ATE416254T1 - Chromatographisches verfahren zur reinigung von albumin - Google Patents

Chromatographisches verfahren zur reinigung von albumin

Info

Publication number
ATE416254T1
ATE416254T1 AT00901252T AT00901252T ATE416254T1 AT E416254 T1 ATE416254 T1 AT E416254T1 AT 00901252 T AT00901252 T AT 00901252T AT 00901252 T AT00901252 T AT 00901252T AT E416254 T1 ATE416254 T1 AT E416254T1
Authority
AT
Austria
Prior art keywords
albumin
cell
coding sequence
disclosed
recombinant
Prior art date
Application number
AT00901252T
Other languages
English (en)
Inventor
Urk Hendrik Van
David John Mead
Philip Harvey Morton
Andrew John Cartwright
Jason Cameron
David James Ballance
Michel G J Grandgeorge
Stephen Berezenko
John Rodney Woodrow
Darrell Sleep
Jean-Luc Bernard Veron
Original Assignee
Novozymes Biopharma Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes Biopharma Uk Ltd filed Critical Novozymes Biopharma Uk Ltd
Application granted granted Critical
Publication of ATE416254T1 publication Critical patent/ATE416254T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
AT00901252T 1999-01-30 2000-01-31 Chromatographisches verfahren zur reinigung von albumin ATE416254T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9902000A GB9902000D0 (en) 1999-01-30 1999-01-30 Process

Publications (1)

Publication Number Publication Date
ATE416254T1 true ATE416254T1 (de) 2008-12-15

Family

ID=10846743

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901252T ATE416254T1 (de) 1999-01-30 2000-01-31 Chromatographisches verfahren zur reinigung von albumin

Country Status (16)

Country Link
US (3) US7993877B2 (de)
EP (3) EP2048234B1 (de)
JP (3) JP4586150B2 (de)
KR (2) KR100886554B1 (de)
CN (4) CN1974599A (de)
AT (1) ATE416254T1 (de)
AU (2) AU763899B2 (de)
CA (1) CA2359705C (de)
DE (1) DE60040967D1 (de)
DK (1) DK2048234T3 (de)
ES (1) ES2317827T3 (de)
GB (1) GB9902000D0 (de)
HK (1) HK1042521B (de)
MX (1) MXPA01007719A (de)
SG (2) SG119194A1 (de)
WO (1) WO2000044772A2 (de)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
US6926898B2 (en) 2000-04-12 2005-08-09 Human Genome Sciences, Inc. Albumin fusion proteins
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
ITBO20010426A1 (it) 2001-07-06 2003-01-06 Alfa Wassermann Spa Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
CA2841097A1 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin and g-csf fusion proteins
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
GB0202633D0 (en) * 2002-02-05 2002-03-20 Delta Biotechnology Ltd Stabilization of protein preparations
US20060122374A1 (en) 2002-02-07 2006-06-08 Peter Mertins Albumin-fused anti-angiogenesis peptides
SE526227C2 (sv) * 2002-05-15 2005-08-02 North China Pharmaceutical Group Metod för rening av rekombinant humant serumalbumin
GB0217033D0 (en) 2002-07-23 2002-08-28 Delta Biotechnology Ltd Gene and polypeptide sequences
GB0304576D0 (en) 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
CN1938333A (zh) 2003-12-03 2007-03-28 达尔塔生物技术有限公司 白介素-11融合蛋白
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
US9057061B2 (en) 2003-12-23 2015-06-16 Novozymes Biopharma Dk A/S Gene expression technique
EP1831373A2 (de) * 2004-12-22 2007-09-12 Novozymes A/S Rekombinante serumalbuminproduktion
EP2330200B1 (de) 2004-12-23 2017-04-05 Albumedix A/S Genexpressionstechnik
WO2007063129A2 (en) * 2005-12-02 2007-06-07 Novozymes A/S Insolation of peptides , polypeptides and proteins
JP2007284425A (ja) * 2006-03-20 2007-11-01 Nokodai Tlo Kk タンパク質の精製方法
CA2657277C (en) 2006-07-13 2015-11-24 Upperton Limited Process for preparing particles of proteinaceous material
DK2046826T3 (da) 2006-07-24 2011-10-24 Biorexis Pharmaceutical Corp Exendin-fusionsproteiner
WO2008019368A2 (en) 2006-08-07 2008-02-14 Teva Biopharmaceuticals Usa, Inc. Albumin-insulin fusion proteins
CN101687030B (zh) 2007-02-02 2014-07-02 环球免疫公司 用于生产基于酵母的疫苗的方法
EP2594583A1 (de) 2007-08-08 2013-05-22 Novozymes Biopharma DK A/S Transferrinvarianten und Konjugate
EP2261661A4 (de) 2008-03-31 2011-04-20 Sekisui Medical Co Ltd Gereinigtes serumalbumin und immunologie-messverfahren
CN101684459B (zh) * 2008-09-22 2012-01-25 上海普天欣生物技术有限公司 CehA突变体蛋白、基因、重组载体及其用途和制备方法
CN101747437B (zh) 2008-12-10 2012-09-26 浙江日升昌药业有限公司 凋亡素-ec-sod羧基末端蛋白转导域融合蛋白
SG172789A1 (en) 2009-02-11 2011-08-29 Novozymes Biopharma Dk As Albumin variants and conjugates
SG173469A1 (en) 2009-02-20 2011-09-29 Ventria Bioscience Cell culture media containing combinations of proteins
CN102405279B (zh) 2009-04-09 2015-10-21 塞尔卡有限公司 改善单细胞克隆的方法
CN102549012B (zh) * 2009-05-07 2015-07-01 诺维信生物制药丹麦公司 纯化白蛋白的方法
CN101691581B (zh) * 2009-06-25 2012-10-03 南京农业大学 染色体无标记随机整合载体pUTTns及其应用
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
CN101690801B (zh) 2009-10-26 2012-08-01 上海交通大学 白细胞介素-1受体拮抗剂的用途及其药物组合物
AU2010311332B2 (en) 2009-10-30 2015-04-23 Albumedix Ltd. Albumin variants
KR20130070576A (ko) 2010-04-09 2013-06-27 노보자임스 바이오파마 디케이 에이/에스 알부민 유도체 및 변이체
CN103025757A (zh) * 2010-04-29 2013-04-03 巴克斯特国际有限公司 二价阳离子结合蛋白在阴离子交换树脂上的纯化方法
WO2012059486A1 (en) 2010-11-01 2012-05-10 Novozymes Biopharma Dk A/S Albumin variants
CN102127164B (zh) * 2010-12-20 2013-01-30 武汉禾元生物科技有限公司 一种从水稻种子中提取重组人血清白蛋白的方法
CN102532254B (zh) 2010-12-24 2015-06-24 武汉禾元生物科技股份有限公司 一种从水稻种子中分离纯化重组人血清白蛋白的方法
WO2012150319A1 (en) 2011-05-05 2012-11-08 Novozymes Biopharma Dk A/S Albumin variants
JP6247210B2 (ja) * 2011-07-05 2017-12-13 アルブミディクス アクティーゼルスカブ アルブミン製剤及び用途
HK1200842A1 (en) 2011-11-18 2015-08-14 Albumedix Ltd Proteins with improved half-life and other properties
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
EP3260140B1 (de) 2011-12-05 2021-02-03 Factor Bioscience Inc. Verfahren und produkte zur transfektion von zellen
ES2923757T3 (es) 2011-12-16 2022-09-30 Modernatx Inc Composiciones de ARNm modificado
WO2013151664A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins
EP3330283A3 (de) 2012-03-16 2018-07-11 Albumedix A/S Albuminvarianten
US10501513B2 (en) * 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
CN102952836A (zh) * 2012-11-02 2013-03-06 浙江海正药业股份有限公司 重组人长效白介素1受体拮抗剂融合蛋白的纯化方法
CA2890766A1 (en) 2012-11-08 2014-05-15 Novozymes Biopharma Dk A/S Albumin variants
CN103880947B (zh) 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
WO2014138371A1 (en) * 2013-03-06 2014-09-12 Glaxosmithkline Llc Host cells and methods of use
AU2014226126B2 (en) 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
RU2016103373A (ru) 2013-07-04 2017-08-10 Новартис Аг Клетки нитчатых грибов с дефицитом о-маннозилтрансферазы и способы их применения
EP3063171B1 (de) 2013-11-01 2019-07-24 University Of Oslo Albuminvarianten und verwendungen davon
TWI709569B (zh) * 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
KR102409341B1 (ko) * 2014-04-23 2022-06-14 알렉시온 파마슈티칼스, 인코포레이티드 흰자 처리공정
AU2015293949B2 (en) 2014-07-21 2019-07-25 Teknologian Tutkimuskeskus Vtt Oy Production of glycoproteins with mammalian-like N-glycans in filamentous fungi
PT3240798T (pt) * 2015-01-01 2020-05-07 Shilpa Medicare Ltd Novo método para purificação eficiente de albumina do soro humana
US11241505B2 (en) 2015-02-13 2022-02-08 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
CA2979397A1 (en) 2015-03-12 2016-09-15 Board Of Trustees Of Michigan State University Compositions and methods for measuring c-peptide binding and diagnosing immune-mediated diseases
WO2016207730A1 (en) 2015-06-22 2016-12-29 The University Of Oslo Targeting of vaccine antigen to an intracellular compartment
CN105037487B (zh) * 2015-08-12 2017-03-22 山东泰邦生物制品有限公司 一种人血白蛋白的制备方法
BR112018003179A2 (pt) 2015-08-20 2018-09-25 Albumedix As conjugados e variantes de albumina
WO2017112847A1 (en) 2015-12-22 2017-06-29 Albumedix A/S Improved protein expression strains
JP7146637B2 (ja) 2015-12-22 2022-10-04 アルブミディクス リミティド 改善されたタンパク質発現株
IL264439B2 (en) 2016-08-17 2024-08-01 Factor Bioscience Inc non-viral, cell-free composition comprising a synthetic messenger RNA (MRNA) encoding a gene-editing protein for use in treating cancer, and a synthetic RNA encoding a gene-editing protein for use in treatment
EP3429345B1 (de) 2016-10-04 2019-09-11 Albumedix Ltd. Verwendungen von rekombinantem, von hefe abgeleitetem serumalbumin
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
WO2018193033A1 (en) * 2017-04-20 2018-10-25 Novo Nordisk A/S Methods of purification of albumin fusion proteins
EP4026908A1 (de) 2017-06-20 2022-07-13 Albumedix Ltd Verbesserte proteinexpressionsstämme
EP3808837A4 (de) * 2018-06-15 2022-04-06 Fuso Pharmaceutical Industries, Ltd. Kulturmedium für technologie zur assistierten reproduktion
JP7699537B2 (ja) 2018-08-31 2025-06-27 ジェンザイム・コーポレーション 無菌クロマトグラフィー樹脂および製造方法におけるその使用
CN111229023B (zh) * 2018-11-29 2022-01-28 内蒙古东盛硅藻土科技创新产业园有限公司 一种化学降解添加剂
CN109879958A (zh) * 2019-03-08 2019-06-14 中国人民解放军军事科学院军事医学研究院 一种低糖基化血清白蛋白的制备方法
CA3145425A1 (en) 2019-07-03 2021-01-07 Factor Bioscience Inc. Cationic lipids and uses thereof
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
CA3151959A1 (en) * 2019-10-01 2021-04-08 James Ronald Peyser Determination of protein concentration in a fluid
CN112858682B (zh) * 2019-11-27 2023-06-02 广东唯实生物技术有限公司 用于尿微量白蛋白的检测试纸条及其制备方法、检测试剂盒和检测方法
EP4069200A1 (de) 2019-12-04 2022-10-12 Albumedix Ltd Verfahren und damit hergestellte zusammensetzungen
US12629445B2 (en) 2020-03-20 2026-05-19 Bard Peripheral Vascular, Inc. Reactive hydrogel forming formulations and related methods, including methods of preparation
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
US12161777B2 (en) 2020-07-02 2024-12-10 Davol Inc. Flowable hemostatic suspension
CN112062833A (zh) * 2020-10-09 2020-12-11 国药集团武汉血液制品有限公司 一种从血浆组分ⅳ沉淀中提取人血白蛋白的方法
US12559518B2 (en) 2020-12-08 2026-02-24 Tonghua Anrate Biopharmaceutical Co., Ltd Method for purification of recombinant proteins
WO2022146917A1 (en) 2020-12-28 2022-07-07 Davol Inc. Reactive dry powdered hemostatic materials comprising a protein and a multifunctionalized modified polyethylene glycol based crosslinking agent
CN112646045A (zh) * 2021-01-06 2021-04-13 海默斯(重庆)医学生物技术有限公司 一种重组角蛋白分离纯化方法
CN114907469A (zh) * 2021-02-08 2022-08-16 首都医科大学附属北京朝阳医院 一种人血清中白蛋白分离纯化方法
CN113735963A (zh) * 2021-09-10 2021-12-03 山东健通生物科技有限公司 一种重组人血清白蛋白纯化过程去除色素的方法
EP4558516B1 (de) 2022-07-18 2025-08-13 Yeda Research and Development Co. Ltd Albumin protein varianten, deren herstellung und verwendungen
CN116444648A (zh) * 2023-05-12 2023-07-18 苏州赛分科技股份有限公司 一种人血白蛋白糖基化蛋白去除的方法
CN118166053B (zh) * 2024-03-15 2025-02-07 通化安睿特生物制药股份有限公司 一种制备低o-糖基化水平的重组人白蛋白的方法
WO2026029079A1 (ja) * 2024-07-31 2026-02-05 富士レビオ株式会社 リン酸化タウタンパク質の測定方法およびリン酸化タウタンパク質の測定キット
WO2026074121A1 (en) 2024-10-02 2026-04-09 Sartorius Albumedix Limited Albumin formulations and uses thereof
CN120770321B (zh) * 2025-07-07 2026-07-17 山西农业大学 一种基于多组分营养液控制的马铃薯无土栽培系统及方法

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5625041A (en) * 1990-09-12 1997-04-29 Delta Biotechnology Limited Purification of proteins
GB9019919D0 (en) 1990-09-12 1990-10-24 Delta Biotechnology Ltd Purification of proteins
US2433905A (en) * 1943-11-01 1948-01-06 Jr Walter L Hughes Method for the crystallization of albumin and the preparation of protein products therefrom
AT317418B (de) 1972-06-16 1974-08-25 Brigitte Panhofer Verfahren zur Herstellung von intravenös beim Menschen anwendbarem Humanalbumin aus menschlichen Placenten
FR2190437B1 (de) * 1972-07-05 1975-08-08 Merieux Inst
CA1044537A (en) 1973-05-09 1978-12-19 Amf Incorporated Filter medium and process
DE2537123A1 (de) 1975-08-20 1977-03-03 New Zealand Inventions Dev Verfahren zur herstellung von albumin
SE405549B (sv) * 1975-10-09 1978-12-18 Pharmacia Fine Chemicals Ab Forfarande for isolering av albumin ur plasmaprodukter genom kromatografisk fraktionering
US4043997A (en) * 1976-05-28 1977-08-23 Cutter Laboratories, Inc. Method for isolating albumin using insoluble supports coupled to a dye
US4075197A (en) * 1976-09-20 1978-02-21 Monsanto Company Serum albumin production
US4269605A (en) 1978-06-28 1981-05-26 Amicon Corporation Method and kit for separation of glycoproteins
IN150740B (de) * 1978-11-24 1982-12-04 Hoffmann La Roche
US4228154A (en) * 1979-02-26 1980-10-14 Armour Pharmaceutical Company Purification of plasma albumin by ion exchange chromatography
US4222934A (en) * 1979-04-12 1980-09-16 American National Red Cross Preparation of albumin using ethanol
CA1149298A (en) 1979-04-12 1983-07-05 Eugene H. Wegner Production of yeast cells at high cell densities
GB2053926B (en) 1979-07-20 1983-02-23 Atkinson A Albumin extraction by affinity chromatography
US4350156A (en) * 1980-05-29 1982-09-21 Japan Foundation For Artificial Organs Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid
NZ199722A (en) 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
US4491946A (en) 1981-03-09 1985-01-01 Gould Inc. Multi-station token pass communication system
US4562251A (en) 1981-03-26 1985-12-31 Amicon Corporation Agarose derivatives of amino phenyl boronic acid
IL66614A (en) 1981-08-28 1985-09-29 Genentech Inc Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it
US4391801A (en) * 1981-10-29 1983-07-05 Cutter Laboratories, Inc. Plasma protein fraction substantially free of acetate ions
FR2543448A1 (fr) * 1983-04-01 1984-10-05 Rhone Poulenc Spec Chim Procede de fractionnement du plasma
US4748120A (en) * 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
DE3344656A1 (de) 1983-12-09 1985-06-13 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Verfahren zur herstellung einer serumproteinloesung
CA1286622C (en) 1986-04-28 1991-07-23 Chokyun Rha Method for clarifying and stabilizing cell culture media
JPS62294621A (ja) 1986-06-13 1987-12-22 Green Cross Corp:The アルブミンの回収方法
JPS6383100A (ja) 1986-09-26 1988-04-13 Green Cross Corp:The ヒト尿中アルブミンの製造方法
ES2052712T3 (es) 1987-04-09 1994-07-16 Delta Biotechnology Ltd Vector de levadura.
US4833233A (en) 1987-08-20 1989-05-23 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Human serum albumin crystals and method of preparation
CA1293217C (en) 1987-11-09 1991-12-17 Sooyoung Stanford Lee Controlled growth rate fermentation
IL88326A (en) 1987-11-18 1993-03-15 Gist Brocades Nv Purification of serum albumin
GB2214508A (en) 1988-01-27 1989-09-06 Bayer Ag Plasmid vector for the efficient expression of foreign genes fused with newly conceived transcriptional and translational signal sequences.
JPH01215289A (ja) 1988-02-22 1989-08-29 Toa Nenryo Kogyo Kk 遺伝子組換えによる正常ヒト血清アルブミンaの製造方法
US4990447A (en) * 1988-06-24 1991-02-05 Gist-Brocades Nv Process for the purification of serum albumin
ATE135045T1 (de) 1988-07-23 1996-03-15 Delta Biotechnology Ltd Sekretorische leader-sequenzen
FR2649991B2 (fr) 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
JP3554796B2 (ja) 1988-10-31 2004-08-18 三菱ウェルファーマ株式会社 アルブミン製剤及びその製造方法
US5277818A (en) * 1988-10-31 1994-01-11 The Green Cross Corporation Albumin preparation and process for preparing the same
US4891221A (en) 1988-11-23 1990-01-02 Edward Shanborm Whole blood antiviral process and composition
FR2648048B1 (fr) 1989-06-08 1994-06-03 Lille Transfusion Sanguine Procede de preparation de solutions d'albumine purifiee
GB8913586D0 (en) 1989-06-13 1989-08-02 Technicol Limited A method of determining the glycosylated protein level of a sample and an apparatus for use in the method
JPH0768137B2 (ja) 1989-06-15 1995-07-26 株式会社ミドリ十字 アルブミン製剤及びその製法
SE500110C2 (sv) * 1989-06-27 1994-04-18 Kabi Pharmacia Ab Sätt att rena ett protein från därtill bundna flervärda metalljoner
GB8927480D0 (en) 1989-12-05 1990-02-07 Delta Biotechnology Ltd Mutant fungal strain detection and new promoter
JPH0671434B2 (ja) 1989-09-18 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
CA2022165C (en) 1989-10-05 1999-11-23 Chong E. Chang Albumin purification
US5250662A (en) * 1989-10-05 1993-10-05 Alpha Therapeutic Corporation Albumin purification
JP3127232B2 (ja) 1990-03-08 2001-01-22 ウェルファイド株式会社 蛋白質製剤の製造法
DE69133399T2 (de) 1990-04-19 2005-06-30 Bayer Corp. Methode zur Herstellung von im Wesentlichen monomeren normalen menschlichen Serum-Albumin
SE9002212D0 (sv) 1990-06-21 1990-06-21 Hightech Receptor Ab Igg binding protein
JP3230091B2 (ja) 1990-06-25 2001-11-19 ウェルファイド株式会社 ヒト血清アルブミンの着色抑制方法
JP2982296B2 (ja) 1990-11-19 1999-11-22 吉富製薬株式会社 アルブミン含有水溶液の精製法
JP2949846B2 (ja) * 1990-11-30 1999-09-20 吉富製薬株式会社 アルブミン製剤の保存方法
FR2672604B1 (fr) 1991-02-07 1995-05-05 Pasteur Merieux Serums Vacc Procede pour isoler de l'albumine humaine a partir du surnageant iv, notamment iv-4, ou de la fraction v de cohn ou d'un surnageant ou fraction analogue.
US5284777A (en) * 1991-03-04 1994-02-08 Isolab, Inc. Combined glycated hemoglobin and immunoturbidometric glycated albumin assay from whole blood lysate
JPH0671432B2 (ja) 1991-03-20 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
DE69230273T2 (de) 1991-07-12 2000-05-31 Dsm N.V., Heerlen Verfahren zur Reinigung von Serumalbumin
US5260308A (en) * 1991-11-06 1993-11-09 Mayo Foundation For Medical Education And Research Method to increase permeability of the blood-nerve/brain barriers to proteins
FR2686620B1 (fr) * 1992-01-27 1995-06-23 Rhone Poulenc Rorer Sa Serum-albumine humaine, preparation et utilisation.
US5281582A (en) 1992-02-27 1994-01-25 Alliance Pharmaceuticals, Corp. Serum growth factor
JPH07102148B2 (ja) * 1992-05-20 1995-11-08 株式会社ミドリ十字 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物
US5440018A (en) 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
ES2099450T3 (es) * 1992-06-24 1997-05-16 Notetry Ltd Limpiador de vacio ciclonico.
JP3360315B2 (ja) 1992-07-31 2002-12-24 三菱ウェルファーマ株式会社 ヒト血清アルブミンの高度精製方法
ES2154648T3 (es) 1992-08-03 2001-04-16 Abbott Lab Deteccion y amplificacion de acidos nucleicos blanco con actividad exonucleolitica.
DE4244915C2 (de) * 1992-08-14 1998-12-03 Widmar Prof Dr Tanner DNA-Moleküle codierend Proteine, die an der O-Glykosylierung von Proteinen beteiligt sind
US5728553A (en) * 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
CA2116385A1 (en) 1993-02-25 1994-08-26 Akinori Sumi Human serum albumin and process for producing the same
DE4308532A1 (de) 1993-03-17 1994-09-22 Boehringer Mannheim Gmbh Monoklonale Antikörper gegen in vivo glykiertes Albumin
SE9301583D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Yeast strain and methods for expressing heterologous proteins in yeast
CA2136564C (en) 1993-11-26 2008-04-08 Kaoru Kobayashi Process for producing human serum albumin
GB9404270D0 (en) 1994-03-05 1994-04-20 Delta Biotechnology Ltd Yeast strains and modified albumins
JPH07308199A (ja) 1994-05-18 1995-11-28 Green Cross Corp:The ヒト血清アルブミンの製造方法
JP3702474B2 (ja) 1994-06-01 2005-10-05 三菱ウェルファーマ株式会社 血清アルブミン製剤の製造方法
GB9411356D0 (en) 1994-06-07 1994-07-27 Delta Biotechnology Ltd Yeast strains
AU2628595A (en) * 1994-07-21 1996-02-22 Gregory Lowell Millspaugh Method of and system for controlling energy, including in fusion reactors
US5561115A (en) 1994-08-10 1996-10-01 Bayer Corporation Low temperature albumin fractionation using sodium caprylate as a partitioning agent
DK0699687T3 (da) 1994-08-31 2004-04-26 Mitsubishi Pharma Corp Fremgangsmåde til oprensning af rekombinant humant serumalbumin
DE4432689A1 (de) 1994-09-14 1996-03-21 Basf Ag Mischung aus Alkylierungsprodukten von acetalisierten Monosacchariden mit Epoxiden
US6068995A (en) * 1994-10-25 2000-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Method for producing protein
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
WO1997031947A1 (en) * 1996-02-29 1997-09-04 Delta Biotechnology Limited High purity albumin production process
GB9721892D0 (en) 1997-10-15 1997-12-17 British Tech Group Apparatus for and method of testing a sample
GB9902000D0 (en) * 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
JP4798832B2 (ja) 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法
US6693173B2 (en) 2000-12-26 2004-02-17 Alpha Therapeutic Corporation Method to remove citrate and aluminum from proteins
SE0201680L (sv) 2002-06-04 2003-09-02 Wexioedisk Ab Diskmaskin med uppsamlingsorgan för att ta emot diskvätska och sköljvätska

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