ATE366932T1 - Nanopartikel mit polymerschalen - Google Patents

Nanopartikel mit polymerschalen

Info

Publication number
ATE366932T1
ATE366932T1 AT99962951T AT99962951T ATE366932T1 AT E366932 T1 ATE366932 T1 AT E366932T1 AT 99962951 T AT99962951 T AT 99962951T AT 99962951 T AT99962951 T AT 99962951T AT E366932 T1 ATE366932 T1 AT E366932T1
Authority
AT
Austria
Prior art keywords
analyte
monomers
attached
activity
propagation
Prior art date
Application number
AT99962951T
Other languages
English (en)
Inventor
Chad Mirkin
Sonbinh Nguyen
Original Assignee
Nanosphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosphere Inc filed Critical Nanosphere Inc
Application granted granted Critical
Publication of ATE366932T1 publication Critical patent/ATE366932T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587Nanoparticles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346Nanoparticles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/583Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Composite Materials (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Materials Engineering (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Polymerisation Methods In General (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT99962951T 1998-11-30 1999-11-30 Nanopartikel mit polymerschalen ATE366932T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11032798P 1998-11-30 1998-11-30

Publications (1)

Publication Number Publication Date
ATE366932T1 true ATE366932T1 (de) 2007-08-15

Family

ID=22332416

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99962951T ATE366932T1 (de) 1998-11-30 1999-11-30 Nanopartikel mit polymerschalen

Country Status (9)

Country Link
US (1) US7115688B1 (de)
EP (2) EP1135682B1 (de)
JP (1) JP3650582B2 (de)
CN (2) CN1182395C (de)
AT (1) ATE366932T1 (de)
AU (1) AU768535B2 (de)
CA (1) CA2352362C (de)
DE (1) DE69936534T2 (de)
WO (1) WO2000033079A1 (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
AU4043497A (en) 1996-07-29 1998-02-20 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6767702B2 (en) 1996-07-29 2004-07-27 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
WO2000024941A1 (en) 1998-10-27 2000-05-04 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
EP1135682B1 (de) 1998-11-30 2007-07-11 Nanosphere, Inc. Nanopartikel mit polymerschalen
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
AU2001238440A1 (en) * 2000-02-18 2001-08-27 Biophan, Llc Hybrid nucleic acid assembly
DE60119170T2 (de) 2000-07-11 2007-05-24 Northwestern University, Evanston Nachweismethode mittels verstärkter silberfärbung
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
EP1348034B1 (de) * 2000-11-15 2016-07-20 Minerva Biotechnologies Corporation Oligonukleotididentifikatoren
FI20002623A7 (fi) * 2000-11-30 2002-05-31 Inno Trac Diagnostics Oy Bioanalyyttinen määritysmenetelmä
WO2002046483A2 (en) 2000-12-06 2002-06-13 Northwestern University Silver stain removal from dna detection chips by cyanide etching or sonication
DE10105711B4 (de) * 2001-02-08 2005-03-10 Ibidi Gmbh Probenträger für chemische und biologische Proben
AU2002367709A1 (en) * 2001-04-26 2003-10-27 Nanosphere, Inc. Oligonucleotide-modified romp polymers and co-polymers
AU2002239726A1 (en) 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
US7147687B2 (en) 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
JP3728411B2 (ja) * 2001-09-18 2005-12-21 ソニー株式会社 磁性粒子の作製方法、磁性粒子および磁性材料
WO2003031561A1 (en) * 2001-10-10 2003-04-17 Biomed Solutions, Llc Hybrid nucleic acid assembly
KR100969086B1 (ko) 2001-10-10 2010-07-09 제이에스알 가부시끼가이샤 노르보르넨 유도체 및 그의 노르보르넨계 개환 중합체
EP1466015B1 (de) 2001-11-09 2008-08-06 Nanosphere, Inc. Biokonjugat-nanopartikelsonden
DE10203907A1 (de) * 2002-01-31 2003-08-21 Karlsruhe Forschzent Fluoreszierende Nanoteilchen und deren Herstellung
WO2003083478A1 (en) * 2002-04-03 2003-10-09 Japan Science And Technology Agency Biochip sensor surface carrying polyethylene glycolated nanoparticles
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
WO2004004647A2 (en) 2002-07-02 2004-01-15 Nanosphere Inc. Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
EP1439391A3 (de) * 2003-01-15 2005-07-27 Agilent Technologies, Inc. Biosensorsysteme und Verfahren zur Detektion der Anwesenheit von Biomolekülen
US7825200B2 (en) * 2003-02-28 2010-11-02 The Regents Of The University Of California Controlled free radical grafting from polyolefins
EP1624306A4 (de) * 2003-04-30 2008-12-24 Chengdu Kuachang Medical Ind L Zur trennung oder analyse verwendete nanostrukturen enthaltende vorrichtung sowie herstellung und anwendung davon
EP1634050A4 (de) * 2003-05-16 2008-06-18 Univ Rochester Kolorimetrische und fluoreszenzverfahren zur wahrnehmung von oligonukleotiden
US7488451B2 (en) 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
CN1297253C (zh) * 2004-06-15 2007-01-31 复旦大学 一种可脑内递药的药物传递系统
FR2871701B1 (fr) * 2004-06-21 2006-09-22 Centre Nat Rech Scient Cnrse Biomateriaux bioactifs pour le relarguage controle de principes actifs
US7288134B2 (en) 2004-09-10 2007-10-30 International Business Machines Corporation Dumbbell-like nanoparticles and a process of forming the same
JP5014796B2 (ja) * 2004-09-30 2012-08-29 株式会社カネカ ポリマー修飾金属カルコゲン化物ナノ粒子の製造方法
US7820394B2 (en) * 2005-12-02 2010-10-26 Catassays Ultrasensitive bioanalytical assays based on the use of high-gain catalytic chemical amplification
CN101489777B (zh) * 2006-05-22 2014-02-12 纳诺麦克有限公司 涂有金属的非金属纳米粒子/微粒子及其方法和应用
US8481161B2 (en) * 2006-06-28 2013-07-09 Samsung Electronics Co., Ltd. Functionalized metal nanoparticle and method for formation of conductive pattern using the same
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
CN101663581A (zh) * 2007-04-19 2010-03-03 3M创新有限公司 水分散性二氧化硅纳米颗粒在连接生物分子方面的用途
WO2008131063A1 (en) * 2007-04-19 2008-10-30 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
US8268638B2 (en) 2007-07-18 2012-09-18 Advantageous Systems, Llc Methods and apparatuses for detecting analytes in biological fluid of an animal
WO2009145813A1 (en) 2008-03-04 2009-12-03 Qd Vision, Inc. Particles including nanoparticles, uses thereof, and methods
KR101462653B1 (ko) * 2008-05-20 2014-11-17 삼성전자 주식회사 카르벤 유도체를 이용한 나노입자 제조방법
DE102009015470A1 (de) * 2008-12-12 2010-06-17 Byk-Chemie Gmbh Verfahren zur Herstellung von Metallnanopartikeln und auf diese Weise erhaltene Metallnanopartikel und ihre Verwendung
WO2010118336A1 (en) * 2009-04-10 2010-10-14 Rensselaer Polytechnic Institute Diblock copolymer modified nanoparticle-polymer nanocomposites for electrical insulation
EP2246376B1 (de) 2009-04-27 2014-03-05 Leibniz-Institut für Polymerforschung Dresden e.V. Verfahren zur Herstellung von Partikeln mit einer Polymerkonjugathülle
US8268359B2 (en) * 2009-08-26 2012-09-18 Indian Institute Of Technology Madras Organic polymer-inorganic fine particle antimicrobial composites and uses thereof
CN102482457B (zh) 2009-09-09 2015-04-15 Qd视光有限公司 包含纳米颗粒的颗粒、其应用和方法
WO2011031876A1 (en) 2009-09-09 2011-03-17 Qd Vision, Inc. Formulations including nanoparticles
WO2012134629A1 (en) 2011-04-01 2012-10-04 Qd Vision, Inc. Quantum dots, method, and devices
CA2778561C (en) * 2011-05-31 2020-10-13 Ghandi, Khashayar Magnetic nanocomposite material and processes for the production thereof
US10332657B2 (en) * 2011-09-23 2019-06-25 Nanyang Technological University Methods for forming gold nanowires on a substrate and gold nanowires formed thereof
EP2636693A1 (de) * 2012-03-09 2013-09-11 Universitätsklinikum Freiburg Synthese und Mikro-/Nanostrukturierung von oberflächenanhaftenden, vernetzten antimikrobiellen und/der antibiofaulenden Polymernetzwerken
US9512468B2 (en) 2012-11-06 2016-12-06 Industrial Technology Research Institute Detection method uses magnetic and detectable nanoparticles with oligonucleotides attached thereto
WO2014143383A1 (en) 2013-03-13 2014-09-18 Agilent Technologies, Inc. Transposome tethered to a gene delivery vehicle
DE102013106432A1 (de) * 2013-06-20 2014-12-24 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Optische Indikator-Einheit und Vorrichtung und Verfahren zur Bestimmung einer physikalisch-chemischen Eigenschaft eines Prozessmediums in einer prozesstechnischen Anlage
JP6360345B2 (ja) * 2014-04-22 2018-07-18 五稜化薬株式会社 キサンテン化合物及びその用途
WO2017041061A1 (en) * 2015-09-04 2017-03-09 Massachusetts Institute Of Technology Synthesis of nanocrystals
CN111848472A (zh) * 2016-08-05 2020-10-30 深圳深见医药科技有限公司 含金团簇的物质在制备预防和治疗阿兹海默病药物中的应用
CN110139828B (zh) 2016-08-25 2021-05-28 豪夫迈·罗氏有限公司 多官能化硅纳米颗粒、其制备方法及其在基于电化学发光的检测方法中的用途
US20190292310A1 (en) * 2018-03-20 2019-09-26 Northeastern University Synthesis of high density molecular dna brushes via organic-phase ring-opening metathesis (co)polymerization
CN108997520B (zh) * 2018-06-07 2020-07-28 上海应用技术大学 一种降冰片烯衍生物含异类糖单元均聚物及其合成方法
WO2020080833A1 (ko) 2018-10-17 2020-04-23 주식회사 이지다이아텍 생체물질 검출용 미세 입자 및 이를 이용한 생체물질 검출방법
CN111229169A (zh) * 2018-11-29 2020-06-05 天津大学 蛋白功能化磁性复合材料及其制备方法和应用
CN114522728B (zh) * 2020-11-04 2024-04-19 中国科学院宁波材料技术与工程研究所慈溪生物医学工程研究所 一种二茂铁功能化的纳米催化剂及其制备方法与应用
CN112067647B (zh) * 2020-11-11 2021-01-15 东南大学 一种检测液体生物样本葡萄糖含量的弛豫核磁共振方法

Family Cites Families (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2283189A2 (fr) 1974-06-14 1976-03-26 Ugine Kuhlmann Procede de preparation de particules pigmentaires revetues d'un polymere organique et compositions en resultant
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
NL7807532A (nl) 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4318707A (en) 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4256834A (en) 1979-04-09 1981-03-17 Syva Company Fluorescent scavenger particle immunoassay
US4261968A (en) 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4650770A (en) 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
US4454234A (en) * 1981-12-30 1984-06-12 Czerlinski George H Coated magnetizable microparticles, reversible suspensions thereof, and processes relating thereto
US4713348A (en) 1983-04-05 1987-12-15 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4868104A (en) 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4996143A (en) 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
US5137827A (en) 1986-03-25 1992-08-11 Midwest Research Technologies, Inc. Diagnostic element for electrical detection of a binding reaction
US5514602A (en) 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
JPS63191864A (ja) * 1987-02-04 1988-08-09 Fuji Xerox Co Ltd 表面処理顔料の製造方法
US5360895A (en) 1987-04-22 1994-11-01 Associated Universities, Inc. Derivatized gold clusters and antibody-gold cluster conjugates
US4853335A (en) 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
EP0317262B1 (de) * 1987-11-17 1996-01-31 Japan Synthetic Rubber Co., Ltd. Transparentes Harzmaterial
GB8800702D0 (en) 1988-01-13 1988-02-10 Nycomed As Test method & reagent kit therefor
WO1990002205A1 (en) 1988-08-25 1990-03-08 Angenics, Inc. Detection of nucleic acid sequences using particle agglutination
FR2654836B1 (fr) * 1989-11-17 1994-01-28 Biotrol Sa Laboratoires Appareil d'execution automatique d'un immunodosage en plusieurs etapes successives d'au moins une substance biologique dans une pluralite d'echantillons biologiques, procede et reactif mettant en óoeuvre ledit appareil.
US5460831A (en) 1990-06-22 1995-10-24 The Regents Of The University Of California Targeted transfection nanoparticles
GB9019512D0 (en) 1990-09-06 1990-10-24 Ici Plc Assay method
US5665582A (en) 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
WO1992008133A1 (en) 1990-10-29 1992-05-14 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
US5639620A (en) * 1990-10-31 1997-06-17 Coulter Corporation Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
ES2034891B1 (es) 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
EP0613585A4 (de) 1991-11-22 1995-06-21 Univ California Halbleitende nanokristalle, die durch selbstzusammengesetzte einzelschichten mit festen anorganischen oberflüchen verbunden sind.
US5225064A (en) 1992-01-15 1993-07-06 Enzyme Technology Research Group, Inc. Peroxidase colloidal gold oxidase biosensors for mediatorless glucose determination
US5710298A (en) 1992-04-03 1998-01-20 California Institute Of Technology Method of preparing ruthenium and osmium carbene complexes
AU691645B2 (en) 1992-04-03 1998-05-21 California Institute Of Technology High activity ruthenium or osmium metal carbene complexes for olefin metathesis reactions and synthesis thereof
US5312940A (en) 1992-04-03 1994-05-17 California Institute Of Technology Ruthenium and osmium metal carbene complexes for olefin metathesis polymerization
GB9212164D0 (en) 1992-06-09 1992-07-22 Medical Res Council Preparation of nucleic acids
US5472881A (en) 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
US5384265A (en) 1993-03-26 1995-01-24 Geo-Centers, Inc. Biomolecules bound to catalytic inorganic particles, immunoassays using the same
US5637508A (en) 1993-03-26 1997-06-10 Geo-Centers, Inc. Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same
FR2703359B1 (fr) 1993-03-31 1995-06-23 Cis Bio Int Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation .
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
US5512635A (en) 1993-05-27 1996-04-30 Amoco Corporation Process for preparing linear monofunctional and telechelic difunctional polymers and compositions obtained thereby
EP0702728B1 (de) 1993-06-09 1998-04-15 Gamera Bioscience Corporation Magnetische zyklusreaktionen
EP0630974A3 (de) 1993-06-25 1995-11-15 Clinical Diagnostic Syst Verfahren und Testkit zum Nachweis von anorganischen Orthophosphat bei der Amplifizierung von Zielnukleinsäuren.
EP0706709A1 (de) * 1993-06-30 1996-04-17 Carnegie Mellon University Metall, legierung, oder metallkarbid nanopartikeln und ihrer herstellungsverfahren
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US5468819A (en) 1993-11-16 1995-11-21 The B.F. Goodrich Company Process for making polymers containing a norbornene repeating unit by addition polymerization using an organo (nickel or palladium) complex
US5639900A (en) 1993-12-29 1997-06-17 Metton America, Inc. Thermally activated olefin metathesis catalyst precursor
JPH07227299A (ja) 1994-02-14 1995-08-29 Kyoto Daiichi Kagaku:Kk Dnaの特定塩基配列の検出方法及びその装置
ES2078190B1 (es) * 1994-05-20 1996-08-01 Cusi Lab Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
MX9606616A (es) 1994-07-08 1997-04-30 Minnesota Mining & Mfg Reaccion superatmosferica.
US5521289A (en) 1994-07-29 1996-05-28 Nanoprobes, Inc. Small organometallic probes
US5599668A (en) 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5634620A (en) * 1994-11-10 1997-06-03 Verot; Thierry R. E. Clamp assembly for motor flushing device
US5747248A (en) 1994-12-05 1998-05-05 Chiron Corporation Discontinuous probe design using hybritope mapping
US6025202A (en) 1995-02-09 2000-02-15 The Penn State Research Foundation Self-assembled metal colloid monolayers and detection methods therewith
US5609907A (en) 1995-02-09 1997-03-11 The Penn State Research Foundation Self-assembled metal colloid monolayers
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US5840820A (en) 1995-04-13 1998-11-24 The University Of North Carolina At Chapel Hill Olefin metathesis reactions in carbon dioxide medium
US5677405A (en) 1995-05-24 1997-10-14 The B.F. Goodrich Company Homopolymers and copolymers of cationically polymerizable monomers and method of their preparation
US6509459B1 (en) 1995-06-01 2003-01-21 Hybridon, Inc. Base protecting groups and rapid process for oligonucleotide synthesis
US5811515A (en) 1995-06-12 1998-09-22 California Institute Of Technology Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis
AU704867B2 (en) 1995-06-23 1999-05-06 Minnesota Mining And Manufacturing Company Composition and process for imparting durable repellency to substrates
US5728785A (en) 1995-07-07 1998-03-17 California Institute Of Technology Romp polymerization in the presence of peroxide crosslinking agents to form high-density crosslinked polymers
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
DE19527124A1 (de) 1995-07-25 1997-01-30 Henkel Kgaa Oxidationsfärbemittel
US5831108A (en) 1995-08-03 1998-11-03 California Institute Of Technology High metathesis activity ruthenium and osmium metal carbene complexes
US5939504A (en) 1995-12-07 1999-08-17 Advanced Polymer Technologies Method for extending the pot life of an olefin metathesis polymerization reaction
US6020443A (en) 1996-02-08 2000-02-01 Advanced Polymer Technologies, Inc. Polymerization of low grade DCPD monomers using an olefin metathesis catalyst
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
RU2251572C2 (ru) 1996-04-25 2005-05-10 Дженикон Сайенсиз Корпорейшн, Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Анализ аналитов с использованием частиц в качестве метки
US6156692A (en) 1996-04-30 2000-12-05 Bp Amoco Corporation Ruthenium-containing catalyst composition for olefin metathesis
US6159890A (en) 1996-04-30 2000-12-12 Bp Amoco Corporation Ruthenium-containing catalyst system for olefin metathesis
US5766764A (en) 1996-06-04 1998-06-16 The Boeing Company Nanoscale amorphous magnetic metals
FR2750136B1 (fr) 1996-06-25 1998-08-14 Cis Bio Int Conjugues d'un oligonucleotide/polymere conducteur electronique avec une molecule d'interet, et leurs utilisations
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
AU4043497A (en) 1996-07-29 1998-02-20 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6767702B2 (en) 1996-07-29 2004-07-27 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6060570A (en) 1996-08-12 2000-05-09 Bp Amoco Corporation Process for preparation of addition products of difunctional telechelic polyolefins from cyclic olefins by olefin metathesis reaction
WO1998010289A1 (en) 1996-09-04 1998-03-12 The Penn State Research Foundation Self-assembled metal colloid monolayers
AU6810898A (en) 1996-10-23 1998-05-15 Skw Trostberg Aktiengesellschaft Process for producing biologically active polymer nanoparticle-nucleic acid conjugates
US5830986A (en) 1996-10-28 1998-11-03 Massachusetts Institute Of Technology Methods for the synthesis of functionalizable poly(ethylene oxide) star macromolecules
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US5922537A (en) 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US5917071A (en) 1996-11-15 1999-06-29 California Institute Of Technology Synthesis of ruthenium or osmium metathesis catalysts
US6310121B1 (en) 1996-12-02 2001-10-30 Cymetech, Llc Polymeric composites including dicyclopentadiene and related monomers
US5760126A (en) 1996-12-20 1998-06-02 Minnesota Mining And Manufacturing Company Aqueous fluorochemical compositions and abrasion-resistant coatings therefrom
US6080826A (en) 1997-01-06 2000-06-27 California Institute Of Technology Template-directed ring-closing metathesis and ring-opening metathesis polymerization of functionalized dienes
US5939021A (en) 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
JP4065573B2 (ja) 1997-04-18 2008-03-26 ベーリンガー・インゲルハイム・インテルナツィオナール・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 反応媒体として圧縮二酸化炭素中における二官能性または多官能性基質の選択的オレフィンメタセシス
US5916983A (en) 1997-05-27 1999-06-29 Bend Research, Inc. Biologically active compounds by catalytic olefin metathesis
US6107237A (en) 1997-07-10 2000-08-22 University Of Florida Homogeneous metathesis/heterogeneous hydrogenation
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
DE19736609A1 (de) 1997-08-22 1999-02-25 Basf Ag Verfahren zur Herstellung von Rutheniumkomplexen
US5808126A (en) 1997-09-03 1998-09-15 Dow Corning Corporation Synthesis of functional silyl terminated branched polyalkenylenes and polyolefins
CA2246155A1 (en) 1997-09-05 1999-03-05 Michael A. Giardello Metathesis polymerized olefin articles containing flame-retarding agents
AU9303798A (en) 1997-09-05 1999-03-22 A.O. Smith Corporation Metathesis polymerized olefin composites including sized reinforcement material
AUPP004497A0 (en) 1997-10-28 1997-11-20 University Of Melbourne, The Stabilized particles
US6149868A (en) 1997-10-28 2000-11-21 The Penn State Research Foundation Surface enhanced raman scattering from metal nanoparticle-analyte-noble metal substrate sandwiches
US6284852B1 (en) 1997-10-30 2001-09-04 California Institute Of Technology Acid activation of ruthenium metathesis catalysts and living ROMP metathesis polymerization in water
JP2002509443A (ja) 1997-10-31 2002-03-26 ジェン−プローブ・インコーポレーテッド 核酸検出法
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5972615A (en) 1998-01-21 1999-10-26 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6121473A (en) 1998-02-19 2000-09-19 Massachusetts Institute Of Technology Asymmetric ring-closing metathesis reactions
AU3763299A (en) 1998-04-27 1999-11-16 University Of Akron, The Supramolecular structures and process for making the same
US6287765B1 (en) 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6346652B1 (en) 1998-07-13 2002-02-12 Massachusetts Institute Of Technology Asymmetric ring-closing metathesis reactions involving achiral and meso substrates
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6107420A (en) 1998-07-31 2000-08-22 California Institute Of Technology Thermally initiated polymerization of olefins using Ruthenium or osmium vinylidene complexes
US6306610B1 (en) 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
IL126776A (en) 1998-10-27 2001-04-30 Technion Res & Dev Foundation A method of investing gold
EP1135682B1 (de) 1998-11-30 2007-07-11 Nanosphere, Inc. Nanopartikel mit polymerschalen
US6277489B1 (en) 1998-12-04 2001-08-21 The Regents Of The University Of California Support for high performance affinity chromatography and other uses
CA2297343A1 (en) 1999-01-29 2000-07-29 Vernon L. Kyllingstad Ruthenium catalysts for metathesis reactions of olefins
US6225488B1 (en) 1999-04-02 2001-05-01 Nippon Zeon Co., Ltd. Ruthenium or osmium catalysts for olefin metathesis reactions
US6271315B1 (en) 1999-06-17 2001-08-07 Wisconsin Alumni Research Foundation Methods for making multivalent arrays
US6291616B1 (en) 1999-06-17 2001-09-18 Wisconsin Alumni Research Foundation Methods and reagents for capping ruthenium or osmium carbene-catalyzed ROMP products
EP1198591B1 (de) 1999-06-25 2011-03-16 Nanosphere, Inc. Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
AU2001255203A1 (en) 2000-03-28 2001-10-08 Nanosphere Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6927033B2 (en) 2000-05-11 2005-08-09 Toudai Tlo, Ltd. Polymer composition for forming surface of biosensor
DE60119170T2 (de) 2000-07-11 2007-05-24 Northwestern University, Evanston Nachweismethode mittels verstärkter silberfärbung
AU2001281248A1 (en) 2000-08-11 2002-03-13 Nanosphere Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
WO2002036169A2 (en) 2000-10-31 2002-05-10 Pr Pharmaceuticals, Inc. Methods and compositions for enhanced delivery of bioactive molecules
WO2002046483A2 (en) 2000-12-06 2002-06-13 Northwestern University Silver stain removal from dna detection chips by cyanide etching or sonication
EP1356109A2 (de) 2000-12-08 2003-10-29 Nanosphere, Inc. Nanopartikel an denen oligonukleotide gebunden sind und deren verwendung
ATE431853T1 (de) 2001-03-28 2009-06-15 Nanosphere Inc Auf oligonukleotid-modifizierten partikeln basierende bio-strichcodes
US20030113740A1 (en) 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
AU2002367709A1 (en) 2001-04-26 2003-10-27 Nanosphere, Inc. Oligonucleotide-modified romp polymers and co-polymers
AU2002239726A1 (en) 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
US7147687B2 (en) 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
CA2455118C (en) 2001-08-03 2012-01-17 Nanosphere, Inc. Nanoparticle imaging system and method
WO2003035829A2 (en) 2001-10-09 2003-05-01 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
EP1466015B1 (de) 2001-11-09 2008-08-06 Nanosphere, Inc. Biokonjugat-nanopartikelsonden
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
WO2004004647A2 (en) 2002-07-02 2004-01-15 Nanosphere Inc. Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
AU2003302253B2 (en) 2002-12-12 2007-06-28 Nanosphere, Inc. Direct SNP detection with unamplified DNA

Also Published As

Publication number Publication date
EP2000803A1 (de) 2008-12-10
DE69936534D1 (de) 2007-08-23
AU1928600A (en) 2000-06-19
EP1135682A1 (de) 2001-09-26
CN1182395C (zh) 2004-12-29
CN1607390A (zh) 2005-04-20
JP3650582B2 (ja) 2005-05-18
CN100406890C (zh) 2008-07-30
EP1135682B1 (de) 2007-07-11
EP1135682A4 (de) 2002-09-25
US7115688B1 (en) 2006-10-03
WO2000033079A1 (en) 2000-06-08
CA2352362A1 (en) 2000-06-08
AU768535B2 (en) 2003-12-18
CN1328641A (zh) 2001-12-26
JP2002531830A (ja) 2002-09-24
DE69936534T2 (de) 2008-03-13
CA2352362C (en) 2009-02-17

Similar Documents

Publication Publication Date Title
ATE366932T1 (de) Nanopartikel mit polymerschalen
Islam et al. Polyelectrolyte mediated intra and intermolecular crosslinking in microgel-based etalons for sensing protein concentration in solution
SE0201468D0 (sv) Metod att använda luminescenta polymerer för detektion av biospecifik växelverkan
WO1999049293A3 (en) Methods, kits and compositions pertaining to detection complexes
ATE514084T1 (de) Sensor zum nachweis von kohlenhydrat
DE60325743D1 (de) Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
TW200508610A (en) Biosensor and method of measuring object to be measured
Shiddiky et al. An electrochemical immunosensor to minimize the nonspecific adsorption and to improve sensitivity of protein assays in human serum
WO2001059453A3 (en) Biosensor compositions and methods of use
EP1692486A4 (de) Biosensoren zum nachweis von makromolekülen und anderen analyten
DE69841304D1 (de) Nucleinsäure enthaltender polymerisierbarer komplex
ATE515693T1 (de) Nachweis einer zielsubstanz in einer probe
ATE286066T1 (de) Verfahren, kits und zusammenfassungen mit beziehung zu linearen baken
DE60039905D1 (de) Enzyme enthaltende polymerische sensoren
WO2002018951A3 (en) Methods employing fluorescence quenching by metal surfaces
EP1671118A4 (de) Cyanid wahrnehmende verbindungen und verwendungen davon
EP0142810B1 (de) Integralantikörper enthaltende polymerisierbare Verbindungen und deren Anwendungen in Immuntesten mit durch Polymerisation induzierter Trennung
FR2824323B1 (fr) Reactif de marquage et procede de detection de molecules biologiques
US4711840A (en) Polymerization-induced separation immunoassays
CA2078184A1 (en) Acoustic reflection process for molecular sensing and applications of the process
Torres-Rodriguez et al. Synthesis of a biotin functionalized pyrrole and its electropolymerization: toward a versatile avidin biosensor
DK1246945T3 (da) Fremgangsmåde til identifikation af en mærkning anbragt på et fast legeme
ATE259964T1 (de) Kompetitives assay-verfahren
DE602004027085D1 (de) M für leberkrebs sowie heilmittel gegen krebs
Tuncel et al. A novel approach for albumin determination in aqueous media by using temperature‐and pH‐sensitive N‐isopropylacrylamide‐co‐N‐[3‐(dimethylamino)‐propyl] methacrylamide random copolymers

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties