1602655A4 (de) *	2003-03-07	2010-06-09	Kowa Co	Benzofuranderivat
GB0316915D0 (en) *	2003-07-18	2003-08-20	Glaxo Group Ltd	Compounds
ES2232292B1 (es) *	2003-07-30	2006-11-01	Laboratorios Del Dr. Esteve, S.A.	Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos.
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AR049478A1 (es)	2004-03-25	2006-08-09	Solvay Pharm Bv	Un procedimiento para la preparacion de 3-amino-8-(1-piperazinil)-2h-1-benzopiran-2-ona. sales e hidratos y composiciones farmaceuticas.
US7405216B2 (en)	2004-08-18	2008-07-29	Solvay Pharmaceuticals, B.V.	Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7371769B2 (en)	2004-12-07	2008-05-13	Solvay Pharmaceuticals B.V.	Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US8101619B2 (en)	2004-12-08	2012-01-24	Solvay Pharmaceuticals B.V.	Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
US7964604B2 (en)	2005-02-18	2011-06-21	Solvay Pharmaceuticals B.V.	Bifeprunox mesylate maintenance dose compositions and methods for using the same
US7423040B2 (en)	2005-02-18	2008-09-09	Irene Eijgendaal	Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
TWI320783B (en)	2005-04-14	2010-02-21	Otsuka Pharma Co Ltd	Heterocyclic compound
ATE417834T1 (de) *	2005-08-22	2009-01-15	Solvay Pharm Bv	N-oxide als prodrugs von piperazin- und piperidinderivaten
AR058022A1 (es) *	2005-08-22	2008-01-23	Solvay Pharm Bv	Derivados de benzooxazoles, composiciones farmaceuticas y su uso para el tratamiento de desordenes del sistema nervioso.
US7750013B2 (en)	2005-08-22	2010-07-06	Solvay Pharmaceuticals, B.V.	N-oxides as prodrugs of piperazine and piperidine derivatives
US7786126B2 (en)	2006-06-16	2010-08-31	Solvay Pharmaceuticals B.V.	Combination preparations comprising SLV308 and a dopamine agonist
US8106056B2 (en)	2006-06-16	2012-01-31	Solvay Pharmaceuticals B.V.	Combination preparations comprising bifeprunox and a dopamine agonist
AU2007291234A1 (en)	2006-08-31	2008-03-06	Solvay Pharmaceuticals B.V.	Titration schedule for bifeprunox for treating schizophrenia and kits for use therein
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1997
- 1997-03-20 AU AU20294/97A patent/AU708053B2/en not_active Ceased
- 1997-03-20 TR TR1998/01942T patent/TR199801942T2/xx unknown
- 1997-03-20 WO PCT/EP1997/001461 patent/WO1997036893A1/en not_active Ceased
- 1997-03-20 IL IL12618797A patent/IL126187A0/xx not_active IP Right Cessation
- 1997-03-20 PT PT97908288T patent/PT889889E/pt unknown
- 1997-03-20 AT AT97908288T patent/ATE340173T1/de active
- 1997-03-20 EP EP97908288A patent/EP0889889B1/de not_active Expired - Lifetime
- 1997-03-20 NZ NZ331860A patent/NZ331860A/xx not_active IP Right Cessation
- 1997-03-20 US US09/155,608 patent/US6225312B1/en not_active Expired - Lifetime
- 1997-03-20 DE DE69736704T patent/DE69736704T2/de not_active Expired - Lifetime
- 1997-03-20 JP JP53488697A patent/JP3989554B2/ja not_active Expired - Fee Related
- 1997-03-20 UA UA98105745A patent/UA52656C2/uk unknown
- 1997-03-20 RU RU98119523/04A patent/RU2178414C2/ru not_active IP Right Cessation
- 1997-03-20 PL PL97329123A patent/PL189256B1/pl not_active IP Right Cessation
- 1997-03-20 ES ES97908288T patent/ES2271967T3/es not_active Expired - Lifetime
- 1997-03-20 CN CN97193520A patent/CN1100055C/zh not_active Expired - Fee Related
- 1997-03-20 CA CA002250347A patent/CA2250347C/en not_active Expired - Fee Related
- 1997-03-20 CZ CZ19983068A patent/CZ294413B6/cs not_active IP Right Cessation
- 1997-03-20 DK DK97908288T patent/DK0889889T3/da active
- 1997-03-20 HU HU9902471A patent/HU227454B1/hu not_active IP Right Cessation
- 1997-03-20 BR BRPI9708389A patent/BRPI9708389B8/pt not_active IP Right Cessation
- 1997-03-20 SK SK1331-98A patent/SK285119B6/sk not_active IP Right Cessation
- 1997-03-26 ZA ZA9702639A patent/ZA972639B/xx unknown
- 1997-03-28 TW TW086104056A patent/TW422846B/zh not_active IP Right Cessation
1998
- 1998-09-28 NO NO19984533A patent/NO320970B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69736704D1 (de)	2006-11-02
NO320970B1 (no)	2006-02-20
JP3989554B2 (ja)	2007-10-10
BR9708389B1 (pt)	2009-12-01
TR199801942T2 (xx)	2000-08-21
HUP9902471A3 (en)	2000-04-28
US6225312B1 (en)	2001-05-01
PL329123A1 (en)	1999-03-15
HU227454B1 (en)	2011-06-28
CN1215400A (zh)	1999-04-28
NZ331860A (en)	2000-04-28
PT889889E (pt)	2007-01-31
DE69736704T2 (de)	2007-09-13
IL126187A0 (en)	1999-05-09
BRPI9708389B8 (pt)	2015-12-08
UA52656C2 (uk)	2003-01-15
RU2178414C2 (ru)	2002-01-20
DK0889889T3 (da)	2007-01-29
EP0889889B1 (de)	2006-09-20
ZA972639B (en)	1997-10-02
NO984533D0 (no)	1998-09-28
ES2271967T3 (es)	2007-04-16
BR9708389A (pt)	2000-01-04
CN1100055C (zh)	2003-01-29
TW422846B (en)	2001-02-21
CA2250347A1 (en)	1997-10-09
WO1997036893A1 (en)	1997-10-09
CA2250347C (en)	2006-02-21
EP0889889A1 (de)	1999-01-13
AU2029497A (en)	1997-10-22
AU708053B2 (en)	1999-07-29
JP2000507949A (ja)	2000-06-27
SK285119B6 (sk)	2006-06-01
SK133198A3 (en)	1999-02-11
CZ294413B6 (cs)	2004-12-15
CZ306898A3 (cs)	1999-01-13
NO984533L (no)	1998-11-02
PL189256B1 (pl)	2005-07-29
HUP9902471A2 (hu)	2000-03-28

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