ATE414711T1 - Polymerstabilisierte proteinasen - Google Patents
Polymerstabilisierte proteinasenInfo
- Publication number
- ATE414711T1 ATE414711T1 AT02744682T AT02744682T ATE414711T1 AT E414711 T1 ATE414711 T1 AT E414711T1 AT 02744682 T AT02744682 T AT 02744682T AT 02744682 T AT02744682 T AT 02744682T AT E414711 T1 ATE414711 T1 AT E414711T1
- Authority
- AT
- Austria
- Prior art keywords
- proteinases
- polymer
- stabilized
- admixture
- stabilization
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Food Science & Technology (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89407101A | 2001-06-28 | 2001-06-28 | |
| US10312802A | 2002-03-22 | 2002-03-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE414711T1 true ATE414711T1 (de) | 2008-12-15 |
Family
ID=26800115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02744682T ATE414711T1 (de) | 2001-06-28 | 2002-06-28 | Polymerstabilisierte proteinasen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7229810B2 (de) |
| EP (1) | EP1421175B1 (de) |
| AT (1) | ATE414711T1 (de) |
| AU (1) | AU2002345938A1 (de) |
| CA (1) | CA2450985A1 (de) |
| DE (1) | DE60229958D1 (de) |
| DK (1) | DK1421175T3 (de) |
| WO (1) | WO2003002716A2 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020065397A1 (en) * | 2000-10-12 | 2002-05-30 | Joseph Roberts | Protecting therapeutic compositions from host-mediated inactivation |
| WO2003064605A2 (en) | 2002-01-28 | 2003-08-07 | Ambion, Inc. | Crude biological derivatives competent for nucleic acid detection |
| US8129330B2 (en) | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| US20040062748A1 (en) * | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| JP2007530440A (ja) * | 2003-05-12 | 2007-11-01 | アフィーマックス・インコーポレイテッド | 新規ポリ(エチレングリコール)修飾化合物およびその用途 |
| PL1625156T3 (pl) * | 2003-05-12 | 2013-03-29 | Affymax Inc | Peptydy wiążące się do receptora erytropoetyny |
| CN1849141A (zh) * | 2003-05-12 | 2006-10-18 | 阿费麦克斯公司 | 用于聚(乙二醇)修饰的肽的间隔臂部分 |
| EP1814910A4 (de) * | 2004-11-11 | 2009-04-29 | Affymax Inc | Neue am erythropoietinrezeptor bindende peptide |
| WO2006062685A2 (en) * | 2004-11-11 | 2006-06-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| EP1859038B1 (de) * | 2005-02-11 | 2010-08-04 | Invitrogen Dynal AS | Verfahren zur isolierung von nukleinsäuren mit verwendung von ethylenglykol-multimeren |
| US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US7550433B2 (en) * | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US7919461B2 (en) | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| US20070212865A1 (en) * | 2006-03-08 | 2007-09-13 | Craig Amrine | Method for planarizing vias formed in a substrate |
| US7964350B1 (en) | 2007-05-18 | 2011-06-21 | Applied Biosystems, Llc | Sample preparation for in situ nucleic acid analysis |
| EP2955233A1 (de) * | 2008-12-19 | 2015-12-16 | Life Technologies Corporation | Proteinase K Inhibitore, Verfahren und Zusammensetzungen davon |
| JP2021517143A (ja) * | 2018-03-14 | 2021-07-15 | バ、ヨン | Peg化不凍タンパク質およびそれを作製する方法およびそれを使用する方法 |
| CN118165964B (zh) * | 2024-04-11 | 2025-01-24 | 铭诚惠众(江苏)药物研究有限公司 | 一种重组蛋白酶k的纯化方法及其应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4002531A (en) * | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| JPS5599189A (en) | 1979-01-22 | 1980-07-28 | Mihama Hisaharu | Modified uricase free from antigenicity and its preparation |
| JPS5816685A (ja) | 1981-07-22 | 1983-01-31 | Takeda Chem Ind Ltd | 固定化酵素,その製造法および製剤 |
| JPS57118789A (en) | 1981-01-13 | 1982-07-23 | Eisai Co Ltd | Modified streptokinase and its preparation |
| US4609546A (en) * | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4844897A (en) | 1985-09-13 | 1989-07-04 | Hiroshi Maeda | Anti-tumor protease preparations |
| JPS6255079A (ja) | 1986-04-23 | 1987-03-10 | Mihama Hisaharu | 修飾ウリカ−ゼ |
| US5278062A (en) * | 1987-04-03 | 1994-01-11 | Amgen | Proteolytic enzymes |
| US5080891A (en) * | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5006333A (en) * | 1987-08-03 | 1991-04-09 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| CA1340807C (en) * | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US5246849A (en) * | 1988-04-12 | 1993-09-21 | Enzon, Inc. | Thermally stable serine proteases |
| JP2958019B2 (ja) * | 1988-05-06 | 1999-10-06 | 住友製薬株式会社 | ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法 |
| US5498523A (en) * | 1988-07-12 | 1996-03-12 | President And Fellows Of Harvard College | DNA sequencing with pyrophosphatase |
| US4962020A (en) * | 1988-07-12 | 1990-10-09 | President And Fellows Of Harvard College | DNA sequencing |
| JPH02219571A (ja) | 1989-02-20 | 1990-09-03 | Kanebo Ltd | 修飾プロテアーゼ及びその製造法 |
| US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| US5455166A (en) * | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| ZA927323B (en) | 1991-09-24 | 1993-08-30 | Keygene Nv | Selective restriction fragment amplification: A general method for DNA fingerprinting |
| ZA933926B (en) * | 1992-06-17 | 1994-01-03 | Amgen Inc | Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules |
| US5321095A (en) * | 1993-02-02 | 1994-06-14 | Enzon, Inc. | Azlactone activated polyalkylene oxides |
| US5482996A (en) * | 1993-12-08 | 1996-01-09 | University Of Pittsburgh | Protein-containing polymers and a method of synthesis of protein-containing polymers in organic solvents |
| US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| JPH10510516A (ja) * | 1994-12-07 | 1998-10-13 | ノボ ノルディスク アクティーゼルスカブ | アレルゲン性を減らしたポリペプチド |
| US5837517A (en) * | 1995-05-05 | 1998-11-17 | Novo Nordisk A/S | Protease variants and compositions |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US6214966B1 (en) * | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| KR100591553B1 (ko) * | 1996-11-04 | 2006-06-19 | 노보자임스 에이/에스 | 섭틸라제 변종과 조성물 |
| US6416756B1 (en) * | 1997-01-10 | 2002-07-09 | Novozymes A/S | Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care |
| AU740207B2 (en) * | 1997-02-06 | 2001-11-01 | Novozymes A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| DE69838551T2 (de) | 1997-06-25 | 2008-07-24 | Novozymes A/S | Modifiziertes polypeptid |
| US5847110A (en) * | 1997-08-15 | 1998-12-08 | Biomedical Frontiers, Inc. | Method of reducing a schiff base |
| US6495136B1 (en) | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
| CA2333491A1 (en) | 1998-07-17 | 2000-01-27 | Novozymes A/S | A polypeptide-polymer conjugate with improved wash performance |
| PL202799B1 (pl) | 1998-08-06 | 2009-07-31 | Mountain View Pharmaceuticals | Sposób izolowania urykazy w postaci tetramerycznej oraz wyizolowana tetrameryczna urykaza |
| US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| US6964764B2 (en) * | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
-
2002
- 2002-06-28 AT AT02744682T patent/ATE414711T1/de active
- 2002-06-28 US US10/183,607 patent/US7229810B2/en not_active Expired - Fee Related
- 2002-06-28 CA CA002450985A patent/CA2450985A1/en not_active Abandoned
- 2002-06-28 AU AU2002345938A patent/AU2002345938A1/en not_active Abandoned
- 2002-06-28 EP EP02744682A patent/EP1421175B1/de not_active Expired - Lifetime
- 2002-06-28 DK DK02744682T patent/DK1421175T3/da active
- 2002-06-28 WO PCT/US2002/020417 patent/WO2003002716A2/en not_active Ceased
- 2002-06-28 DE DE60229958T patent/DE60229958D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1421175A4 (de) | 2004-12-08 |
| US7229810B2 (en) | 2007-06-12 |
| DE60229958D1 (de) | 2009-01-02 |
| US20030012777A1 (en) | 2003-01-16 |
| EP1421175A2 (de) | 2004-05-26 |
| WO2003002716A2 (en) | 2003-01-09 |
| WO2003002716A3 (en) | 2003-10-16 |
| DK1421175T3 (da) | 2009-03-23 |
| AU2002345938A1 (en) | 2003-03-03 |
| EP1421175B1 (de) | 2008-11-19 |
| CA2450985A1 (en) | 2003-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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