ATE358276T1 - Elektrochemilumineszenz-enzymimmunoassay - Google Patents

Elektrochemilumineszenz-enzymimmunoassay

Info

Publication number
ATE358276T1
ATE358276T1 AT96923291T AT96923291T ATE358276T1 AT E358276 T1 ATE358276 T1 AT E358276T1 AT 96923291 T AT96923291 T AT 96923291T AT 96923291 T AT96923291 T AT 96923291T AT E358276 T1 ATE358276 T1 AT E358276T1
Authority
AT
Austria
Prior art keywords
electrochemiluminescence
analyte
electrochemiluminescent
molecule
immunoassays
Prior art date
Application number
AT96923291T
Other languages
German (de)
English (en)
Inventor
Mark T Martin
Richard Saul
Pam Liang
Original Assignee
Bioveris Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioveris Corp filed Critical Bioveris Corp
Application granted granted Critical
Publication of ATE358276T1 publication Critical patent/ATE358276T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT96923291T 1995-06-07 1996-06-06 Elektrochemilumineszenz-enzymimmunoassay ATE358276T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48476695A 1995-06-07 1995-06-07

Publications (1)

Publication Number Publication Date
ATE358276T1 true ATE358276T1 (de) 2007-04-15

Family

ID=23925520

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96923291T ATE358276T1 (de) 1995-06-07 1996-06-06 Elektrochemilumineszenz-enzymimmunoassay

Country Status (9)

Country Link
US (2) US6524865B1 (2)
EP (1) EP0871887B1 (2)
JP (1) JP3784072B2 (2)
AT (1) ATE358276T1 (2)
AU (1) AU718767B2 (2)
CA (1) CA2223027A1 (2)
DE (1) DE69637001T2 (2)
ES (1) ES2285713T3 (2)
WO (1) WO1996041175A1 (2)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866434A (en) * 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
US5641623A (en) * 1995-01-04 1997-06-24 Martin; Mark T. Electrochemiluminescence assay
US6319670B1 (en) * 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
JP2002524021A (ja) * 1997-02-06 2002-07-30 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 分子相互作用の検出および薬剤発見のための電気化学的プローブ
AU6115300A (en) * 1999-07-19 2001-02-05 California Institute Of Technology Detection of biomolecules by sensitizer-linked substrates
KR101076578B1 (ko) 2004-06-23 2011-10-24 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 2입자 착물을 이용한 생물학적 분자의 검출을 위한 방법 및조성물
US7094528B2 (en) * 2004-06-30 2006-08-22 Kimberly-Clark Worldwide, Inc. Magnetic enzyme detection techniques
US7906276B2 (en) 2004-06-30 2011-03-15 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
JP4798801B2 (ja) * 2004-10-06 2011-10-19 ウェルスタット バイオロジクス コーポレイション 循環する癌細胞におけるＨｅｒ−２／ｎｅｕタンパク質のレベルの上昇の検出および処置
US20090145485A1 (en) * 2005-08-11 2009-06-11 Eksigent Technologies, Llc Microfluidic methods and apparatuses for fluid mixing and valving
EP2390312A1 (en) 2005-11-29 2011-11-30 Gamida Cell Ltd. Methods of improving stem cell homing and engraftment
US7820394B2 (en) * 2005-12-02 2010-10-26 Catassays Ultrasensitive bioanalytical assays based on the use of high-gain catalytic chemical amplification
EP2008102A4 (en) * 2006-04-18 2009-07-08 Wellstat Biologics Corp DETECTION OF PROTEINS IN NEOPLASTIC CELLS IN CIRCULATION
MX2009011228A (es) * 2007-04-19 2009-11-02 Wellstat Biologics Corp Deteccion de niveles elevados de la proteina her-2/neu de celulas cancerosas circulantes no aisladas y tratamiento.
JP4887319B2 (ja) 2008-03-17 2012-02-29 株式会社日立ハイテクノロジーズ 自動分析装置、及び光電子増倍管を用いた分析システム
JP5490095B2 (ja) * 2008-04-11 2014-05-14 ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム ナノ粒子による電気化学発光の増幅方法および増幅装置
WO2009137002A2 (en) 2008-05-08 2009-11-12 Board Of Regents Of The University Of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
US20110058984A1 (en) 2008-05-08 2011-03-10 Hitachi High-Technologies Corporation Automatic analyzer
JP5124498B2 (ja) 2009-01-30 2013-01-23 株式会社日立ハイテクノロジーズ 自動分析装置
EP2662385A4 (en) * 2011-01-07 2015-11-11 Chugai Pharmaceutical Co Ltd METHOD FOR IMPROVING THE PHYSICAL PROPERTIES OF ANTIBODIES
WO2013053953A1 (en) * 2011-10-14 2013-04-18 Université de Liège Method for measuring beta-lactam antibiotics
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US10077426B2 (en) 2012-12-06 2018-09-18 Enlivex Therapeutics Ltd Therapeutic apoptotic cell preparations, method for producing same and uses thereof
EP3258269B1 (en) * 2015-02-10 2019-06-05 Shenzhen New Industries Biomedical Engineering Co. Ltd. Reagent kit used for detecting lipoprotein-associated phospholipase a2, and preparation method and application for reagent kit
BR112018001956A2 (pt) 2015-08-20 2018-09-11 Hoffmann La Roche ?método de medição de analitos e kit?
CN108780092A (zh) 2016-03-07 2018-11-09 豪夫迈·罗氏有限公司 抗p53抗体的检测
WO2018141768A1 (en) 2017-02-02 2018-08-09 Roche Diagnostics Gmbh Immunoassay using at least two pegylated analyte-specific binding agents
CN106645111A (zh) * 2017-03-01 2017-05-10 桂林理工大学 一种电化学发光快速检测抗生素ZwittermicinA浓度的方法
WO2019201901A1 (en) 2018-04-18 2019-10-24 F. Hoffmann-La Roche Ag Novel anti-thymidine kinase antibodies
CN112639475A (zh) 2018-08-31 2021-04-09 豪夫迈·罗氏有限公司 Dlbcl的预后指数中的胸苷激酶(tk-1)
WO2020146497A1 (en) * 2019-01-09 2020-07-16 The Regents Of The University Of California An electrochemiluminescence elisa for ps129-a-synuclein
CN109839501B (zh) * 2019-01-30 2022-04-08 东南大学 一种测定循环肿瘤细胞的电致化学发光免疫传感器及其制备方法与应用
WO2021013781A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag Substance p as blood biomarker for the non-invasive diagnosis of endometriosis
JP2022542056A (ja) 2019-07-22 2022-09-29 エフ．ホフマン－ラ ロシュ アーゲー 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのｓ１００ａ６
EP4004553A1 (en) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis
EP4004552A1 (en) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a12 as blood biomarker for the non-invasive diagnosis of endometriosis
EP4004554A1 (en) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a9 as blood biomarker for the non-invasive diagnosis of endometriosis
JP7783809B2 (ja) 2019-11-15 2025-12-10 エフ． ホフマン－ラ ロシュ アーゲー 患者試料における質量分析測定のためのβ－ラクタム抗生物質の誘導体化
WO2022090455A1 (en) 2020-11-02 2022-05-05 F. Hoffmann-La Roche Ag Sars-cov-2 nucleocapsid antibodies
CN112964768A (zh) * 2021-03-23 2021-06-15 海南微氪生物科技股份有限公司 一种Bst DNA聚合酶电致化学发光测定方法
WO2022207628A1 (en) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf as blood biomarker for the non-invasive diagnosis of endometriosis
WO2022207685A1 (en) 2021-04-01 2022-10-06 F. Hoffmann-La Roche Ag Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis
CN117337394A (zh) 2021-05-17 2024-01-02 豪夫迈·罗氏有限公司 sFRP4作为血液生物标志物用于子宫腺肌病的非侵入性诊断
WO2023072904A1 (en) 2021-10-26 2023-05-04 F. Hoffmann-La Roche Ag Monoclonal antibodies specific for sars-cov-2 rbd
WO2023131594A1 (en) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm)
WO2023247752A1 (en) 2022-06-23 2023-12-28 F. Hoffmann-La Roche Ag Method for diagnosing endometriosis and for classifying the stage of endometriosis
US20260036596A1 (en) 2022-07-22 2026-02-05 Roche Diagnostics Operations, Inc. Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
CN119585618A (zh) 2022-07-22 2025-03-07 豪夫迈·罗氏有限公司 成纤维细胞生长因子结合蛋白1(fgfbp1)作为（血液）生物标志物用于诊断多囊卵巢综合征
EP4558825A1 (en) 2022-07-22 2025-05-28 F. Hoffmann-La Roche AG Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
CN121532654A (zh) 2023-07-20 2026-02-13 豪夫迈·罗氏有限公司 针对抗体组合物的筛选方法
WO2025026908A1 (en) 2023-07-28 2025-02-06 Roche Diagnostics Gmbh Serum epha1 as biomarker for endometriosis

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293310A (en) * 1980-03-14 1981-10-06 University Of Pittsburgh Photoelectrochemical immunoassay
US4818709A (en) * 1983-01-21 1989-04-04 Primus Frederick J CEA-family antigens, Anti-CEA antibodies and CEA immunoassay
GB8305324D0 (en) 1983-02-25 1983-03-30 Unilever Plc Microbiological test processes
US4470459A (en) 1983-05-09 1984-09-11 Halliburton Company Apparatus and method for controlled temperature heating of volumes of hydrocarbonaceous materials in earth formations
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5221605A (en) * 1984-10-31 1993-06-22 Igen, Inc. Luminescent metal chelate labels and means for detection
US4877725A (en) * 1985-04-01 1989-10-31 New York Blood Center, Inc. Immunoassays for antibodies which bind to the acquired immunodeficiency virus
CA1339465C (en) * 1986-04-30 1997-09-16 Richard J. Massey Electrochemiluminescent assays
US5147806A (en) 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
US4931223A (en) * 1986-07-24 1990-06-05 Tropix, Inc. Methods of using chemiluminescent 1,2-dioxetanes
ATE259064T1 (de) * 1987-11-04 2004-02-15 Igen Int Inc Lumineszente rhenium-komplexe und verfahren zur herstellung
US5247243A (en) 1988-11-03 1993-09-21 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5296191A (en) 1988-11-03 1994-03-22 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5061445A (en) 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
US5068808A (en) 1988-11-22 1991-11-26 Reality Imaging Corporation Imager and process
US4978613A (en) * 1989-01-17 1990-12-18 Abbott Laboratories Beta-lactamase assay employing chromogenic precipitating substrates
US5187068A (en) * 1989-06-09 1993-02-16 Nicolae Luca Method for determination of lipid moiety and apolipoprotein expressed epitope immunoreactivity on intact lipoprotein
US5264346A (en) 1991-06-03 1993-11-23 Chen Kirk C S Colorimetric method for beta-lactamase assay and its applications
US6030773A (en) * 1992-07-08 2000-02-29 Agnello; Vincent Chemiluminescent assay for DSDNA antibodies
US5527710A (en) * 1994-12-02 1996-06-18 Igen, Inc. Rate measurements of biomolecular reactions using electrochemiluminescence
US5641623A (en) * 1995-01-04 1997-06-24 Martin; Mark T. Electrochemiluminescence assay
FR2729759A1 (fr) * 1995-01-19 1996-07-26 Pasteur Sanofi Diagnostics Procede de dosage ultrasensible de la troponine i cardiaque

Also Published As

Publication number Publication date
AU718767B2 (en) 2000-04-20
EP0871887B1 (en) 2007-03-28
ES2285713T3 (es) 2007-11-16
US7018802B2 (en) 2006-03-28
WO1996041175A1 (en) 1996-12-19
JP3784072B2 (ja) 2006-06-07
DE69637001T2 (de) 2007-12-06
JPH11507726A (ja) 1999-07-06
US6524865B1 (en) 2003-02-25
US20040096918A1 (en) 2004-05-20
AU6384496A (en) 1996-12-30
CA2223027A1 (en) 1996-12-19
DE69637001D1 (de) 2007-05-10
EP0871887A1 (en) 1998-10-21
EP0871887A4 (en) 2000-04-26

Similar Documents

Publication Publication Date Title
DE69637001D1 (de) Elektrochemilumineszenz-enzymimmunoassay
EP0175560A2 (en) Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody
SE9502196D0 (sv) Ultrasensitive immunoassays
ATE212130T1 (de) Chemilumineszenz-immunoassay für den antikörpernachweis
DE3869775D1 (de) Verwendung von polyoxyaethylenaethern zur verbesserung der resultate von immunologischen analysen, die peroxidase-konjugate verwenden.
ATE22730T1 (de) Chromatographisches enzym-immunoverfahren.
ATE85434T1 (de) Verfahren zur immunoassay.
BG97041A (bg) Проби на база протеин-нуклеинова киселина и метод за използването им при имуноизследване
ATE86670T1 (de) Verwendung von oxidase-enzymsystemen in chemilumineszierenden tests.
DE69841388D1 (de) Verfahren für verbesserte lumineszenztests unter verwendung von mikropartikeln
DE69004587D1 (de) Verfahren und Vorrichtung zur quantitativen Chromatographierung.
NO163920C (no) Fremgangsmaate for bestemmelse av pivka-ii i fysiologiske proever.
ES511156A0 (es) Un metodo de determinar la presencia de un antigeno en un medio liquido sospechoso de contenerlo.
ES468934A1 (es) Una unidad de ensayo para realizar un metodo de inmunoensayoque emplea enzimas.
ATE177208T1 (de) Nichttrennender chemilumineszenzassay durch spezifische bindung
KR960024367A (ko) N-펩티드의 샌드위치 면역학적 측정법
DE3785567D1 (de) Immunologischer testkit.
KR890006828A (ko) 효소 분석법
EP0152254A3 (en) Chromogenic support immunoassay utilizing labeled complement components
KR940000870A (ko) β-N- 아세틸글루코사미니다제의 샌드위치 면역 측정법 및 그 측정법에 사용된 모노클론 항체
KR850008620A (ko) Atl 바이러스 항체의 측정방법 및 시약
NO903820D0 (no) Fremgangsmaate for paavisning av analytter.
KR970048453A (ko) 면역학적 결정방법
ATE104058T1 (de) Rezeptorpreincubations-enzymtest.
KR880000796A (ko) 아테롬성동맥경화 안티 요오도형 항체 면역분석법 및 시약

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties