ES2316154T3 - Peptidos cationicos antimicrobianos y procedimientos de seleccion de los mismos. - Google Patents

Peptidos cationicos antimicrobianos y procedimientos de seleccion de los mismos. Download PDF

Info

Publication number
ES2316154T3
ES2316154T3 ES96930303T ES96930303T ES2316154T3 ES 2316154 T3 ES2316154 T3 ES 2316154T3 ES 96930303 T ES96930303 T ES 96930303T ES 96930303 T ES96930303 T ES 96930303T ES 2316154 T3 ES2316154 T3 ES 2316154T3
Authority
ES
Spain
Prior art keywords
sub
baselineskip
peptide
seq
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96930303T
Other languages
English (en)
Spanish (es)
Inventor
Timothy J. Falla
Robert E. W. Hancock
Monisha Gough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia filed Critical University of British Columbia
Application granted granted Critical
Publication of ES2316154T3 publication Critical patent/ES2316154T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723Cationic antimicrobial peptides, e.g. defensins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ES96930303T 1995-08-23 1996-08-23 Peptidos cationicos antimicrobianos y procedimientos de seleccion de los mismos. Expired - Lifetime ES2316154T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US268795P 1995-08-23 1995-08-23
US2687P 1995-08-23

Publications (1)

Publication Number Publication Date
ES2316154T3 true ES2316154T3 (es) 2009-04-01

Family

ID=21701983

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96930303T Expired - Lifetime ES2316154T3 (es) 1995-08-23 1996-08-23 Peptidos cationicos antimicrobianos y procedimientos de seleccion de los mismos.

Country Status (9)

Country Link
US (2) US6191254B1 (2)
EP (1) EP0846128B1 (2)
JP (1) JP3860838B2 (2)
AT (1) ATE412668T1 (2)
AU (1) AU6940796A (2)
CA (1) CA2230160A1 (2)
DE (1) DE69637731D1 (2)
ES (1) ES2316154T3 (2)
WO (1) WO1997008199A2 (2)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1174439B1 (en) * 1996-08-21 2008-10-08 Migenix Inc. Compositions and methods for treating infections using analogues of indolicidin
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6180604B1 (en) * 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6303575B1 (en) 1998-05-12 2001-10-16 The Regents Of The University Of California Indolicidin analogs and methods of using same
US6444645B1 (en) * 1998-06-18 2002-09-03 The Regents Of The University Of California Crosslink-stabilized indolicidin analogs
US6288212B1 (en) * 1998-08-28 2001-09-11 The University Of British Columbia Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor
WO2000026344A1 (en) * 1998-10-30 2000-05-11 Interlink Biotechnologies Llc Peptides with enhanced stability to protease degradation
US6946261B1 (en) 1998-11-20 2005-09-20 Migenix Inc. Efficient methods for producing anti-microbial cationic peptides in host cells
US6335318B1 (en) 1999-05-10 2002-01-01 The Regents Of The University Of California Antimicrobial theta defensins and methods of using same
US6497676B1 (en) 2000-02-10 2002-12-24 Baxter International Method and apparatus for monitoring and controlling peritoneal dialysis therapy
US6337317B1 (en) * 2000-06-27 2002-01-08 The University Of British Columbia Antimicrobial peptides and methods of use thereof
US6835536B2 (en) 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof
JP4511173B2 (ja) 2001-08-24 2010-07-28 マイジェニックス インコーポレイテッド 抗菌性および抗炎症性ペプチド
KR100438416B1 (ko) * 2001-09-19 2004-07-02 학교법인조선대학교 Ca-ma 펩타이드의 아미노산 중 하나 또는 그 이상을치환하여 + 전극과 소수성 영역이 증가된 신규한펩타이드 및 그를 포함하는 약학적 조성물
US7507787B2 (en) * 2001-12-03 2009-03-24 The University Of British Columbia Effectors of innate immunity
US20030125662A1 (en) * 2002-01-03 2003-07-03 Tuan Bui Method and apparatus for providing medical treatment therapy based on calculated demand
US20030219854A1 (en) * 2002-03-21 2003-11-27 Micrologix Biotech Inc. Methods for producing modified anti-infective peptides
DE60335101D1 (de) * 2002-04-25 2011-01-05 Toagosei Co Ltd Antimikrobielles polypeptid und nutzung davon
US7119070B2 (en) 2002-04-30 2006-10-10 The Regents Of The University Of California Antimicrobial theta defensins, analogs thereof, and methods of use
US7033769B2 (en) * 2002-05-23 2006-04-25 The United States Of America As Represented By The Secretary Of The Army Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
US7238164B2 (en) * 2002-07-19 2007-07-03 Baxter International Inc. Systems, methods and apparatuses for pumping cassette-based therapies
WO2005019241A2 (en) * 2003-08-18 2005-03-03 E.I. Dupont De Nemours And Company Cationic antimicrobial peptides and compositions thereof
JP4524671B2 (ja) * 2003-10-29 2010-08-18 東亞合成株式会社 抗菌ペプチド及びその利用
US20050209563A1 (en) * 2004-03-19 2005-09-22 Peter Hopping Cassette-based dialysis medical fluid therapy systems, apparatuses and methods
JP4507080B2 (ja) * 2004-07-30 2010-07-21 東亞合成株式会社 抗菌ペプチド及びその利用
JP4730584B2 (ja) * 2004-12-06 2011-07-20 東亞合成株式会社 抗菌ペプチド及びその利用
CN101111256B (zh) * 2004-12-15 2012-04-25 科罗拉多大学 抗菌肽及其使用方法
WO2006088010A1 (ja) * 2005-02-15 2006-08-24 Toagosei Co., Ltd. 抗菌ペプチド及びその利用
US8558964B2 (en) 2007-02-15 2013-10-15 Baxter International Inc. Dialysis system having display with electromagnetic compliance (“EMC”) seal
US8361023B2 (en) * 2007-02-15 2013-01-29 Baxter International Inc. Dialysis system with efficient battery back-up
US7731689B2 (en) 2007-02-15 2010-06-08 Baxter International Inc. Dialysis system having inductive heating
US8870812B2 (en) * 2007-02-15 2014-10-28 Baxter International Inc. Dialysis system having video display with ambient light adjustment
US7998115B2 (en) * 2007-02-15 2011-08-16 Baxter International Inc. Dialysis system having optical flowrate detection
CN101842107B (zh) * 2007-07-26 2014-04-23 雷文斯治疗公司 抗微生物肽,组合物和使用方法
US20100099614A1 (en) * 2008-10-06 2010-04-22 Hodges Robert S Antimicrobial Peptides and Methods of Use
GB0821616D0 (en) * 2008-11-26 2008-12-31 Lytix Biopharma As Compounds
EP2437770A4 (en) * 2009-06-05 2013-11-06 Univ Colorado Regents ANTIMICROBIAL PEPTIDES
WO2011068801A2 (en) 2009-12-01 2011-06-09 The Rockefeller University Methods for identifying compounds that modulate ion channel activity of a kir channel
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
EP3384938A1 (en) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2868391A1 (en) 2012-04-02 2013-10-10 Stephane Bancel Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same
AU2013243948A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
US20150072922A1 (en) * 2012-04-17 2015-03-12 The Research Institute At Nationwide Children's Hospital Rnase 7 antimicrobial peptides
MY151307A (en) * 2012-06-18 2014-05-05 Univ Malaya Peptides having antimicrobial activity
GB201401877D0 (en) 2014-02-04 2014-03-19 Univ Tromsoe Peptides
EP3067608A1 (en) * 2015-03-10 2016-09-14 Abu Dhabi Polymers Co. Ltd (Borouge) LLC. Eccentric polyolefin pipe
AU2016353073A1 (en) 2015-11-10 2018-06-07 Visterra, Inc. Antibody molecule-drug conjugates that specifically binds to lipopolysaccharide and uses thereof
CN110431150A (zh) 2017-01-18 2019-11-08 威特拉公司 抗体分子-药物偶联物及其用途
WO2018160791A1 (en) 2017-03-03 2018-09-07 Massachusetts Institute Of Technology Antimicrobial constructs and uses thereof
US10934943B2 (en) 2017-04-27 2021-03-02 General Electric Company Compressor apparatus with bleed slot and supplemental flange
US11179516B2 (en) 2017-06-22 2021-11-23 Baxter International Inc. Systems and methods for incorporating patient pressure into medical fluid delivery
AU2021248643A1 (en) 2020-04-03 2022-10-27 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
CU24750B1 (es) * 2020-11-19 2025-06-11 Centro De Investig Y Desarrollo De Medicamentos Cidem Entidades peptídicas con actividad antimicrobiana frente a patógenos multi-drogoresistentes

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166321A (en) 1985-01-28 1992-11-24 International Genetic Engineering, Inc. Cecropin polypetides with activity against Gram-positive and Gram-negative bacteria
US5206154A (en) 1985-01-28 1993-04-27 Xoma Corporation Method of producing cecropins by microbiological techniques
US5028530A (en) 1985-01-28 1991-07-02 Xoma Corporation AraB promoters and method of producing polypeptides, including cecropins, by microbiological techniques
US4810777A (en) 1987-03-04 1989-03-07 The United States Of America As Represented By The Department Of Health And Human Services Antimicrobial compounds
US4822608A (en) 1987-09-14 1989-04-18 Vespa Laboratories, Inc. Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof
ATE115146T1 (de) 1988-05-27 1994-12-15 Philadelphia Children Hospital Amphiphile peptide und deren verwendung.
SE8802939D0 (sv) 1988-08-19 1988-08-19 Kabigen Ab A method for the production and isolation of a fusion protein in eukaryotic cells
JPH04502904A (ja) 1988-10-21 1992-05-28 マゲイニン サイエンセス インコーポレーテッド 両親媒性ペプチドの投与方法およびその組成物
US5217956A (en) 1988-10-21 1993-06-08 The Children's Hospital Of Philadelphia Composition and treatment with biologically active peptides and certain anions
DE68918453T2 (de) 1988-10-21 1995-02-23 Philadelphia Children Hospital Zusammensetzungen auf Basis von CPF Peptiden sowie deren Verwendungen.
CA2007913A1 (en) 1989-01-30 1990-07-30 Michael Zasloff Composition and treatment with peptide combinations
US5254535A (en) 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
FR2646777B1 (fr) 1989-05-12 1993-09-03 Bio Serae Lab Procede de preparation d'un produit particulaire antimicrobien, produit antimicrobien obtenu et applications
US5073542A (en) 1989-06-07 1991-12-17 Magainin Sciences Inc. CPF peptide compositions and their use in inhibiting growth of target cells or a virus
US5045531A (en) 1989-12-18 1991-09-03 Magainin Sciences Inc. Wound treatment employing biologically active ion channel forming peptides and proteins
EP0514464A4 (en) 1990-02-08 1993-04-28 Magainin Sciences, Inc. Biologically active amphiphilic peptides and method of inhibiting growth of target cells, virus or virally-infected cell
US5227469A (en) 1990-02-14 1993-07-13 Genentech, Inc. Platelet aggregation inhibitors from the leech
WO1991016066A1 (en) 1990-04-23 1991-10-31 Magainin Sciences Inc. Composition and treatment with biologically active peptides and toxic cations
EP0526570A4 (en) 1990-04-27 1993-04-21 Magainin Sciences, Inc. Composition and treatment with biologically active peptides and anti-parasitic agents or anti-fungal agents
JPH05507273A (ja) 1990-05-14 1993-10-21 マゲイニン サイエンセズ インコーポレーテッド Dアミノ酸残基を有する生物活性ペプチドの組成物およびそれによる治療方法
US5208220A (en) 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
US5202420A (en) 1990-10-25 1993-04-13 The Children's Hospital Of Philadelphia Tracheal antimicrobial peptides, dna sequences and methods for the production and use thereof
US5235038A (en) 1991-01-22 1993-08-10 Torry Pines Institute For Molecular Studies Deletion and substitution analogues of melittin peptide
CA2107674A1 (en) 1991-04-08 1992-10-09 W. Lee Maloy Novel peptide compositions and uses therefor
CA2111214A1 (en) 1991-06-12 1992-12-23 W. Lee Maloy Composition and treatment with biologically active peptides having c-terminal substitutions
AU667479B2 (en) 1991-06-12 1996-03-28 Magainin Pharmaceuticals, Inc. Treating the oral cavity with ion-channel forming peptides
US5324716A (en) * 1991-06-14 1994-06-28 Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5547939A (en) * 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
AU665030B2 (en) 1991-09-13 1995-12-14 Magainin Pharmaceuticals, Inc. Biologically active amphiphilic peptide compositions and uses therefor
EP0661988A1 (en) 1991-12-09 1995-07-12 Magainin Pharmaceuticals Inc. Composition and treatment with biologically active peptides and chelating agents
EP0644769A4 (en) 1992-06-01 1995-08-09 Magainin Pharma BIOLOGICALLY ACTIVE PEPTIDES WITH N-TERMINAL SUBSTITUTIONS.
EP0656952B1 (en) * 1992-08-21 2003-03-05 The University Of British Columbia Cationic peptides and method for production
CA2106720C (en) 1992-09-23 1997-12-16 Charles L. Deschenes Needle for use as part of a plastic fastener dispensing tool
US5635594A (en) * 1994-03-11 1997-06-03 University Of California, Los Angeles Gallinacins - antibiotic peptides
US5877274A (en) * 1995-06-02 1999-03-02 University Of British Columbia Antimicrobial cationic peptides

Also Published As

Publication number Publication date
US6191254B1 (en) 2001-02-20
US20040019181A1 (en) 2004-01-29
EP0846128B1 (en) 2008-10-29
CA2230160A1 (en) 1997-03-06
JP3860838B2 (ja) 2006-12-20
EP0846128A2 (en) 1998-06-10
HK1011867A1 (en) 1999-07-23
AU6940796A (en) 1997-03-19
ATE412668T1 (de) 2008-11-15
WO1997008199A3 (en) 1997-09-12
JPH11511971A (ja) 1999-10-19
DE69637731D1 (de) 2008-12-11
US7390873B2 (en) 2008-06-24
WO1997008199A2 (en) 1997-03-06

Similar Documents

Publication Publication Date Title
ES2316154T3 (es) Peptidos cationicos antimicrobianos y procedimientos de seleccion de los mismos.
US6465429B1 (en) Antimicrobial cationic peptides
DK2938352T3 (en) CYLIC CATIONIC PEPTIDES WITH ANTIBMICROBIAL ACTIVITY
Jung et al. Fungicidal effect of pleurocidin by membrane-active mechanism and design of enantiomeric analogue for proteolytic resistance
US6040435A (en) Antimicrobial cationic peptides
US20110262508A1 (en) Antimicrobial compositions, formulations and uses thereof
JPH08508165A (ja) ウシ好中球由来の新規な抗微生物性ペプチド
JP2001520631A (ja) 抗真菌性ペプチド
Wood et al. Modified cysteine-deleted tachyplesin (CDT) analogs as linear antimicrobial peptides: Influence of chain length, positive charge, and hydrophobicity on antimicrobial and hemolytic activity
US20080234188A1 (en) Antimicrobial Peptides
EP0824547B1 (en) Anti-fungal peptides
JPH08500818A (ja) N末端置換を有する生物活性ペプチド
EP1294745A2 (en) Antimicrobial peptides and methods of use thereof
JP4902919B2 (ja) ペプチド作成の方法
Shafer et al. Tailoring an antibacterial peptide of human lysosomal cathepsin G to enhance its broad-spectrum action against antibiotic-resistant bacterial pathogens
US5654274A (en) Biologically active peptides having N-terminal substitutions
WO1999060016A2 (en) Antimicrobial cationic peptide derivatives of bactenecin
JPH03504501A (ja) 両親媒性ペプチドとその用途
US20100221272A1 (en) Immunomodulatory compositions and methods for treating disease with modified host defense peptides
AU2002317071A1 (en) Antimicrobial peptides
AU693518B2 (en) Ion-channel forming amphiphilic peptides having n-terminal modifications
CN112778424B (zh) 嵌合肽r7及其应用
TW202317598A (zh) 具有抗微生物活性的胜肽
WO2004058798A9 (en) Antimicrobial peptides
HK1011867B (en) Antimicrobial cationic peptides and methods of screening for the same