ATE403719T1 - Konditionelles selex - Google Patents

Konditionelles selex

Info

Publication number
ATE403719T1
ATE403719T1 AT00947548T AT00947548T ATE403719T1 AT E403719 T1 ATE403719 T1 AT E403719T1 AT 00947548 T AT00947548 T AT 00947548T AT 00947548 T AT00947548 T AT 00947548T AT E403719 T1 ATE403719 T1 AT E403719T1
Authority
AT
Austria
Prior art keywords
selex
conditional
nucleic acid
signal
target molecule
Prior art date
Application number
AT00947548T
Other languages
English (en)
Inventor
Jonathan Smith
Larry Gold
Original Assignee
Somalogic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Somalogic Inc filed Critical Somalogic Inc
Application granted granted Critical
Publication of ATE403719T1 publication Critical patent/ATE403719T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Glass Compositions (AREA)
  • Prostheses (AREA)
  • Polyesters Or Polycarbonates (AREA)
AT00947548T 1999-07-29 2000-07-19 Konditionelles selex ATE403719T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/364,541 US6506887B1 (en) 1999-07-29 1999-07-29 Conditional-selex

Publications (1)

Publication Number Publication Date
ATE403719T1 true ATE403719T1 (de) 2008-08-15

Family

ID=23434946

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00947548T ATE403719T1 (de) 1999-07-29 2000-07-19 Konditionelles selex

Country Status (9)

Country Link
US (2) US6506887B1 (de)
EP (1) EP1203006B1 (de)
JP (1) JP4565787B2 (de)
AT (1) ATE403719T1 (de)
AU (1) AU6113200A (de)
CA (1) CA2380395C (de)
DE (1) DE60039765D1 (de)
DK (1) DK1203006T3 (de)
WO (1) WO2001009158A1 (de)

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JP2005533862A (ja) 2002-07-25 2005-11-10 アーケミックス コーポレイション 調節されたアプタマー治療剤
US9303262B2 (en) * 2002-09-17 2016-04-05 Archemix Llc Methods for identifying aptamer regulators
GB0226374D0 (en) * 2002-11-12 2002-12-18 Isis Innovation Ligands
US20050106594A1 (en) * 2003-08-22 2005-05-19 Andrew Ellington In vitro selection of aptamer beacons
WO2005051174A2 (en) * 2003-11-21 2005-06-09 The Trustees Of Columbia University In The City Of New York Nucleic acid aptamer-based compositions and methods
JP5543052B2 (ja) * 2003-11-22 2014-07-09 株式会社テクノメディカ アプタマーを用いた標的分子の検出方法
CN101208437B (zh) * 2003-12-12 2012-07-04 圣路易斯大学 检测大分子和其它分析物的生物传感器
US7207206B2 (en) 2004-02-19 2007-04-24 Ut-Battelle, Llc Chemically-functionalized microcantilevers for detection of chemical, biological and explosive material
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
US7795009B2 (en) * 2005-06-15 2010-09-14 Saint Louis University Three-component biosensors for detecting macromolecules and other analytes
US8956857B2 (en) 2005-06-06 2015-02-17 Mediomics, Llc Three-component biosensors for detecting macromolecules and other analytes
EP1907410B1 (de) 2005-06-10 2012-07-04 Saint Louis University Verfahren zur selektion von aptameren
US7811809B2 (en) * 2005-06-15 2010-10-12 Saint Louis University Molecular biosensors for use in competition assays
US9267937B2 (en) * 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
ES2776100T3 (es) * 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
US8367113B2 (en) 2006-05-15 2013-02-05 Massachusetts Institute Of Technology Polymers for functional particles
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US20100144845A1 (en) * 2006-08-04 2010-06-10 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
US9725713B1 (en) 2007-01-22 2017-08-08 Steven A Benner In vitro selection with expanded genetic alphabets
US8586303B1 (en) 2007-01-22 2013-11-19 Steven Albert Benner In vitro selection with expanded genetic alphabets
US9217129B2 (en) * 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
WO2008124632A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
EP2630966B1 (de) 2007-10-12 2017-04-19 Massachusetts Institute of Technology Impfstoffnanotechnologie
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8277812B2 (en) * 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
EP2350657A4 (de) 2008-11-21 2013-06-12 Univ Saint Louis Biosensor zur erkennung mehrerer epitope auf einem ziel
US8841429B2 (en) * 2009-11-03 2014-09-23 Vivonics, Inc. Nucleic acid ligands against infectious prions
US8236570B2 (en) 2009-11-03 2012-08-07 Infoscitex Methods for identifying nucleic acid ligands
US9040287B2 (en) 2010-02-12 2015-05-26 Mediomics, Llc Molecular biosensors capable of signal amplification
CN112587671A (zh) 2012-07-18 2021-04-02 博笛生物科技有限公司 癌症的靶向免疫治疗
AU2013340414B2 (en) 2012-10-23 2019-05-02 Caris Science, Inc. Aptamers and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
EP2935628B1 (de) 2012-12-19 2018-03-21 Caris Life Sciences Switzerland Holdings GmbH Zusammensetzungen und verfahren für aptamer-screening
CN105899539B (zh) 2014-01-10 2021-11-09 博笛生物科技有限公司 用于免疫疗法的化合物和组合物
EP3166976B2 (de) 2014-07-09 2026-04-08 Birdie Biopharmaceuticals Inc. Anti-pd-l1-kombinationen zur tumorbehandlung
CN105233291A (zh) 2014-07-09 2016-01-13 博笛生物科技有限公司 用于治疗癌症的联合治疗组合物和联合治疗方法
CN112587672A (zh) 2014-09-01 2021-04-02 博笛生物科技有限公司 用于治疗肿瘤的抗-pd-l1结合物
WO2016040830A1 (en) 2014-09-12 2016-03-17 Mediomics, Llc Molecular biosensors with a modular design
EP3302467A4 (de) 2015-05-31 2019-01-02 Curegenix Corporation Kombinationszusammensetzungen zur immuntherapie
JP2018526030A (ja) * 2015-09-04 2018-09-13 ネオベンチャーズ バイオテクノロジー インコーポレイテッド 結合していない標的についてのアプタマーの選抜のための方法
ES2972849T3 (es) 2016-10-14 2024-06-17 Cns Biosciences Inc Tratamiento del dolor neuropático en personas con lesión de la médula espinal
EP3332812A1 (de) 2016-12-07 2018-06-13 Rheinische Friedrich-Wilhelms-Universität Bonn Nukleinsäurebasierte anordnung und verwendung der anordnung in der krebstherapie
WO2022073965A1 (en) 2020-10-07 2022-04-14 Centre National De La Recherche Scientifique (Cnrs) Process for selection of aptamers, riboswitches and desoxyriboswitches

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WO1989006694A1 (en) 1988-01-15 1989-07-27 Trustees Of The University Of Pennsylvania Process for selection of proteinaceous substances which mimic growth-inducing molecules
US5683867A (en) * 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5641629A (en) * 1990-06-11 1997-06-24 Nexstar Pharmacueticals Inc Spectroscopically detectable nucleic acid ligands
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WO1998008974A2 (en) 1996-08-26 1998-03-05 Intelligene Ltd. Catalytic nucleic acid and its medical use
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US6242246B1 (en) * 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
JP4153068B2 (ja) * 1997-12-24 2008-09-17 浜松ホトニクス株式会社 蛍光免疫測定方法
IL126731A0 (en) 1998-10-23 1999-08-17 Intelligene Ltd A method of detection
EP1133513A4 (de) 1998-11-03 2002-07-03 Univ Yale Aus mehreren domänen von polynukleotiden bestehende molekulare sensoren
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US20010046674A1 (en) 2000-02-03 2001-11-29 Andrew Ellington Signaling aptamers that transduce molecular recognition to a differential signal
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WO2001064956A2 (en) 2000-03-01 2001-09-07 Amgen Inc. The identification and use of effectors and allosteric molecules for the alteration of gene expression
JP2003525631A (ja) 2000-03-06 2003-09-02 リボザイム・ファーマシューティカルズ・インコーポレーテッド 核酸センサー分子

Also Published As

Publication number Publication date
DK1203006T3 (da) 2008-12-15
DE60039765D1 (de) 2008-09-18
AU6113200A (en) 2001-02-19
EP1203006B1 (de) 2008-08-06
EP1203006A1 (de) 2002-05-08
JP4565787B2 (ja) 2010-10-20
US6706482B2 (en) 2004-03-16
US20030087301A1 (en) 2003-05-08
CA2380395A1 (en) 2001-02-08
CA2380395C (en) 2010-10-19
EP1203006A4 (de) 2005-01-12
JP2003506670A (ja) 2003-02-18
US6506887B1 (en) 2003-01-14
WO2001009158A1 (en) 2001-02-08

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