ATE360608T1 - Verfahren zur herstellung von 1,3-diolen - Google Patents

Verfahren zur herstellung von 1,3-diolen

Info

Publication number
ATE360608T1
ATE360608T1 AT98961855T AT98961855T ATE360608T1 AT E360608 T1 ATE360608 T1 AT E360608T1 AT 98961855 T AT98961855 T AT 98961855T AT 98961855 T AT98961855 T AT 98961855T AT E360608 T1 ATE360608 T1 AT E360608T1
Authority
AT
Austria
Prior art keywords
diols
producing
Prior art date
Application number
AT98961855T
Other languages
English (en)
Inventor
Richard Joseph Mccabe
Thomas Norman Nanninga
Robert Lee Bosch
Robert Joseph Stahl
Original Assignee
Pfizer Ireland Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
Application granted granted Critical
Publication of ATE360608T1 publication Critical patent/ATE360608T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/20—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00—Formation or introduction of functional groups containing oxygen
    • C07B41/02—Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT98961855T 1997-12-19 1998-12-02 Verfahren zur herstellung von 1,3-diolen ATE360608T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6819397P 1997-12-19 1997-12-19

Publications (1)

Publication Number Publication Date
ATE360608T1 true ATE360608T1 (de) 2007-05-15

Family

ID=22081016

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98961855T ATE360608T1 (de) 1997-12-19 1998-12-02 Verfahren zur herstellung von 1,3-diolen

Country Status (31)

Country Link
US (4) US6433213B1 (de)
EP (1) EP1054860B1 (de)
JP (1) JP2001526256A (de)
KR (2) KR100668575B1 (de)
AR (1) AR014943A1 (de)
AT (1) ATE360608T1 (de)
AU (1) AU755543B2 (de)
BR (1) BR9813760A (de)
CA (1) CA2305618C (de)
CO (1) CO4990941A1 (de)
CU (1) CU22939A3 (de)
CY (1) CY1106612T1 (de)
DE (1) DE69837681T2 (de)
DK (1) DK1054860T3 (de)
ES (1) ES2284219T3 (de)
GT (2) GT199800197AA (de)
HN (1) HN1998000187A (de)
HU (1) HUP0100252A3 (de)
IL (1) IL135562A (de)
IS (1) IS5447A (de)
MY (1) MY118726A (de)
NO (1) NO20003139L (de)
NZ (1) NZ504346A (de)
PA (1) PA8464901A1 (de)
PE (1) PE20000136A1 (de)
PL (1) PL193678B1 (de)
PT (1) PT1054860E (de)
SV (1) SV1998000153A (de)
TW (1) TW444000B (de)
WO (1) WO1999032434A1 (de)
ZA (1) ZA9811586B (de)

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EP1237865B1 (de) 1999-12-17 2005-11-16 Pfizer Science and Technology Ireland Limited Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form
US7608445B1 (en) 1999-12-29 2009-10-27 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US20040014195A1 (en) * 1999-12-29 2004-01-22 Diversa Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US7521216B2 (en) 1999-12-29 2009-04-21 Verenium Corporation Nitrilases and methods for making and using them
US7300775B2 (en) * 1999-12-29 2007-11-27 Verenium Corporation Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
SK287922B6 (sk) 2001-04-05 2012-04-03 Nissan Chemical Industries, Ltd. Method for preparing a 7-qunolinyl-3,5-dihydroxyhept-6-enoate
CA2451159A1 (en) 2001-07-06 2003-01-16 Teva Pharmaceutical Industries Ltd. Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
IL159718A0 (en) 2001-07-06 2004-06-20 Teva Pharma Synthesis of intermediates for preparation of stating derivatives
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US7932064B2 (en) 2002-06-13 2011-04-26 Verenium Corporation Processes for making (R)-ethyl 4-cyano-3-hydroxybutyric acid
JP4578240B2 (ja) * 2002-08-09 2010-11-10 コデクシス， インコーポレイテッド ４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス
US7232920B2 (en) * 2003-04-22 2007-06-19 Biocon Process for stereoselective reduction of β-ketoesters
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
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US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
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US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
JP2007502124A (ja) * 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド
RU2315755C2 (ru) * 2003-09-17 2008-01-27 Уорнер-Ламберт Компани Ллс Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1н-пиррол-1-гептановой кислоты
WO2005026107A1 (en) * 2003-09-18 2005-03-24 Biocon Limited Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
US20050159615A1 (en) * 2003-12-24 2005-07-21 Entire Interest. Process for preparation of statins with high syn to anti ratio
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
CA2562844A1 (en) * 2004-04-16 2005-10-27 Pfizer Products Inc. Process for forming amorphous atorvastatin calcium
US7875731B2 (en) 2004-05-05 2011-01-25 Pfizer Inc. Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)Carbonyl]-1H-pyrrole-1-heptanoic acid
AU2005263550C1 (en) * 2004-07-16 2013-01-17 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
JP2008506764A (ja) 2004-07-20 2008-03-06 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー ［Ｒ−（Ｒ＊，Ｒ＊）］−２−（４−フルオロフェニル）−β、δ−ジヒドロキシ−５−（１−メチルエチル）−３−フェニル−４−［（フェニルアミノ）カルボニル］−１Ｈ−ピロール−１−ヘプタン酸カルシウム塩（２：１）の新規形態
CA2585836A1 (en) 2004-10-28 2006-05-04 Warner-Lambert Company Llc Process for forming amorphous atorvastatin
AU2005308575A1 (en) 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia
CA2589537A1 (en) * 2004-12-02 2006-06-08 Stephen Craig Dyar Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
EP1922301A1 (de) * 2005-09-09 2008-05-21 Pfizer Science and Technology Ireland Limited Herstellung eines atorvastatin-zwischenprodukts
ATE432276T1 (de) * 2005-09-09 2009-06-15 Pfizer Science & Tech Ltd Herstellung eines atorvastatin-zwischenprodukts
CA2547216A1 (en) * 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
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CN101528917B (zh) 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
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WO2012158833A2 (en) * 2011-05-16 2012-11-22 The Regents Of The University Of California Methods for production of hydrocarbons and oxygen-containing hydrocarbons
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CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法
CN111978286A (zh) * 2020-08-21 2020-11-24 江苏万年长药业有限公司 一种制备ats-8的方法

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Also Published As

Publication number Publication date
IS5447A (is) 2000-04-14
CO4990941A1 (es) 2000-12-26
HUP0100252A3 (en) 2002-12-28
EP1054860A1 (de) 2000-11-29
HUP0100252A1 (hu) 2001-07-30
CA2305618A1 (en) 1999-07-01
CU22939A3 (es) 2004-04-13
GT199800197A (es) 2000-06-06
PT1054860E (pt) 2007-06-22
PE20000136A1 (es) 2000-03-11
CY1106612T1 (el) 2012-01-25
KR100668575B1 (ko) 2007-01-17
NZ504346A (en) 2001-11-30
PL341294A1 (en) 2001-04-09
KR100681366B1 (ko) 2007-02-12
ZA9811586B (en) 1999-06-17
IL135562A0 (en) 2001-05-20
NO20003139D0 (no) 2000-06-16
NO20003139L (no) 2000-06-16
MY118726A (en) 2005-01-31
BR9813760A (pt) 2000-10-03
US20050197500A1 (en) 2005-09-08
US6596879B2 (en) 2003-07-22
US7232915B2 (en) 2007-06-19
US20020161021A1 (en) 2002-10-31
AU1707499A (en) 1999-07-12
HN1998000187A (es) 1999-10-22
TW444000B (en) 2001-07-01
US20040006231A1 (en) 2004-01-08
DE69837681T2 (de) 2008-01-10
PA8464901A1 (es) 2000-05-24
AR014943A1 (es) 2001-04-11
SV1998000153A (es) 1999-09-30
EP1054860B1 (de) 2007-04-25
KR20010033315A (ko) 2001-04-25
AU755543B2 (en) 2002-12-12
ES2284219T3 (es) 2007-11-01
KR20060080941A (ko) 2006-07-11
CA2305618C (en) 2004-08-17
WO1999032434A1 (en) 1999-07-01
IL135562A (en) 2005-08-31
US6433213B1 (en) 2002-08-13
GT199800197AA (es) 2000-06-06
DE69837681D1 (de) 2007-06-06
DK1054860T3 (da) 2007-07-02
US6962994B2 (en) 2005-11-08
JP2001526256A (ja) 2001-12-18
PL193678B1 (pl) 2007-03-30

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