ATE404679T1 - Neue expressionsvektoren - Google Patents

Neue expressionsvektoren

Info

Publication number
ATE404679T1
ATE404679T1 AT02708018T AT02708018T ATE404679T1 AT E404679 T1 ATE404679 T1 AT E404679T1 AT 02708018 T AT02708018 T AT 02708018T AT 02708018 T AT02708018 T AT 02708018T AT E404679 T1 ATE404679 T1 AT E404679T1
Authority
AT
Austria
Prior art keywords
vectors
present
expression vectors
provides
expression
Prior art date
Application number
AT02708018T
Other languages
English (en)
Inventor
John Daly
Original Assignee
Gene Stream Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gene Stream Pty Ltd filed Critical Gene Stream Pty Ltd
Application granted granted Critical
Publication of ATE404679T1 publication Critical patent/ATE404679T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Animal Husbandry (AREA)
  • Physiology (AREA)
  • Analytical Chemistry (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Image Generation (AREA)
AT02708018T 2001-03-09 2002-03-08 Neue expressionsvektoren ATE404679T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27477001P 2001-03-09 2001-03-09

Publications (1)

Publication Number Publication Date
ATE404679T1 true ATE404679T1 (de) 2008-08-15

Family

ID=23049549

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02708018T ATE404679T1 (de) 2001-03-09 2002-03-08 Neue expressionsvektoren

Country Status (13)

Country Link
US (3) US7157272B2 (de)
EP (1) EP1373528B1 (de)
JP (2) JP2004530425A (de)
KR (1) KR100917939B1 (de)
CN (1) CN100471956C (de)
AT (1) ATE404679T1 (de)
AU (1) AU2002242474B2 (de)
CA (1) CA2440148C (de)
DE (2) DE02708018T1 (de)
IL (2) IL157756A0 (de)
NZ (1) NZ528000A (de)
WO (1) WO2002072844A1 (de)
ZA (1) ZA200306885B (de)

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EP1903054A3 (de) 2001-06-05 2008-07-23 CureVac GmbH Stabilisierte mRNA mit erhöhtem G/C-Gehalt und optimierter Codon Usage für die Gentherapie
JP4528623B2 (ja) * 2002-09-16 2010-08-18 プロメガ コーポレイション 迅速分解性レポーター融合タンパク質
DE102004042546A1 (de) * 2004-09-02 2006-03-09 Curevac Gmbh Kombinationstherapie zur Immunstimulation
AR053279A1 (es) * 2005-05-19 2007-04-25 Monsanto Technology Llc Regulacion post-transcripcional de la expresion genica
US20070212332A1 (en) * 2005-08-11 2007-09-13 Department Of Veterans Affairs Methods for accelerating bone repair
EP1760092A1 (de) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System für Screening von Zellen mit hoher Expression von einem interessierenden Protein
DE102005046490A1 (de) 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
WO2007038757A2 (en) * 2005-09-28 2007-04-05 Attagene Inc. Methods and compositions for non-invasive assessment of gene expression
US20070245258A1 (en) * 2006-04-13 2007-10-18 Codman Neuro Sciences Sàrl Graphical user interface of an external control device for controlling an implantable medical device while minimizing human error
US20080189804A1 (en) * 2006-12-13 2008-08-07 Dickman Martin B Novel genes and rna molecules that confer stress tolerance
US20080189805A1 (en) * 2006-12-13 2008-08-07 Serbin John J Novel genes and rna molecules that confer stress tolerance
AU2007335194B2 (en) 2006-12-21 2014-01-23 Gene Stream Pty Ltd Bioluminescent assays utilising secreted luciferases
CN101688252A (zh) * 2007-07-11 2010-03-31 皇家飞利浦电子股份有限公司 使用超声诱导的报道分子构建体转染的体内表达分析
US20090111099A1 (en) * 2007-10-27 2009-04-30 Yongsheng Ma Promoter Detection and Analysis
US20110071047A1 (en) * 2007-10-27 2011-03-24 O.D. 260 Inc. Promoter detection and analysis
KR101204895B1 (ko) 2010-01-27 2012-11-26 단국대학교 산학협력단 Ｐｒｃ１ 유전자 프로모터의 삭제변이 프로모터를 함유하는 암세포 특이적 발현벡터
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
ES3005233T3 (en) 2010-10-01 2025-03-14 Modernatx Inc Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
WO2012071631A1 (en) 2010-12-03 2012-06-07 Gene Stream Pty Ltd Improved light-emitting molecules
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2763701B1 (de) 2011-10-03 2018-12-19 Moderna Therapeutics, Inc. Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon
JP2015501844A (ja) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
WO2013151663A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of membrane proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014166429A1 (zh) * 2013-04-12 2014-10-16 中国科学院上海生命科学研究院 检测蛋白质稳定性的方法及其应用
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
WO2017191274A2 (en) * 2016-05-04 2017-11-09 Curevac Ag Rna encoding a therapeutic protein
CN109312362B (zh) * 2016-06-20 2022-06-28 扬森疫苗与预防公司 有效和平衡的双向启动子
EP4342978A3 (de) * 2016-09-01 2024-07-03 Chimera Bioengineering Inc. Goldoptimierte car-t-zellen
CN111989108B (zh) * 2018-02-13 2024-07-16 嵌合体生物工程公司 利用rna去稳定元件协调基因表达
CN114846145A (zh) * 2019-11-26 2022-08-02 韩国生命工学研究院 用于蛋白质表达的mRNA构建体及其用途
WO2022204471A1 (en) * 2021-03-26 2022-09-29 Ptc Therapeutics Inc. Regulation of transgene expression using a small molecule inducible splicing switch
KR102900116B1 (ko) * 2021-05-25 2025-12-16 한국생명공학연구원 단백질 발현용 mRNA 제조방법 및 이에 의해 제조된 mRNA의 용도

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Also Published As

Publication number Publication date
EP1373528B1 (de) 2008-08-13
ZA200306885B (en) 2009-03-25
DE02708018T1 (de) 2004-09-30
CA2440148A1 (en) 2002-09-19
JP2011015685A (ja) 2011-01-27
US20180305705A1 (en) 2018-10-25
DE60228212D1 (de) 2008-09-25
AU2002242474B2 (en) 2004-05-20
NZ528000A (en) 2005-09-30
JP2004530425A (ja) 2004-10-07
EP1373528A1 (de) 2004-01-02
KR100917939B1 (ko) 2009-09-21
US20040115704A1 (en) 2004-06-17
US20070298417A1 (en) 2007-12-27
CN1503844A (zh) 2004-06-09
IL157756A0 (en) 2004-03-28
WO2002072844A1 (en) 2002-09-19
CN100471956C (zh) 2009-03-25
US9994858B2 (en) 2018-06-12
CA2440148C (en) 2012-07-10
EP1373528A4 (de) 2004-12-29
IL157756A (en) 2010-12-30
US7157272B2 (en) 2007-01-02
KR20030092013A (ko) 2003-12-03
US20040209274A2 (en) 2004-10-21

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