ATE35266T1 - 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6dihydro-5-methyl-6-oxo-4h-imidazo(1,5a)(1,4)benzodiazepin, verfahren zu seiner herstellung und pharmazeutische zubereitungen. - Google Patents

3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6dihydro-5-methyl-6-oxo-4h-imidazo(1,5a)(1,4)benzodiazepin, verfahren zu seiner herstellung und pharmazeutische zubereitungen.

Info

Publication number: ATE35266T1
Authority: AT; Austria
Prior art keywords: oxadiazol; imidazo; cyclopropyl; oxo; methyl
Prior art date: 1985-05-17

Application number

AT86102951T

Other languages

English (en)

Inventor

Frank Waetjen

Mogens Engelstoft

John Bondo Hansen

Leif Helth Jensen

Original Assignee

Ferrosan As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-05-17

Filing date

1986-03-06

Publication date

1988-07-15

1985-05-17 Priority claimed from DK220485A external-priority patent/DK220485D0/da

1985-08-12 Priority claimed from DK365985A external-priority patent/DK365985D0/da

1985-10-17 Priority claimed from DK476985A external-priority patent/DK476985D0/da

1986-03-06 Application filed by Ferrosan As filed Critical Ferrosan As

1988-07-15 Application granted granted Critical

1988-07-15 Publication of ATE35266T1 publication Critical patent/ATE35266T1/de

Links

238000000034 method Methods 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
YZIWCURGXWGKPE-UHFFFAOYSA-N 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-methyl-4h-imidazo[1,5-a][1,4]benzodiazepin-6-one Chemical compound N1=CN2C3=CC=CC=C3C(=O)N(C)CC2=C1C(N=1)=NOC=1C1CC1 YZIWCURGXWGKPE-UHFFFAOYSA-N 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
-1 3-(5-cyclopropyl-1 Chemical class 0.000 abstract 1
206010010904 Convulsion Diseases 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940049706 benzodiazepine Drugs 0.000 abstract 1
239000000759 benzodiazepine receptor stimulating agent Substances 0.000 abstract 1
150000001557 benzodiazepines Chemical class 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000036461 convulsion Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Phenolic Resins Or Amino Resins (AREA)
Polyesters Or Polycarbonates (AREA)
Polyethers (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Diaphragms For Electromechanical Transducers (AREA)

AT86102951T 1985-05-17 1986-03-06 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6dihydro-5-methyl-6-oxo-4h-imidazo(1,5a)(1,4)benzodiazepin, verfahren zu seiner herstellung und pharmazeutische zubereitungen. ATE35266T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK220485A DK220485D0 (da)	1985-05-17	1985-05-17	Nye oxadiazolylimidazobenzodiazepinderivater samt fremgangsmaade tilfremstilling heraf
DK365985A DK365985D0 (da)	1985-08-12	1985-08-12	Nye oxadiazolylimidazobenzodiazepinderivater samt fremgangsmaade tilfremstilling heraf
DK476985A DK476985D0 (da)	1985-10-17	1985-10-17	Fremgangsmaade til fremstilling af oxadiazolylderivater af imidazobenzodiazepiner og mellemprodukt til brug ved fremgangsmaaden
EP86102951A EP0201678B1 (de)	1985-05-17	1986-03-06	3-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepin, Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen

Publications (1)

Publication Number	Publication Date
ATE35266T1 true ATE35266T1 (de)	1988-07-15

Family

ID=27221528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86102951T ATE35266T1 (de)	1985-05-17	1986-03-06	3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6dihydro-5-methyl-6-oxo-4h-imidazo(1,5a)(1,4)benzodiazepin, verfahren zu seiner herstellung und pharmazeutische zubereitungen.

Country Status (16)

Country	Link
US (2)	US4622321A (de)
EP (1)	EP0201678B1 (de)
JP (1)	JPH01279877A (de)
AT (1)	ATE35266T1 (de)
AU (2)	AU590273B2 (de)
CA (2)	CA1256864A (de)
DE (2)	DE3660331D1 (de)
DK (2)	DK157194C (de)
ES (1)	ES8707205A1 (de)
FI (1)	FI82049C (de)
GR (1)	GR861260B (de)
IE (1)	IE59494B1 (de)
IL (1)	IL78790A (de)
NO (1)	NO163228C (de)
NZ (1)	NZ216202A (de)
PT (1)	PT82594B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CS249146B2 (en) *	1984-01-19	1987-03-12	Hoffmann La Roche	Method of new imidazodiazepine's derivatives production
US4745112A (en) *	1985-05-17	1988-05-17	A/S Ferrosan	Oxadiazolylimidazobenzodiazepine, compositions, and method III
US4622321A (en) *	1985-05-17	1986-11-11	As Ferrosan	Oxadiazolylimidazobenzodiazepine, compositions, and method
US4771051A (en) *	1985-05-17	1988-09-13	A/S Ferrosan	3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments
EP0226282B1 (de) *	1985-10-17	1989-07-05	A/S Ferrosan	Heterocyclische Verbindungen und ihre Herstellung und Verwendung
DK174086D0 (da) *	1986-04-16	1986-04-16	Ferrosan As	Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
DK522187D0 (da) *	1987-10-06	1987-10-06	Ferrosan As	Imidozothienopyrimidiner, deres fremstilling og anvendelse
GB8823475D0 (en) *	1988-10-06	1988-11-16	Merck Sharp & Dohme	Chemical compounds
CA2143246C (en) *	1994-03-16	2000-08-22	Thierry Godel	Imidazodiazepines
FI101305B1 (fi) *	1996-03-18	1998-05-29	Map Medical Technologies Oy	Radiofarmaseuttisena aineena käyttökelpoiset radiojodatut bentsodiatsepiini-johdannaiset ja niiden käyttö diagnostiikassa
US20090054412A1 (en) *	2007-08-20	2009-02-26	John Alan Kemp	Treatment of Sleep Disorders
CN101827597B (zh) *	2007-08-20	2013-03-13	伊沃泰克国际有限责任公司	睡眠障碍的治疗

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4031029A (en) *	1975-07-02	1977-06-21	General Electric Company	Process for producing uranium oxide rich compositions from uranium hexafluoride using fluid injection into the reaction zone
CA1143728A (en) *	1979-10-04	1983-03-29	Max Gerecke	Imidazodiazepine derivatives
JPS57123180A (en) *	1980-12-17	1982-07-31	Schering Ag	3-substituted beta-carboline, manufacture and psychotropic drug containing same
DK151808C (da) *	1982-11-16	1988-06-20	Ferrosan As	Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
CS249146B2 (en) *	1984-01-19	1987-03-12	Hoffmann La Roche	Method of new imidazodiazepine's derivatives production
AU587802B2 (en) *	1985-03-08	1989-08-31	Ferrosan A/S	Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4622321A (en) *	1985-05-17	1986-11-11	As Ferrosan	Oxadiazolylimidazobenzodiazepine, compositions, and method
EP0226282B1 (de) *	1985-10-17	1989-07-05	A/S Ferrosan	Heterocyclische Verbindungen und ihre Herstellung und Verwendung
DK174086D0 (da) *	1986-04-16	1986-04-16	Ferrosan As	Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme

1986
- 1986-01-06 US US06/816,731 patent/US4622321A/en not_active Expired - Fee Related
- 1986-01-06 US US06/816,732 patent/US4622320A/en not_active Expired - Fee Related
- 1986-03-06 AT AT86102951T patent/ATE35266T1/de not_active IP Right Cessation
- 1986-03-06 DE DE8686102951T patent/DE3660331D1/de not_active Expired
- 1986-03-06 EP EP86102951A patent/EP0201678B1/de not_active Expired
- 1986-03-06 DE DE198686102951T patent/DE201678T1/de active Pending
- 1986-04-30 CA CA000507956A patent/CA1256864A/en not_active Expired
- 1986-04-30 CA CA000507955A patent/CA1256863A/en not_active Expired
- 1986-05-14 GR GR861260A patent/GR861260B/el unknown
- 1986-05-14 AU AU57429/86A patent/AU590273B2/en not_active Ceased
- 1986-05-15 IL IL78790A patent/IL78790A/xx not_active IP Right Cessation
- 1986-05-16 DK DK231686A patent/DK157194C/da not_active IP Right Cessation
- 1986-05-16 FI FI862061A patent/FI82049C/fi not_active IP Right Cessation
- 1986-05-16 NO NO861954A patent/NO163228C/no unknown
- 1986-05-16 NZ NZ216202A patent/NZ216202A/xx unknown
- 1986-05-16 PT PT82594A patent/PT82594B/pt not_active IP Right Cessation
- 1986-05-16 IE IE130686A patent/IE59494B1/en not_active IP Right Cessation
- 1986-05-16 ES ES555035A patent/ES8707205A1/es not_active Expired
1988
- 1988-02-08 DK DK063288A patent/DK160097C/da not_active IP Right Cessation
1989
- 1989-03-17 JP JP1065783A patent/JPH01279877A/ja active Pending
- 1989-08-04 AU AU39333/89A patent/AU614407B2/en not_active Ceased

Also Published As

Publication number	Publication date
DK160097B (da)	1991-01-28
DE3660331D1 (en)	1988-07-28
AU590273B2 (en)	1989-11-02
IE59494B1 (en)	1994-02-23
DK231686A (da)	1986-11-18
US4622321A (en)	1986-11-11
PT82594A (en)	1986-06-01
NO861954L (no)	1986-11-18
DK63288A (da)	1988-02-08
AU614407B2 (en)	1991-08-29
IL78790A0 (en)	1986-08-31
CA1256864A (en)	1989-07-04
NZ216202A (en)	1989-08-29
FI82049C (fi)	1991-01-10
ES8707205A1 (es)	1987-07-16
EP0201678A1 (de)	1986-11-20
US4622320A (en)	1986-11-11
IL78790A (en)	1990-01-18
JPH01279877A (ja)	1989-11-10
CA1256863A (en)	1989-07-04
FI862061A0 (fi)	1986-05-16
FI82049B (fi)	1990-09-28
FI862061L (fi)	1986-11-18
IE861306L (en)	1986-11-17
GR861260B (en)	1986-09-10
NO163228C (no)	1990-04-25
NO163228B (no)	1990-01-15
DK157194B (da)	1989-11-20
DK231686D0 (da)	1986-05-16
PT82594B (pt)	1988-03-03
ES555035A0 (es)	1987-07-16
AU5742986A (en)	1986-11-20
DE201678T1 (de)	1987-02-26
DK157194C (da)	1990-04-23
AU3933389A (en)	1989-11-23
DK160097C (da)	1991-06-24
EP0201678B1 (de)	1988-06-22
DK63288D0 (da)	1988-02-08

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Legal Events

Date	Code	Title
1988-10-15	UEP	Publication of translation of european patent specification
1992-11-15	EEIH	Change in the person of patent owner
1996-12-15	REN	Ceased due to non-payment of the annual fee