ATE364603T1 - Totalsynthese von myriaporonen - Google Patents

Totalsynthese von myriaporonen

Info

Publication number: ATE364603T1
Authority: AT; Austria
Prior art keywords: substituted; unsubstituted; group; aralkyl; aryl
Prior art date: 2002-07-30

Application number

AT03771210T

Other languages

English (en)

Inventor

Alvarez Marta Perez

Pozo Losada C Del

Solloso A Francesch

Marchante C Cuevas

Original Assignee

Pharma Mar Sau

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-30

Filing date

2003-07-30

Publication date

2007-07-15

2003-07-30 Application filed by Pharma Mar Sau filed Critical Pharma Mar Sau

2007-07-15 Application granted granted Critical

2007-07-15 Publication of ATE364603T1 publication Critical patent/ATE364603T1/de

Links

238000006257 total synthesis reaction Methods 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
125000000304 alkynyl group Chemical group 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 2
229910006080 SO2X Inorganic materials 0.000 abstract 1
125000001118 alkylidene group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229940125904 compound 1 Drugs 0.000 abstract 1
229940126214 compound 3 Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Plant Substances (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT03771210T 2002-07-30 2003-07-30 Totalsynthese von myriaporonen ATE364603T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0217638.6A GB0217638D0 (en)	2002-07-30	2002-07-30	Total synthesis of myriaporones

Publications (1)

Publication Number	Publication Date
ATE364603T1 true ATE364603T1 (de)	2007-07-15

Family

ID=9941374

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03771210T ATE364603T1 (de)	2002-07-30	2003-07-30	Totalsynthese von myriaporonen

Country Status (20)

Country	Link
US (1)	US7521478B2 (de)
EP (1)	EP1532139B1 (de)
JP (1)	JP2006504659A (de)
KR (1)	KR20050053599A (de)
CN (1)	CN100390167C (de)
AT (1)	ATE364603T1 (de)
AU (1)	AU2003248984A1 (de)
CA (1)	CA2494532A1 (de)
DE (1)	DE60314426T2 (de)
DK (1)	DK1532139T3 (de)
ES (1)	ES2289337T3 (de)
GB (1)	GB0217638D0 (de)
IL (1)	IL166484A0 (de)
MX (1)	MXPA05001176A (de)
NO (1)	NO20051037L (de)
NZ (1)	NZ537678A (de)
PT (1)	PT1532139E (de)
RU (1)	RU2328492C2 (de)
SI (1)	SI1532139T1 (de)
WO (1)	WO2004011458A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LT3615544T (lt)	2017-04-27	2023-05-10	Pharma Mar S.A.	Priešnavikiniai junginiai

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5514708A (en) *	1994-02-18	1996-05-07	Pharmamar, S.A.	Cytotoxic metabolites from Myriapora truncata
HRP970141A2 (en) *	1997-03-12	1999-02-28	Banić-Tomaueić Zrinka	New secomacrolydes of erythromicin a, and a process for the preparation thereof

2002
- 2002-07-30 GB GBGB0217638.6A patent/GB0217638D0/en not_active Ceased
2003
- 2003-07-30 EP EP03771210A patent/EP1532139B1/de not_active Expired - Lifetime
- 2003-07-30 JP JP2004523987A patent/JP2006504659A/ja active Pending
- 2003-07-30 CA CA002494532A patent/CA2494532A1/en not_active Abandoned
- 2003-07-30 US US10/523,172 patent/US7521478B2/en not_active Expired - Fee Related
- 2003-07-30 CN CNB038233142A patent/CN100390167C/zh not_active Expired - Fee Related
- 2003-07-30 DE DE60314426T patent/DE60314426T2/de not_active Expired - Fee Related
- 2003-07-30 AT AT03771210T patent/ATE364603T1/de not_active IP Right Cessation
- 2003-07-30 KR KR1020057001661A patent/KR20050053599A/ko not_active Ceased
- 2003-07-30 DK DK03771210T patent/DK1532139T3/da active
- 2003-07-30 WO PCT/GB2003/003327 patent/WO2004011458A1/en not_active Ceased
- 2003-07-30 RU RU2005105329/04A patent/RU2328492C2/ru not_active IP Right Cessation
- 2003-07-30 SI SI200330909T patent/SI1532139T1/sl unknown
- 2003-07-30 ES ES03771210T patent/ES2289337T3/es not_active Expired - Lifetime
- 2003-07-30 MX MXPA05001176A patent/MXPA05001176A/es active IP Right Grant
- 2003-07-30 NZ NZ537678A patent/NZ537678A/en unknown
- 2003-07-30 AU AU2003248984A patent/AU2003248984A1/en not_active Abandoned
- 2003-07-30 PT PT03771210T patent/PT1532139E/pt unknown
2005
- 2005-01-25 IL IL16648405A patent/IL166484A0/xx unknown
- 2005-02-25 NO NO20051037A patent/NO20051037L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2289337T3 (es)	2008-02-01
US7521478B2 (en)	2009-04-21
US20080269511A2 (en)	2008-10-30
RU2328492C2 (ru)	2008-07-10
CA2494532A1 (en)	2004-02-05
DE60314426T2 (de)	2008-02-14
EP1532139A1 (de)	2005-05-25
AU2003248984A1 (en)	2004-02-16
US20080103320A2 (en)	2008-05-01
KR20050053599A (ko)	2005-06-08
US20060084819A1 (en)	2006-04-20
SI1532139T1 (sl)	2007-10-31
JP2006504659A (ja)	2006-02-09
NZ537678A (en)	2006-11-30
PT1532139E (pt)	2007-09-20
DK1532139T3 (da)	2007-10-15
CN100390167C (zh)	2008-05-28
EP1532139B1 (de)	2007-06-13
NO20051037L (no)	2005-04-13
CN1684956A (zh)	2005-10-19
RU2005105329A (ru)	2005-08-27
GB0217638D0 (en)	2002-09-11
WO2004011458A1 (en)	2004-02-05
DE60314426D1 (de)	2007-07-26
IL166484A0 (en)	2006-01-15
MXPA05001176A (es)	2005-09-12

Legal Events

Date

Code

Title

Description

2007-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1532139

Country of ref document: EP

2010-04-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK1117297T3 (da)	2006-01-09	Syntetiske analoger af ecteinascidin-743
NO20012617L (no)	2001-09-14	Kinolin- og kinzolinderivater
DK0535231T3 (da)	1995-08-21	Pyrimidinnucleosid-derivater
CY1112899T1 (el)	2016-04-13	Παραγωγα θειαδιαζολινης για τη θεραπεια του καρκινου
TR200403436T2 (tr)	2005-03-21	Kristalin 1-metilkarbapenem türevleri.
NO20040189L (no)	2004-03-16	Nye antitumorderivater av ET-743
EP1022276A4 (de)	2001-12-12	Epoxybernsteinsäureamid-derivate
DE69617909D1 (de)	2002-01-24	2-substituierte vitamin-d3-derivate
MXPA03000341A (es)	2004-04-05	Derivados de variolina como agentes anit-cancer.
DE60314426D1 (de)	2007-07-26	Totalsynthese von myriaporonen
DE60237652D1 (de)	2010-10-21	Variolinderivate und ihre Verwendung als Cytostatika
ATE552003T1 (de)	2012-04-15	Chinoxalinderivate
ATE316524T1 (de)	2006-02-15	Oxy- und aminosubstituierte tetrahydrofurylderivate mit antitumoraktivität