ATE404679T1 - Neue expressionsvektoren - Google Patents

Neue expressionsvektoren

Info

Publication number
ATE404679T1
ATE404679T1 AT02708018T AT02708018T ATE404679T1 AT E404679 T1 ATE404679 T1 AT E404679T1 AT 02708018 T AT02708018 T AT 02708018T AT 02708018 T AT02708018 T AT 02708018T AT E404679 T1 ATE404679 T1 AT E404679T1
Authority
AT
Austria
Prior art keywords
vectors
present
expression vectors
provides
expression
Prior art date
Application number
AT02708018T
Other languages
English (en)
Inventor
John Daly
Original Assignee
Gene Stream Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gene Stream Pty Ltd filed Critical Gene Stream Pty Ltd
Application granted granted Critical
Publication of ATE404679T1 publication Critical patent/ATE404679T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Immunology (AREA)
  • Physiology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Image Generation (AREA)
AT02708018T 2001-03-09 2002-03-08 Neue expressionsvektoren ATE404679T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27477001P 2001-03-09 2001-03-09

Publications (1)

Publication Number Publication Date
ATE404679T1 true ATE404679T1 (de) 2008-08-15

Family

ID=23049549

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02708018T ATE404679T1 (de) 2001-03-09 2002-03-08 Neue expressionsvektoren

Country Status (13)

Country Link
US (3) US7157272B2 (de)
EP (1) EP1373528B1 (de)
JP (2) JP2004530425A (de)
KR (1) KR100917939B1 (de)
CN (1) CN100471956C (de)
AT (1) ATE404679T1 (de)
AU (1) AU2002242474B2 (de)
CA (1) CA2440148C (de)
DE (2) DE60228212D1 (de)
IL (2) IL157756A0 (de)
NZ (1) NZ528000A (de)
WO (1) WO2002072844A1 (de)
ZA (1) ZA200306885B (de)

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CN100471956C (zh) * 2001-03-09 2009-03-25 基因流股份有限公司 新型表达载体
ATE291925T1 (de) 2001-06-05 2005-04-15 Curevac Gmbh Stabilisierte mrna mit erhöhtem g/c-gehalt und optimierter codon usage für die gentherapie
CA2499221A1 (en) * 2002-09-16 2004-03-25 Promega Corporation Rapidly degraded reporter fusion proteins
DE102004042546A1 (de) * 2004-09-02 2006-03-09 Curevac Gmbh Kombinationstherapie zur Immunstimulation
AR053279A1 (es) * 2005-05-19 2007-04-25 Monsanto Technology Llc Regulacion post-transcripcional de la expresion genica
US20070212332A1 (en) * 2005-08-11 2007-09-13 Department Of Veterans Affairs Methods for accelerating bone repair
EP1760092A1 (de) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System für Screening von Zellen mit hoher Expression von einem interessierenden Protein
WO2007038757A2 (en) * 2005-09-28 2007-04-05 Attagene Inc. Methods and compositions for non-invasive assessment of gene expression
DE102005046490A1 (de) * 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
US20070245258A1 (en) * 2006-04-13 2007-10-18 Codman Neuro Sciences Sàrl Graphical user interface of an external control device for controlling an implantable medical device while minimizing human error
US20080189805A1 (en) * 2006-12-13 2008-08-07 Serbin John J Novel genes and rna molecules that confer stress tolerance
WO2008076844A2 (en) * 2006-12-13 2008-06-26 Unl Technology Development Corporation Novel genes and rna molecules that confer stress tolerance
KR101478373B1 (ko) 2006-12-21 2014-12-31 진 스트림 피티와이 리미티드 분비성 루시페라아제를 이용하는 생물 발광 검사
EP2176423A1 (de) * 2007-07-11 2010-04-21 Koninklijke Philips Electronics N.V. In-vivo-expressionsanalyse mithilfe ultraschallinduzierter transfektion von reporterkonstrukten
US20090111099A1 (en) * 2007-10-27 2009-04-30 Yongsheng Ma Promoter Detection and Analysis
US20110071047A1 (en) * 2007-10-27 2011-03-24 O.D. 260 Inc. Promoter detection and analysis
KR101204895B1 (ko) 2010-01-27 2012-11-26 단국대학교 산학협력단 Ｐｒｃ１ 유전자 프로모터의 삭제변이 프로모터를 함유하는 암세포 특이적 발현벡터
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2857499A1 (de) 2010-10-01 2015-04-08 Moderna Therapeutics, Inc. Manipulierte Nukleinsäuren und Verfahren zur Verwendung davon
AU2011335901B2 (en) 2010-12-03 2016-12-15 Gene Stream Pty Ltd Improved light-emitting molecules
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PT3682905T (pt) 2011-10-03 2022-04-07 Modernatx Inc Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações
ES2923757T3 (es) 2011-12-16 2022-09-30 Modernatx Inc Composiciones de ARNm modificado
WO2013151664A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
PT2922554T (pt) 2012-11-26 2022-06-28 Modernatx Inc Arn modificado nas porções terminais
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP2985347B1 (de) * 2013-04-12 2021-01-06 Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences Verfahren zum nachweis einer proteinstabilität und verwendungen davon
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
WO2017191274A2 (en) * 2016-05-04 2017-11-09 Curevac Ag Rna encoding a therapeutic protein
US11001858B2 (en) 2016-06-20 2021-05-11 Janssen Vaccines & Prevention B.V. Potent and balanced bidirectional promoter
CN110121352B (zh) * 2016-09-01 2020-12-11 嵌合体生物工程公司 Gold优化的car t-细胞
EP3806870A4 (de) * 2018-02-13 2021-12-22 Chimera Bioengineering, Inc. Koordination der genexpression unter verwendung von rna-destabilisierenden elementen
KR102490457B1 (ko) * 2019-11-26 2023-01-19 한국생명공학연구원 단백질 발현용 mRNA 구조체 및 이의 용도
WO2022204471A1 (en) * 2021-03-26 2022-09-29 Ptc Therapeutics Inc. Regulation of transgene expression using a small molecule inducible splicing switch
KR102900116B1 (ko) * 2021-05-25 2025-12-16 한국생명공학연구원 단백질 발현용 mRNA 제조방법 및 이에 의해 제조된 mRNA의 용도

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US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5587300A (en) * 1994-04-26 1996-12-24 Wisconsin Ulumni Research Foundation Method to increase regulatory molecule production
US5650135A (en) 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US5777079A (en) 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5804387A (en) 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
DE69738737D1 (de) * 1996-12-16 2008-07-10 Eisai R&D Man Co Ltd Verfahren zur herstellung von retroviralen vektoren für die gentherapie
US6231880B1 (en) * 1997-05-30 2001-05-15 Susan P. Perrine Compositions and administration of compositions for the treatment of blood disorders
EP1021549A2 (de) * 1997-09-19 2000-07-26 Sequitur, Inc. Sense mrna therapie
US6306600B1 (en) * 1998-04-17 2001-10-23 Clontech Laboratories, Inc. Rapidly degrading GFP-fusion proteins and methods of use
US6130313A (en) * 1997-10-02 2000-10-10 Clontech Laboratories, Inc. Rapidly degrading GFP-fusion proteins
US5965421A (en) * 1997-11-26 1999-10-12 Human Genome Sciences, Inc. Human IRAK-2
JPH11266872A (ja) * 1998-03-20 1999-10-05 Suntory Ltd ＮＦ−κＢの活性化を抑制する物質のスクリーニング方法
US20040002056A1 (en) * 1998-05-12 2004-01-01 Lorens James B. Methods of screening for bioactive agents using cells transformed with self-inactivating viral vectors
US6307123B1 (en) * 1998-05-18 2001-10-23 Dekalb Genetics Corporation Methods and compositions for transgene identification
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US6841362B1 (en) * 2000-02-29 2005-01-11 The Trustees Of Columbia University In The City Of New York Melanoma differentiation associated gene-7 promoter and uses thereof
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US20180305776A1 (en) * 2017-04-20 2018-10-25 The Board Of Trustees Of The Leland Stanford Junior University Myc-reporters, cells containing myc-reporters and methods of use thereof

Also Published As

Publication number Publication date
EP1373528A4 (de) 2004-12-29
US20180305705A1 (en) 2018-10-25
US20040209274A2 (en) 2004-10-21
US20040115704A1 (en) 2004-06-17
IL157756A0 (en) 2004-03-28
CN1503844A (zh) 2004-06-09
EP1373528B1 (de) 2008-08-13
KR100917939B1 (ko) 2009-09-21
JP2004530425A (ja) 2004-10-07
DE60228212D1 (de) 2008-09-25
IL157756A (en) 2010-12-30
KR20030092013A (ko) 2003-12-03
CA2440148A1 (en) 2002-09-19
US9994858B2 (en) 2018-06-12
NZ528000A (en) 2005-09-30
DE02708018T1 (de) 2004-09-30
ZA200306885B (en) 2009-03-25
AU2002242474B2 (en) 2004-05-20
CN100471956C (zh) 2009-03-25
EP1373528A1 (de) 2004-01-02
CA2440148C (en) 2012-07-10
US20070298417A1 (en) 2007-12-27
US7157272B2 (en) 2007-01-02
JP2011015685A (ja) 2011-01-27
WO2002072844A1 (en) 2002-09-19

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