ATE378345T1 - Verfahren zur aufreinigung von makroliden - Google Patents

Verfahren zur aufreinigung von makroliden

Info

Publication number: ATE378345T1
Authority: AT; Austria
Prior art keywords: purifying; macrolids; macrolide; eluting; tetrahydrofuran
Prior art date: 2003-07-24

Application number

AT04779384T

Other languages

English (en)

Inventor

Vilmos Keri

Zoltan Czovek

Ferenc Rantal

Andrea Csorvasi

Original Assignee

Teva Gyogyszergyar Zartkoeruee

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-24

Filing date

2004-07-26

Publication date

2007-11-15

2004-07-26 Application filed by Teva Gyogyszergyar Zartkoeruee filed Critical Teva Gyogyszergyar Zartkoeruee

2007-11-15 Application granted granted Critical

2007-11-15 Publication of ATE378345T1 publication Critical patent/ATE378345T1/de

Links

238000000034 method Methods 0.000 title abstract 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
239000003120 macrolide antibiotic agent Substances 0.000 abstract 2
QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 abstract 1
239000003480 eluent Substances 0.000 abstract 1
239000011347 resin Substances 0.000 abstract 1
229920005989 resin Polymers 0.000 abstract 1
238000001179 sorption measurement Methods 0.000 abstract 1
229960001967 tacrolimus Drugs 0.000 abstract 1
QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 abstract 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pathology (AREA)
Genetics & Genomics (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT04779384T 2003-07-24 2004-07-26 Verfahren zur aufreinigung von makroliden ATE378345T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49007003P	2003-07-24	2003-07-24
US53936304P	2004-01-26	2004-01-26

Publications (1)

Publication Number	Publication Date
ATE378345T1 true ATE378345T1 (de)	2007-11-15

Family

ID=34107827

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04779384T ATE378345T1 (de)	2003-07-24	2004-07-26	Verfahren zur aufreinigung von makroliden

Country Status (13)

Country	Link
US (2)	US7220357B2 (de)
EP (1)	EP1558622B1 (de)
JP (1)	JP2007521013A (de)
KR (1)	KR20060052874A (de)
AT (1)	ATE378345T1 (de)
CA (1)	CA2533548C (de)
DE (1)	DE602004010059T2 (de)
DK (1)	DK1558622T3 (de)
ES (1)	ES2297481T3 (de)
PL (1)	PL1558622T3 (de)
PT (1)	PT1558622E (de)
TW (1)	TW200523266A (de)
WO (1)	WO2005010015A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1697383B1 (de) *	2003-12-05	2014-04-23	Biocon Limited	Verfahren zur aufreinigung von tacrolimus
JP2007519758A (ja)	2004-12-01	2007-07-19	テバジョジセルジャールザ−トケルエンムケドレ−スベニュタ−ルシャシャ−グ	結晶マクロライドの生成方法
EP1828204A1 (de) *	2004-12-22	2007-09-05	Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság	Verfahren zur aufreinigung von makroliden
US20070128731A1 (en) *	2005-12-07	2007-06-07	Wyeth	Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
KR100859670B1 (ko) *	2006-09-13	2008-09-23	동국제약 주식회사	타크로리무스를 고수율 및 고순도로 정제하는 방법
WO2008057511A2 (en) *	2006-11-06	2008-05-15	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
KR100891313B1 (ko) *	2007-08-17	2009-03-31	(주) 제노텍	담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법
ES2612343T3 (es)	2009-04-16	2017-05-16	Ocean Spray Cranberries, Inc.	Extracción de compuestos fenólicos y su uso en composiciones con ácido fumárico
CN106478664B (zh) *	2016-08-29	2017-12-05	广东蓝宝制药有限公司	一种发酵液中提取纯化他克莫司的方法
US10975097B2 (en)	2017-05-01	2021-04-13	Meda Ab	Process to convert technical ascomycin into purified pimecrolimus
CN108409751A (zh) *	2018-02-24	2018-08-17	海正药业(杭州)有限公司	一种子囊霉素的纯化方法
CN111693635A (zh) *	2020-07-23	2020-09-22	北京和合医学诊断技术股份有限公司	检测血液中雷帕霉素含量的方法
CN113325108B (zh) *	2021-06-04	2022-12-09	山东霆科药业有限公司	一种他克莫司软膏的样品前处理方法
CN115716839A (zh) *	2022-11-15	2023-02-28	无锡福祈制药有限公司	一种依维莫司杂质的合成方法

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DE2121517C3 (de)	1971-04-30	1974-06-27	Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Ssr, Leningrad (Sowjetunion)	Verfahren zur Gewinnung von Amphoterizin B
US3993749A (en) *	1974-04-12	1976-11-23	Ayerst Mckenna And Harrison Ltd.	Rapamycin and process of preparation
US4160861A (en) *	1977-10-03	1979-07-10	Merck & Co., Inc.	Method for the separation of antibiotic macrolides
US4894366A (en) *	1984-12-03	1990-01-16	Fujisawa Pharmaceutical Company, Ltd.	Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
JP2639737B2 (ja) *	1990-01-23	1997-08-13	寳酒造株式会社	新規ｒ１０６類化合物
US5116756A (en) *	1991-01-28	1992-05-26	Merck & Co., Inc.	Process for producing FK-506
FI934447A7 (fi)	1991-04-11	1993-10-08	Pfizer	Uusi immuunivastetta heikentävä aine lajilta Streptomyces braegensis
US5091389A (en) *	1991-04-23	1992-02-25	Merck & Co., Inc.	Lipophilic macrolide useful as an immunosuppressant
ES2160593T3 (es) *	1992-03-02	2001-11-16	Pfizer	Desosamino-derivados de microlidos como inmunosupresores y agentes antifungicos.
UA41884C2 (uk)	1993-11-05	2001-10-15	Амерікан Хоум Продактс Корпорейшн	Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
US5622866A (en) *	1994-06-23	1997-04-22	Merck & Co., Inc.	Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces
GB9618952D0 (en)	1996-09-11	1996-10-23	Sandoz Ltd	Process
GB9826882D0 (en)	1998-12-07	1999-01-27	Novartis Ag	Organic compounds
TW553946B (en) *	1999-09-08	2003-09-21	Fujisawa Pharmaceutical Co	Method for separating lactone-containing high-molecular weight compounds
ES2177373B1 (es)	1999-11-26	2003-11-01	Astur Pharma Sa	Preparacion de azitromicina en su forma no cristalina
FR2803307A1 (fr) *	1999-12-30	2001-07-06	Centre Nat Rech Scient	Lignees de lymphocytes t cd4 specifiques de type th1 et procede pour leur induction ex vivo
AU2001236543B2 (en) *	2000-02-24	2005-02-03	Teva Gyogyszergyar Reszvenytarsasag	Method of purifying a fermentation broth
AUPQ801700A0 (en) *	2000-06-07	2000-06-29	Peplin Research Pty Ltd	Enzyme and viral activation
AUPQ923100A0 (en) *	2000-08-07	2000-08-31	Peplin Research Pty Ltd	Treatment of prostate cancer
MXPA04007847A (es) *	2002-02-13	2005-02-24	Biogal Gyogyszergyar	Metodo para extraer un macrolido de biomateria.

2004
- 2004-07-26 CA CA2533548A patent/CA2533548C/en not_active Expired - Fee Related
- 2004-07-26 PL PL04779384T patent/PL1558622T3/pl unknown
- 2004-07-26 EP EP04779384A patent/EP1558622B1/de not_active Expired - Lifetime
- 2004-07-26 KR KR1020067001618A patent/KR20060052874A/ko not_active Abandoned
- 2004-07-26 PT PT04779384T patent/PT1558622E/pt unknown
- 2004-07-26 WO PCT/US2004/024318 patent/WO2005010015A1/en not_active Ceased
- 2004-07-26 AT AT04779384T patent/ATE378345T1/de active
- 2004-07-26 DE DE602004010059T patent/DE602004010059T2/de not_active Expired - Lifetime
- 2004-07-26 ES ES04779384T patent/ES2297481T3/es not_active Expired - Lifetime
- 2004-07-26 JP JP2006521315A patent/JP2007521013A/ja not_active Ceased
- 2004-07-26 DK DK04779384T patent/DK1558622T3/da active
- 2004-07-26 TW TW093122295A patent/TW200523266A/zh unknown
- 2004-07-26 US US10/899,757 patent/US7220357B2/en not_active Expired - Fee Related
2007
- 2007-01-17 US US11/654,758 patent/US20070117976A1/en not_active Abandoned

Also Published As

Publication number	Publication date
TW200523266A (en)	2005-07-16
WO2005010015B1 (en)	2005-03-17
JP2007521013A (ja)	2007-08-02
DK1558622T3 (da)	2008-02-25
EP1558622B1 (de)	2007-11-14
DE602004010059T2 (de)	2008-09-11
WO2005010015A1 (en)	2005-02-03
PT1558622E (pt)	2007-12-04
CA2533548C (en)	2010-02-16
ES2297481T3 (es)	2008-05-01
US20070117976A1 (en)	2007-05-24
EP1558622A1 (de)	2005-08-03
PL1558622T3 (pl)	2008-06-30
US7220357B2 (en)	2007-05-22
DE602004010059D1 (de)	2007-12-27
US20050027112A1 (en)	2005-02-03
CA2533548A1 (en)	2005-02-03
KR20060052874A (ko)	2006-05-19

Legal Events

Date

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Title

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2008-06-15

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Publication of translation of european patent specification

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