ATE348896T1 - Bestimmung von nukleinsäuren - Google Patents

Bestimmung von nukleinsäuren

Info

Publication number
ATE348896T1
ATE348896T1 AT03702748T AT03702748T ATE348896T1 AT E348896 T1 ATE348896 T1 AT E348896T1 AT 03702748 T AT03702748 T AT 03702748T AT 03702748 T AT03702748 T AT 03702748T AT E348896 T1 ATE348896 T1 AT E348896T1
Authority
AT
Austria
Prior art keywords
group
determination
nucleic acids
moiety
substituted
Prior art date
Application number
AT03702748T
Other languages
English (en)
Inventor
Helen Braven
Russell Keay
Original Assignee
Atlas Genetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atlas Genetics Ltd filed Critical Atlas Genetics Ltd
Application granted granted Critical
Publication of ATE348896T1 publication Critical patent/ATE348896T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/308—Electrodes, e.g. test electrodes; Half-cells at least partially made of carbon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Food Science & Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AT03702748T 2002-03-07 2003-02-11 Bestimmung von nukleinsäuren ATE348896T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0205455.9A GB0205455D0 (en) 2002-03-07 2002-03-07 Nucleic acid probes, their synthesis and use

Publications (1)

Publication Number Publication Date
ATE348896T1 true ATE348896T1 (de) 2007-01-15

Family

ID=9932564

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03702748T ATE348896T1 (de) 2002-03-07 2003-02-11 Bestimmung von nukleinsäuren
AT06026271T ATE427313T1 (de) 2002-03-07 2003-02-11 Elektrochemisch aktive verbindungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06026271T ATE427313T1 (de) 2002-03-07 2003-02-11 Elektrochemisch aktive verbindungen

Country Status (10)

Country Link
US (4) US9127308B2 (de)
EP (2) EP1808494B1 (de)
JP (2) JP4381819B2 (de)
AT (2) ATE348896T1 (de)
AU (1) AU2003205870A1 (de)
DE (2) DE60310532T2 (de)
DK (1) DK1481083T3 (de)
ES (2) ES2279092T3 (de)
GB (1) GB0205455D0 (de)
WO (1) WO2003074731A2 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10327756B4 (de) * 2003-06-18 2005-12-29 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Verfahren zum Echtzeit-Quantifizieren einer Nukleinsäure
GB0316075D0 (en) * 2003-07-09 2003-08-13 Molecular Sensing Plc Protease detection assay
ES2348130T3 (es) 2004-02-26 2010-11-30 Delta Dansk Elektronik, Lys Og Akustik Procedimiento, chip, dispositivo y sistema de extracción de materiales biológicos.
JP4671058B2 (ja) 2004-02-26 2011-04-13 デルタ，ダンスク エレクトロニック，リス アンド アクスティック 生物学的粒子を収集する方法、チップ、装置、及びシステム
JP4750781B2 (ja) 2004-02-26 2011-08-17 デルタ，ダンスク エレクトロニック，リス アンド アクスティック 生体粒子を検出するための方法、チップ、装置及び統合システム
JP2006182757A (ja) * 2004-10-06 2006-07-13 Japan Science & Technology Agency π共役型電気化学活性非天然ヌクレオシドを用いる相補鎖核酸分子配列検出方法及びＳＮＰ検出方法
GB2419880B (en) * 2004-10-22 2008-04-30 E2V Tech Monitoring enzyme-substrate reactions
US8551697B1 (en) 2005-12-09 2013-10-08 Applied Biosystems, Llc Electrochemical polynucleotide detection comprising ligation
US20100320096A1 (en) * 2007-02-06 2010-12-23 Toppan Printing Co., Ltd. Biomolecules detection method and biomolecules detection chip
ES2310125B1 (es) * 2007-05-25 2010-01-07 Universidad Autonoma De Madrid Metodo para la deteccion electroquimica de secuencias de acidos nucleicos.
ES2353706B1 (es) * 2008-11-21 2012-01-25 Universidad Politecnica De Valencia Celda electroquímica de generación de gases para el análisis de procesos electroquímicos.
GB0922097D0 (en) 2009-12-17 2010-02-03 Atlas Genetics Ltd Microbial assay
GB201021896D0 (en) 2010-12-22 2011-02-02 Atlas Genetics Ltd Novel compounds and their use in analytical methods
MX352460B (es) 2011-01-11 2017-11-24 Seegene Inc Detección de secuencias de ácido nucleico objetivo mediante ensayo de escisión y extensión del pto.
US11078525B2 (en) 2011-03-29 2021-08-03 Seegene, Inc. Detection of target nucleic acid sequence by PTO cleavage and extension-dependent cleavage
US20140045190A1 (en) * 2011-04-19 2014-02-13 The Hong Kong University Of Science And Technology Method and device for monitoring real-time polymerase chain reaction (pcr) utilizing electro-active hydrolysis probe (e-tag probe)
WO2012150749A1 (en) 2011-05-04 2012-11-08 Seegene, Inc. Detection of target nucleic acid sequences by po cleavage and hybridization
CN103159801B (zh) * 2011-12-08 2016-09-07 天承南运(天津)科技有限公司 N-二茂铁基-n′-芳基脲化合物及其应用
KR20130101952A (ko) 2012-02-02 2013-09-16 주식회사 씨젠 Ｐｔｏ 절단과 연장-의존적 혼성화를 이용한 타겟 핵산서열의 검출
CA2864523C (en) 2012-03-05 2019-02-05 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence by pto cleavage and extension assay
CN102702271A (zh) * 2012-05-23 2012-10-03 新乡医学院 新型二茂铁衍生物的制备方法及其应用
GB201211157D0 (en) 2012-06-22 2012-08-08 Atlas Genetics Ltd Novel compounds and their use in analytical methods
AU2013371128B2 (en) * 2012-12-27 2017-08-10 Seegene, Inc. Detection of target nucleic acid sequence by PTO Cleavage and Extension-Dependent Non-Hybridization assay
GB201312995D0 (en) 2013-07-19 2013-09-04 Atlas Genetics Ltd Methods and kits for specific nucleic acid amplification and detection
GB2516669B (en) 2013-07-29 2015-09-09 Atlas Genetics Ltd A method for processing a liquid sample in a fluidic cartridge
GB2516675A (en) 2013-07-29 2015-02-04 Atlas Genetics Ltd A valve which depressurises, and a valve system
GB2516666B (en) 2013-07-29 2015-09-09 Atlas Genetics Ltd Fluidic cartridge for nucleic acid amplification and detection
GB2516667A (en) 2013-07-29 2015-02-04 Atlas Genetics Ltd An improved cartridge, cartridge reader and method for preventing reuse
GB2516672B (en) 2013-07-29 2015-05-20 Atlas Genetics Ltd A system and method for expelling liquid from a fluidic cartridge
WO2015052516A1 (en) 2013-10-08 2015-04-16 Atlas Genetics Limited Labelling compounds and their use in assays
GB201416459D0 (en) 2014-09-17 2014-10-29 Atlas Genetics Ltd Detection method
GB2530596B (en) 2015-02-02 2016-08-24 Atlas Genetics Ltd Improved blister assembly
GB2531616B (en) 2015-02-02 2017-11-22 Atlas Genetics Ltd Instrument for performing a diagnostic test on a fluidic cartridge
GB2531615B (en) 2015-02-02 2017-11-22 Atlas Genetics Ltd Instrument for performing a diagnostic test on a fluidic cartridge
GB201501705D0 (en) 2015-02-02 2015-03-18 Atlas Genetics Ltd Instrument for performing a diagnostic test on a fluidic cartridge
WO2016208776A1 (ja) 2015-06-25 2016-12-29 株式会社国際電気通信基礎技術研究所 多器官連関システムを基盤とした予測装置、及び予測プログラム
EP3409779A4 (de) * 2016-01-26 2019-07-03 Nissan Chemical Corporation Einzelsträngiges oligonukleotid
ES3032616T3 (en) 2016-02-26 2025-07-22 Abbott Diagnostics Scarborough Inc Redox labeled oligonucleotide probes and their use
JP6332780B2 (ja) 2016-03-29 2018-05-30 株式会社国際電気通信基礎技術研究所 医薬組成物又は食品組成物、及び有効成分の体内での効果の評価方法
CN114594268A (zh) 2016-03-29 2022-06-07 无限生物制药公司 用以预防或治疗肾脏疾病的活性组分的候选物质的筛选装置和筛选方法
JP6917540B2 (ja) * 2016-10-21 2021-08-11 パナソニックＩｐマネジメント株式会社 コカインアプタマーおよびそれを用いてコカインを検出する方法
JP2018074995A (ja) * 2016-11-02 2018-05-17 パナソニックＩｐマネジメント株式会社 コカインアプタマーおよびそれを用いてコカインを検出する方法
WO2019066461A2 (en) 2017-09-29 2019-04-04 Seegene, Inc. DETECTION OF TARGET NUCLEIC ACID SEQUENCES BY CLEAVAGE ANALYSIS AND EXTENSION OF PTO
US10935561B2 (en) 2018-06-01 2021-03-02 Genmark Diagnostics, Inc. Integrated diagnostic instrument
CN111793096B (zh) * 2019-12-20 2021-05-04 南京晓庄学院 一种衍生物的制备方法
CN111018920B (zh) * 2019-12-26 2023-02-14 安徽大学 一种具有活细胞骨架肌动蛋白靶向性的铱配合物及其制备方法和用途
CN111172024A (zh) * 2019-12-31 2020-05-19 福建农林大学 一种原位表征种间直接电子传递的装置
CN114324506B (zh) * 2021-12-31 2024-08-09 军事科学院军事医学研究院军事兽医研究所 电化学生物传感组合物、工作液、传感器、装置及其应用
WO2024013271A1 (en) 2022-07-12 2024-01-18 Testmate Health Sa Colorimetric nucleic acid detection
WO2024160854A1 (en) 2023-01-31 2024-08-08 Testmate Health Sa Colorimetric detection of nucleic acids with rhodamine dyes

Family Cites Families (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1219040A (en) 1983-05-05 1987-03-10 Elliot V. Plotkin Measurement of enzyme-catalysed reactions
CA1220818A (en) 1983-05-05 1987-04-21 Hugh A.O. Hill Assay techniques utilising specific binding agents
GB2154003B (en) 1983-12-16 1988-02-17 Genetics Int Inc Diagnostic aid
CA1218704A (en) 1983-05-05 1987-03-03 Graham Davis Assay systems using more than one enzyme
CA1226036A (en) 1983-05-05 1987-08-25 Irving J. Higgins Analytical equipment and sensor electrodes therefor
GB8328520D0 (en) 1983-10-25 1983-11-23 Serono Diagnostics Ltd Methods of assay
US4840893A (en) 1983-12-16 1989-06-20 Medisense, Inc. Electrochemical assay for nucleic acids and nucleic acid probes
GB8402058D0 (en) 1984-01-26 1984-02-29 Serono Diagnostics Ltd Methods of assay
GB8417301D0 (en) 1984-07-06 1984-08-08 Serono Diagnostics Ltd Assay
GB8504522D0 (en) * 1985-02-21 1985-03-27 Genetics Int Inc Electrochemistry of mediators
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US5333675C1 (en) 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5038852A (en) 1986-02-25 1991-08-13 Cetus Corporation Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
CA1339653C (en) 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5374553A (en) 1986-08-22 1994-12-20 Hoffmann-La Roche Inc. DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima
US5079352A (en) 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US5310652A (en) 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5407800A (en) 1986-08-22 1995-04-18 Hoffmann-La Roche Inc. Reverse transcription with Thermus thermophilus polymerase
CA1338457C (en) 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
US6127155A (en) 1986-08-22 2000-10-03 Roche Molecular Systems, Inc. Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
NL8900725A (nl) 1989-03-23 1990-10-16 Az Univ Amsterdam Werkwijze en combinatie van middelen voor het isoleren van nucleinezuur.
US5312590A (en) * 1989-04-24 1994-05-17 National University Of Singapore Amperometric sensor for single and multicomponent analysis
US5219727A (en) 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
JP2968585B2 (ja) 1989-12-22 1999-10-25 エフ．ホフマン ― ラ ロシュ アーゲー 高温度逆転写酵素
AU646430B2 (en) 1989-12-22 1994-02-24 F. Hoffmann-La Roche Ag Recombinant expression vectors and purification methods for thermus thermophilus DNA polymerase
EP0540693B1 (de) 1990-07-24 1999-01-20 F. Hoffmann-La Roche Ag Verringerung von nicht spezifischer amplifikation während einer (in vitro) nukleinsäure amplifikation unter verwendung von modifizierten nukleinsäure basen
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5221586A (en) * 1990-09-19 1993-06-22 Ishikawajima-Harima Heavy Industries Co., Ltd. Power generation system using fuel cells
JP2709311B2 (ja) 1990-09-28 1998-02-04 エフ．ホフマン−ラ ロシュ アクチェンゲゼルシャフト 熱安定性ｄｎａポリメラーゼの５→３′のエキソヌクレアーゼ突然変異
ATE197718T1 (de) 1990-09-28 2000-12-15 Hoffmann La Roche Gereinigte thermostabile nukleinsäurepolymerase aus thermosipho africanus
US5776672A (en) * 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
JP3643375B2 (ja) 1990-12-06 2005-04-27 エフ．ホフマン ― ラ ロシュ アーゲー ＨＬＡ ＤＲβのＤＮＡタイピングのための方法および試薬
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
US5518900A (en) * 1993-01-15 1996-05-21 Molecular Tool, Inc. Method for generating single-stranded DNA molecules
US5556751A (en) 1991-04-25 1996-09-17 Amoco Corporation Selective amplification system using Q-β replicase
US6759226B1 (en) 2000-05-24 2004-07-06 Third Wave Technologies, Inc. Enzymes for the detection of specific nucleic acid sequences
US7045289B2 (en) 1991-09-09 2006-05-16 Third Wave Technologies, Inc. Detection of RNA Sequences
US6872816B1 (en) 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US7150982B2 (en) 1991-09-09 2006-12-19 Third Wave Technologies, Inc. RNA detection assays
US6051380A (en) 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US6569382B1 (en) 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US6652808B1 (en) 1991-11-07 2003-11-25 Nanotronics, Inc. Methods for the electronic assembly and fabrication of devices
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5787032A (en) 1991-11-07 1998-07-28 Nanogen Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group
EP1067134B1 (de) 1991-11-07 2004-07-28 Nanotronics, Inc. Hybridisierung von mit Chromophoren und Fluorophoren konjugierten Polynukleotiden zur Erzeugung eines Donor-Donor Energietransfersystems
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5312527A (en) 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
DE69333991T2 (de) 1992-11-27 2006-12-14 Canon K.K. Verfahren und Sonde zum Nachweis von Nukleinsäuren
US5614402A (en) 1992-12-07 1997-03-25 Third Wave Technologies, Inc. 5' nucleases derived from thermostable DNA polymerase
US20060035257A1 (en) 1992-12-07 2006-02-16 Dahlberg James E Cleavage of nucleic acids
US5719028A (en) 1992-12-07 1998-02-17 Third Wave Technologies Inc. Cleavase fragment length polymorphism
US5888780A (en) 1992-12-07 1999-03-30 Third Wave Technologies, Inc. Rapid detection and identification of nucleic acid variants
US6673616B1 (en) 1992-12-07 2004-01-06 Third Wave Technologies, Inc. Methods and compositions for characterizing nucleic acids
US5541311A (en) 1992-12-07 1996-07-30 Third Wave Technologies, Inc. Nucleic acid encoding synthesis-deficient thermostable DNA polymerase
US5843654A (en) 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US6372424B1 (en) 1995-08-30 2002-04-16 Third Wave Technologies, Inc Rapid detection and identification of pathogens
ES2161731T3 (es) 1993-07-01 2001-12-16 Hoffmann La Roche Reactivos y metodos para la transcripcion inversa acoplada a alta temperatura y reaccion en cadena de la polimerasa.
US6207373B1 (en) 1998-02-25 2001-03-27 Nanogen, Inc. Methods for determining nature of repeat units in DNA
US6129828A (en) 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US6287517B1 (en) 1993-11-01 2001-09-11 Nanogen, Inc. Laminated assembly for active bioelectronic devices
CA2175695A1 (en) 1993-11-03 1995-05-11 Philip Goelet Single nucleotide polymorphisms and their use in genetic analysis
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
AU8102694A (en) 1993-11-17 1995-06-06 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
US5610287A (en) 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
AU700008B2 (en) 1993-12-23 1998-12-17 Orchid Biosciences, Inc. Automatic genotype determination
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5871918A (en) 1996-06-20 1999-02-16 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
FR2722294B1 (fr) 1994-07-07 1996-10-04 Lyon Ecole Centrale Procede d'analyse qualitative et/ou quantitative de substances biologiques presentes dans un milieu liquide conducteur et capteurs biochimiques d'affinite utilises pour la mise en oeuvre de ce procede
US6071394A (en) 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US6379897B1 (en) 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
US20030165908A1 (en) 1994-12-30 2003-09-04 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
DE69535882D1 (de) 1994-12-30 2008-12-18 Univ Georgetown Fluoreszenztest zum nachweis der spaltung einer nukleinsäure
FR2733985B1 (fr) 1995-05-10 1997-07-18 Univ Lille Sciences Tech Complexes organometalliques du fer antipaludiques
US5705365A (en) 1995-06-07 1998-01-06 Gen-Probe Incorporated Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US6180346B1 (en) 1995-06-27 2001-01-30 The Universtiy Of North Carolina At Chapel Hill Electropolymerizable film, and method of making and use thereof
ATE223498T1 (de) 1995-06-27 2002-09-15 Univ North Carolina Elektrochemische erkennung von nukleinsäurehybridation
US6127127A (en) 1995-06-27 2000-10-03 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6361951B1 (en) 1995-06-27 2002-03-26 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
US5605622A (en) * 1995-07-18 1997-02-25 Ferraro; Michael J. Swimming pool vacuum system
DE19533093C1 (de) 1995-09-07 1996-12-05 Deutsches Krebsforsch Metallocen-Phosphoramidit-Konjugate, Verfahren zu ihrer Herstellung sowie deren Verwendung
EP0854937B9 (de) 1995-10-06 2006-06-28 Perseptive Biosystems, Inc. Verfahren und testsystem zur hybridisierungsanalyse unter verwendung von peptidnukleinsäure-sonden
PT850320E (pt) 1996-01-23 2000-05-31 Rapigene Inc Metodos para a deteccao da ligacao num par de ligantes com sensibilidade aumentada
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
PT840804E (pt) 1996-01-23 2000-10-31 Qiagen Genomics Inc Metodos e composicoes para a analise de moleculas de acidos nocleicos usando tecnicas de separacao por dimensoes
US7195871B2 (en) 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US7432048B2 (en) 1996-11-29 2008-10-07 Third Wave Technologies, Inc. Reactions on a solid surface
US6875572B2 (en) 1996-01-24 2005-04-05 Third Wave Technologies, Inc. Nucleic acid detection assays
US7122364B1 (en) 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
WO1998023774A1 (en) 1996-11-29 1998-06-04 Third Wave Technologies, Inc. Fen-1 endonucleases, mixtures and cleavage methods
US6913881B1 (en) 1996-01-24 2005-07-05 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US7527928B2 (en) 1996-11-29 2009-05-05 Third Wave Technologies, Inc. Reactions on a solid surface
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
EP1634890B1 (de) 1996-01-24 2008-11-19 Third Wave Technologies, Inc. Invasive Spaltung von Nukleinsäuren
US7256020B2 (en) 1996-11-29 2007-08-14 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
GB9606850D0 (en) 1996-04-01 1996-06-05 Univ Liverpool An assay system and novel labelled compounds for use therwith
US6355436B1 (en) 1996-05-17 2002-03-12 L'ecole Centrale De Lyon Method for analyzing biological substances in a conductive liquid medium
US6444423B1 (en) 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
CA2257534A1 (en) 1996-06-07 1997-12-11 California Institute Of Technology Nucleic acid mediated electron transfer
US6063259A (en) 1996-06-11 2000-05-16 New Mexico State University Technology Transfer Corporation Microfabricated thick-film electrochemical sensor for nucleic acid determination
US5770370A (en) * 1996-06-14 1998-06-23 David Sarnoff Research Center, Inc. Nuclease protection assays
US6780982B2 (en) 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
DE19633206C2 (de) 1996-08-17 2001-03-29 Univ Schiller Jena Steroidverbindungen mit antimikrobieller Wirkung
NZ334314A (en) 1996-09-06 2000-09-29 Nanogen Inc Methods and materials for optimization of electronic hybridization reactions
US5958791A (en) 1996-09-27 1999-09-28 Innovative Biotechnologies, Inc. Interdigitated electrode arrays for liposome-enhanced immunoassay and test device
DE19640186A1 (de) 1996-09-30 1998-04-02 Clariant Gmbh Tensidhaltige Formulierungen
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US6649350B2 (en) 1997-04-09 2003-11-18 California Institute Of Technology Electrochemical sensor using intercalative, redox-active moieties
US6221586B1 (en) 1997-04-09 2001-04-24 California Institute Of Technology Electrochemical sensor using intercalative, redox-active moieties
US7101672B2 (en) 1998-05-05 2006-09-05 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US6194149B1 (en) 1998-03-03 2001-02-27 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
ATE498838T1 (de) 1997-06-12 2011-03-15 Clinical Micro Sensors Inc Elektronische verfahren und vorrichtung zum nachweis von analyten
AU8162498A (en) 1997-06-25 1999-01-04 Orchid Biosciences, Inc. Methods for the detection of multiple single nucleotide polymorphisms in a single reaction
US20050037397A1 (en) 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
EP0990047B1 (de) 1997-07-22 2003-05-14 Qiagen Genomics, Inc. Verfahren und verbindungen zur analysierung von nukleinsaeuren durch massenspektrometrie
US5837469A (en) 1997-11-04 1998-11-17 Becton Dickinson And Company Assay for chlamydia trachomatis by amplification and detection of chlamydia trachomatis nucleic acid
GB9725197D0 (en) * 1997-11-29 1998-01-28 Secr Defence Detection system
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
NZ506204A (en) 1998-02-20 2003-06-30 Nanogen Inc Advanced active devices and methods for molecular biological analysis and diagnostics
WO1999057317A1 (en) 1998-05-06 1999-11-11 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes utilizing monolayers
CA2327525A1 (en) 1998-05-06 1999-11-11 Cynthia Bamdad Electronic detection of nucleic acids using monolayers
US6180350B1 (en) 1998-05-26 2001-01-30 Georgia University Research Foundation Inc. Methods and apparatus for the photo-electrochemical detection of nucleic acid
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
JP2967197B1 (ja) 1998-08-11 1999-10-25 九州大学長 遺伝子の特殊一本鎖核酸部位の検出用プローブ、遺伝子の特殊一本鎖核酸部位の検出方法およびその装置
US6288221B1 (en) 1998-08-20 2001-09-11 Duke University Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling with a metal-catalyzed reaction
RU2161653C2 (ru) 1998-08-24 2001-01-10 ФАРМАКОВСКИЙ Дмитрий Александрович Способ количественного электрохимического анализа биомолекул
US6927024B2 (en) 1998-11-30 2005-08-09 Genentech, Inc. PCR assay
IL132966A0 (en) 1998-12-01 2001-03-19 Yissum Res Dev Co Method and system for detecting oligonucleotides in a sample
US6468657B1 (en) * 1998-12-04 2002-10-22 The Regents Of The University Of California Controllable ion-exchange membranes
KR20010102961A (ko) 1998-12-23 2001-11-17 해리 제이. 레온 하르트 집적된 휴대용 생물학적 검출시스템
EP1144685B1 (de) 1999-01-18 2003-04-23 Friz Biochem GmbH Verfahren zur elektrochemischen detektion von nukleinsäure -oligomer- hybridisierungsereignissen
US6432723B1 (en) 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
US6322980B1 (en) * 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
AU769929B2 (en) 1999-04-12 2004-02-12 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
WO2001004131A1 (en) 1999-07-14 2001-01-18 Solvias Ag Diphosphine ligands for metal complexes
CA2379693A1 (en) * 1999-07-20 2001-01-25 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
CA2380258C (en) 1999-07-26 2008-07-15 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
KR100348786B1 (ko) * 1999-10-01 2002-08-17 엘지전자주식회사 핵산검출방법, 및 핵산검출기와 이의 제조방법
US6262832B1 (en) 1999-12-03 2001-07-17 Gentex Corporation Anodic electrochromic materials having a solublizing moiety
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
EP1294863B1 (de) 2000-05-24 2009-07-08 Third Wave Technologies, Inc. Nachweis von rna
US6531283B1 (en) 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
JP4272800B2 (ja) 2000-06-22 2009-06-03 富士フイルム株式会社 複数の電位を用いる遺伝子の発現解析
GB0019841D0 (en) 2000-08-11 2000-09-27 Univ London Bonding to polymeric surfaces
JP2006170615A (ja) 2001-01-19 2006-06-29 Shigeori Takenaka 遺伝子の検出方法、検出装置、並びに検出用チップ
DE10112778A1 (de) 2001-03-16 2002-10-02 Infineon Technologies Ag Biosensor, Vorrichtung und Verfahren zum Erfassen von Nukleinsäuren mittels mindestens zwei Einheiten zum Immobilisieren von Nukleinsäuren
US7029919B2 (en) 2001-05-04 2006-04-18 Agilent Technologies, Inc. Electro-optical device and methods for hybridization and detection
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
GB0116384D0 (en) 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
DE10133058A1 (de) 2001-07-07 2003-01-23 Messer Griesheim Gmbh Verfahren zum Zerstäuben und Verbrennen von Brennstoffen mittels Sauerstoff und Brenner hierzu
US7052591B2 (en) 2001-09-21 2006-05-30 Therasense, Inc. Electrodeposition of redox polymers and co-electrodeposition of enzymes by coordinative crosslinking
US20030148335A1 (en) 2001-10-10 2003-08-07 Li Shen Detecting targets by unique identifier nucleotide tags
JP2003144152A (ja) 2001-11-09 2003-05-20 Fuji Photo Film Co Ltd ターゲット核酸断片の検出方法及びターゲット核酸断片の検出キット
US7482118B2 (en) 2001-11-15 2009-01-27 Third Wave Technologies, Inc. Endonuclease-substrate complexes
AUPR975201A0 (en) 2001-12-24 2002-01-24 Unisearch Limited Enzymatic redox labelling of nucleic acids
FR2835836B1 (fr) 2002-02-14 2006-03-17 Bio Merieux Metallocenes bifonctionnalises, procede d'obtention, utilisation pour le marquage de molecules biologiques
US20030219801A1 (en) 2002-03-06 2003-11-27 Affymetrix, Inc. Aptamer base technique for ligand identification
ATE496880T1 (de) 2002-05-15 2011-02-15 Kamaluddin Abdur-Rashid Prozess zur hydrierung von nicht-aktivierten iminen unter verwendung von ruthenium-komplexen als katalysatoren
US7005265B1 (en) 2002-06-20 2006-02-28 Wenhong Fan Nonenzymatic catalytic signal amplification for nucleic acid hybridization assays
AU2003246083A1 (en) 2002-06-27 2004-01-19 Chugai Seiyaku Kabushiki Kaisya Ferrocene compound and use thereof
WO2004016160A2 (en) 2002-08-19 2004-02-26 Iowa State University Research Foundation, Inc. Redox polymer nanoparticles
US20040086892A1 (en) 2002-11-06 2004-05-06 Crothers Donald M. Universal tag assay
US7851150B2 (en) 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
DE10327756B4 (de) 2003-06-18 2005-12-29 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Verfahren zum Echtzeit-Quantifizieren einer Nukleinsäure
KR101041106B1 (ko) 2003-11-25 2011-06-13 한면기 핵산과 단백질의 신규한 실시간 탐지방법
KR100590569B1 (ko) 2004-02-14 2006-06-15 삼성전자주식회사 실시간 중합효소연쇄반응 검사 방법
KR100590546B1 (ko) 2004-02-28 2006-06-19 삼성전자주식회사 마이크로 ｐｃｒ 장치, 이를 이용한 핵산의 증폭방법 및ｐｃｒ 증폭산물의 농도를 측정하는 방법
JP2005275273A (ja) 2004-03-26 2005-10-06 Fuji Photo Film Co Ltd ホログラム記録材料、ホログラム記録方法及び光記録媒体
US7030257B2 (en) 2004-04-13 2006-04-18 Agency For Science, Technology And Research Metallocenes and processes for their preparation
WO2005106034A1 (en) 2004-04-29 2005-11-10 Agency For Science, Technology And Research Method and device for detection of nucleic acids and/or polypeptides
CN101124235B (zh) 2004-07-08 2010-12-15 埃克森美孚化学专利公司 烯烃聚合催化剂体系及其使用方法
ITMI20041427A1 (it) 2004-07-15 2004-10-15 Univ Degli Studi Milano Sintesi di molecole organometalliche utilizzabili come marcatori di sostanze organiche
AU2006243370B2 (en) 2005-05-02 2012-06-28 Basf Aktiengesellschaft New labelling strategies for the sensitive detection of analytes
US7482127B2 (en) 2005-11-03 2009-01-27 Third Wave Technologies, Inc. Nucleic acid detection assays employing blocker oligonucleotides
JP4869018B2 (ja) 2005-11-25 2012-02-01 株式会社Ａｄｅｋａ 光学記録材料
US7803542B2 (en) 2005-11-29 2010-09-28 The Regents Of The University Of California Signal-on architecture for electronic, oligonucleotide-based detectors
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
CN101506380A (zh) 2006-08-11 2009-08-12 香港科技大学 用电导或电化学活跃标签实时定量分析与监察核酸扩增的方法与系统
EP1970378A1 (de) 2007-03-16 2008-09-17 Universite Libre De Bruxelles Auf Oligonukleotiden verankerte lichtreaktive Ru (II)-Komplexe, Verfahren zu ihrer Gewinnung und ihre Verwendung
US8198039B2 (en) 2007-09-04 2012-06-12 University of Pittsburgh—of the Commonwealth System of Higher Education Biosensors and related methods
JP2009292955A (ja) 2008-06-05 2009-12-17 Adeka Corp シアニン化合物及び該化合物を用いた光学記録材料
FR2933700B1 (fr) 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
GB2467148A (en) 2009-01-23 2010-07-28 Acal Energy Ltd Redox Fuel Cells

Also Published As

Publication number Publication date
EP1808494A1 (de) 2007-07-18
US20150159203A1 (en) 2015-06-11
DE60327008D1 (de) 2009-05-14
WO2003074731A2 (en) 2003-09-12
EP1481083B1 (de) 2006-12-20
US10094800B2 (en) 2018-10-09
ES2324488T3 (es) 2009-08-07
DE60310532T2 (de) 2007-10-11
JP2009148284A (ja) 2009-07-09
US9127308B2 (en) 2015-09-08
US20050221315A1 (en) 2005-10-06
JP4381819B2 (ja) 2009-12-09
EP1481083A2 (de) 2004-12-01
JP2005518810A (ja) 2005-06-30
US20160025703A1 (en) 2016-01-28
GB0205455D0 (en) 2002-04-24
WO2003074731A3 (en) 2004-01-08
DK1481083T3 (da) 2007-04-30
AU2003205870A1 (en) 2003-09-16
ES2279092T3 (es) 2007-08-16
US20160077041A1 (en) 2016-03-17
JP4934159B2 (ja) 2012-05-16
ATE427313T1 (de) 2009-04-15
EP1808494B1 (de) 2009-04-01
DE60310532D1 (de) 2007-02-01

Similar Documents

Publication Publication Date Title
DE60310532D1 (de) Bestimmung von nukleinsäuren
WO2001017972A3 (de) Neue herbizide
DE69628368D1 (de) Heterocyclische Verbindungen, ihre Herstellung und Verwendung
DE69023171D1 (de) Kondensierte heterozyklische Verbindungen, ihre Herstellung und Verwendung.
WO2001017973A3 (de) Neue herbizide
ATE425983T1 (de) Siloxy substituierte metallocenkatalysatoren
WO2004085539A3 (en) Cyanine dye labelling reagents with meso-substitution
ES2076471T3 (es) Compuestos anionicos.
FI931190A0 (fi) Triazolopyridazinfoereningar, deras framstaellning och anvaendning
EA200000452A1 (ru) Сульфамоильные соединения и фунгициды для сельского хозяйства и садоводства
DE69923300D1 (de) Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung
ATE201195T1 (de) Tricyclische verbindungen
ATE225771T1 (de) Prostaglandin-pharmazeutische-zusammensetzungen
EP0760368A4 (de) Neue pyrimidinderivate
ES2043807T3 (es) Compuestos anticancer.
ATE97410T1 (de) 6-amino-6-desoxyfumagillole, ihre herstellung und ihre verwendung.
ATE278697T1 (de) Katalysatoren
ATE322470T1 (de) Funktionalisierte höhere diamantoide
SE0101651D0 (sv) Synthesis and evaluation of new cyanine dyes as minor groove binders
TR200002851T2 (tr) MRP1'i inhibe etmek için yöntemler.
WO2001010861A3 (de) Substituierte heterocyclyl-2h-chromene
WO2003075928A3 (en) Stable pharmaceutical compositions
DE60000402D1 (de) Prozess zur herstellung von zwischebprodukten für imidazodeazepinen
TR200002803T2 (tr) MRP1 inhibe etmek için yöntemler.
EP1403268A4 (de) Fluoreszente sonden für zink

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties