ATE406463T1 - Methode zur krebsdiagnose mittels nachweis von dna und rna im kreislauf - Google Patents
Methode zur krebsdiagnose mittels nachweis von dna und rna im kreislaufInfo
- Publication number
- ATE406463T1 ATE406463T1 AT05007508T AT05007508T ATE406463T1 AT E406463 T1 ATE406463 T1 AT E406463T1 AT 05007508 T AT05007508 T AT 05007508T AT 05007508 T AT05007508 T AT 05007508T AT E406463 T1 ATE406463 T1 AT E406463T1
- Authority
- AT
- Austria
- Prior art keywords
- rna
- dna
- cancer
- circulation
- detection
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 5
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 230000004544 DNA amplification Effects 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000003208 gene overexpression Methods 0.000 abstract 1
- 238000011002 quantification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05007508A EP1712639B1 (de) | 2005-04-06 | 2005-04-06 | Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE406463T1 true ATE406463T1 (de) | 2008-09-15 |
Family
ID=34934801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05007508T ATE406463T1 (de) | 2005-04-06 | 2005-04-06 | Methode zur krebsdiagnose mittels nachweis von dna und rna im kreislauf |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7700286B2 (de) |
| EP (1) | EP1712639B1 (de) |
| AT (1) | ATE406463T1 (de) |
| DE (1) | DE602005009324D1 (de) |
| ES (1) | ES2313143T3 (de) |
| PL (1) | PL1712639T3 (de) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7425217B2 (en) * | 2000-11-16 | 2008-09-16 | Maier Nathan C | System and method for inhibiting cellular proliferation with tachykinins |
| EP1712639B1 (de) | 2005-04-06 | 2008-08-27 | Maurice Stroun | Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| PL2557520T3 (pl) | 2007-07-23 | 2021-10-11 | The Chinese University Of Hong Kong | Określanie zaburzenia równowagi sekwencji kwasu nukleinowego |
| FR2928657B1 (fr) * | 2008-03-14 | 2013-12-20 | Chu Saint Etienne Chu Hopital Nord | Methode, procede, et kit de diagnostic, pronostic, suivi d'un cancer |
| WO2010028288A2 (en) | 2008-09-05 | 2010-03-11 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| US9090948B2 (en) | 2008-09-30 | 2015-07-28 | Abbott Molecular Inc. | Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples |
| JP5410722B2 (ja) * | 2008-09-30 | 2014-02-05 | 三菱化学メディエンス株式会社 | 膵臓の組織傷害あるいは細胞増殖性疾患の検出方法 |
| US8404444B2 (en) * | 2009-02-25 | 2013-03-26 | Diacarta Llc | Method for predicting the level of damage to cells by measuring free circulating Alu nucleic acid |
| US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| WO2011127099A1 (en) | 2010-04-05 | 2011-10-13 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| EP2619329B1 (de) | 2010-09-24 | 2019-05-22 | The Board of Trustees of The Leland Stanford Junior University | Direkte erfassung, amplifikation und sequenzierung einer ziel-dna unter verwendung immobilisierter primer |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| CN105243295B (zh) | 2010-11-30 | 2018-08-17 | 香港中文大学 | 与癌症相关的遗传或分子畸变的检测 |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| ES2986436T3 (es) | 2011-04-15 | 2024-11-11 | Univ Johns Hopkins | Sistema de secuenciación segura |
| WO2013123442A1 (en) | 2012-02-17 | 2013-08-22 | Fred Hutchinson Cancer Research Center | Compositions and methods for accurately identifying mutations |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| CN104781421B (zh) | 2012-09-04 | 2020-06-05 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| EP4592400A3 (de) | 2012-10-17 | 2025-10-29 | 10x Genomics Sweden AB | Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe |
| ES2886507T5 (es) | 2012-10-29 | 2024-11-15 | Univ Johns Hopkins | Prueba de Papanicolaou para cánceres de ovario y de endometrio |
| CA2902916C (en) | 2013-03-14 | 2018-08-28 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| CA2916662C (en) | 2013-06-25 | 2022-03-08 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
| DK3063295T3 (en) | 2013-10-29 | 2018-03-19 | Region Syddanmark | METHOD OF ANALYSIS OF BODY FLUID SAMPLES |
| US11286519B2 (en) | 2013-12-11 | 2022-03-29 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| US10767222B2 (en) | 2013-12-11 | 2020-09-08 | Accuragen Holdings Limited | Compositions and methods for detecting rare sequence variants |
| US11859246B2 (en) | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| WO2017062863A1 (en) | 2015-10-09 | 2017-04-13 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| ES2660989T3 (es) | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
| TWI813141B (zh) | 2014-07-18 | 2023-08-21 | 香港中文大學 | Dna混合物中之組織甲基化模式分析 |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| US10435755B2 (en) | 2015-03-27 | 2019-10-08 | Exact Sciences Development Company, Llc | Detecting esophageal disorders |
| EP3901282B1 (de) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| CN114574585A (zh) | 2015-08-31 | 2022-06-03 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| CN108350485A (zh) | 2015-10-30 | 2018-07-31 | 精密科学发展有限责任公司 | 血浆dna的多重扩增检测测定以及分离和检测 |
| WO2017096322A1 (en) | 2015-12-03 | 2017-06-08 | Accuragen Holdings Limited | Methods and compositions for forming ligation products |
| SG11201805119QA (en) | 2015-12-17 | 2018-07-30 | Guardant Health Inc | Methods to determine tumor gene copy number by analysis of cell-free dna |
| CN109563546B (zh) | 2016-05-05 | 2022-09-09 | 精密科学发展有限责任公司 | 通过分析甲基化dna来检测肺肿瘤 |
| CN109511265B (zh) | 2016-05-16 | 2023-07-14 | 安可济控股有限公司 | 通过链鉴定改进测序的方法 |
| CN109844133A (zh) | 2016-08-15 | 2019-06-04 | 安可济控股有限公司 | 检测罕见序列变体的组合物和方法 |
| EP3461274B1 (de) | 2016-09-30 | 2020-11-04 | Guardant Health, Inc. | Verfahren zur mehrauflösungsanalyse von zellfreien nukleinsäuren |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| KR20260032575A (ko) | 2016-11-30 | 2026-03-09 | 더 차이니즈 유니버시티 오브 홍콩 | 소변 및 기타 샘플에서의 무세포 dna의 분석 |
| KR102892245B1 (ko) | 2017-01-27 | 2025-11-27 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 |
| US10907211B1 (en) | 2017-02-16 | 2021-02-02 | Quantgene Inc. | Methods and compositions for detecting cancer biomarkers in bodily fluids |
| WO2018183942A1 (en) | 2017-03-31 | 2018-10-04 | Grail, Inc. | Improved library preparation and use thereof for sequencing-based error correction and/or variant identification |
| CN111868260B (zh) | 2017-08-07 | 2025-02-21 | 约翰斯霍普金斯大学 | 用于评估和治疗癌症的方法和材料 |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
| WO2019241290A1 (en) | 2018-06-12 | 2019-12-19 | Accuragen Holdings Limited | Methods and compositions for forming ligation products |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| WO2020123316A2 (en) | 2018-12-10 | 2020-06-18 | 10X Genomics, Inc. | Methods for determining a location of a biological analyte in a biological sample |
| US12529094B2 (en) | 2018-12-10 | 2026-01-20 | 10X Genomics, Inc. | Imaging system hardware |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| WO2020160414A1 (en) | 2019-01-31 | 2020-08-06 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
| EP3969616A2 (de) | 2019-05-17 | 2022-03-23 | The Johns Hopkins University | Schneller nachweis von aneuploidie |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
| ES2982420T3 (es) | 2019-12-23 | 2024-10-16 | 10X Genomics Inc | Métodos para el análisis espacial mediante el uso de la ligazón con plantilla de ARN |
| EP4103748A4 (de) | 2020-02-14 | 2024-03-13 | The Johns Hopkins University | Verfahren und materialien zur beurteilung von nukleinsäuren |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| EP4600376A3 (de) | 2020-06-02 | 2025-10-22 | 10X Genomics, Inc. | Räumliche transkriptomik für antigenrezeptoren |
| AU2021283174A1 (en) | 2020-06-02 | 2023-01-05 | 10X Genomics, Inc. | Nucleic acid library methods |
| EP4421186B1 (de) | 2020-06-08 | 2025-08-13 | 10X Genomics, Inc. | Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon |
| US12553898B1 (en) | 2020-08-10 | 2026-02-17 | 10X Genomics, Inc. | Fluorescent hybridization of antibody-oligonucleotide for multiplexing and signal amplification |
| EP4729631A2 (de) | 2020-12-21 | 2026-04-22 | 10X Genomics, Inc. | Verfahren, zusammensetzungen und systeme zur erfassung von sonden und/oder barcodes |
| EP4301499A4 (de) | 2021-03-05 | 2025-01-22 | Enumerix, Inc. | Systeme und verfahren zur erzeugung von tröpfchen und zur durchführung digitaler analysen |
| AU2022238446A1 (en) | 2021-03-18 | 2023-09-07 | 10X Genomics, Inc. | Multiplex capture of gene and protein expression from a biological sample |
| CN113238052B (zh) * | 2021-04-27 | 2023-07-25 | 中国人民解放军空军军医大学 | MG7-Ag、hTERT及TFF2表达分析在肠上皮化生风险分层及胃癌预警中的应用 |
| WO2022256503A1 (en) | 2021-06-03 | 2022-12-08 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| CN118139987A (zh) | 2021-09-23 | 2024-06-04 | 基因组检测合作社公司 | 用于cfrna和cftna靶向ngs测序的组合物和方法 |
| WO2023102118A2 (en) | 2021-12-01 | 2023-06-08 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2115611T3 (es) | 1990-01-04 | 1998-07-01 | Univ Johns Hopkins | Gen suprimido en el cancer colorrectal humano. |
| ATE198358T1 (de) | 1992-04-27 | 2001-01-15 | Dartmouth College | Detektion von gensequenzen in biologischen flüssigkeiten |
| CH686982A5 (fr) | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| US5569753A (en) | 1994-12-20 | 1996-10-29 | Cold Spring Harbor Laboratory | Cancer detection probes |
| US5648245A (en) | 1995-05-09 | 1997-07-15 | Carnegie Institution Of Washington | Method for constructing an oligonucleotide concatamer library by rolling circle replication |
| AU2324997A (en) | 1996-03-15 | 1997-10-01 | Penn State Research Foundation, The | Detection of extracellular tumor-associated nucleic acid in blood plasma or ser um using nucleic acid amplification assays |
| DE69739909D1 (de) | 1996-03-26 | 2010-07-29 | Michael S Kopreski | Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden |
| US7785842B2 (en) | 1996-03-26 | 2010-08-31 | Oncomedx, Inc. | Comparative analysis of extracellular RNA species |
| US6607898B1 (en) | 1996-03-26 | 2003-08-19 | Oncomedx, Inc. | Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum |
| US6590088B1 (en) * | 1996-07-19 | 2003-07-08 | Human Genome Sciences, Inc. | CD33-like protein |
| CA2321259A1 (en) | 1998-02-16 | 1999-08-19 | University Of Maryland, Baltimore | Telomerase assay of body fluids for cancer screening and assessment of disease stage and prognosis |
| JP2002539849A (ja) | 1999-03-26 | 2002-11-26 | ホワイトヘッド インスチチュート フォアー バイオメディカル リサーチ | ユニバーサルアレイ |
| EP1046717B1 (de) | 1999-04-20 | 2010-10-06 | National Institute of Advanced Industrial Science and Technology | Verfahren und Sonden zur Bestimmung der Konzentration von Nukleinsäure-Molekülen und Verfahren zur Analyse der gewonnenen Daten |
| US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
| US6586177B1 (en) | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
| US6849403B1 (en) | 1999-09-08 | 2005-02-01 | Exact Sciences Corporation | Apparatus and method for drug screening |
| US6664046B1 (en) | 1999-12-16 | 2003-12-16 | Roche Molecular Systems, Inc. | Quantitation of hTERT mRNA expression |
| GB2364054B (en) | 2000-03-24 | 2002-05-29 | Smithkline Beecham Corp | Method of amplifying quinolone-resistance-determining-regions and identifying polymorphic variants thereof |
| EP1158055A1 (de) * | 2000-05-26 | 2001-11-28 | Xu Qi University of Teaxs Laboratoire de Leucémie Chen | Verfahren zur Diagnose von Krebs |
| WO2003068054A2 (en) * | 2002-02-13 | 2003-08-21 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health Services | Identification of ovarian cancer tumor markers and therapeutic targets |
| AU2003261101A1 (en) * | 2002-06-28 | 2004-01-19 | Hong Kong University Of Science And Technology | Plasma or serum marker and process for detection of cancer |
| ITMI20022743A1 (it) * | 2002-12-23 | 2004-06-24 | Ist Naz Stud Cura Dei Tumori | Metodo per la determinazione del rischio di comparsa, della presenza o del decorso di malattie tumorali. |
| US20040259101A1 (en) * | 2003-06-20 | 2004-12-23 | Shuber Anthony P. | Methods for disease screening |
| US8048627B2 (en) | 2003-07-05 | 2011-11-01 | The Johns Hopkins University | Method and compositions for detection and enumeration of genetic variations |
| US20100216153A1 (en) | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| US7937225B2 (en) | 2004-09-03 | 2011-05-03 | New York University | Systems, methods and software arrangements for detection of genome copy number variation |
| US20060073506A1 (en) | 2004-09-17 | 2006-04-06 | Affymetrix, Inc. | Methods for identifying biological samples |
| US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
| EP1712639B1 (de) | 2005-04-06 | 2008-08-27 | Maurice Stroun | Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf |
| ES2381204T3 (es) | 2005-10-24 | 2012-05-24 | The Johns Hopkins University | Métodos mejorados para BEAMING |
| US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
| CA2669728C (en) | 2006-11-15 | 2017-04-11 | Biospherex Llc | Multitag sequencing and ecogenomics analysis |
| JP2010528608A (ja) | 2007-06-01 | 2010-08-26 | 454 ライフ サイエンシーズ コーポレイション | 複合的な混合物から個々の試料を特定するためのシステムおよび方法 |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| PL2557520T3 (pl) | 2007-07-23 | 2021-10-11 | The Chinese University Of Hong Kong | Określanie zaburzenia równowagi sekwencji kwasu nukleinowego |
| US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
| EP2321642B1 (de) | 2008-08-04 | 2017-01-11 | Natera, Inc. | Verfahren für allelzuordnung und ploidiezuordnung |
| US20100069250A1 (en) | 2008-08-16 | 2010-03-18 | The Board Of Trustees Of The Leland Stanford Junior University | Digital PCR Calibration for High Throughput Sequencing |
| US20100323348A1 (en) | 2009-01-31 | 2010-12-23 | The Regents Of The University Of Colorado, A Body Corporate | Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process |
| US20120100548A1 (en) | 2010-10-26 | 2012-04-26 | Verinata Health, Inc. | Method for determining copy number variations |
| EP2370599B1 (de) | 2010-01-19 | 2015-01-21 | Verinata Health, Inc | Verfahren zur bestimmung von kopiennummer-variationen |
| US20110177512A1 (en) | 2010-01-19 | 2011-07-21 | Predictive Biosciences, Inc. | Method for assuring amplification of an abnormal nucleic acid in a sample |
| US9079155B2 (en) | 2010-07-29 | 2015-07-14 | Toto Ltd. | Photocatalyst coated body and photocatalyst coating liquid |
| EP2426217A1 (de) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytische Verfahren für zellfreie Nucleinsäuren und Anwendungen |
| ES2523140T3 (es) | 2010-09-21 | 2014-11-21 | Population Genetics Technologies Ltd. | Aumento de la confianza en las identificaciones de alelos con el recuento molecular |
| CA3210003A1 (en) | 2010-10-22 | 2012-04-26 | Cold Spring Harbor Laboratory | Varietal counting of nucleic acids for obtaining genomic copy number information |
| EP3395957B1 (de) | 2011-04-25 | 2020-08-12 | Bio-Rad Laboratories, Inc. | Verfahren und zusammensetzungen zur nukleinsäureanalyse |
| SG10201605049QA (en) | 2011-05-20 | 2016-07-28 | Fluidigm Corp | Nucleic acid encoding reactions |
| KR101454886B1 (ko) | 2011-08-01 | 2014-11-03 | 주식회사 셀레믹스 | 핵산분자의 제조방법 |
-
2005
- 2005-04-06 EP EP05007508A patent/EP1712639B1/de not_active Expired - Lifetime
- 2005-04-06 ES ES05007508T patent/ES2313143T3/es not_active Expired - Lifetime
- 2005-04-06 DE DE602005009324T patent/DE602005009324D1/de not_active Expired - Lifetime
- 2005-04-06 PL PL05007508T patent/PL1712639T3/pl unknown
- 2005-04-06 AT AT05007508T patent/ATE406463T1/de not_active IP Right Cessation
-
2006
- 2006-01-23 US US11/336,780 patent/US7700286B2/en not_active Ceased
-
2012
- 2012-04-13 US US13/447,104 patent/USRE44596E1/en active Active
-
2013
- 2013-09-27 US US14/039,168 patent/USRE49542E1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20060228727A1 (en) | 2006-10-12 |
| US7700286B2 (en) | 2010-04-20 |
| EP1712639A1 (de) | 2006-10-18 |
| USRE49542E1 (en) | 2023-06-06 |
| USRE44596E1 (en) | 2013-11-12 |
| EP1712639B1 (de) | 2008-08-27 |
| DE602005009324D1 (de) | 2008-10-09 |
| PL1712639T3 (pl) | 2009-02-27 |
| ES2313143T3 (es) | 2009-03-01 |
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