ATE360613T1 - Verfahren zur synthese von pioglitazon- wasserstoffchlorid - Google Patents
Verfahren zur synthese von pioglitazon- wasserstoffchloridInfo
- Publication number
- ATE360613T1 ATE360613T1 AT04806275T AT04806275T ATE360613T1 AT E360613 T1 ATE360613 T1 AT E360613T1 AT 04806275 T AT04806275 T AT 04806275T AT 04806275 T AT04806275 T AT 04806275T AT E360613 T1 ATE360613 T1 AT E360613T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen chloride
- formula
- pyridinyl
- ethoxy
- ethyl
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title abstract 5
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 title abstract 4
- 229910000041 hydrogen chloride Inorganic materials 0.000 title abstract 3
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229960005095 pioglitazone Drugs 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- YNTUJOCADSTMCL-GZTJUZNOSA-N (5e)-5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1\C=C\1C(=O)NC(=O)S/1 YNTUJOCADSTMCL-GZTJUZNOSA-N 0.000 abstract 1
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 abstract 1
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 abstract 1
- NTSWGSRJHHXHBB-UHFFFAOYSA-N 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde Chemical class N1=CC(CC)=CC=C1CCOC1=CC=C(C=O)C=C1 NTSWGSRJHHXHBB-UHFFFAOYSA-N 0.000 abstract 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 1
- 229940127003 anti-diabetic drug Drugs 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N butenedioic acid Chemical compound OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 1
- 235000011087 fumaric acid Nutrition 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0304096A HUP0304096A2 (hu) | 2003-12-19 | 2003-12-19 | Eljárás pioglitazon hidrogénklorid előállítására és intermedierjei |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360613T1 true ATE360613T1 (de) | 2007-05-15 |
Family
ID=89981865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04806275T ATE360613T1 (de) | 2003-12-19 | 2004-12-16 | Verfahren zur synthese von pioglitazon- wasserstoffchlorid |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1694646B1 (de) |
| AT (1) | ATE360613T1 (de) |
| DE (1) | DE602004006163T2 (de) |
| ES (1) | ES2286712T3 (de) |
| HU (1) | HUP0304096A2 (de) |
| PL (1) | PL1694646T3 (de) |
| WO (1) | WO2005058827A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8722710B2 (en) | 2007-09-26 | 2014-05-13 | Deuterx, Llc | Deuterium-enriched pioglitazone |
| WO2012153312A1 (en) | 2011-05-11 | 2012-11-15 | Ranbaxy Laboratories Limited | Process for the purification of pioglitazone |
| WO2014152843A1 (en) | 2013-03-14 | 2014-09-25 | Deuterx, Llc | Deuterium-enriched 2,4-thiazolidinediones and methods of treatment |
| EP3094328B1 (de) | 2014-01-15 | 2020-08-19 | Poxel SA | Verfahren zur behandlung von neurologischen, stoffwechsel- und anderen erkrankungen mit enantiomerenreinem deuterium-angereicherten pioglitazon |
| ES2926580T3 (es) | 2016-12-23 | 2022-10-27 | Minoryx Therapeutics S L | Proceso para preparar 5-[[4-[2-[5-(1-hidroxietil)-2-piridinil]etoxi]fenil]metil]-2,4-tiazolidindiona y sales de la misma |
| US11319313B2 (en) | 2020-06-30 | 2022-05-03 | Poxel Sa | Crystalline forms of deuterium-enriched pioglitazone |
| US11767317B1 (en) | 2020-06-30 | 2023-09-26 | Poxel Sa | Methods of synthesizing enantiopure deuterium-enriched pioglitazone |
| WO2025019361A1 (en) | 2023-07-14 | 2025-01-23 | Modulation Therapeutics, Inc. | Scd1 inhibitors for treating hematolymphoid neoplasms |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4812570A (en) * | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
| US5952509A (en) * | 1996-06-27 | 1999-09-14 | Takeda Chemical Industries, Ltd. | Production of benzaldehyde compounds |
-
2003
- 2003-12-19 HU HU0304096A patent/HUP0304096A2/hu unknown
-
2004
- 2004-12-16 DE DE602004006163T patent/DE602004006163T2/de not_active Expired - Lifetime
- 2004-12-16 WO PCT/HU2004/000118 patent/WO2005058827A1/en not_active Ceased
- 2004-12-16 PL PL04806275T patent/PL1694646T3/pl unknown
- 2004-12-16 ES ES04806275T patent/ES2286712T3/es not_active Expired - Lifetime
- 2004-12-16 EP EP04806275A patent/EP1694646B1/de not_active Expired - Lifetime
- 2004-12-16 AT AT04806275T patent/ATE360613T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004006163D1 (de) | 2007-06-06 |
| EP1694646A1 (de) | 2006-08-30 |
| EP1694646B1 (de) | 2007-04-25 |
| ES2286712T3 (es) | 2007-12-01 |
| PL1694646T3 (pl) | 2007-09-28 |
| DE602004006163T2 (de) | 2008-01-03 |
| HU0304096D0 (en) | 2004-03-29 |
| HUP0304096A2 (hu) | 2005-08-29 |
| WO2005058827A1 (en) | 2005-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |