ATE411294T1 - 4-amino-azepan-3-on-derivate als protease- inhibitors - Google Patents

4-amino-azepan-3-on-derivate als protease- inhibitors

Info

Publication number: ATE411294T1
Authority: AT; Austria
Prior art keywords: disease; azepan; amino; protease inhibitors; compounds
Prior art date: 1998-12-23

Application number

AT03076211T

Other languages

English (en)

Inventor

Robert Wells Marquis Jr

Yu Ru

Daniel Frank Veber

Maxwell David Cummings

Scott Kevin Thompson

Dennis Yamashita

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-23

Filing date

1999-12-21

Publication date

2008-10-15

1999-12-21 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2008-10-15 Application granted granted Critical

2008-10-15 Publication of ATE411294T1 publication Critical patent/ATE411294T1/de

Links

QTLLOLTVQMFWDZ-UHFFFAOYSA-N 4-aminoazepan-3-one Chemical class NC1CCCNCC1=O QTLLOLTVQMFWDZ-UHFFFAOYSA-N 0.000 title abstract 2
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title abstract 2
239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
206010065687 Bone loss Diseases 0.000 abstract 2
210000000845 cartilage Anatomy 0.000 abstract 2
230000015556 catabolic process Effects 0.000 abstract 2
238000006731 degradation reaction Methods 0.000 abstract 2
239000011159 matrix material Substances 0.000 abstract 2
102000004171 Cathepsin K Human genes 0.000 abstract 1
108090000625 Cathepsin K Proteins 0.000 abstract 1
206010020584 Hypercalcaemia of malignancy Diseases 0.000 abstract 1
208000030136 Marchiafava-Bignami Disease Diseases 0.000 abstract 1
208000029725 Metabolic bone disease Diseases 0.000 abstract 1
208000010191 Osteitis Deformans Diseases 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
208000027868 Paget disease Diseases 0.000 abstract 1
102000035195 Peptidases Human genes 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
206010003246 arthritis Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000024693 gingival disease Diseases 0.000 abstract 1
208000007565 gingivitis Diseases 0.000 abstract 1
208000008750 humoral hypercalcemia of malignancy Diseases 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
208000027202 mammary Paget disease Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
201000008482 osteoarthritis Diseases 0.000 abstract 1
201000001245 periodontitis Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT03076211T 1998-12-23 1999-12-21 4-amino-azepan-3-on-derivate als protease- inhibitors ATE411294T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US11363698P	1998-12-23	1998-12-23
US16458199P	1999-11-10	1999-11-10

Publications (1)

Publication Number	Publication Date
ATE411294T1 true ATE411294T1 (de)	2008-10-15

Family

ID=26811293

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03076211T ATE411294T1 (de)	1998-12-23	1999-12-21	4-amino-azepan-3-on-derivate als protease- inhibitors

Country Status (24)

Country	Link
US (2)	US20020147188A1 (de)
EP (1)	EP1158986A4 (de)
JP (1)	JP2002533397A (de)
KR (1)	KR100630986B1 (de)
CN (1)	CN1253441C (de)
AT (1)	ATE411294T1 (de)
AU (1)	AU768565B2 (de)
BR (1)	BR9916488A (de)
CA (1)	CA2356671A1 (de)
CZ (1)	CZ20012277A3 (de)
DE (1)	DE69939752D1 (de)
DZ (1)	DZ2977A1 (de)
ES (1)	ES2315456T3 (de)
GC (1)	GC0000178A (de)
HK (1)	HK1043536A1 (de)
HU (1)	HUP0104768A3 (de)
IL (2)	IL143142A0 (de)
NO (1)	NO318910B1 (de)
NZ (1)	NZ511710A (de)
PE (1)	PE20001340A1 (de)
PL (1)	PL350132A1 (de)
TR (1)	TR200101869T2 (de)
UY (1)	UY25874A1 (de)
WO (1)	WO2000038687A1 (de)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030144175A1 (en)	1998-12-23	2003-07-31	Smithkline Beecham Corporation	Protease inhibitors
US6596715B1 (en)	1999-11-10	2003-07-22	Smithkline Beecham Corporation	Protease inhibitors
EP1229911A4 (de) *	1999-11-10	2003-05-07	Smithkline Beecham Corp	Proteaseinhibitoren
AU1474601A (en) *	1999-11-10	2001-06-06	Smithkline Beecham Corporation	Protease inhibitors
US6583137B1 (en)	1999-11-10	2003-06-24	Smithkline Beecham Corporation	Protease inhibitors
JP2003513922A (ja) *	1999-11-10	2003-04-15	スミスクライン・ビーチャム・コーポレイション	プロテアーゼ阻害剤
WO2001034158A1 (en) *	1999-11-10	2001-05-17	Smithkline Beecham Corporation	Protease inhibitors
EP1235577A4 (de) *	1999-11-10	2003-04-09	Smithkline Beecham Corp	Proteaseinhibitoren
JP2003513927A (ja) *	1999-11-10	2003-04-15	スミスクライン・ビーチャム・コーポレイション	プロテア−ゼ阻害剤
EP1351930A4 (de) *	1999-11-10	2004-09-15	Smithkline Beecham Corp	Protease inhibitoren
EP1231923A4 (de) *	1999-11-10	2003-05-14	Smithkline Beecham Corp	Proteaseinhibitoren
WO2001034160A1 (en) *	1999-11-10	2001-05-17	Smithkline Beecham Corporation	Protease inhibitors
EP1229914A4 (de) *	1999-11-10	2004-06-23	Smithkline Beecham Corp	Proteasehemmer
AU4344101A (en)	2000-03-21	2001-10-03	Smithkline Beecham Corp	Protease inhibitors
CO5280088A1 (es) *	2000-04-18	2003-05-30	Smithkline Beecham Corp	Inhibidores de proteasa
CO5280093A1 (es) *	2000-04-18	2003-05-30	Smithkline Beecham Corp	Metodos de tratamiento
HUP0301231A2 (hu) *	2000-06-14	2003-08-28	Smithkline Beecham Corp.	Proteáz inhibitorok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
WO2002017924A1 (en) *	2000-09-01	2002-03-07	Smithkline Beecham Corporation	Method of treatment
CN1635903A (zh) *	2000-11-22	2005-07-06	史密丝克莱恩比彻姆公司	蛋白酶抑制剂
US7709510B2 (en)	2001-02-20	2010-05-04	Chugai Seiyaku Kabushiki Kaisha	Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
JP4155351B2 (ja)	2001-02-20	2008-09-24	中外製薬株式会社	代謝調節剤として有用なマロニル−ＣｏＡ脱炭酸酵素阻害剤としてのアゾール
AU2002342682A1 (en) *	2001-05-17	2002-11-25	Smithkline Beecham Corporation	Protease inhibitors
US6982263B2 (en)	2001-06-08	2006-01-03	Boehringer Ingelheim Pharmaceuticals, Inc.	Nitriles useful as reversible inhibitors of cysteine proteases
EP1534292A4 (de) *	2002-05-22	2008-04-02	Smithkline Beecham Corp	Protease-hemmer
AU2003263738A1 (en) *	2002-05-22	2003-12-02	Smithkline Beecham Corporation	Protease inhibitors
KR100962972B1 (ko) *	2002-07-26	2010-06-09	주식회사유한양행	1-페닐피페리딘-3-온 유도체 및 그의 제조방법
AU2003273697A1 (en) *	2002-10-08	2004-05-04	Merck Frosst Canada Ltd	4-amino-azepan-3-one compounds as cathepsin k inhibitors useful in the treatment of osteoporosis
ES2887054T3 (es)	2003-04-11	2021-12-21	Ptc Therapeutics Inc	Compuesto de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades
EP1653957B1 (de)	2003-08-01	2008-07-09	Chugai Seiyaku Kabushiki Kaisha	Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer
EP2208495B1 (de)	2003-08-01	2011-12-14	Chugai Seiyaku Kabushiki Kaisha	Azol-Verbindungen auf Cyanoguanidin-Basis als Malonyl-Coa Decarboxylase-Hemmer
DE602004030017D1 (de)	2003-08-01	2010-12-23	Chugai Pharmaceutical Co Ltd	Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer
AU2005203920A1 (en) *	2004-01-08	2005-07-21	Merck Frosst Canada Ltd	Cathepsin cysteine protease inhibitors
EP1796793A4 (de) *	2004-09-07	2009-08-05	Smithkline Beecham Corp	Neue verbindungen
US20090264479A1 (en) *	2005-07-26	2009-10-22	Cameron Black	Papain Family Cysteine Protease Inhibitors for the Treatment of Parasitic Diseases
IN2014CN04406A (de)	2006-03-30	2015-09-04	Ptc Therapeutics Inc
BR112013029672A2 (pt)	2011-05-16	2017-01-17	Bayer Ip Gmbh	uso de inibição da catepsina k para o tratamento e/ou profilaxia da hipertensão pulmonar e/ou insuficiência cardíaca
CN103275070A (zh) *	2013-05-10	2013-09-04	郑彪	调节单核细胞增殖的四环化合物及其应用
TWI695717B (zh)	2014-03-06	2020-06-11	美商 Ptc 治療公司	１,２,４-二唑苯甲酸之鹽及醫藥組合物
HK1251965A1 (zh)	2015-10-30	2019-05-10	Ptc医疗公司	用於治疗癫痫的方法

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1999
- 1999-12-21 TR TR2001/01869T patent/TR200101869T2/xx unknown
- 1999-12-21 JP JP2000590640A patent/JP2002533397A/ja active Pending
- 1999-12-21 CN CNB998150932A patent/CN1253441C/zh not_active Expired - Fee Related
- 1999-12-21 IL IL14314299A patent/IL143142A0/xx active IP Right Grant
- 1999-12-21 HU HU0104768A patent/HUP0104768A3/hu unknown
- 1999-12-21 CA CA002356671A patent/CA2356671A1/en not_active Abandoned
- 1999-12-21 CZ CZ20012277A patent/CZ20012277A3/cs unknown
- 1999-12-21 WO PCT/US1999/030730 patent/WO2000038687A1/en not_active Ceased
- 1999-12-21 KR KR1020017007989A patent/KR100630986B1/ko not_active Expired - Fee Related
- 1999-12-21 DE DE69939752T patent/DE69939752D1/de not_active Expired - Lifetime
- 1999-12-21 AU AU19411/00A patent/AU768565B2/en not_active Ceased
- 1999-12-21 EP EP99963112A patent/EP1158986A4/de not_active Withdrawn
- 1999-12-21 AT AT03076211T patent/ATE411294T1/de not_active IP Right Cessation
- 1999-12-21 PL PL99350132A patent/PL350132A1/xx not_active Application Discontinuation
- 1999-12-21 NZ NZ511710A patent/NZ511710A/en unknown
- 1999-12-21 ES ES03076211T patent/ES2315456T3/es not_active Expired - Lifetime
- 1999-12-21 HK HK02103610.2A patent/HK1043536A1/zh unknown
- 1999-12-21 BR BR9916488-4A patent/BR9916488A/pt not_active IP Right Cessation
- 1999-12-22 UY UY25874A patent/UY25874A1/es not_active Application Discontinuation
- 1999-12-22 DZ DZ990277A patent/DZ2977A1/xx active
- 1999-12-22 GC GCP1999461 patent/GC0000178A/en active
- 1999-12-23 PE PE1999001312A patent/PE20001340A1/es not_active Application Discontinuation
2001
- 2001-05-14 IL IL143142A patent/IL143142A/en not_active IP Right Cessation
- 2001-06-22 NO NO20013124A patent/NO318910B1/no unknown
2002
- 2002-02-13 US US10/074,940 patent/US20020147188A1/en not_active Abandoned
2003
- 2003-04-01 US US10/404,142 patent/US20030225061A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1253441C (zh)	2006-04-26
AU768565B2 (en)	2003-12-18
PE20001340A1 (es)	2001-01-28
GC0000178A (en)	2006-03-29
US20020147188A1 (en)	2002-10-10
CN1350458A (zh)	2002-05-22
CZ20012277A3 (cs)	2001-11-14
ES2315456T3 (es)	2009-04-01
JP2002533397A (ja)	2002-10-08
IL143142A (en)	2006-08-20
TR200101869T2 (tr)	2002-01-21
AU1941100A (en)	2000-07-31
EP1158986A4 (de)	2002-03-27
KR20010089677A (ko)	2001-10-08
NO20013124L (no)	2001-06-22
NZ511710A (en)	2003-12-19
US20030225061A1 (en)	2003-12-04
CA2356671A1 (en)	2000-07-06
EP1158986A1 (de)	2001-12-05
DE69939752D1 (de)	2008-11-27
NO318910B1 (no)	2005-05-23
HK1043536A1 (zh)	2002-09-20
IL143142A0 (en)	2002-04-21
HUP0104768A2 (hu)	2002-04-29
HUP0104768A3 (en)	2002-05-28
WO2000038687A1 (en)	2000-07-06
BR9916488A (pt)	2001-10-09
PL350132A1 (en)	2002-11-04
NO20013124D0 (no)	2001-06-22
KR100630986B1 (ko)	2006-10-09
UY25874A1 (es)	2001-08-27
DZ2977A1 (fr)	2004-03-15

Legal Events

Date	Code	Title	Description
2009-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69939752D1 (de)	2008-11-27	4-Amino-azepan-3-on-Derivate als Protease-Inhibitors
MY141596A (en)	2010-05-31	Protease inhibitors
AP9801222A0 (en)	1998-06-30	Proatease inhibitors.
NZ537853A (en)	2007-02-23	Inhibitors of cathepsin K and related cysteine protesases of the CA clan
NO995268L (no)	1999-11-15	Proteaseinhibitorer
WO1999059526A3 (en)	2000-01-20	Protease inhibitors
AP2002002671A0 (en)	2002-12-31	Protease inhibitors.
ATE272633T1 (de)	2004-08-15	Aromatische amiden
HK1042695A1 (zh)	2002-08-23	蛋白酶抑制剂
HK1041690A1 (zh)	2002-07-19	蛋白酶抑制剂
HK1044758A1 (zh)	2002-11-01	蛋白酶抑制剂
WO2002092563A3 (en)	2003-04-03	Protease inhibitors
WO2003053331A3 (en)	2003-11-13	Protease inhibitors
UY26026A1 (es)	2000-10-31	Inhibidores de proteasas
ECSP992959A (es)	1999-10-06	Inhibidores de proteasa de bis- aminometil carbonilo
AR021971A1 (es)	2002-09-04	Inhibidores de proteasas
ECSP982486A (es)	1999-01-12	Inhibidores de proteasas ii
ECSP993293A (es)	2000-05-25	Inhibidores de proteasas viii
ECSP003403A (es)	2000-05-25	Inhibidores de proteasas xi
ECSP982481A (es)	1999-01-19	Inhibidores de proteasas
UY26771A1 (es)	2002-01-31	Inhibidores de proteasas
NZ324101A (en)	1999-11-29	Protease inhibitors, pharmaceutical compositions and use thereof
AR004703A1 (es)	1999-03-10	Hidrazidil, bis-hidrazil y bis-aminometil-carbonil, inhibidores de proteasas, una composicin farmaceutica, metodo para inhibir proteasas, y uso en la preparacion de medicamentos.