ATE416254T1 - Chromatographisches verfahren zur reinigung von albumin - Google Patents
Chromatographisches verfahren zur reinigung von albuminInfo
- Publication number
- ATE416254T1 ATE416254T1 AT00901252T AT00901252T ATE416254T1 AT E416254 T1 ATE416254 T1 AT E416254T1 AT 00901252 T AT00901252 T AT 00901252T AT 00901252 T AT00901252 T AT 00901252T AT E416254 T1 ATE416254 T1 AT E416254T1
- Authority
- AT
- Austria
- Prior art keywords
- albumin
- cell
- coding sequence
- disclosed
- recombinant
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title abstract 9
- 108010088751 Albumins Proteins 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 6
- 108091026890 Coding region Proteins 0.000 abstract 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 2
- 108020004705 Codon Proteins 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 238000011210 chromatographic step Methods 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 238000012239 gene modification Methods 0.000 abstract 1
- 230000005017 genetic modification Effects 0.000 abstract 1
- 235000013617 genetically modified food Nutrition 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000005621 mannosylation reaction Methods 0.000 abstract 1
- 229910052759 nickel Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9902000A GB9902000D0 (en) | 1999-01-30 | 1999-01-30 | Process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE416254T1 true ATE416254T1 (de) | 2008-12-15 |
Family
ID=10846743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00901252T ATE416254T1 (de) | 1999-01-30 | 2000-01-31 | Chromatographisches verfahren zur reinigung von albumin |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7993877B2 (de) |
| EP (3) | EP1149163B1 (de) |
| JP (3) | JP4586150B2 (de) |
| KR (2) | KR100577493B1 (de) |
| CN (4) | CN1974599A (de) |
| AT (1) | ATE416254T1 (de) |
| AU (2) | AU763899B2 (de) |
| CA (1) | CA2359705C (de) |
| DE (1) | DE60040967D1 (de) |
| DK (1) | DK2048234T3 (de) |
| ES (1) | ES2317827T3 (de) |
| GB (1) | GB9902000D0 (de) |
| HK (1) | HK1042521B (de) |
| MX (1) | MXPA01007719A (de) |
| SG (2) | SG119194A1 (de) |
| WO (1) | WO2000044772A2 (de) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| GB9902000D0 (en) * | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| JP2003530838A (ja) | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | アルブミン融合タンパク質 |
| US7507413B2 (en) | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| ITBO20010426A1 (it) | 2001-07-06 | 2003-01-06 | Alfa Wassermann Spa | Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico |
| US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
| ES2425738T3 (es) | 2001-12-21 | 2013-10-17 | Human Genome Sciences, Inc. | Proteínas de fusión de la albúmina |
| GB0202633D0 (en) * | 2002-02-05 | 2002-03-20 | Delta Biotechnology Ltd | Stabilization of protein preparations |
| KR20110014661A (ko) | 2002-02-07 | 2011-02-11 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민-융합 쿠니츠 도메인 펩타이드 |
| SE526227C2 (sv) * | 2002-05-15 | 2005-08-02 | North China Pharmaceutical Group | Metod för rening av rekombinant humant serumalbumin |
| GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
| EP1594530A4 (de) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | Albuminfusionsproteine |
| GB0304576D0 (en) | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
| US20080292581A1 (en) | 2003-12-03 | 2008-11-27 | Delta Biotechnology Limited | Interleukin-11 Fusion Proteins |
| GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
| GB0329722D0 (en) * | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
| AU2005318697A1 (en) * | 2004-12-22 | 2006-06-29 | Novozymes A/S | Recombinant production of serum albumin |
| JP5631533B2 (ja) | 2004-12-23 | 2014-11-26 | ノボザイムス バイオファーマ デーコー アクティーゼルスカブ | 遺伝子発現技術 |
| WO2007063129A2 (en) * | 2005-12-02 | 2007-06-07 | Novozymes A/S | Insolation of peptides , polypeptides and proteins |
| JP2007284425A (ja) * | 2006-03-20 | 2007-11-01 | Nokodai Tlo Kk | タンパク質の精製方法 |
| AU2007274035A1 (en) * | 2006-07-13 | 2008-01-17 | Novozymes Biopharma Dk A/S | Process for preparing particles of proteinaceous material |
| ATE524493T1 (de) | 2006-07-24 | 2011-09-15 | Biorexis Pharmaceutical Corp | Exendin-fusionsproteine |
| EP2054437A2 (de) | 2006-08-07 | 2009-05-06 | Teva Biopharmaceuticals USA, Inc. | Albumin-insulin-fusionsproteine |
| CA2676783C (en) * | 2007-02-02 | 2016-04-05 | Globeimmune, Inc. | Improved methods for producing yeast-based vaccines |
| EP2201036A1 (de) | 2007-08-08 | 2010-06-30 | Novozymes Biopharma DK A/S | Transferrinvarianten und konjugate |
| US8445213B2 (en) | 2008-03-31 | 2013-05-21 | Sekisui Medical Co., Ltd. | Purified serum albumin, and immunological measurement method |
| CN101684459B (zh) * | 2008-09-22 | 2012-01-25 | 上海普天欣生物技术有限公司 | CehA突变体蛋白、基因、重组载体及其用途和制备方法 |
| CN101747437B (zh) | 2008-12-10 | 2012-09-26 | 浙江日升昌药业有限公司 | 凋亡素-ec-sod羧基末端蛋白转导域融合蛋白 |
| SG172789A1 (en) | 2009-02-11 | 2011-08-29 | Novozymes Biopharma Dk As | Albumin variants and conjugates |
| SG173469A1 (en) | 2009-02-20 | 2011-09-29 | Ventria Bioscience | Cell culture media containing combinations of proteins |
| HUE045635T2 (hu) | 2009-04-09 | 2020-01-28 | Sartorius Stedim Cellca Gmbh | Eljárás továbbfejlesztett egysejtes klónozásra |
| EP2427486B1 (de) | 2009-05-07 | 2015-02-25 | Novozymes Biopharma DK A/S | Verfahren zur Aufreinigung von Albumin |
| CN101691581B (zh) * | 2009-06-25 | 2012-10-03 | 南京农业大学 | 染色体无标记随机整合载体pUTTns及其应用 |
| US8129139B2 (en) * | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
| CN101690801B (zh) | 2009-10-26 | 2012-08-01 | 上海交通大学 | 白细胞介素-1受体拮抗剂的用途及其药物组合物 |
| BR112012009450A2 (pt) | 2009-10-30 | 2017-05-23 | Novozymes Biopharma Dk As | variantes de albumina |
| EP2556087A1 (de) | 2010-04-09 | 2013-02-13 | Novozymes Biopharma DK A/S | Albuminderivate und varianten |
| PT2563805T (pt) * | 2010-04-29 | 2020-05-18 | Baxalta Inc | Método de purificação de proteínas que se ligam a catiões divalentes em resina de permuta aniónica |
| EP2635598A1 (de) | 2010-11-01 | 2013-09-11 | Novozymes Biopharma DK A/S | Albuminvarianten |
| CN102127164B (zh) | 2010-12-20 | 2013-01-30 | 武汉禾元生物科技有限公司 | 一种从水稻种子中提取重组人血清白蛋白的方法 |
| CN102532254B (zh) | 2010-12-24 | 2015-06-24 | 武汉禾元生物科技股份有限公司 | 一种从水稻种子中分离纯化重组人血清白蛋白的方法 |
| AU2012251583B2 (en) | 2011-05-05 | 2017-06-08 | Albumedix Ltd. | Albumin variants |
| SG10201606161UA (en) * | 2011-07-05 | 2016-09-29 | Novozymes Biopharma Dk As | Albumin Formulation and Use |
| EP2780364A2 (de) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteine mit verbesserter halbwertzeit und anderen eigenschaften |
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| RU2624139C2 (ru) | 2011-12-05 | 2017-06-30 | Фэктор Байосайенс Инк. | Способы и препараты для трансфекции клеток |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| ES2664328T3 (es) | 2012-03-16 | 2018-04-19 | Albumedix A/S | Variantes de albúmina |
| US10501513B2 (en) * | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| EP2834259A4 (de) | 2012-04-02 | 2016-08-24 | Moderna Therapeutics Inc | Modifizierte polynukleotide |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| CN102952836A (zh) * | 2012-11-02 | 2013-03-06 | 浙江海正药业股份有限公司 | 重组人长效白介素1受体拮抗剂融合蛋白的纯化方法 |
| CA2890766A1 (en) | 2012-11-08 | 2014-05-15 | Novozymes Biopharma Dk A/S | Albumin variants |
| CN103880947B (zh) | 2012-12-21 | 2016-01-13 | 武汉禾元生物科技股份有限公司 | 一种分离纯化高纯度重组人血清白蛋白的层析方法 |
| EP2964666B1 (de) * | 2013-03-06 | 2020-11-18 | GlaxoSmithKline LLC | Wirtszellen und verfahren zur verwendung |
| US9650412B2 (en) | 2013-03-08 | 2017-05-16 | Genzyme Corporation | Integrated continuous manufacturing of therapeutic protein drug substances |
| MX364532B (es) | 2013-07-04 | 2019-04-29 | Glykos Finland Oy | Celulas de hongos filamentosos deficientes de o-manosiltransferasa y metodos de uso de las mismas. |
| JP6306700B2 (ja) | 2013-11-01 | 2018-04-04 | ユニバーシティ オブ オスロUniversity of Oslo | アルブミン改変体及びその使用 |
| TWI671312B (zh) | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
| TWI709569B (zh) * | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| CN106455621B (zh) * | 2014-04-23 | 2021-07-20 | 阿雷克森制药公司 | 蛋清处理 |
| CN108064266A (zh) | 2014-07-21 | 2018-05-22 | 格利科斯芬兰公司 | 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备 |
| WO2016108211A1 (en) * | 2015-01-01 | 2016-07-07 | Navya Biologicals Pvt Ltd | Novel method for efficient purification of human serum albumin |
| EP3543339A1 (de) | 2015-02-13 | 2019-09-25 | Factor Bioscience Inc. | Nukleinsäureprodukte und verabreichungsverfahren dafür |
| US10627415B2 (en) | 2015-03-12 | 2020-04-21 | Board Of Trustees Of Michigan State University | Compositions and methods for diagnosing, monitoring, and treating an autoimmune disease |
| WO2016207730A1 (en) | 2015-06-22 | 2016-12-29 | The University Of Oslo | Targeting of vaccine antigen to an intracellular compartment |
| CN105037487B (zh) * | 2015-08-12 | 2017-03-22 | 山东泰邦生物制品有限公司 | 一种人血白蛋白的制备方法 |
| CA2989966C (en) | 2015-08-20 | 2024-04-30 | Albumedix A/S | Albumin variants and conjugates |
| JP7146637B2 (ja) | 2015-12-22 | 2022-10-04 | アルブミディクス リミティド | 改善されたタンパク質発現株 |
| CN108431204A (zh) | 2015-12-22 | 2018-08-21 | 阿尔布梅迪克斯医疗有限公司 | 改良的表达蛋白质的菌株 |
| CA3033788A1 (en) | 2016-08-17 | 2018-02-22 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| EP3429345B1 (de) | 2016-10-04 | 2019-09-11 | Albumedix Ltd. | Verwendungen von rekombinantem, von hefe abgeleitetem serumalbumin |
| WO2018096396A1 (en) | 2016-11-22 | 2018-05-31 | University Of Oslo | Albumin variants and uses thereof |
| WO2018193033A1 (en) * | 2017-04-20 | 2018-10-25 | Novo Nordisk A/S | Methods of purification of albumin fusion proteins |
| CA3064037A1 (en) | 2017-06-20 | 2018-12-27 | Albumedix Ltd | Improved protein expression strains |
| EP3808837A4 (de) * | 2018-06-15 | 2022-04-06 | Fuso Pharmaceutical Industries, Ltd. | Kulturmedium für technologie zur assistierten reproduktion |
| AU2019332764B2 (en) | 2018-08-31 | 2025-05-29 | Genzyme Corporation | Sterile chromatography resin and use thereof in manufacturing processes |
| CN111229023B (zh) * | 2018-11-29 | 2022-01-28 | 内蒙古东盛硅藻土科技创新产业园有限公司 | 一种化学降解添加剂 |
| CN109879958A (zh) * | 2019-03-08 | 2019-06-14 | 中国人民解放军军事科学院军事医学研究院 | 一种低糖基化血清白蛋白的制备方法 |
| US12344572B2 (en) | 2019-07-03 | 2025-07-01 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| AU2020357863B2 (en) * | 2019-10-01 | 2023-07-06 | Repligen Corporation | Determination of protein concentration in a fluid |
| CN112858682B (zh) * | 2019-11-27 | 2023-06-02 | 广东唯实生物技术有限公司 | 用于尿微量白蛋白的检测试纸条及其制备方法、检测试剂盒和检测方法 |
| US20230000774A1 (en) | 2019-12-04 | 2023-01-05 | Albumedix Limited | Methods and compositions produced thereby |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
| US12161777B2 (en) | 2020-07-02 | 2024-12-10 | Davol Inc. | Flowable hemostatic suspension |
| CN112062833A (zh) * | 2020-10-09 | 2020-12-11 | 国药集团武汉血液制品有限公司 | 一种从血浆组分ⅳ沉淀中提取人血白蛋白的方法 |
| WO2022120547A1 (zh) | 2020-12-08 | 2022-06-16 | 通化安睿特生物制药股份有限公司 | 纯化重组蛋白的方法 |
| CN116744984A (zh) | 2020-12-28 | 2023-09-12 | 达沃有限公司 | 包含蛋白质和多官能化改性的基于聚乙二醇的交联剂的反应性干粉状止血材料 |
| CN112646045A (zh) * | 2021-01-06 | 2021-04-13 | 海默斯(重庆)医学生物技术有限公司 | 一种重组角蛋白分离纯化方法 |
| CN114907469A (zh) * | 2021-02-08 | 2022-08-16 | 首都医科大学附属北京朝阳医院 | 一种人血清中白蛋白分离纯化方法 |
| CN113735963A (zh) * | 2021-09-10 | 2021-12-03 | 山东健通生物科技有限公司 | 一种重组人血清白蛋白纯化过程去除色素的方法 |
| CN118166053B (zh) * | 2024-03-15 | 2025-02-07 | 通化安睿特生物制药股份有限公司 | 一种制备低o-糖基化水平的重组人白蛋白的方法 |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5625041A (en) * | 1990-09-12 | 1997-04-29 | Delta Biotechnology Limited | Purification of proteins |
| GB9019919D0 (en) | 1990-09-12 | 1990-10-24 | Delta Biotechnology Ltd | Purification of proteins |
| US2433905A (en) * | 1943-11-01 | 1948-01-06 | Jr Walter L Hughes | Method for the crystallization of albumin and the preparation of protein products therefrom |
| AT317418B (de) | 1972-06-16 | 1974-08-25 | Brigitte Panhofer | Verfahren zur Herstellung von intravenös beim Menschen anwendbarem Humanalbumin aus menschlichen Placenten |
| FR2190437B1 (de) * | 1972-07-05 | 1975-08-08 | Merieux Inst | |
| CA1044537A (en) | 1973-05-09 | 1978-12-19 | Amf Incorporated | Filter medium and process |
| DE2537123A1 (de) | 1975-08-20 | 1977-03-03 | New Zealand Inventions Dev | Verfahren zur herstellung von albumin |
| SE405549B (sv) * | 1975-10-09 | 1978-12-18 | Pharmacia Fine Chemicals Ab | Forfarande for isolering av albumin ur plasmaprodukter genom kromatografisk fraktionering |
| US4043997A (en) * | 1976-05-28 | 1977-08-23 | Cutter Laboratories, Inc. | Method for isolating albumin using insoluble supports coupled to a dye |
| US4075197A (en) * | 1976-09-20 | 1978-02-21 | Monsanto Company | Serum albumin production |
| US4269605A (en) | 1978-06-28 | 1981-05-26 | Amicon Corporation | Method and kit for separation of glycoproteins |
| IN150740B (de) * | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
| US4228154A (en) * | 1979-02-26 | 1980-10-14 | Armour Pharmaceutical Company | Purification of plasma albumin by ion exchange chromatography |
| CA1149298A (en) | 1979-04-12 | 1983-07-05 | Eugene H. Wegner | Production of yeast cells at high cell densities |
| US4222934A (en) * | 1979-04-12 | 1980-09-16 | American National Red Cross | Preparation of albumin using ethanol |
| GB2053926B (en) | 1979-07-20 | 1983-02-23 | Atkinson A | Albumin extraction by affinity chromatography |
| US4350156A (en) * | 1980-05-29 | 1982-09-21 | Japan Foundation For Artificial Organs | Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid |
| NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| US4491946A (en) | 1981-03-09 | 1985-01-01 | Gould Inc. | Multi-station token pass communication system |
| US4562251A (en) | 1981-03-26 | 1985-12-31 | Amicon Corporation | Agarose derivatives of amino phenyl boronic acid |
| IL66614A (en) | 1981-08-28 | 1985-09-29 | Genentech Inc | Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it |
| US4391801A (en) * | 1981-10-29 | 1983-07-05 | Cutter Laboratories, Inc. | Plasma protein fraction substantially free of acetate ions |
| FR2543448A1 (fr) * | 1983-04-01 | 1984-10-05 | Rhone Poulenc Spec Chim | Procede de fractionnement du plasma |
| US4748120A (en) * | 1983-05-02 | 1988-05-31 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
| DE3344656A1 (de) | 1983-12-09 | 1985-06-13 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur herstellung einer serumproteinloesung |
| CA1286622C (en) | 1986-04-28 | 1991-07-23 | Chokyun Rha | Method for clarifying and stabilizing cell culture media |
| JPS62294621A (ja) | 1986-06-13 | 1987-12-22 | Green Cross Corp:The | アルブミンの回収方法 |
| JPS6383100A (ja) | 1986-09-26 | 1988-04-13 | Green Cross Corp:The | ヒト尿中アルブミンの製造方法 |
| GB2210621B (en) | 1987-04-09 | 1990-11-21 | Delta Biotechnology Ltd | Two micron yeast plasmid vector |
| US4833233A (en) | 1987-08-20 | 1989-05-23 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Human serum albumin crystals and method of preparation |
| CA1293217C (en) | 1987-11-09 | 1991-12-17 | Sooyoung Stanford Lee | Controlled growth rate fermentation |
| IL88326A (en) | 1987-11-18 | 1993-03-15 | Gist Brocades Nv | Purification of serum albumin |
| GB2214508A (en) | 1988-01-27 | 1989-09-06 | Bayer Ag | Plasmid vector for the efficient expression of foreign genes fused with newly conceived transcriptional and translational signal sequences. |
| JPH01215289A (ja) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | 遺伝子組換えによる正常ヒト血清アルブミンaの製造方法 |
| US4990447A (en) * | 1988-06-24 | 1991-02-05 | Gist-Brocades Nv | Process for the purification of serum albumin |
| KR100195632B1 (ko) | 1988-07-23 | 1999-06-15 | 스티븐 조지 가랜드 | 펩티드 및 dna 배열 |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| US5277818A (en) * | 1988-10-31 | 1994-01-11 | The Green Cross Corporation | Albumin preparation and process for preparing the same |
| JP3554796B2 (ja) | 1988-10-31 | 2004-08-18 | 三菱ウェルファーマ株式会社 | アルブミン製剤及びその製造方法 |
| US4891221A (en) | 1988-11-23 | 1990-01-02 | Edward Shanborm | Whole blood antiviral process and composition |
| FR2648048B1 (fr) | 1989-06-08 | 1994-06-03 | Lille Transfusion Sanguine | Procede de preparation de solutions d'albumine purifiee |
| GB8913586D0 (en) | 1989-06-13 | 1989-08-02 | Technicol Limited | A method of determining the glycosylated protein level of a sample and an apparatus for use in the method |
| JPH0768137B2 (ja) | 1989-06-15 | 1995-07-26 | 株式会社ミドリ十字 | アルブミン製剤及びその製法 |
| SE500110C2 (sv) * | 1989-06-27 | 1994-04-18 | Kabi Pharmacia Ab | Sätt att rena ett protein från därtill bundna flervärda metalljoner |
| GB8927480D0 (en) | 1989-12-05 | 1990-02-07 | Delta Biotechnology Ltd | Mutant fungal strain detection and new promoter |
| JPH0671434B2 (ja) | 1989-09-18 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
| CA2022165C (en) | 1989-10-05 | 1999-11-23 | Chong E. Chang | Albumin purification |
| US5250662A (en) * | 1989-10-05 | 1993-10-05 | Alpha Therapeutic Corporation | Albumin purification |
| JP3127232B2 (ja) | 1990-03-08 | 2001-01-22 | ウェルファイド株式会社 | 蛋白質製剤の製造法 |
| ES2224094T3 (es) | 1990-04-19 | 2005-03-01 | Bayer Corporation | Procedimiento para preparar seroalbumina normal (humana) esencialmente monomerica. |
| SE9002212D0 (sv) | 1990-06-21 | 1990-06-21 | Hightech Receptor Ab | Igg binding protein |
| JP3230091B2 (ja) | 1990-06-25 | 2001-11-19 | ウェルファイド株式会社 | ヒト血清アルブミンの着色抑制方法 |
| JP2982296B2 (ja) | 1990-11-19 | 1999-11-22 | 吉富製薬株式会社 | アルブミン含有水溶液の精製法 |
| JP2949846B2 (ja) * | 1990-11-30 | 1999-09-20 | 吉富製薬株式会社 | アルブミン製剤の保存方法 |
| FR2672604B1 (fr) * | 1991-02-07 | 1995-05-05 | Pasteur Merieux Serums Vacc | Procede pour isoler de l'albumine humaine a partir du surnageant iv, notamment iv-4, ou de la fraction v de cohn ou d'un surnageant ou fraction analogue. |
| US5284777A (en) * | 1991-03-04 | 1994-02-08 | Isolab, Inc. | Combined glycated hemoglobin and immunoturbidometric glycated albumin assay from whole blood lysate |
| JPH0671432B2 (ja) | 1991-03-20 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
| US5330901A (en) * | 1991-04-26 | 1994-07-19 | Research Corporation Technologies, Inc. | Expression of human serum albumin in Pichia pastoris |
| DK0524681T3 (da) | 1991-07-12 | 2000-04-10 | Dsm Nv | Fremgangsmåde til oprensning af serumalbumin |
| US5260308A (en) * | 1991-11-06 | 1993-11-09 | Mayo Foundation For Medical Education And Research | Method to increase permeability of the blood-nerve/brain barriers to proteins |
| FR2686620B1 (fr) * | 1992-01-27 | 1995-06-23 | Rhone Poulenc Rorer Sa | Serum-albumine humaine, preparation et utilisation. |
| US5281582A (en) | 1992-02-27 | 1994-01-25 | Alliance Pharmaceuticals, Corp. | Serum growth factor |
| US5440018A (en) | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| JPH07102148B2 (ja) * | 1992-05-20 | 1995-11-08 | 株式会社ミドリ十字 | 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物 |
| AU669539B2 (en) * | 1992-06-24 | 1996-06-13 | Dyson Technology Limited | Vacuum cleaner |
| JP3360315B2 (ja) | 1992-07-31 | 2002-12-24 | 三菱ウェルファーマ株式会社 | ヒト血清アルブミンの高度精製方法 |
| DE69329824T2 (de) | 1992-08-03 | 2001-08-09 | Abbott Laboratories, Abbott Park | Nachweis und amplifikation bestimmter nukleinsäuren mittels exonukleolytischer aktivität |
| DE4226971C2 (de) | 1992-08-14 | 1997-01-16 | Widmar Prof Dr Tanner | Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte |
| US5728553A (en) * | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| CA2116385A1 (en) | 1993-02-25 | 1994-08-26 | Akinori Sumi | Human serum albumin and process for producing the same |
| DE4308532A1 (de) | 1993-03-17 | 1994-09-22 | Boehringer Mannheim Gmbh | Monoklonale Antikörper gegen in vivo glykiertes Albumin |
| SE9301583D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Yeast strain and methods for expressing heterologous proteins in yeast |
| CA2136564C (en) | 1993-11-26 | 2008-04-08 | Kaoru Kobayashi | Process for producing human serum albumin |
| GB9404270D0 (en) | 1994-03-05 | 1994-04-20 | Delta Biotechnology Ltd | Yeast strains and modified albumins |
| JPH07308199A (ja) | 1994-05-18 | 1995-11-28 | Green Cross Corp:The | ヒト血清アルブミンの製造方法 |
| JP3702474B2 (ja) | 1994-06-01 | 2005-10-05 | 三菱ウェルファーマ株式会社 | 血清アルブミン製剤の製造方法 |
| GB9411356D0 (en) | 1994-06-07 | 1994-07-27 | Delta Biotechnology Ltd | Yeast strains |
| WO1996003751A1 (en) * | 1994-07-21 | 1996-02-08 | Gregory Lowell Millspaugh | Method of and system for controlling energy, including in fusion reactors |
| US5561115A (en) | 1994-08-10 | 1996-10-01 | Bayer Corporation | Low temperature albumin fractionation using sodium caprylate as a partitioning agent |
| EP0699687B1 (de) | 1994-08-31 | 2004-01-28 | Mitsubishi Pharma Corporation | Verfahren zur Reinigung von rekombinantem menschlichem Serumalbumin |
| DE4432689A1 (de) | 1994-09-14 | 1996-03-21 | Basf Ag | Mischung aus Alkylierungsprodukten von acetalisierten Monosacchariden mit Epoxiden |
| US6068995A (en) * | 1994-10-25 | 2000-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Method for producing protein |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| AU4837996A (en) * | 1996-02-29 | 1997-09-16 | Delta Biotechnology Limited | High purity albumin production process |
| GB9721892D0 (en) | 1997-10-15 | 1997-12-17 | British Tech Group | Apparatus for and method of testing a sample |
| GB9902000D0 (en) * | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| JP4798832B2 (ja) | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | ヒト血清アルブミン多量体の除去方法 |
| US6693173B2 (en) | 2000-12-26 | 2004-02-17 | Alpha Therapeutic Corporation | Method to remove citrate and aluminum from proteins |
| SE0201680L (sv) | 2002-06-04 | 2003-09-02 | Wexioedisk Ab | Diskmaskin med uppsamlingsorgan för att ta emot diskvätska och sköljvätska |
-
1999
- 1999-01-30 GB GB9902000A patent/GB9902000D0/en not_active Ceased
-
2000
- 2000-01-31 CN CNA2006101006640A patent/CN1974599A/zh active Pending
- 2000-01-31 MX MXPA01007719A patent/MXPA01007719A/es active IP Right Grant
- 2000-01-31 DK DK08166355T patent/DK2048234T3/da active
- 2000-01-31 CN CN2005101086585A patent/CN1810834B/zh not_active Expired - Lifetime
- 2000-01-31 KR KR1020017009551A patent/KR100577493B1/ko not_active Expired - Lifetime
- 2000-01-31 JP JP2000596028A patent/JP4586150B2/ja not_active Expired - Lifetime
- 2000-01-31 CA CA2359705A patent/CA2359705C/en not_active Expired - Lifetime
- 2000-01-31 DE DE60040967T patent/DE60040967D1/de not_active Expired - Lifetime
- 2000-01-31 ES ES00901252T patent/ES2317827T3/es not_active Expired - Lifetime
- 2000-01-31 SG SG200304297A patent/SG119194A1/en unknown
- 2000-01-31 KR KR1020057009776A patent/KR100886554B1/ko not_active Expired - Lifetime
- 2000-01-31 CN CN2004100050153A patent/CN1526732B/zh not_active Expired - Lifetime
- 2000-01-31 WO PCT/GB2000/000257 patent/WO2000044772A2/en not_active Ceased
- 2000-01-31 EP EP00901252A patent/EP1149163B1/de not_active Expired - Lifetime
- 2000-01-31 HK HK02104220.2A patent/HK1042521B/zh unknown
- 2000-01-31 SG SG2007061591A patent/SG174629A1/en unknown
- 2000-01-31 EP EP20100075421 patent/EP2272961A1/de not_active Withdrawn
- 2000-01-31 AT AT00901252T patent/ATE416254T1/de not_active IP Right Cessation
- 2000-01-31 CN CNB008032920A patent/CN1211485C/zh not_active Expired - Lifetime
- 2000-01-31 EP EP20080166355 patent/EP2048234B1/de not_active Expired - Lifetime
- 2000-01-31 AU AU21207/00A patent/AU763899B2/en not_active Expired
-
2003
- 2003-09-23 AU AU2003248302A patent/AU2003248302B2/en not_active Expired
-
2008
- 2008-09-09 US US12/207,325 patent/US7993877B2/en not_active Expired - Fee Related
-
2010
- 2010-05-27 JP JP2010121914A patent/JP5474661B2/ja not_active Expired - Lifetime
-
2011
- 2011-07-01 US US13/175,155 patent/US9029102B2/en not_active Expired - Fee Related
-
2013
- 2013-01-15 JP JP2013004867A patent/JP5774612B2/ja not_active Expired - Lifetime
-
2014
- 2014-07-14 US US14/330,703 patent/US9555344B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE416254T1 (de) | Chromatographisches verfahren zur reinigung von albumin | |
| ATE77104T1 (de) | Menge und verfahren zur herstellung rekombinierter erzeugnisse in grosser ausbeute. | |
| CA2174746A1 (en) | Embryonic stem cells capable of differentiating into desired cell lines | |
| PL322611A1 (en) | Methods of obtaining l-amini acid by fermentation, dna as well as micro-organism | |
| JPS6447381A (en) | Preparation of liposome containing sealed gene | |
| AU1032597A (en) | Process for preparing recombinant proteins in E. coli by means of high cell density fermentation | |
| DE69931394D1 (de) | Verfahren zur herstellung von ascorbinsäure-zwischenprodukten | |
| DE69939947D1 (de) | Verfahren zur herstellung von polypeptiden in mutierten aspergillus zellen | |
| AU7575487A (en) | Method for the preparation of proteins with factor VIII activity by microbial host cells; expression, vectors, host cells, antibodies | |
| AU2969095A (en) | Thermophilic fungal expression system | |
| CA2058930A1 (en) | Media for cell growth and method for making them | |
| WO1998014602A3 (en) | Preparation of d-amino acids by direct fermentative means | |
| AU2670688A (en) | Co-expression in eukaryotic cells | |
| DE69723855D1 (de) | Verfahren zur herstellung von polypeptiden in surfaktinmutanten von bacillus zellen | |
| CA2022752A1 (en) | Hepatic parenchymal cell growth factor, gene encoding the same, process for producing the factor, and transformants producing the factor | |
| AU7471698A (en) | Intracellular production of hepatitis c e1 and e2 truncated polypeptides | |
| AU4940096A (en) | Host cell expressing reduced levels of a metalloprotease and methods using the host cell in protein production | |
| CA2051375A1 (en) | Process and compositions for the isolation of human relaxin | |
| CA2011833A1 (en) | Novel polypeptide and production thereof | |
| KR840008697A (ko) | 상동 효모 신호를 이용한 이종단백질의 합성, 분비 및 표현매개체 제조방법 | |
| AU3696189A (en) | Improved composition for isolating and purifying nucleic acid and improved method using same | |
| CA2040810A1 (en) | Process for producing foreign proteins in streptomyces | |
| AU7546687A (en) | Method for producing a new proteolytic complex stimulating the activity of the pancreas and its applications in zootechny | |
| ATE358681T1 (de) | Verfahren zur rekombinanten herstellung von plazenta wachstumsfaktor | |
| WO2000073420A3 (en) | Creation of human tumorigenic cells and uses therefor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |