DK2048234T3 - Kromatografisk fremgangsmåde til oprensning af albumin - Google Patents

Kromatografisk fremgangsmåde til oprensning af albumin

Info

Publication number
DK2048234T3
DK2048234T3 DK08166355T DK08166355T DK2048234T3 DK 2048234 T3 DK2048234 T3 DK 2048234T3 DK 08166355 T DK08166355 T DK 08166355T DK 08166355 T DK08166355 T DK 08166355T DK 2048234 T3 DK2048234 T3 DK 2048234T3
Authority
DK
Denmark
Prior art keywords
albumin
cell
coding sequence
disclosed
recombinant
Prior art date
Application number
DK08166355T
Other languages
English (en)
Inventor
Urk Hendrik Van
David John Mead
Philip Harvey Morton
Andrew John Cartwright
Jason Cameron
David James Ballance
Michel Gaston Joseph Grandgeorge
Stephen Berezenko
John Rodney Woodrow
Darrell Sleep
Jean-Luc Bernard Veron
Original Assignee
Novozymes Biopharma Dk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes Biopharma Dk As filed Critical Novozymes Biopharma Dk As
Application granted granted Critical
Publication of DK2048234T3 publication Critical patent/DK2048234T3/da

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804Affinity chromatography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361Ion-exchange
    • B01D15/362Cation-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361Ion-exchange
    • B01D15/363Anion-exchange
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • C07K14/765Serum albumin, e.g. HSA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK08166355T 1999-01-30 2000-01-31 Kromatografisk fremgangsmåde til oprensning af albumin DK2048234T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9902000A GB9902000D0 (en) 1999-01-30 1999-01-30 Process
EP00901252A EP1149163B1 (en) 1999-01-30 2000-01-31 Chromatographic method for purification of albumin

Publications (1)

Publication Number Publication Date
DK2048234T3 true DK2048234T3 (da) 2013-03-04

Family

ID=10846743

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08166355T DK2048234T3 (da) 1999-01-30 2000-01-31 Kromatografisk fremgangsmåde til oprensning af albumin

Country Status (16)

Country Link
US (3) US7993877B2 (da)
EP (3) EP1149163B1 (da)
JP (3) JP4586150B2 (da)
KR (2) KR100886554B1 (da)
CN (4) CN1526732B (da)
AT (1) ATE416254T1 (da)
AU (2) AU763899B2 (da)
CA (1) CA2359705C (da)
DE (1) DE60040967D1 (da)
DK (1) DK2048234T3 (da)
ES (1) ES2317827T3 (da)
GB (1) GB9902000D0 (da)
HK (1) HK1042521B (da)
MX (1) MXPA01007719A (da)
SG (2) SG174629A1 (da)
WO (1) WO2000044772A2 (da)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
EP1274720A4 (en) 2000-04-12 2004-08-18 Human Genome Sciences Inc FUSION PROTEINS CONTAINING ALBUMIN
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
ITBO20010426A1 (it) 2001-07-06 2003-01-06 Alfa Wassermann Spa Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
PT1463751E (pt) 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
GB0202633D0 (en) * 2002-02-05 2002-03-20 Delta Biotechnology Ltd Stabilization of protein preparations
CA2475382A1 (en) 2002-02-07 2003-08-14 Delta Biotechnology Limited Albumin-fused anti-angiogenesis peptides
SE526227C2 (sv) * 2002-05-15 2005-08-02 North China Pharmaceutical Group Metod för rening av rekombinant humant serumalbumin
GB0217033D0 (en) 2002-07-23 2002-08-28 Delta Biotechnology Ltd Gene and polypeptide sequences
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
GB0304576D0 (en) 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
ZA200605449B (en) 2003-12-03 2007-11-28 Delta Biotechnology Ltd Interleukin-11 fusion proteins
GB0329722D0 (en) * 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
WO2006067511A1 (en) 2004-12-23 2006-06-29 Novozymes Delta Limited Gene expression technique
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
US9057061B2 (en) 2003-12-23 2015-06-16 Novozymes Biopharma Dk A/S Gene expression technique
WO2006066595A2 (en) * 2004-12-22 2006-06-29 Novozymes A/S Recombinant production of serum albumin
WO2007063129A2 (en) * 2005-12-02 2007-06-07 Novozymes A/S Insolation of peptides , polypeptides and proteins
JP2007284425A (ja) * 2006-03-20 2007-11-01 Nokodai Tlo Kk タンパク質の精製方法
EP2049560B1 (en) * 2006-07-13 2013-05-15 Novozymes Biopharma DK A/S Process for preparing particles of proteinaceous material
KR101193722B1 (ko) 2006-07-24 2013-01-11 바이오렉시스 파마슈티칼 코포레이션 엑센딘 융합 단백질
US9505823B2 (en) 2006-08-07 2016-11-29 TEV A Biopharmaceuticals USA, Inc. Albumin-insulin fusion proteins
EP2121013B1 (en) 2007-02-02 2014-10-15 Globeimmune, Inc. Methods for producing yeast-based vaccines
CA2695830A1 (en) 2007-08-08 2009-02-12 Novozymes Biopharma Dk A/S Transferrin variants and conjugates
CN101978268B (zh) * 2008-03-31 2014-04-23 积水医疗株式会社 纯化血清白蛋白及免疫学测定方法
CN101684459B (zh) * 2008-09-22 2012-01-25 上海普天欣生物技术有限公司 CehA突变体蛋白、基因、重组载体及其用途和制备方法
CN101747437B (zh) 2008-12-10 2012-09-26 浙江日升昌药业有限公司 凋亡素-ec-sod羧基末端蛋白转导域融合蛋白
WO2010092135A2 (en) 2009-02-11 2010-08-19 Novozymes Biopharma Uk Ltd. Albumin variants and conjugates
WO2010096588A2 (en) 2009-02-20 2010-08-26 Ventria Bioscience Cell culture media containing combinations of proteins
WO2010115634A1 (en) 2009-04-09 2010-10-14 Cellca Gmbh Method for improved single cell cloning
EP2427486B1 (en) 2009-05-07 2015-02-25 Novozymes Biopharma DK A/S Method for purifying albumin
CN101691581B (zh) * 2009-06-25 2012-10-03 南京农业大学 染色体无标记随机整合载体pUTTns及其应用
US8129139B2 (en) 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
CN101690801B (zh) 2009-10-26 2012-08-01 上海交通大学 白细胞介素-1受体拮抗剂的用途及其药物组合物
CN102741280B (zh) 2009-10-30 2015-12-02 诺维信生物制药丹麦公司 白蛋白变体
CN106977608A (zh) 2010-04-09 2017-07-25 阿尔布麦狄克斯公司 白蛋白衍生物和变体
JP5883849B2 (ja) * 2010-04-29 2016-03-15 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated 陰イオン交換樹脂を用いる二価カチオン結合タンパク質の精製方法
US20130225496A1 (en) 2010-11-01 2013-08-29 Novozymes Biopharma Dk A/S Albumin Variants
CN102127164B (zh) 2010-12-20 2013-01-30 武汉禾元生物科技有限公司 一种从水稻种子中提取重组人血清白蛋白的方法
CN102532254B (zh) 2010-12-24 2015-06-24 武汉禾元生物科技股份有限公司 一种从水稻种子中分离纯化重组人血清白蛋白的方法
MX353816B (es) 2011-05-05 2018-01-30 Albumedix As Variantes de albumina.
BR112014000042A2 (pt) 2011-07-05 2017-02-21 Novozymes Biopharma Dk As composição, meio de cultura celular, uso de uma composição, e, método para cultivar células
HK1200842A1 (en) 2011-11-18 2015-08-14 Albumedix Ltd Proteins with improved half-life and other properties
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
RU2691027C2 (ru) 2011-12-05 2019-06-07 Фэктор Байосайенс Инк. Способы и препараты для трансфекции клеток
JP2015501844A (ja) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物
MX2014010278A (es) 2012-03-16 2015-03-05 Novozymes Biopharma Dk As Variantes de albumina.
US10501513B2 (en) * 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
WO2013151663A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of membrane proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
CN102952836A (zh) * 2012-11-02 2013-03-06 浙江海正药业股份有限公司 重组人长效白介素1受体拮抗剂融合蛋白的纯化方法
WO2014072481A1 (en) 2012-11-08 2014-05-15 Novozymes Biopharma Dk A/S Albumin variants
CN103880947B (zh) 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
CA2903739A1 (en) * 2013-03-06 2014-09-12 Glaxosmithkline Llc Host cells and methods of use
CN118388581A (zh) 2013-03-08 2024-07-26 建新公司 治疗性蛋白药物物质的整合连续制造
MX364532B (es) 2013-07-04 2019-04-29 Glykos Finland Oy Celulas de hongos filamentosos deficientes de o-manosiltransferasa y metodos de uso de las mismas.
JP6306700B2 (ja) 2013-11-01 2018-04-04 ユニバーシティ オブ オスロUniversity of Oslo アルブミン改変体及びその使用
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
MX384829B (es) * 2014-04-23 2025-03-14 Alexion Pharma Inc Procesamiento de clara de huevo.
AU2015293949B2 (en) 2014-07-21 2019-07-25 Teknologian Tutkimuskeskus Vtt Oy Production of glycoproteins with mammalian-like N-glycans in filamentous fungi
SMT202000256T1 (it) * 2015-01-01 2020-07-08 Shilpa Medicare Ltd Nuovo metodo per un'efficace purificazione di albumina serica umana
WO2016131052A1 (en) 2015-02-13 2016-08-18 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
WO2016145389A1 (en) * 2015-03-12 2016-09-15 Board Of Trustees Of Michigan State University Compositions and methods for measuring c-peptide binding and diagnosing immune-mediated diseases
WO2016207730A1 (en) 2015-06-22 2016-12-29 The University Of Oslo Targeting of vaccine antigen to an intracellular compartment
CN105037487B (zh) * 2015-08-12 2017-03-22 山东泰邦生物制品有限公司 一种人血白蛋白的制备方法
WO2017029407A1 (en) 2015-08-20 2017-02-23 Albumedix A/S Albumin variants and conjugates
WO2017112847A1 (en) 2015-12-22 2017-06-29 Albumedix A/S Improved protein expression strains
JP7146637B2 (ja) 2015-12-22 2022-10-04 アルブミディクス リミティド 改善されたタンパク質発現株
IL308824A (en) 2016-08-17 2024-01-01 Factor Bioscience Inc Nucleic acid products and methods of administration thereof
DK3429345T3 (da) 2016-10-04 2019-11-25 Albumedix Ltd Anvendelser af rekombinant gær-afledt serumalbumin
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
MA50141A (fr) * 2017-04-20 2020-07-29 Novo Nordisk As Procédés de purification de protéines de fusion d'albumine
DK3642343T3 (en) 2017-06-20 2022-03-14 Albumedix Ltd Improved protein expression strains
EP3808837A4 (en) * 2018-06-15 2022-04-06 Fuso Pharmaceutical Industries, Ltd. CULTURE MEDIUM FOR ASSISTED REPRODUCTION TECHNOLOGY
BR112021003420A2 (pt) 2018-08-31 2021-05-18 Genzyme Corporation resina cromatográfica estéril e uso da mesma em processos de manufatura
CN111229023B (zh) * 2018-11-29 2022-01-28 内蒙古东盛硅藻土科技创新产业园有限公司 一种化学降解添加剂
CN109879958A (zh) * 2019-03-08 2019-06-14 中国人民解放军军事科学院军事医学研究院 一种低糖基化血清白蛋白的制备方法
JP7699552B2 (ja) 2019-07-03 2025-06-27 ファクター バイオサイエンス インコーポレイテッド カチオン性脂質及びその使用
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
KR20220066161A (ko) * 2019-10-01 2022-05-23 리플리겐 코포레이션 유체의 단백질 농도 측정
CN112858682B (zh) * 2019-11-27 2023-06-02 广东唯实生物技术有限公司 用于尿微量白蛋白的检测试纸条及其制备方法、检测试剂盒和检测方法
WO2021111143A1 (en) 2019-12-04 2021-06-10 Albumedix Limited Methods and compositions produced thereby
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
US12161777B2 (en) 2020-07-02 2024-12-10 Davol Inc. Flowable hemostatic suspension
CN112062833A (zh) * 2020-10-09 2020-12-11 国药集团武汉血液制品有限公司 一种从血浆组分ⅳ沉淀中提取人血白蛋白的方法
JP7674630B2 (ja) 2020-12-08 2025-05-12 通化安睿特生物製薬股▲フェン▼有限公司 組換えタンパク質を精製する方法
CN116744984A (zh) 2020-12-28 2023-09-12 达沃有限公司 包含蛋白质和多官能化改性的基于聚乙二醇的交联剂的反应性干粉状止血材料
CN112646045A (zh) * 2021-01-06 2021-04-13 海默斯(重庆)医学生物技术有限公司 一种重组角蛋白分离纯化方法
CN114907469A (zh) * 2021-02-08 2022-08-16 首都医科大学附属北京朝阳医院 一种人血清中白蛋白分离纯化方法
CN113735963A (zh) * 2021-09-10 2021-12-03 山东健通生物科技有限公司 一种重组人血清白蛋白纯化过程去除色素的方法
WO2024018452A1 (en) 2022-07-18 2024-01-25 Yeda Research And Development Co. Ltd. Albumin protein variants, production thereof and uses of same
CN118166053B (zh) * 2024-03-15 2025-02-07 通化安睿特生物制药股份有限公司 一种制备低o-糖基化水平的重组人白蛋白的方法
WO2026029079A1 (ja) * 2024-07-31 2026-02-05 富士レビオ株式会社 リン酸化タウタンパク質の測定方法およびリン酸化タウタンパク質の測定キット
WO2026074121A1 (en) 2024-10-02 2026-04-09 Sartorius Albumedix Limited Albumin formulations and uses thereof

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9019919D0 (en) 1990-09-12 1990-10-24 Delta Biotechnology Ltd Purification of proteins
US5625041A (en) 1990-09-12 1997-04-29 Delta Biotechnology Limited Purification of proteins
US2433905A (en) 1943-11-01 1948-01-06 Jr Walter L Hughes Method for the crystallization of albumin and the preparation of protein products therefrom
AT317418B (de) 1972-06-16 1974-08-25 Brigitte Panhofer Verfahren zur Herstellung von intravenös beim Menschen anwendbarem Humanalbumin aus menschlichen Placenten
FR2190437B1 (da) 1972-07-05 1975-08-08 Merieux Inst
CA1044537A (en) 1973-05-09 1978-12-19 Amf Incorporated Filter medium and process
DE2537123A1 (de) 1975-08-20 1977-03-03 New Zealand Inventions Dev Verfahren zur herstellung von albumin
SE405549B (sv) 1975-10-09 1978-12-18 Pharmacia Fine Chemicals Ab Forfarande for isolering av albumin ur plasmaprodukter genom kromatografisk fraktionering
US4043997A (en) 1976-05-28 1977-08-23 Cutter Laboratories, Inc. Method for isolating albumin using insoluble supports coupled to a dye
US4075197A (en) 1976-09-20 1978-02-21 Monsanto Company Serum albumin production
US4269605A (en) 1978-06-28 1981-05-26 Amicon Corporation Method and kit for separation of glycoproteins
IN150740B (da) 1978-11-24 1982-12-04 Hoffmann La Roche
US4228154A (en) 1979-02-26 1980-10-14 Armour Pharmaceutical Company Purification of plasma albumin by ion exchange chromatography
CA1149298A (en) 1979-04-12 1983-07-05 Eugene H. Wegner Production of yeast cells at high cell densities
US4222934A (en) 1979-04-12 1980-09-16 American National Red Cross Preparation of albumin using ethanol
GB2053926B (en) 1979-07-20 1983-02-23 Atkinson A Albumin extraction by affinity chromatography
US4350156A (en) 1980-05-29 1982-09-21 Japan Foundation For Artificial Organs Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid
NZ199722A (en) 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
US4491946A (en) 1981-03-09 1985-01-01 Gould Inc. Multi-station token pass communication system
US4562251A (en) 1981-03-26 1985-12-31 Amicon Corporation Agarose derivatives of amino phenyl boronic acid
IL66614A (en) 1981-08-28 1985-09-29 Genentech Inc Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it
US4391801A (en) 1981-10-29 1983-07-05 Cutter Laboratories, Inc. Plasma protein fraction substantially free of acetate ions
FR2543448A1 (fr) 1983-04-01 1984-10-05 Rhone Poulenc Spec Chim Procede de fractionnement du plasma
US4748120A (en) 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
DE3344656A1 (de) 1983-12-09 1985-06-13 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Verfahren zur herstellung einer serumproteinloesung
CA1286622C (en) 1986-04-28 1991-07-23 Chokyun Rha Method for clarifying and stabilizing cell culture media
JPS62294621A (ja) 1986-06-13 1987-12-22 Green Cross Corp:The アルブミンの回収方法
JPS6383100A (ja) 1986-09-26 1988-04-13 Green Cross Corp:The ヒト尿中アルブミンの製造方法
EP0286424B1 (en) 1987-04-09 1994-03-16 Delta Biotechnology Limited Yeast vector
US4833233A (en) 1987-08-20 1989-05-23 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Human serum albumin crystals and method of preparation
CA1293217C (en) 1987-11-09 1991-12-17 Sooyoung Stanford Lee Controlled growth rate fermentation
IL88326A (en) 1987-11-18 1993-03-15 Gist Brocades Nv Purification of serum albumin
GB2214508A (en) 1988-01-27 1989-09-06 Bayer Ag Plasmid vector for the efficient expression of foreign genes fused with newly conceived transcriptional and translational signal sequences.
JPH01215289A (ja) 1988-02-22 1989-08-29 Toa Nenryo Kogyo Kk 遺伝子組換えによる正常ヒト血清アルブミンaの製造方法
US4990447A (en) 1988-06-24 1991-02-05 Gist-Brocades Nv Process for the purification of serum albumin
AU633020B2 (en) 1988-07-23 1993-01-21 Novozymes Delta Limited New secretory leader sequences
FR2649991B2 (fr) 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
US5277818A (en) 1988-10-31 1994-01-11 The Green Cross Corporation Albumin preparation and process for preparing the same
JP3554796B2 (ja) 1988-10-31 2004-08-18 三菱ウェルファーマ株式会社 アルブミン製剤及びその製造方法
US4891221A (en) 1988-11-23 1990-01-02 Edward Shanborm Whole blood antiviral process and composition
FR2648048B1 (fr) 1989-06-08 1994-06-03 Lille Transfusion Sanguine Procede de preparation de solutions d'albumine purifiee
GB8913586D0 (en) 1989-06-13 1989-08-02 Technicol Limited A method of determining the glycosylated protein level of a sample and an apparatus for use in the method
JPH0768137B2 (ja) 1989-06-15 1995-07-26 株式会社ミドリ十字 アルブミン製剤及びその製法
SE500110C2 (sv) * 1989-06-27 1994-04-18 Kabi Pharmacia Ab Sätt att rena ett protein från därtill bundna flervärda metalljoner
GB8927480D0 (en) 1989-12-05 1990-02-07 Delta Biotechnology Ltd Mutant fungal strain detection and new promoter
JPH0671434B2 (ja) 1989-09-18 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
CA2022165C (en) 1989-10-05 1999-11-23 Chong E. Chang Albumin purification
US5250662A (en) 1989-10-05 1993-10-05 Alpha Therapeutic Corporation Albumin purification
JP3127232B2 (ja) 1990-03-08 2001-01-22 ウェルファイド株式会社 蛋白質製剤の製造法
ES2224094T3 (es) 1990-04-19 2005-03-01 Bayer Corporation Procedimiento para preparar seroalbumina normal (humana) esencialmente monomerica.
SE9002212D0 (sv) 1990-06-21 1990-06-21 Hightech Receptor Ab Igg binding protein
JP3230091B2 (ja) 1990-06-25 2001-11-19 ウェルファイド株式会社 ヒト血清アルブミンの着色抑制方法
JP2982296B2 (ja) 1990-11-19 1999-11-22 吉富製薬株式会社 アルブミン含有水溶液の精製法
JP2949846B2 (ja) 1990-11-30 1999-09-20 吉富製薬株式会社 アルブミン製剤の保存方法
FR2672604B1 (fr) 1991-02-07 1995-05-05 Pasteur Merieux Serums Vacc Procede pour isoler de l'albumine humaine a partir du surnageant iv, notamment iv-4, ou de la fraction v de cohn ou d'un surnageant ou fraction analogue.
US5284777A (en) * 1991-03-04 1994-02-08 Isolab, Inc. Combined glycated hemoglobin and immunoturbidometric glycated albumin assay from whole blood lysate
JPH0671432B2 (ja) 1991-03-20 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
US5330901A (en) 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
JPH06501033A (ja) 1991-07-12 1994-01-27 ギスト ブロカデス ナムローゼ フェンノートシャップ 血清アルブミンの精製方法
US5260308A (en) * 1991-11-06 1993-11-09 Mayo Foundation For Medical Education And Research Method to increase permeability of the blood-nerve/brain barriers to proteins
FR2686620B1 (fr) 1992-01-27 1995-06-23 Rhone Poulenc Rorer Sa Serum-albumine humaine, preparation et utilisation.
US5281582A (en) 1992-02-27 1994-01-25 Alliance Pharmaceuticals, Corp. Serum growth factor
JPH07102148B2 (ja) * 1992-05-20 1995-11-08 株式会社ミドリ十字 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物
US5440018A (en) 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
DE69309275T3 (de) * 1992-06-24 2002-06-27 Notetry Ltd., Little Somerford Zyklonstaubsauger
JP3360315B2 (ja) 1992-07-31 2002-12-24 三菱ウェルファーマ株式会社 ヒト血清アルブミンの高度精製方法
CA2140331C (en) 1992-08-03 2000-01-18 John J. Carrino Detecting and amplifying target nucleic acids using exonucleolytic activity
DE4244915C2 (de) * 1992-08-14 1998-12-03 Widmar Prof Dr Tanner DNA-Moleküle codierend Proteine, die an der O-Glykosylierung von Proteinen beteiligt sind
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
CA2116385A1 (en) 1993-02-25 1994-08-26 Akinori Sumi Human serum albumin and process for producing the same
DE4308532A1 (de) 1993-03-17 1994-09-22 Boehringer Mannheim Gmbh Monoklonale Antikörper gegen in vivo glykiertes Albumin
SE9301583D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Yeast strain and methods for expressing heterologous proteins in yeast
CA2136564C (en) 1993-11-26 2008-04-08 Kaoru Kobayashi Process for producing human serum albumin
GB9404270D0 (en) 1994-03-05 1994-04-20 Delta Biotechnology Ltd Yeast strains and modified albumins
JPH07308199A (ja) 1994-05-18 1995-11-28 Green Cross Corp:The ヒト血清アルブミンの製造方法
JP3702474B2 (ja) 1994-06-01 2005-10-05 三菱ウェルファーマ株式会社 血清アルブミン製剤の製造方法
GB9411356D0 (en) 1994-06-07 1994-07-27 Delta Biotechnology Ltd Yeast strains
AU2628595A (en) * 1994-07-21 1996-02-22 Gregory Lowell Millspaugh Method of and system for controlling energy, including in fusion reactors
US5561115A (en) 1994-08-10 1996-10-01 Bayer Corporation Low temperature albumin fractionation using sodium caprylate as a partitioning agent
CA2157219C (en) 1994-08-31 2010-10-05 Munehiro Noda Process for purifying recombinant human serum albumin
DE4432689A1 (de) 1994-09-14 1996-03-21 Basf Ag Mischung aus Alkylierungsprodukten von acetalisierten Monosacchariden mit Epoxiden
US6068995A (en) * 1994-10-25 2000-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Method for producing protein
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
WO1997031947A1 (en) * 1996-02-29 1997-09-04 Delta Biotechnology Limited High purity albumin production process
GB9721892D0 (en) 1997-10-15 1997-12-17 British Tech Group Apparatus for and method of testing a sample
GB9902000D0 (en) * 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
JP4798832B2 (ja) 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法
US6693173B2 (en) 2000-12-26 2004-02-17 Alpha Therapeutic Corporation Method to remove citrate and aluminum from proteins
SE0201680L (sv) 2002-06-04 2003-09-02 Wexioedisk Ab Diskmaskin med uppsamlingsorgan för att ta emot diskvätska och sköljvätska

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