ATE365325T1 - Screening von kombinatorischen peptidbibliotheken zur selektion von peptidliganden zur verwendung in der affinitätsreinigung von zielproteinen - Google Patents
Screening von kombinatorischen peptidbibliotheken zur selektion von peptidliganden zur verwendung in der affinitätsreinigung von zielproteinenInfo
- Publication number
- ATE365325T1 ATE365325T1 AT96106717T AT96106717T ATE365325T1 AT E365325 T1 ATE365325 T1 AT E365325T1 AT 96106717 T AT96106717 T AT 96106717T AT 96106717 T AT96106717 T AT 96106717T AT E365325 T1 ATE365325 T1 AT E365325T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide
- target protein
- target
- peptides
- support material
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 8
- 108090000623 proteins and genes Proteins 0.000 title abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 239000003446 ligand Substances 0.000 title abstract 5
- 108010067902 Peptide Library Proteins 0.000 title abstract 2
- 238000001261 affinity purification Methods 0.000 title abstract 2
- 238000012216 screening Methods 0.000 title 1
- 230000003993 interaction Effects 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 abstract 3
- 238000001514 detection method Methods 0.000 abstract 3
- 239000011347 resin Substances 0.000 abstract 3
- 229920005989 resin Polymers 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 239000011324 bead Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/967—Standards, controls, materials, e.g. validation studies, buffer systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/438,331 US5834318A (en) | 1995-05-10 | 1995-05-10 | Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE365325T1 true ATE365325T1 (de) | 2007-07-15 |
Family
ID=23740236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96106717T ATE365325T1 (de) | 1995-05-10 | 1996-04-29 | Screening von kombinatorischen peptidbibliotheken zur selektion von peptidliganden zur verwendung in der affinitätsreinigung von zielproteinen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5834318A (de) |
| EP (1) | EP0742438B1 (de) |
| JP (1) | JPH09101306A (de) |
| AT (1) | ATE365325T1 (de) |
| AU (1) | AU716309B2 (de) |
| CA (1) | CA2175868A1 (de) |
| DE (1) | DE69637136T2 (de) |
| DK (1) | DK0742438T3 (de) |
| ES (1) | ES2289746T3 (de) |
| PT (1) | PT742438E (de) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277583B1 (en) | 1996-02-07 | 2001-08-21 | Conjuchem, Inc. | Affinity labeling libraries and applications thereof |
| EP1025437A4 (de) * | 1996-03-08 | 2002-10-23 | Smithkline Beecham Corp | Verfahren zum bestimmen der affinität von proteinen für chemische verbindungen beim screenen von kombinatorischen bibliotheken |
| AU4351897A (en) | 1996-09-16 | 1998-04-02 | Conjuchem, Inc. | Affinity labeling libraries with tagged leaving groups |
| GB9800378D0 (en) * | 1998-01-08 | 1998-03-04 | Univ Liverpool | Proteome analysis |
| US6287874B1 (en) | 1998-02-02 | 2001-09-11 | Signature Bioscience, Inc. | Methods for analyzing protein binding events |
| US6720190B1 (en) | 1998-03-27 | 2004-04-13 | Ole Hindsgaul | Methods for screening compound libraries |
| US6613575B1 (en) | 1998-03-27 | 2003-09-02 | Ole Hindsgaul | Methods for screening compound libraries |
| CA2240325A1 (en) | 1998-03-27 | 1998-11-14 | Synsorb Biotech, Inc. | Methods for screening compound libraries |
| US6054047A (en) | 1998-03-27 | 2000-04-25 | Synsorb Biotech, Inc. | Apparatus for screening compound libraries |
| US6261848B1 (en) * | 1998-05-08 | 2001-07-17 | The Johns Hopkins University | Miniature immuno-optical rapid analyte sensor platform |
| US6908770B1 (en) | 1998-07-16 | 2005-06-21 | Board Of Regents, The University Of Texas System | Fluid based analysis of multiple analytes by a sensor array |
| US5994310A (en) * | 1998-09-03 | 1999-11-30 | Bayer Corporation | Peptide ligands for affinity purification of human Factor VIII |
| US6864359B1 (en) | 1999-02-11 | 2005-03-08 | Xencor | Structure-based screening techniques for drug discovery |
| WO2000047612A2 (en) * | 1999-02-11 | 2000-08-17 | Xencor, Inc. | Structure-based screening techniques for drug discovery |
| CA2369868A1 (en) * | 1999-04-15 | 2000-10-26 | The University Of Virginia Patent Foundation | Proteome mining |
| CA2379130A1 (en) | 1999-07-16 | 2001-01-25 | Board Of Regents, The University Of Texas System | Method and apparatus for the delivery of samples to a chemical sensor array |
| US7022517B1 (en) | 1999-07-16 | 2006-04-04 | Board Of Regents, The University Of Texas System | Method and apparatus for the delivery of samples to a chemical sensor array |
| DE19943743C2 (de) * | 1999-09-03 | 2002-02-07 | Jerini Biotools Gmbh | Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays |
| AU4309201A (en) * | 1999-12-02 | 2001-06-12 | V.I. Technologies, Inc. | Method of identifying a ligand for a target molecule |
| ATE403145T1 (de) | 2000-01-31 | 2008-08-15 | Univ Texas | Tragbare vorrichtung mit einer sensor-array- anordnung |
| US6365355B1 (en) | 2000-03-28 | 2002-04-02 | The Regents Of The University Of California | Chimeric proteins for detection and quantitation of DNA mutations, DNA sequence variations, DNA damage and DNA mismatches |
| AU2001251358A1 (en) * | 2000-04-05 | 2001-10-23 | V.I. Technologies, Inc. | Prion-binding ligands and methods of using same |
| EP1326892A2 (de) | 2000-10-12 | 2003-07-16 | University of Rochester | Zusammensetzungen die die proliferation von krebszellen hemmen |
| WO2002058533A2 (en) * | 2000-11-17 | 2002-08-01 | Slanetz Alfred E | Process for determining target function and identifying drug leads |
| WO2002076489A1 (en) * | 2001-03-09 | 2002-10-03 | Dyax Corp. | Serum albumin binding moieties |
| CA2441071C (en) | 2001-03-14 | 2010-06-22 | Myriad Genetics, Inc. | Tsg101-gag interaction and use thereof |
| US7291456B2 (en) | 2002-01-24 | 2007-11-06 | The Regents Of The University Of California | Method for determining differences in molecular interactions and for screening a combinatorial library |
| WO2003062831A1 (en) * | 2002-01-24 | 2003-07-31 | The Regents Of The University Of California | Method for determining differences in molecular interactions and for screening a combinatorial library |
| MXPA04007586A (es) | 2002-02-06 | 2005-06-08 | Vicor Technologies Inc | Moleculas anti-infarto. |
| US20070015230A1 (en) * | 2002-04-15 | 2007-01-18 | Hammond David J | Identification and characterization of analytes from whole blood |
| JP4585766B2 (ja) * | 2002-04-15 | 2010-11-24 | アメリカン ナショナル レッド クロス | 混合物中のリガンドおよび標的を検出する方法 |
| WO2003090605A2 (en) | 2002-04-26 | 2003-11-06 | Board Of Regents, The University Of Texas System | Method and system for the detection of cardiac risk factors |
| EP1578781A4 (de) * | 2002-05-17 | 2007-05-30 | Alfred E Slanetz | Verfahren zur bestimmung der targetfunktion und der identifizierung von arzneimittelleitstrukturen |
| CA2490009A1 (en) * | 2002-06-21 | 2003-12-31 | Dyax Corporation | Serum protein-associated target-specific ligands and identification method therefor |
| US20050287648A1 (en) | 2002-08-05 | 2005-12-29 | University Of Rochester | Protein Transducing Domain/Deaminase Chimeric Proteins, Related Compounds, and Uses Thereof |
| US7863411B2 (en) * | 2002-12-03 | 2011-01-04 | Pathogen Removal and Diagnostics Technologies Inc. | Prion protein ligands and methods of use |
| US20040142379A1 (en) | 2003-01-16 | 2004-07-22 | Carlsberg Research Laboratory | Affinity fishing for ligands and proteins receptors |
| US7510848B2 (en) * | 2003-04-04 | 2009-03-31 | North Carolina State University | Prion protein binding materials and methods of use |
| NZ543371A (en) | 2003-04-04 | 2008-04-30 | Pathogen Removal And Diagnosti | Prion protein binding materials and methods of use |
| CN1806053A (zh) * | 2003-04-14 | 2006-07-19 | 美国红十字会 | 对蛋白的结构同工型特异的配体的鉴定方法 |
| WO2004097371A2 (en) * | 2003-04-25 | 2004-11-11 | Board Of Regents, The University Of Texas System | System and method for the detection of analytes |
| US9317922B2 (en) | 2003-05-16 | 2016-04-19 | Board Of Regents The University Of Texas System | Image and part recognition technology |
| US7651850B2 (en) | 2003-05-16 | 2010-01-26 | Board Of Regents, The University Of Texas System | Image and part recognition technology |
| US20050059083A1 (en) * | 2003-09-15 | 2005-03-17 | Becton Dickinson And Company | High throughput method to identify ligands for cell attachment |
| US8101431B2 (en) | 2004-02-27 | 2012-01-24 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems |
| US8105849B2 (en) | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
| GB0416699D0 (en) * | 2004-07-27 | 2004-09-01 | Prometic Biosciences Ltd | Prion protein ligands and methods of use |
| US7408030B2 (en) * | 2005-01-13 | 2008-08-05 | North Carolina State University | Purification of immunoglobulins using affinity chromatography and peptide ligands |
| US7338775B1 (en) | 2005-02-09 | 2008-03-04 | Myriad Genetics, Inc. | Enzyme assay and use thereof |
| CA2602913C (en) * | 2005-03-23 | 2016-01-05 | Bio-Rad Laboratories, Inc. | Method for purifying proteins |
| CN101500481B (zh) | 2005-04-05 | 2014-07-02 | 康宁股份有限公司 | 一种测定刺激事件对细胞产生的影响的方法 |
| ES2431315T3 (es) | 2005-05-19 | 2013-11-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Epítopos funcionales del antígeno PsaA de Streptococcus pneumoniae y usos de los mismos |
| US8377398B2 (en) | 2005-05-31 | 2013-02-19 | The Board Of Regents Of The University Of Texas System | Methods and compositions related to determination and use of white blood cell counts |
| BRPI0611811A2 (pt) * | 2005-06-10 | 2008-12-09 | Prometic Biosciences Ltd | ligantes de ligaÇço À proteÍna |
| EP2392647A1 (de) | 2005-10-14 | 2011-12-07 | MUSC Foundation For Research Development | Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie |
| US8080534B2 (en) | 2005-10-14 | 2011-12-20 | Phigenix, Inc | Targeting PAX2 for the treatment of breast cancer |
| US20100190689A1 (en) | 2006-09-21 | 2010-07-29 | University Of Rochester | Compositions and methods related to protein displacement therapy for myotonic distrophy |
| US8999317B2 (en) | 2006-11-01 | 2015-04-07 | University Of Rochester | Methods and compositions related to the structure and function of APOBEC3G |
| EP2099957A1 (de) * | 2007-01-10 | 2009-09-16 | GE Healthcare Bio-Sciences AB | Multimodale ionenaustausch-chromotographie-harze |
| WO2008098182A1 (en) | 2007-02-08 | 2008-08-14 | University Of Utah Research Foundation | Methods and compositions related to inhibition of viral entry |
| WO2010027641A2 (en) | 2008-08-15 | 2010-03-11 | Georgetown University | Na channels, disease, and related assays and compositions |
| EP2370080A1 (de) | 2008-12-02 | 2011-10-05 | University of Utah Research Foundation | Pde1 als zieltherapeutikum bei herzkrankheiten |
| KR101183159B1 (ko) * | 2008-12-22 | 2012-09-17 | 한국전자통신연구원 | 바이오 칩 및 이를 이용한 바이오 물질 검출 장치 |
| US20120149663A1 (en) | 2009-08-18 | 2012-06-14 | Georgetown University | Boronic acid compositions and methods related to cancer |
| EP2485768A1 (de) | 2009-10-07 | 2012-08-15 | Sanford-Burnham Medical Research Institute | Verfahren und zusammensetzungen im zusammenhang mit an gerinnseln bindenden lipidzusammensetzungen |
| US20130224730A1 (en) * | 2009-11-18 | 2013-08-29 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Peptide ligands |
| WO2011075725A1 (en) | 2009-12-18 | 2011-06-23 | Sanford-Burnham Medical Research Institute | Methods and compositions related to clot-binding compounds |
| WO2012058726A1 (en) | 2010-11-05 | 2012-05-10 | Transbio Ltd | Markers of endothelial progenitor cells and uses thereof |
| AU2012230880B2 (en) * | 2011-03-24 | 2017-04-13 | Opko Pharmaceuticals, Llc | Biomarker discovery in complex biological fluid using bead or particle based libraries and diagnostic kits and therapeutics |
| JP6205345B2 (ja) | 2011-03-28 | 2017-09-27 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | ウイルス侵入の阻害に関する方法および組成物 |
| EP2850095B1 (de) | 2012-05-17 | 2019-10-09 | RA Pharmaceuticals, Inc. | Peptid- und peptidomimetische inhibitoren |
| CN103513039B (zh) * | 2013-07-10 | 2015-12-23 | 广州美格生物科技有限公司 | 一种利用定向肽库检测蛋白质与其他分子相互作用的方法 |
| HRP20211561T8 (hr) | 2014-06-12 | 2022-03-04 | Ra Pharmaceuticals, Inc. | Modulacija aktivnosti komplementa |
| EP3250230B9 (de) | 2015-01-28 | 2022-02-23 | RA Pharmaceuticals, Inc. | Modulatoren der komplementaktivität |
| EP3380514A4 (de) | 2015-11-27 | 2019-05-22 | CSL Limited | Gdf131-bindende proteine und verwendungen davon |
| EP3685847B1 (de) | 2015-12-16 | 2023-01-11 | RA Pharmaceuticals, Inc. | Modulatoren der komplementaktivität |
| TW201836634A (zh) | 2016-12-07 | 2018-10-16 | 美商Ra製藥公司 | 補體活性之調節劑 |
| US12025615B2 (en) | 2017-09-15 | 2024-07-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods of classifying response to immunotherapy for cancer |
| ES2973767T3 (es) | 2019-06-04 | 2024-06-24 | Ra Pharmaceuticals Inc | Tratamiento de enfermedades inflamatorias con inhibidores del complemento |
| EP4038222A4 (de) | 2019-10-02 | 2023-10-18 | Arizona Board of Regents on behalf of Arizona State University | Verfahren und zusammensetzungen zur identifizierung von neoantigenen zur verwendung bei der behandlung und vorbeugung von krebs |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5133866A (en) * | 1988-03-24 | 1992-07-28 | Terrapin Technologies, Inc. | Method to identify analyte-bending ligands |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| EP0473065A3 (en) * | 1990-08-29 | 1992-08-26 | Abbott Laboratories | Simultaneous assay for detecting two or more analytes |
-
1995
- 1995-05-10 US US08/438,331 patent/US5834318A/en not_active Expired - Lifetime
-
1996
- 1996-04-29 EP EP96106717A patent/EP0742438B1/de not_active Expired - Lifetime
- 1996-04-29 PT PT96106717T patent/PT742438E/pt unknown
- 1996-04-29 ES ES96106717T patent/ES2289746T3/es not_active Expired - Lifetime
- 1996-04-29 DK DK96106717T patent/DK0742438T3/da active
- 1996-04-29 DE DE69637136T patent/DE69637136T2/de not_active Expired - Lifetime
- 1996-04-29 AT AT96106717T patent/ATE365325T1/de active
- 1996-05-06 CA CA002175868A patent/CA2175868A1/en not_active Abandoned
- 1996-05-06 AU AU52087/96A patent/AU716309B2/en not_active Ceased
- 1996-05-07 JP JP8135710A patent/JPH09101306A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69637136T2 (de) | 2008-02-21 |
| AU716309B2 (en) | 2000-02-24 |
| JPH09101306A (ja) | 1997-04-15 |
| EP0742438A2 (de) | 1996-11-13 |
| EP0742438B1 (de) | 2007-06-20 |
| EP0742438A3 (de) | 1998-04-08 |
| CA2175868A1 (en) | 1996-11-11 |
| ES2289746T3 (es) | 2008-02-01 |
| DK0742438T3 (da) | 2007-10-29 |
| PT742438E (pt) | 2007-09-21 |
| US5834318A (en) | 1998-11-10 |
| AU5208796A (en) | 1996-11-21 |
| DE69637136D1 (de) | 2007-08-02 |
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