NO20040198L - Dolastatin 10 derivater - Google Patents

Dolastatin 10 derivater

Info

Publication number
NO20040198L
NO20040198L NO20040198A NO20040198A NO20040198L NO 20040198 L NO20040198 L NO 20040198L NO 20040198 A NO20040198 A NO 20040198A NO 20040198 A NO20040198 A NO 20040198A NO 20040198 L NO20040198 L NO 20040198L
Authority
NO
Norway
Prior art keywords
dolastatin
derivatives
Prior art date
Application number
NO20040198A
Other languages
English (en)
Norwegian (no)
Inventor
Toshihiko Fujii
Takehiro Okada
Mikio Taniguchi
Fumio Watanabe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20040198L publication Critical patent/NO20040198L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20040198A 2001-07-19 2004-01-16 Dolastatin 10 derivater NO20040198L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01117410 2001-07-19
PCT/EP2002/007931 WO2003008378A1 (en) 2001-07-19 2002-07-17 Dolastatin 10 derivatives

Publications (1)

Publication Number Publication Date
NO20040198L true NO20040198L (no) 2004-02-19

Family

ID=8178073

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20040198A NO20040198L (no) 2001-07-19 2004-01-16 Dolastatin 10 derivater

Country Status (30)

Country Link
US (1) US6737409B2 (de)
EP (1) EP1412328B1 (de)
JP (1) JP2004534859A (de)
KR (2) KR100611540B1 (de)
CN (1) CN1553897A (de)
AR (1) AR036175A1 (de)
AT (1) ATE341537T1 (de)
BR (1) BR0211289A (de)
CA (1) CA2453987A1 (de)
CO (1) CO5550462A2 (de)
DE (1) DE60215179T2 (de)
DK (1) DK1412328T3 (de)
ES (1) ES2272763T3 (de)
GT (1) GT200200154A (de)
HR (1) HRP20040043A2 (de)
HU (1) HUP0401253A2 (de)
IL (1) IL159890A0 (de)
MX (1) MXPA04000577A (de)
MY (1) MY127718A (de)
NO (1) NO20040198L (de)
NZ (1) NZ530655A (de)
PA (1) PA8551001A1 (de)
PE (1) PE20030258A1 (de)
PL (1) PL367682A1 (de)
PT (1) PT1412328E (de)
RU (1) RU2296750C2 (de)
SI (1) SI1412328T1 (de)
UY (1) UY27388A1 (de)
WO (1) WO2003008378A1 (de)
ZA (1) ZA200400334B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
CA2479764C (en) 2002-03-22 2013-07-30 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
US7064211B2 (en) 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
ES2544527T3 (es) 2002-07-31 2015-09-01 Seattle Genetics, Inc. Conjugados de fármacos y su uso para tratar el cáncer, una enfermedad autoinmune o una enfermedad infecciosa
EP3434275A1 (de) 2003-11-06 2019-01-30 Seattle Genetics, Inc. Auf die verwendung von auristatin-konjugaten mit antikörpern basierter nachweis für krebszellen
US7312343B2 (en) * 2004-06-02 2007-12-25 Hoffmann-La Roche Inc. Synthesis of α-amino-β-alkoxy-carboxylic acid esters
JP2008519863A (ja) 2004-11-12 2008-06-12 シアトル ジェネティクス インコーポレイティッド Ｎ末端にアミノ安息香酸単位を有するオーリスタチン
BRPI0519023A2 (pt) * 2004-12-13 2008-12-23 Hoffmann La Roche composiÇço farmacÊutica contendo pelo menos um derivado de dolastatina 10
EP1828117A1 (de) * 2004-12-13 2007-09-05 F. Hoffmann-Roche AG Neues verfahren zur herstellung von 3-pyrrolidin-2-yl-propionsäurederivaten
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
BRPI0605940A2 (pt) * 2005-01-13 2009-05-26 Hoffmann La Roche sìntese de aminas dissubstituìdas úteis em uma etapa
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
WO2007008848A2 (en) * 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
JP5171621B2 (ja) 2005-07-07 2013-03-27 シアトル ジェネティックス， インコーポレイテッド フェニルアラニン側鎖修飾をｃ末端に有するモノメチルバリン化合物
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
SG10201407457UA (en) 2006-05-16 2014-12-30 Pharmascience Inc Iap bir domain binding compounds
US20080003652A1 (en) * 2006-06-28 2008-01-03 Hans Iding Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s)
ES2528922T3 (es) 2007-07-16 2015-02-13 Genentech, Inc. Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso
ATE543835T1 (de) 2007-07-16 2012-02-15 Genentech Inc Anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren
PT2247620T (pt) 2008-01-31 2016-08-23 Genentech Inc Anticorpos e imunoconjugados anti-cd79b e métodos de utilização
EP2265283B1 (de) 2008-03-18 2014-09-03 Seattle Genetics, Inc. Auristatin-arznei-linker-konjugate
US9173961B2 (en) 2010-02-10 2015-11-03 Immunogen, Inc. CD20 antibodies and uses thereof
MX340870B (es) 2010-02-12 2016-07-27 Pharmascience Inc Compuestos de unión del dominio de repetición de inhibidores de proteínas de apoptosis de baculovirus.
CA2801971C (en) 2010-06-10 2018-07-24 Hans-Georg Lerchen Novel auristatin derivatives and their use
ES2553874T3 (es) 2010-09-29 2015-12-14 Seattle Genetics, Inc. N-Carboxialquil-auristatinas y su uso
CA2829736C (en) 2011-03-16 2020-07-21 Seattle Genetics, Inc. N-carboxyalkylauristatins and use thereof
CN103717595A (zh) 2011-05-27 2014-04-09 Ambrx公司 含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途
EP2714685B1 (de) * 2011-05-27 2016-10-19 Ambrx, Inc. Zusammensetzungen, enthaltend mit nichtnatürlichen aminosäuren verknüpfte dolastatin-derivate, sowie verfahren dafür und anwendungen davon
ES2604766T3 (es) 2012-09-20 2017-03-09 Celltrion, Inc. Derivado de dolastatina-10, procedimiento de producción del mismo y composición de fármaco anticanceroso que contiene el mismo
ES2916722T3 (es) 2013-12-27 2022-07-05 Zymeworks Inc Sistemas de enlace que contienen sulfonamida para conjugados de fármacos
DK3262071T3 (da) 2014-09-23 2020-06-15 Hoffmann La Roche Fremgangsmåde til anvendelse af anti-CD79b-immunkonjugater
CN105949277B (zh) * 2015-05-05 2019-03-01 成都永泰诺科技有限公司 一种抗肿瘤化合物及其用途
WO2017170637A1 (ja) * 2016-03-29 2017-10-05 東レ株式会社 ペプチド誘導体及びその用途
CN109021065B (zh) * 2017-06-08 2021-10-01 复旦大学 一种制备海兔毒素Dolastatin10的方法
CN119455003A (zh) 2019-02-12 2025-02-18 Ambrx公司 包含抗体-tlr激动剂缀合物的组合物、方法和用途
EP4400121A1 (de) 2021-09-03 2024-07-17 Toray Industries, Inc. Pharmazeutische zusammensetzung zur behandlung und/oder prävention von krebs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2700165B1 (fr) * 1993-01-07 1995-02-17 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides

Also Published As

Publication number Publication date
MY127718A (en) 2006-12-29
UY27388A1 (es) 2003-01-31
BR0211289A (pt) 2004-08-03
GT200200154A (es) 2003-05-16
EP1412328B1 (de) 2006-10-04
PA8551001A1 (es) 2003-09-17
IL159890A0 (en) 2004-06-20
KR20060057652A (ko) 2006-05-26
ATE341537T1 (de) 2006-10-15
AR036175A1 (es) 2004-08-18
RU2296750C2 (ru) 2007-04-10
PT1412328E (pt) 2007-01-31
US6737409B2 (en) 2004-05-18
KR100611540B1 (ko) 2006-08-10
SI1412328T1 (sl) 2007-02-28
US20030055002A1 (en) 2003-03-20
RU2004105145A (ru) 2005-07-10
CO5550462A2 (es) 2005-08-31
DE60215179D1 (de) 2006-11-16
HUP0401253A2 (hu) 2004-12-28
CA2453987A1 (en) 2003-01-30
CN1553897A (zh) 2004-12-08
EP1412328A1 (de) 2004-04-28
JP2004534859A (ja) 2004-11-18
HRP20040043A2 (en) 2004-08-31
PE20030258A1 (es) 2003-03-19
MXPA04000577A (es) 2004-04-20
ES2272763T3 (es) 2007-05-01
WO2003008378A1 (en) 2003-01-30
KR20040023661A (ko) 2004-03-18
DE60215179T2 (de) 2007-10-18
DK1412328T3 (da) 2007-02-12
PL367682A1 (en) 2005-03-07
NZ530655A (en) 2006-08-31
ZA200400334B (en) 2005-06-29

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Legal Events

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