ATE407673T1 - Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer - Google Patents

Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer

Info

Publication number: ATE407673T1
Authority: AT; Austria
Prior art keywords: malonyl; prophylaxis; management; cyanoguanidine; treatment
Prior art date: 2003-08-01

Application number

AT04816789T

Other languages

English (en)

Inventor

Jie Cheng

Bin Liu

Thomas Arrhenius

Mark Wilson

Alex Nadzan

Gary Lopaschuk

Jason R Dyck

Rossy Serafimov

Original Assignee

Chugai Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-08-01

Filing date

2004-07-28

Publication date

2008-09-15

2004-07-28 Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd

2008-09-15 Application granted granted Critical

2008-09-15 Publication of ATE407673T1 publication Critical patent/ATE407673T1/de

Links

108010081805 Malonyl-CoA decarboxylase Proteins 0.000 title 1
102100029461 Malonyl-CoA decarboxylase, mitochondrial Human genes 0.000 title 1
150000003851 azoles Chemical class 0.000 title 1
239000003954 decarboxylase inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
238000007726 management method Methods 0.000 abstract 3
238000011321 prophylaxis Methods 0.000 abstract 3
238000011282 treatment Methods 0.000 abstract 3
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
230000004129 fatty acid metabolism Effects 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
230000004153 glucose metabolism Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
230000037361 pathway Effects 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT04816789T 2003-08-01 2004-07-28 Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer ATE407673T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US49203103P	2003-08-01	2003-08-01

Publications (1)

Publication Number	Publication Date
ATE407673T1 true ATE407673T1 (de)	2008-09-15

Family

ID=34465060

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT04816789T ATE407673T1 (de)	2003-08-01	2004-07-28	Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer
AT08163168T ATE536872T1 (de)	2003-08-01	2004-07-28	Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT08163168T ATE536872T1 (de)	2003-08-01	2004-07-28	Azol-verbindungen auf cyanoguanidin-basis als malonyl-coa decarboxylase-hemmer

Country Status (8)

Country	Link
US (1)	US7786145B2 (de)
EP (2)	EP1658071B1 (de)
JP (1)	JP4773960B2 (de)
AT (2)	ATE407673T1 (de)
CA (1)	CA2533881C (de)
DE (1)	DE602004016530D1 (de)
ES (2)	ES2378418T3 (de)
WO (1)	WO2005037258A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2437409C (en) *	2001-02-20	2010-10-19	Chugai Seiyaku Kabushiki Kaisha	Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators
US7709510B2 (en) *	2001-02-20	2010-05-04	Chugai Seiyaku Kabushiki Kaisha	Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
CN1964630A (zh)	2003-02-13	2007-05-16	耶希瓦大学艾伯塔·爱恩斯坦医学院	通过控制下丘脑的长链脂肪酰基－辅酶A(LC－CoA)的水平来调控食物摄取和葡萄糖产生
CA2533749C (en) *	2003-08-01	2012-07-10	Chugai Seiyaku Kabushiki Kaisha	Piperidine compounds useful as malonyl-coa decarboxylase inhibitors
CA2533747C (en) *	2003-08-01	2012-11-13	Chugai Seiyaku Kabushiki Kaisha	Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors
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2004
- 2004-07-28 US US10/900,706 patent/US7786145B2/en not_active Expired - Fee Related
- 2004-07-28 EP EP04816789A patent/EP1658071B1/de not_active Expired - Lifetime
- 2004-07-28 ES ES08163168T patent/ES2378418T3/es not_active Expired - Lifetime
- 2004-07-28 WO PCT/US2004/024347 patent/WO2005037258A2/en not_active Ceased
- 2004-07-28 AT AT04816789T patent/ATE407673T1/de not_active IP Right Cessation
- 2004-07-28 JP JP2006522615A patent/JP4773960B2/ja not_active Expired - Fee Related
- 2004-07-28 AT AT08163168T patent/ATE536872T1/de active
- 2004-07-28 DE DE602004016530T patent/DE602004016530D1/de not_active Expired - Lifetime
- 2004-07-28 ES ES04816789T patent/ES2314491T3/es not_active Expired - Lifetime
- 2004-07-28 CA CA2533881A patent/CA2533881C/en not_active Expired - Fee Related
- 2004-07-28 EP EP08163168A patent/EP2208495B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP2208495B1 (de)	2011-12-14
ES2314491T3 (es)	2009-03-16
ES2378418T3 (es)	2012-04-12
WO2005037258A3 (en)	2005-09-15
ATE536872T1 (de)	2011-12-15
JP2007501237A (ja)	2007-01-25
EP2208495A1 (de)	2010-07-21
CA2533881C (en)	2012-07-10
EP1658071B1 (de)	2008-09-10
EP1658071A2 (de)	2006-05-24
US20050032824A1 (en)	2005-02-10
US7786145B2 (en)	2010-08-31
DE602004016530D1 (de)	2008-10-23
CA2533881A1 (en)	2005-04-28
WO2005037258A2 (en)	2005-04-28
JP4773960B2 (ja)	2011-09-14

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2009-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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