|
US20050123940A1
(en)
*
|
1999-10-29 |
2005-06-09 |
Stratagene California |
Compositions and methods for synthesizing cDNA
|
|
US20030228616A1
(en)
*
|
1999-10-29 |
2003-12-11 |
Stratagene |
DNA polymerase mutants with reverse transcriptase activity
|
|
US20040009486A1
(en)
*
|
1999-10-29 |
2004-01-15 |
Sorge Joseph A. |
Compositions and methods utilizing DNA polymerases
|
|
US8268605B2
(en)
|
1999-10-29 |
2012-09-18 |
Agilent Technologies, Inc. |
Compositions and methods utilizing DNA polymerases
|
|
EP1259624B1
(de)
*
|
2000-02-17 |
2008-05-14 |
Qiagen GmbH |
Thermostabile chimäre nucleinsäurepolymerasen und ihre verwendungen
|
|
US6627424B1
(en)
*
|
2000-05-26 |
2003-09-30 |
Mj Bioworks, Inc. |
Nucleic acid modifying enzymes
|
|
DE10049211A1
(de)
*
|
2000-10-05 |
2002-04-18 |
Qiagen Gmbh |
Thermostabile Polymerase aus Thermococcus pacificus
|
|
AU2002227156A1
(en)
|
2000-12-01 |
2002-06-11 |
Visigen Biotechnologies, Inc. |
Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
|
|
WO2003046149A2
(en)
*
|
2001-11-28 |
2003-06-05 |
Mj Bioworks Incorporated |
Methods of using improved polymerases
|
|
US7163790B2
(en)
*
|
2001-11-28 |
2007-01-16 |
Bio-Rad Laboratories, Inc. |
Parallel polymorphism scoring by amplification and error correction
|
|
US20060234227A1
(en)
*
|
2002-05-14 |
2006-10-19 |
Alexei Slesarev |
Helix-hairpin-helix motifs to manipulate properties of dna processing enzymes
|
|
US7560260B2
(en)
*
|
2002-07-25 |
2009-07-14 |
Bio-Rad Laboratories, Inc. |
Compositions with polymerase activity
|
|
WO2004011605A2
(en)
|
2002-07-25 |
2004-02-05 |
Mj Bioworks Incorporated |
Hybrid protein methods and compositions
|
|
US7666645B2
(en)
*
|
2002-10-23 |
2010-02-23 |
Bio-Rad Laboratories, Inc. |
Sso7-polymerase conjugate proteins
|
|
US8283148B2
(en)
|
2002-10-25 |
2012-10-09 |
Agilent Technologies, Inc. |
DNA polymerase compositions for quantitative PCR and methods thereof
|
|
JP2006507012A
(ja)
*
|
2002-10-25 |
2006-03-02 |
ストラタジーン カリフォルニア |
減少した塩基類似体検出活性を有するdnaポリメラーゼ
|
|
US7960157B2
(en)
*
|
2002-12-20 |
2011-06-14 |
Agilent Technologies, Inc. |
DNA polymerase blends and uses thereof
|
|
JP4722035B2
(ja)
*
|
2003-03-25 |
2011-07-13 |
アジレント・テクノロジーズ・インク |
Dnaポリメラーゼ融合物およびその使用
|
|
US7417133B2
(en)
*
|
2004-02-27 |
2008-08-26 |
Institut Pasteur |
Methods for obtaining thermostable enzymes, DNA polymerase I variants from Thermus aquaticus having new catalytic activities, methods for obtaining the same, and applications of the same
|
|
EP3489257A1
(de)
*
|
2004-07-23 |
2019-05-29 |
Acceleron Pharma Inc. |
Actrii-rezeptor-polypeptide, verfahren und zusammensetzungen
|
|
US20060105348A1
(en)
*
|
2004-11-15 |
2006-05-18 |
Lee Jun E |
Compositions and methods for the detection and discrimination of nucleic acids
|
|
AU2006203970A1
(en)
*
|
2005-01-06 |
2006-07-13 |
Applied Biosystems, Llc. |
Polypeptides having nucleic acid binding activity
|
|
EP1836319B1
(de)
*
|
2005-01-06 |
2012-09-19 |
Life Technologies Corporation |
Polypeptide mit nukleinsäurebindender aktivität sowie verfahren zur nukleinsäureamplifikation
|
|
WO2007050125A2
(en)
*
|
2005-05-27 |
2007-05-03 |
William Marsh Rice University |
High processivity polymerases
|
|
US20070117114A1
(en)
*
|
2005-07-07 |
2007-05-24 |
Quanta Biosciences, Inc. |
Compositions and methods for increasing amplification efficiency
|
|
EP1910534A4
(de)
*
|
2005-07-15 |
2010-03-10 |
Stratagene California |
Dna-bindungsprotein-polymerase-chimären
|
|
US20070059713A1
(en)
*
|
2005-09-09 |
2007-03-15 |
Lee Jun E |
SSB-DNA polymerase fusion proteins
|
|
PT1973559E
(pt)
|
2005-11-23 |
2013-02-19 |
Acceleron Pharma Inc |
Antagonistas de activina-actriia e utilizações para promover o crescimento ósseo
|
|
US8128933B2
(en)
|
2005-11-23 |
2012-03-06 |
Acceleron Pharma, Inc. |
Method of promoting bone growth by an anti-activin B antibody
|
|
JP5106416B2
(ja)
*
|
2006-01-06 |
2012-12-26 |
アジレント・テクノロジーズ・インク |
濃縮(packed)DNAポリメラーゼを含む核酸複製のための反応緩衝液組成物
|
|
US8568982B2
(en)
|
2006-08-09 |
2013-10-29 |
National University Of Singapore |
Methods of nucleic acid synthesis using particular crowding agents and concentrations
|
|
US8895016B2
(en)
*
|
2006-12-18 |
2014-11-25 |
Acceleron Pharma, Inc. |
Antagonists of activin-actriia and uses for increasing red blood cell levels
|
|
TWI584815B
(zh)
|
2007-02-01 |
2017-06-01 |
艾瑟勒朗法瑪公司 |
活化素-ActRIIa拮抗劑及其治療或預防乳癌之用途
|
|
TWI548647B
(zh)
|
2007-02-02 |
2016-09-11 |
艾瑟勒朗法瑪公司 |
衍生自ActRIIB的變體與其用途
|
|
TWI606062B
(zh)
|
2007-02-09 |
2017-11-21 |
艾瑟勒朗法瑪公司 |
包含ActRIIa-Fc融合蛋白的醫藥組合物;ActRIIa-Fc融合蛋白於治療或預防與癌症相關的骨質流失之用途;ActRIIa-Fc融合蛋白於治療或預防多發性骨髓瘤之用途
|
|
CN107412734A
(zh)
|
2007-09-18 |
2017-12-01 |
阿塞勒隆制药公司 |
活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途
|
|
WO2009070604A1
(en)
|
2007-11-27 |
2009-06-04 |
Bio-Rad Laboratories, Inc. |
Reduced inhibition of one-step rt-pcr
|
|
US20110020877A1
(en)
*
|
2008-01-11 |
2011-01-27 |
Genesys Limited |
Cren7 chimeric protein
|
|
GB0803628D0
(en)
|
2008-02-28 |
2008-04-02 |
Genesys Ltd |
Enzyme
|
|
GB0804722D0
(en)
*
|
2008-03-14 |
2008-04-16 |
Genesys Ltd |
Enzyme
|
|
GB0804721D0
(en)
*
|
2008-03-14 |
2008-04-16 |
Genesys Ltd |
Enzyme
|
|
TWI626945B
(zh)
|
2008-08-14 |
2018-06-21 |
艾瑟勒朗法瑪公司 |
使用gdf阱以增加紅血球水平
|
|
US8216997B2
(en)
|
2008-08-14 |
2012-07-10 |
Acceleron Pharma, Inc. |
Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
|
|
JP5258512B2
(ja)
*
|
2008-10-30 |
2013-08-07 |
株式会社日立製作所 |
エキソヌクレアーゼ活性増強dnaポリメラーゼ変異体
|
|
ES2716402T3
(es)
|
2008-11-03 |
2019-06-12 |
Kapa Biosystems Inc |
ADN polimerasas quiméricas
|
|
WO2010062777A2
(en)
|
2008-11-03 |
2010-06-03 |
Kapabiosystems |
Modified type a dna polymerases
|
|
SG172925A1
(en)
|
2009-01-08 |
2011-08-29 |
Bio Rad Laboratories |
Methods and compositions for improving efficiency of nucleic acids amplification reactions
|
|
CA2754476A1
(en)
|
2009-03-04 |
2010-09-10 |
Alan M. Lambowitz |
Stabilized reverse transcriptase fusion proteins
|
|
US9778188B2
(en)
|
2009-03-11 |
2017-10-03 |
Industrial Technology Research Institute |
Apparatus and method for detection and discrimination molecular object
|
|
WO2010111691A2
(en)
|
2009-03-27 |
2010-09-30 |
Life Technologies Corp |
Conjugates of biomolecules to nanoparticles
|
|
CA2757951A1
(en)
|
2009-04-10 |
2010-10-14 |
Biorad Laboratories, Inc. |
Modified dnase compositions and methods of use thereof
|
|
MX355042B
(es)
|
2009-06-08 |
2018-04-02 |
Acceleon Pharma Inc |
Metodos para aumentar adipositos termogenicos.
|
|
CN102656187A
(zh)
|
2009-06-12 |
2012-09-05 |
阿塞勒隆制药公司 |
截短的actriib-fc融合蛋白
|
|
US8889394B2
(en)
*
|
2009-09-07 |
2014-11-18 |
Empire Technology Development Llc |
Multiple domain proteins
|
|
CN102781518A
(zh)
*
|
2009-09-09 |
2012-11-14 |
阿塞勒隆制药公司 |
Actriib拮抗剂及其给药和用途
|
|
AU2010296086A1
(en)
*
|
2009-09-16 |
2012-05-10 |
Massey University |
Fusion polypeptides and uses thereof
|
|
US8710016B2
(en)
|
2009-11-17 |
2014-04-29 |
Acceleron Pharma, Inc. |
ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
|
|
CN102858962A
(zh)
*
|
2009-11-19 |
2013-01-02 |
索利斯拜欧代因公司 |
用于增加多肽稳定性和活性的组合物及相关方法
|
|
US20110262903A1
(en)
|
2010-02-26 |
2011-10-27 |
Life Technologies Corporation |
Modified Proteins and Methods of Making and Using Same
|
|
US9482615B2
(en)
|
2010-03-15 |
2016-11-01 |
Industrial Technology Research Institute |
Single-molecule detection system and methods
|
|
US9670243B2
(en)
|
2010-06-02 |
2017-06-06 |
Industrial Technology Research Institute |
Compositions and methods for sequencing nucleic acids
|
|
US8865078B2
(en)
|
2010-06-11 |
2014-10-21 |
Industrial Technology Research Institute |
Apparatus for single-molecule detection
|
|
WO2012034007A2
(en)
|
2010-09-10 |
2012-03-15 |
Bio-Rad Laboratories, Inc. |
Size selection of dna for chromatin analysis
|
|
WO2012046140A1
(en)
|
2010-10-05 |
2012-04-12 |
Finnzymes Oy |
Enzyme mixture
|
|
KR20130132824A
(ko)
|
2010-11-08 |
2013-12-05 |
악셀레론 파마 인코포레이티드 |
Actriia 결합제 및 이의 용도
|
|
WO2012097318A2
(en)
|
2011-01-14 |
2012-07-19 |
Kap Abiosystems |
Modified dna polymerases for improved amplification
|
|
US9868945B2
(en)
|
2011-02-08 |
2018-01-16 |
Life Technologies Corporation |
Linking methods, compositions, systems, kits and apparatuses
|
|
WO2012112606A1
(en)
|
2011-02-15 |
2012-08-23 |
Bio-Rad Laboratories, Inc. |
Detecting methylati0n in a subpopulation of genomic dna
|
|
WO2012125123A1
(en)
|
2011-03-11 |
2012-09-20 |
National University Of Singapore |
Pericyte progenitors from peripheral blood
|
|
SG193990A1
(en)
|
2011-04-08 |
2013-11-29 |
Bio Rad Laboratories |
Pcr reaction mixtures with decreased non-specific activity
|
|
US8715987B2
(en)
|
2011-05-02 |
2014-05-06 |
New England Biolabs, Inc. |
Solubilized phospholipids for stabilizing nucleic acid polymerases
|
|
US8921044B2
(en)
|
2011-05-11 |
2014-12-30 |
New England Biolabs, Inc. |
DNA polymerase variants with reduced exonuclease activity and uses thereof
|
|
EP2707481B1
(de)
|
2011-05-11 |
2016-07-13 |
New England Biolabs, Inc. |
Dna-polymerasevarianten mit verminderter exonukleaseaktivität und ihre anwendung
|
|
US8470573B2
(en)
*
|
2011-06-21 |
2013-06-25 |
Bio-Rad Laboratories, Inc. |
Hybrid polymerases having the ability to produce long amplicons
|
|
EP2739752B1
(de)
|
2011-08-03 |
2017-07-19 |
Bio-Rad Laboratories, Inc. |
Filterung von kleinen nukleinsäuren anhand von permeabilisierten zellen
|
|
EP2914277B1
(de)
|
2012-11-02 |
2017-09-13 |
Celgene Corporation |
Activin-actrii-antagonisten und verwendungen zur behandlung von knochen- und anderen erkrankungen
|
|
EP2986719B1
(de)
|
2013-12-06 |
2020-07-29 |
Bio-Rad Laboratories, Inc. |
Fusionspolymerasen
|
|
CN114699529A
(zh)
|
2014-06-13 |
2022-07-05 |
阿塞勒隆制药公司 |
用于治疗溃疡的方法和组合物
|
|
WO2016014493A1
(en)
|
2014-07-22 |
2016-01-28 |
Bio-Rad Laboratories, Inc. |
Buffers for use with polymerases
|
|
CN106661632B
(zh)
|
2014-08-19 |
2021-11-05 |
生物辐射实验室股份有限公司 |
Rna扩增方法
|
|
MA41052A
(fr)
|
2014-10-09 |
2017-08-15 |
Celgene Corp |
Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
|
|
CN108064278B
(zh)
|
2014-11-14 |
2022-02-08 |
亿明达股份有限公司 |
聚合酶
|
|
EP3224359B1
(de)
|
2014-11-25 |
2023-10-25 |
Bio-Rad Laboratories, Inc. |
Arginin zur verbesserung der lagerstabilität von polymerase
|
|
TWI730949B
(zh)
|
2014-12-03 |
2021-06-21 |
美商西建公司 |
活化素-actrii拮抗劑及治療貧血之用途
|
|
JP6736565B2
(ja)
|
2015-02-02 |
2020-08-05 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
ポリメラーゼバリアント
|
|
EP3486329A1
(de)
|
2015-02-17 |
2019-05-22 |
Bio-Rad Laboratories, Inc. |
Verfahren zur erzeugung und amplifizierung von cdns
|
|
WO2017050723A1
(en)
|
2015-09-22 |
2017-03-30 |
Genia Technologies, Inc. |
Pol7 polymerase variants
|
|
CN108350087A
(zh)
*
|
2015-11-27 |
2018-07-31 |
国立大学法人九州大学 |
Dna聚合酶变体
|
|
CN116144626A
(zh)
|
2016-01-13 |
2023-05-23 |
新英格兰生物实验室公司 |
T7 rna聚合酶的热稳定变体
|
|
US10273530B2
(en)
|
2016-01-15 |
2019-04-30 |
Thermo Fisher Scientific Baltics Uab |
Antibodies that bind thermophilic DNA polymerases
|
|
WO2017121836A1
(en)
|
2016-01-15 |
2017-07-20 |
Thermo Fisher Scientific Baltics Uab |
Thermophilic dna polymerase mutants
|
|
EP3423576B1
(de)
|
2016-02-29 |
2021-05-12 |
Genia Technologies, Inc. |
Polymerasevarianten
|
|
ES2882646T3
(es)
|
2016-02-29 |
2021-12-02 |
Genia Tech Inc |
Polimerasas carentes de actividad exonucleasa
|
|
EP3423574B1
(de)
|
2016-02-29 |
2021-03-17 |
Genia Technologies, Inc. |
Polymerase-template-komplexe zur nanoporensequenzierung
|
|
JP6720632B2
(ja)
*
|
2016-03-29 |
2020-07-08 |
東洋紡株式会社 |
融合タンパク質
|
|
US10829747B2
(en)
|
2016-09-22 |
2020-11-10 |
Roche Sequencing Solutions, Inc. |
Polymerase variants
|
|
WO2019002178A1
(en)
|
2017-06-26 |
2019-01-03 |
Thermo Fisher Scientific Baltics Uab |
DNA MUTANTS THERMOPHILIC POLYMERASES
|
|
WO2019122200A1
(en)
|
2017-12-22 |
2019-06-27 |
Thermo Fisher Scientific Baltics Uab |
Polymerase chain reaction composition comprising amines
|
|
US11136565B2
(en)
|
2018-09-11 |
2021-10-05 |
Singular Genomics Systems, Inc. |
Modified archaeal family B polymerases
|
|
CN109266628B
(zh)
*
|
2018-10-09 |
2020-04-14 |
南京市胸科医院 |
一种融合的TaqDNA聚合酶及其应用
|
|
US10934533B1
(en)
|
2018-10-10 |
2021-03-02 |
New England Biolabs, Inc. |
Variant DNA polymerases having improved properties and method for improved isothermal amplification of a target DNA
|
|
CN109679932B
(zh)
*
|
2018-12-05 |
2020-03-17 |
广州奇辉生物科技有限公司 |
一种dna聚合酶、重组载体及它们的制备方法和应用
|
|
CN112175091A
(zh)
*
|
2019-07-05 |
2021-01-05 |
赛纳生物科技(北京)有限公司 |
通过功能结构域嫁接提高聚合酶大片段活性的方法及应用
|
|
US12163164B2
(en)
|
2019-07-15 |
2024-12-10 |
Bio-Rad Laboratories, Inc. |
Hybrid reverse transcriptases
|
|
US11512295B2
(en)
|
2019-09-12 |
2022-11-29 |
Singular Genomics Systems, Inc. |
Modified thermoccocus polymerases
|
|
KR20220125304A
(ko)
*
|
2020-01-06 |
2022-09-14 |
페어와이즈 플랜츠 서비시즈, 인크. |
주형화된 편집을 위한 dna 폴리머라제의 동원
|
|
WO2021163561A1
(en)
|
2020-02-13 |
2021-08-19 |
New England Biolabs, Inc. |
Variant family d dna polymerases
|
|
WO2021163559A1
(en)
|
2020-02-13 |
2021-08-19 |
New England Biolabs, Inc. |
Variant family d dna polymerases
|
|
US20230086471A1
(en)
*
|
2020-02-15 |
2023-03-23 |
Agency For Science, Technology And Research |
A method to amplify a nucleic acid
|
|
US11034942B1
(en)
|
2020-02-27 |
2021-06-15 |
Singular Genomics Systems, Inc. |
Modified pyrococcus polymerases and uses thereof
|
|
CN116209756A
(zh)
|
2020-03-04 |
2023-06-02 |
旗舰先锋创新Vi有限责任公司 |
调控基因组的方法和组合物
|
|
CN111518873B
(zh)
*
|
2020-05-11 |
2024-07-09 |
上海羿鸣生物科技有限公司 |
一种优化的扩增目标核酸的方法及应用
|
|
PL241698B1
(pl)
*
|
2021-01-27 |
2022-11-21 |
Inst Biotechnologii I Medycyny Molekularnej |
Polimeraza Pwo-NeqSSB, sposób jej otrzymywania, plazmid rekombinantowy, startery oraz zastosowanie polimerazy
|
|
WO2022170212A1
(en)
|
2021-02-08 |
2022-08-11 |
Singular Genomics Systems, Inc. |
Methods and compositions for sequencing complementary polynucleotides
|
|
US11993792B2
(en)
|
2021-05-27 |
2024-05-28 |
New England Biolabs, Inc. |
DNase I variants, compositions, methods, and kits
|
|
WO2022250676A1
(en)
|
2021-05-27 |
2022-12-01 |
New England Biolabs, Inc. |
Dnase i variants, compositions, methods, and kits
|
|
EP4095254A3
(de)
|
2021-05-27 |
2022-12-14 |
New England Biolabs, Inc. |
Fragmentierung von dna
|
|
WO2022249133A1
(en)
|
2021-05-28 |
2022-12-01 |
Erebus Enzymes Inc. |
Ultra-processive, stutter-resistant polymerase system
|
|
IL311225A
(en)
|
2021-09-08 |
2024-05-01 |
Flagship Pioneering Innovations Vi Llc |
Methods and compositions for genome modulation
|
|
EP4437090A1
(de)
|
2021-11-22 |
2024-10-02 |
F. Hoffmann-La Roche AG |
Thermostabile polymerasevarianten
|
|
EP4471162A4
(de)
|
2022-01-26 |
2025-12-17 |
Seegene Inc |
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