ATE412668T1 - Antimikrobielle kationische peptide und methoden zu ihrer identifizierung - Google Patents

Antimikrobielle kationische peptide und methoden zu ihrer identifizierung

Info

Publication number
ATE412668T1
ATE412668T1 AT96930303T AT96930303T ATE412668T1 AT E412668 T1 ATE412668 T1 AT E412668T1 AT 96930303 T AT96930303 T AT 96930303T AT 96930303 T AT96930303 T AT 96930303T AT E412668 T1 ATE412668 T1 AT E412668T1
Authority
AT
Austria
Prior art keywords
sub
entry
row
seq
tryptophan
Prior art date
Application number
AT96930303T
Other languages
German (de)
English (en)
Inventor
Timothy Falla
Robert Hancock
Monisha Gough
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia filed Critical Univ British Columbia
Application granted granted Critical
Publication of ATE412668T1 publication Critical patent/ATE412668T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT96930303T 1995-08-23 1996-08-23 Antimikrobielle kationische peptide und methoden zu ihrer identifizierung ATE412668T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US268795P 1995-08-23 1995-08-23

Publications (1)

Publication Number Publication Date
ATE412668T1 true ATE412668T1 (de) 2008-11-15

Family

ID=21701983

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96930303T ATE412668T1 (de) 1995-08-23 1996-08-23 Antimikrobielle kationische peptide und methoden zu ihrer identifizierung

Country Status (9)

Country Link
US (2) US6191254B1 (2)
EP (1) EP0846128B1 (2)
JP (1) JP3860838B2 (2)
AT (1) ATE412668T1 (2)
AU (1) AU6940796A (2)
CA (1) CA2230160A1 (2)
DE (1) DE69637731D1 (2)
ES (1) ES2316154T3 (2)
WO (1) WO1997008199A2 (2)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180604B1 (en) 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
EP1174439B1 (en) * 1996-08-21 2008-10-08 Migenix Inc. Compositions and methods for treating infections using analogues of indolicidin
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6303575B1 (en) * 1998-05-12 2001-10-16 The Regents Of The University Of California Indolicidin analogs and methods of using same
US6444645B1 (en) 1998-06-18 2002-09-03 The Regents Of The University Of California Crosslink-stabilized indolicidin analogs
US6288212B1 (en) * 1998-08-28 2001-09-11 The University Of British Columbia Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor
WO2000026344A1 (en) * 1998-10-30 2000-05-11 Interlink Biotechnologies Llc Peptides with enhanced stability to protease degradation
US6946261B1 (en) 1998-11-20 2005-09-20 Migenix Inc. Efficient methods for producing anti-microbial cationic peptides in host cells
US6335318B1 (en) 1999-05-10 2002-01-01 The Regents Of The University Of California Antimicrobial theta defensins and methods of using same
US6497676B1 (en) 2000-02-10 2002-12-24 Baxter International Method and apparatus for monitoring and controlling peritoneal dialysis therapy
US6337317B1 (en) * 2000-06-27 2002-01-08 The University Of British Columbia Antimicrobial peptides and methods of use thereof
US6835536B2 (en) 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof
US8933029B2 (en) * 2001-08-24 2015-01-13 Carrus Capital Corporation Antimicrobial and anti-inflammatory peptides
KR100438416B1 (ko) * 2001-09-19 2004-07-02 학교법인조선대학교 Ｃａ－ｍａ 펩타이드의 아미노산 중 하나 또는 그 이상을치환하여 ＋ 전극과 소수성 영역이 증가된 신규한펩타이드 및 그를 포함하는 약학적 조성물
US7507787B2 (en) * 2001-12-03 2009-03-24 The University Of British Columbia Effectors of innate immunity
US20030125662A1 (en) * 2002-01-03 2003-07-03 Tuan Bui Method and apparatus for providing medical treatment therapy based on calculated demand
US20030219854A1 (en) * 2002-03-21 2003-11-27 Micrologix Biotech Inc. Methods for producing modified anti-infective peptides
AU2003231471A1 (en) * 2002-04-25 2003-11-10 Toagosei Co., Ltd. Antimicrobial polypeptide and utizliation thereof
US7119070B2 (en) 2002-04-30 2006-10-10 The Regents Of The University Of California Antimicrobial theta defensins, analogs thereof, and methods of use
US7033769B2 (en) * 2002-05-23 2006-04-25 The United States Of America As Represented By The Secretary Of The Army Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
US7238164B2 (en) 2002-07-19 2007-07-03 Baxter International Inc. Systems, methods and apparatuses for pumping cassette-based therapies
US7550430B2 (en) * 2003-08-18 2009-06-23 E.I. Du Pont De Nemours And Company Cationic antimicrobial peptides and compositions
US7674771B2 (en) * 2003-10-29 2010-03-09 Toagosei Co., Ltd Antimicrobial peptides and utilization of the same
US20050209563A1 (en) * 2004-03-19 2005-09-22 Peter Hopping Cassette-based dialysis medical fluid therapy systems, apparatuses and methods
JP4507080B2 (ja) * 2004-07-30 2010-07-21 東亞合成株式会社 抗菌ペプチド及びその利用
JP4730584B2 (ja) * 2004-12-06 2011-07-20 東亞合成株式会社 抗菌ペプチド及びその利用
US8252737B2 (en) 2004-12-15 2012-08-28 The Regents Of The University Of Colorado Antimicrobial peptides and methods of use
EP1849474B1 (en) * 2005-02-15 2016-09-07 Toagosei Co., Ltd. Antimicrobial peptide and use thereof
US7731689B2 (en) 2007-02-15 2010-06-08 Baxter International Inc. Dialysis system having inductive heating
US8558964B2 (en) 2007-02-15 2013-10-15 Baxter International Inc. Dialysis system having display with electromagnetic compliance (“EMC”) seal
US8361023B2 (en) * 2007-02-15 2013-01-29 Baxter International Inc. Dialysis system with efficient battery back-up
US8870812B2 (en) * 2007-02-15 2014-10-28 Baxter International Inc. Dialysis system having video display with ambient light adjustment
US7998115B2 (en) * 2007-02-15 2011-08-16 Baxter International Inc. Dialysis system having optical flowrate detection
DK2178549T3 (en) * 2007-07-26 2017-01-09 Revance Therapeutics Inc Antimicrobial peptide AND COMPOSITIONS THEREOF
WO2010042534A1 (en) * 2008-10-06 2010-04-15 The Regents Of The University Of Colorado, A Body Corporate Peptides and methods of use
GB0821616D0 (en) * 2008-11-26 2008-12-31 Lytix Biopharma As Compounds
EP2437770A4 (en) * 2009-06-05 2013-11-06 Univ Colorado Regents ANTIMICROBIAL PEPTIDES
WO2011068801A2 (en) 2009-12-01 2011-06-09 The Rockefeller University Methods for identifying compounds that modulate ion channel activity of a kir channel
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
EP3384938A1 (en) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
WO2013151664A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins
CN104411338A (zh) 2012-04-02 2015-03-11 现代治疗公司 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸
US20150072922A1 (en) * 2012-04-17 2015-03-12 The Research Institute At Nationwide Children's Hospital Rnase 7 antimicrobial peptides
MY151307A (en) * 2012-06-18 2014-05-05 Univ Malaya Peptides having antimicrobial activity
GB201401877D0 (en) 2014-02-04 2014-03-19 Univ Tromsoe Peptides
EP3067608A1 (en) * 2015-03-10 2016-09-14 Abu Dhabi Polymers Co. Ltd (Borouge) LLC. Eccentric polyolefin pipe
US11168131B2 (en) 2015-11-10 2021-11-09 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
WO2018136626A1 (en) 2017-01-18 2018-07-26 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
US11021529B2 (en) 2017-03-03 2021-06-01 Massachusetts Institute Of Technology Antimicrobial constructs and uses thereof
US10934943B2 (en) 2017-04-27 2021-03-02 General Electric Company Compressor apparatus with bleed slot and supplemental flange
US11179516B2 (en) 2017-06-22 2021-11-23 Baxter International Inc. Systems and methods for incorporating patient pressure into medical fluid delivery
KR20240085798A (ko) 2020-04-03 2024-06-17 비스테라, 인크. 항체 분자-약물 접합체 및 이의 용도
CU24750B1 (es) * 2020-11-19 2025-06-11 Centro De Investig Y Desarrollo De Medicamentos Cidem Entidades peptídicas con actividad antimicrobiana frente a patógenos multi-drogoresistentes

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206154A (en) 1985-01-28 1993-04-27 Xoma Corporation Method of producing cecropins by microbiological techniques
US5028530A (en) 1985-01-28 1991-07-02 Xoma Corporation AraB promoters and method of producing polypeptides, including cecropins, by microbiological techniques
US5166321A (en) 1985-01-28 1992-11-24 International Genetic Engineering, Inc. Cecropin polypetides with activity against Gram-positive and Gram-negative bacteria
US4810777A (en) 1987-03-04 1989-03-07 The United States Of America As Represented By The Department Of Health And Human Services Antimicrobial compounds
US4822608A (en) 1987-09-14 1989-04-18 Vespa Laboratories, Inc. Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof
EP0416035B1 (en) 1988-05-27 1994-12-07 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
SE8802939D0 (sv) 1988-08-19 1988-08-19 Kabigen Ab A method for the production and isolation of a fusion protein in eukaryotic cells
HUT57992A (en) 1988-10-21 1992-01-28 Magainin Sciences Inc Process for producing composition comprising biologically active peptides and certain anions
EP0440688B1 (en) 1988-10-21 1994-09-21 The Children's Hospital Of Philadelphia Cpf peptide compositions and uses
US5217956A (en) 1988-10-21 1993-06-08 The Children's Hospital Of Philadelphia Composition and treatment with biologically active peptides and certain anions
CA2007913A1 (en) 1989-01-30 1990-07-30 Michael Zasloff Composition and treatment with peptide combinations
US5254535A (en) 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
FR2646777B1 (fr) 1989-05-12 1993-09-03 Bio Serae Lab Procede de preparation d'un produit particulaire antimicrobien, produit antimicrobien obtenu et applications
US5073542A (en) 1989-06-07 1991-12-17 Magainin Sciences Inc. CPF peptide compositions and their use in inhibiting growth of target cells or a virus
US5045531A (en) 1989-12-18 1991-09-03 Magainin Sciences Inc. Wound treatment employing biologically active ion channel forming peptides and proteins
JPH07504152A (ja) 1990-02-08 1995-05-11 マゲイニン　ファーマスーティカルズ，　インコーポレーテッド 生物活性ペプチドおよび標的細胞、ウイルス、あるいはウイルス感染細胞の成長を抑制する方法
US5227469A (en) 1990-02-14 1993-07-13 Genentech, Inc. Platelet aggregation inhibitors from the leech
JPH05509295A (ja) 1990-04-23 1993-12-22 マゲイニン　サイエンセズ　インコーポレーテッド 生物学的に活性なペプチドおよび毒性陽イオンを有する組成物およびこれらを使用する治療法
JPH05507077A (ja) 1990-04-27 1993-10-14 マゲイニン　サイエンセズ　インコーポレーテッド 生物活性ペプチドおよび駆虫剤もしくは抗真菌剤を使う組成物および治療法
JPH05507273A (ja) 1990-05-14 1993-10-21 マゲイニン　サイエンセズ　インコーポレーテッド Ｄアミノ酸残基を有する生物活性ペプチドの組成物およびそれによる治療方法
US5208220A (en) 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
US5202420A (en) 1990-10-25 1993-04-13 The Children's Hospital Of Philadelphia Tracheal antimicrobial peptides, dna sequences and methods for the production and use thereof
US5235038A (en) 1991-01-22 1993-08-10 Torry Pines Institute For Molecular Studies Deletion and substitution analogues of melittin peptide
CA2107674A1 (en) 1991-04-08 1992-10-09 W. Lee Maloy Novel peptide compositions and uses therefor
JPH06511234A (ja) 1991-06-12 1994-12-15 マゲイニン　ファーマス−ティカルズ，インコーポレーテッド Ｃ末端置換を有する生物活性ペプチド組成物および治療法
WO1993001723A1 (en) 1991-07-25 1993-02-04 Magainin Pharmaceuticals, Inc. Prophylaxis and treatment of adverse oral conditions with biologically active peptides
US5547939A (en) * 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5324716A (en) * 1991-06-14 1994-06-28 Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
JPH07501519A (ja) 1991-09-13 1995-02-16 マゲイニン　ファーマスーティカルズ，インコーポレーテッド 生物活性両親媒性ペプチド組成物およびその用途
WO1993011783A1 (en) 1991-12-09 1993-06-24 Magainin Pharmaceuticals Inc. Composition and treatment with biologically active peptides and chelating agents
CA2137087A1 (en) 1992-06-01 1993-12-09 U. Prasad Kari Biologically active peptides having n-terminal substitutions
WO1994004688A2 (en) * 1992-08-21 1994-03-03 The University Of British Columbia Cationic peptides and method for production
CA2106720C (en) 1992-09-23 1997-12-16 Charles L. Deschenes Needle for use as part of a plastic fastener dispensing tool
US5635594A (en) * 1994-03-11 1997-06-03 University Of California, Los Angeles Gallinacins - antibiotic peptides
US5877274A (en) 1995-06-02 1999-03-02 University Of British Columbia Antimicrobial cationic peptides

Also Published As

Publication number Publication date
JP3860838B2 (ja) 2006-12-20
DE69637731D1 (de) 2008-12-11
CA2230160A1 (en) 1997-03-06
EP0846128A2 (en) 1998-06-10
US20040019181A1 (en) 2004-01-29
WO1997008199A3 (en) 1997-09-12
ES2316154T3 (es) 2009-04-01
EP0846128B1 (en) 2008-10-29
HK1011867A1 (en) 1999-07-23
AU6940796A (en) 1997-03-19
US6191254B1 (en) 2001-02-20
WO1997008199A2 (en) 1997-03-06
JPH11511971A (ja) 1999-10-19
US7390873B2 (en) 2008-06-24

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