ATE418729T1 - Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie - Google Patents

Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie

Info

Publication number
ATE418729T1
ATE418729T1 AT03793347T AT03793347T ATE418729T1 AT E418729 T1 ATE418729 T1 AT E418729T1 AT 03793347 T AT03793347 T AT 03793347T AT 03793347 T AT03793347 T AT 03793347T AT E418729 T1 ATE418729 T1 AT E418729T1
Authority
AT
Austria
Prior art keywords
result
sample
driven strategy
characterizing biomolecules
biomolecules
Prior art date
Application number
AT03793347T
Other languages
English (en)
Inventor
Armin Graber
Dale Patterson
Peter Juhasz
Stephen Martin
Original Assignee
Applera Corp
Mds Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applera Corp, Mds Inc filed Critical Applera Corp
Application granted granted Critical
Publication of ATE418729T1 publication Critical patent/ATE418729T1/de

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8411—Intermediate storage of effluent, including condensation on surface
    • G01N2030/8417—Intermediate storage of effluent, including condensation on surface the store moving as a whole, e.g. moving wire

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT03793347T 2002-08-22 2003-08-22 Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie ATE418729T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40557802P 2002-08-22 2002-08-22

Publications (1)

Publication Number Publication Date
ATE418729T1 true ATE418729T1 (de) 2009-01-15

Family

ID=31946899

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03793347T ATE418729T1 (de) 2002-08-22 2003-08-22 Verfahren zur charakterisierung von biomolekülen mittels resultat-gesteuerter strategie

Country Status (8)

Country Link
US (1) US6940065B2 (de)
EP (1) EP1530721B1 (de)
JP (1) JP4160558B2 (de)
AT (1) ATE418729T1 (de)
AU (1) AU2003262824B2 (de)
CA (1) CA2495378C (de)
DE (1) DE60325482D1 (de)
WO (1) WO2004019035A2 (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3817523B2 (ja) * 2003-02-14 2006-09-06 株式会社日立製作所 質量分析データ解析システム
US7202473B2 (en) * 2003-04-10 2007-04-10 Micromass Uk Limited Mass spectrometer
US7105806B2 (en) * 2003-11-26 2006-09-12 Applera Corporation Method and apparatus for de-convoluting a convoluted spectrum
WO2005074481A2 (en) * 2004-01-30 2005-08-18 Ciphergen Biosystems, Inc. Method for clustering signals in spectra
JP5009784B2 (ja) * 2004-04-30 2012-08-22 マイクロマス ユーケー リミテッド 質量分析計
US7800055B2 (en) * 2004-05-20 2010-09-21 Waters Technologies Corporation System and method for grouping precursor and fragment ions using selected ion chromatograms
DE112005001166B4 (de) * 2004-05-20 2014-10-09 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Verfahren und Vorrichtung zum Identifizieren von Proteinen in Gemischen
DE102004051043B4 (de) * 2004-10-20 2011-06-01 Bruker Daltonik Gmbh Angleichung von Flugzeitmassenspektren
DE102004051016A1 (de) * 2004-10-20 2006-05-04 Protagen Ag Verfahren und System zur Aufklärung der Primärstruktur von Biopolymeren
DE102005018273B4 (de) * 2005-04-20 2007-11-15 Bruker Daltonik Gmbh Rückgesteuerte Tandem-Massenspektrometrie
US7498568B2 (en) * 2005-04-29 2009-03-03 Agilent Technologies, Inc. Real-time analysis of mass spectrometry data for identifying peptidic data of interest
US8581178B2 (en) * 2005-05-24 2013-11-12 Dh Technologies Development Pte. Ltd. Combined mass and differential mobility spectrometry and associated methods, systems, and devices
JP4522910B2 (ja) * 2005-05-30 2010-08-11 株式会社日立ハイテクノロジーズ 質量分析方法及び質量分析装置
EP1887351A4 (de) * 2005-05-31 2009-04-08 Jcl Bioassay Corp Screening-verfahren für bestimmte proteine bei der umfassenden proteomanalyse
CA2611065A1 (en) * 2005-06-03 2006-12-07 Mds Inc. Doing Business Through Its Mds Sciex Division System and method for analysis of compounds using a mass spectrometer
EP1958006B1 (de) * 2005-11-10 2011-05-11 Microsoft Corporation Entdeckung biologischer merkmale unter verwendung zusammengesetzter bilder
US8105788B2 (en) * 2005-12-08 2012-01-31 The University Of British Columbia Mucopolysaccharidosis (MPS) diagnostic methods, systems, kits and assays associated therewith
US20080319678A1 (en) * 2006-02-15 2008-12-25 University Of Virginia Patent Foundation Mass Tagging for Quantitative Analysis of Biomolecules using 13C Labeled Phenylisocyanate
CA2646890C (en) * 2006-03-21 2012-07-31 Metabolon, Inc. A system, method, and computer program product for analyzing spectrometry data to indentify and quantify individual components in a sample
US20090173876A1 (en) 2006-07-21 2009-07-09 Amgen Inc. Method of detecting and/or measuring hepcidin in a sample
CA2658787C (en) * 2006-08-15 2013-04-09 Alexei Antonov Apparatus and method for elemental analysis of particles by mass spectrometry
GB0622780D0 (en) * 2006-11-15 2006-12-27 Micromass Ltd Mass spectrometer
US7838824B2 (en) * 2007-05-01 2010-11-23 Virgin Instruments Corporation TOF-TOF with high resolution precursor selection and multiplexed MS-MS
US7820964B2 (en) * 2007-08-06 2010-10-26 Metabolic Analyses, Inc Method for generation and use of stable isotope patterns in mass spectral data
US7820963B2 (en) 2007-08-06 2010-10-26 Metabolic Alayses, Inc. Method for generation and use of isotopic patterns in mass spectral data of simple organisms
US8536520B2 (en) * 2007-08-06 2013-09-17 Iroa Technologies Llc Method for generation and use of isotopic patterns in mass spectral data of simple organisms
JP5020742B2 (ja) 2007-08-27 2012-09-05 日本電子株式会社 Ｍａｌｄｉイオン源を備えた質量分析装置およびｍａｌｄｉイオン源用サンプルプレート
JP5227556B2 (ja) * 2007-09-06 2013-07-03 株式会社日立製作所 分析装置
WO2009046204A1 (en) * 2007-10-02 2009-04-09 Metabolic Analyses, Inc. Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms
US8969251B2 (en) * 2007-10-02 2015-03-03 Methabolic Analyses, Inc. Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms
WO2009070457A1 (en) * 2007-11-30 2009-06-04 Waters Technologies Corporation Determining the presence or absence of mineralocorticoids in samples
CA2707166C (en) * 2007-12-04 2016-04-12 Dh Technologies Development Pte. Ltd. Systems and methods for analyzing substances using a mass spectrometer
EP2248147A1 (de) * 2008-01-31 2010-11-10 DH Technologies Development Pte. Ltd. Hochdurchsatz-screening metabolischer erkrankungen unter verwendung einer mit einem massenanalysator gekoppelten laserdesorptions-ionenquelle
US8148677B2 (en) * 2008-02-05 2012-04-03 Thermo Finnigan Llc Peptide identification and quantitation by merging MS/MS spectra
US8067728B2 (en) * 2008-02-22 2011-11-29 Dh Technologies Development Pte. Ltd. Method of improving signal-to-noise for quantitation by mass spectrometry
WO2009146345A1 (en) * 2008-05-29 2009-12-03 Waters Technologies Corporation Techniques for performing retention-time matching of precursor and product ions and for constructing precursor and product ion spectra
US8067243B2 (en) * 2008-09-03 2011-11-29 Oregon Medical Laboratories Methods and systems for analyzing medication levels in a sample
US8321144B2 (en) * 2008-10-23 2012-11-27 Microsoft Corporation Non-contiguous regions processing
BRPI0805608B1 (pt) * 2008-12-15 2018-11-21 Embrapa Pesquisa Agropecuaria método, equipamento e sistema para diagnóstico de estresses e doenças em plantas superiores
WO2010096713A2 (en) 2009-02-20 2010-08-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method for the diagnosis of age-associated vascular disorders
DE102009030395A1 (de) * 2009-06-25 2011-05-26 Tecan Trading Ag Differnziertes chromatographisches Analysenverfahren zur Kompensation von Varianzen in der signalerzeugenden Einheit bei quantifizierenden chromatographischen Analysen
GB201003566D0 (en) * 2010-03-03 2010-04-21 Ilika Technologies Ltd Mass spectrometry apparatus and methods
US8455818B2 (en) 2010-04-14 2013-06-04 Wisconsin Alumni Research Foundation Mass spectrometry data acquisition mode for obtaining more reliable protein quantitation
US10553412B2 (en) * 2010-05-24 2020-02-04 Agilent Technologies, Inc. System and method of data-dependent acquisition by mass spectrometry
JP5505110B2 (ja) * 2010-06-14 2014-05-28 株式会社島津製作所 クロマトグラフ質量分析装置
CA2806211A1 (en) * 2010-07-22 2012-01-26 Georgetown University Mass spectrometric methods for quantifying npy 1-36 and npy 3-36
US8809770B2 (en) * 2010-09-15 2014-08-19 Dh Technologies Development Pte. Ltd. Data independent acquisition of product ion spectra and reference spectra library matching
US8742333B2 (en) 2010-09-17 2014-06-03 Wisconsin Alumni Research Foundation Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer
JP5609509B2 (ja) * 2010-10-04 2014-10-22 富士通株式会社 指示システム、指示方法、及び記憶制御装置。
EP2666114A4 (de) * 2011-01-21 2017-04-26 Massdefect Technologies, LLC Durch hintergrundentfernung gestützte datenabhängige erfassung
DE102012102875B4 (de) 2011-04-04 2024-04-18 Wisconsin Alumni Research Foundation Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben
EP2831904B1 (de) * 2012-03-28 2020-01-01 Ulvac-Phi, Inc. Vorrichtung zur bereitstellung einer parallelen erfassung von massenspektrometrie/massenspektrometriedaten
EP2781916A1 (de) * 2013-03-22 2014-09-24 Biotage AB Kopplungsmodul
JP6136771B2 (ja) * 2013-08-30 2017-05-31 株式会社島津製作所 物質同定方法及び該方法を用いる質量分析装置
US10115576B2 (en) * 2013-12-12 2018-10-30 Waters Technologies Corporation Method and an apparatus for analyzing a complex sample
CN107077592B (zh) * 2014-03-28 2021-02-19 威斯康星校友研究基金会 高分辨率气相色谱-质谱数据与单位分辨率参考数据库的改进谱图匹配的高质量精确度滤波
US9720001B2 (en) * 2014-05-21 2017-08-01 Thermo Finnigan Llc Methods for mass spectrometric biopolymer analysis using optimized weighted oligomer scheduling
GB201410470D0 (en) * 2014-06-12 2014-07-30 Micromass Ltd Self-calibration of spectra using differences in molecular weight from known charge states
WO2016142691A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of swabs and biopsy samples
GB2584972B (en) * 2015-03-06 2021-04-21 Micromass Ltd Liquid trap or separator for electrosurgical applications
CN107533032A (zh) 2015-03-06 2018-01-02 英国质谱公司 用于从块状组织直接映射的原位电离质谱测定成像平台
GB2556436B (en) 2015-03-06 2022-01-26 Micromass Ltd Cell population analysis
EP3265822B1 (de) 2015-03-06 2021-04-28 Micromass UK Limited Gewebeanalyse mittels massenspektrometrie oder ionenmobilitätsspektrometrie
GB2554206B (en) 2015-03-06 2021-03-24 Micromass Ltd Spectrometric analysis of microbes
EP3264989B1 (de) 2015-03-06 2023-12-20 Micromass UK Limited Spektrometrische analyse
US20160350475A1 (en) * 2015-05-29 2016-12-01 Virgin Instruments Corporation Method for Developing and Applying Databases for Idenfication of Microorganisms by MALDI-TOF Mass Spectrometry
WO2017178833A1 (en) 2016-04-14 2017-10-19 Micromass Uk Limited Spectrometric analysis of plants
US10049868B2 (en) * 2016-12-06 2018-08-14 Rapiscan Systems, Inc. Apparatus for detecting constituents in a sample and method of using the same
US10741372B2 (en) 2017-03-06 2020-08-11 Shimadzu Corporation Tandem mass spectrometer and program for the same
EP3410109A1 (de) * 2017-06-02 2018-12-05 Thermo Fisher Scientific (Bremen) GmbH Systeme und verfahren zur extraktion von massenspuren
EP3665476A4 (de) * 2017-08-07 2021-05-05 Agency for Science, Technology and Research Schnelle analyse und identifizierung von lipiden aus daten der flüssigkeitschromatografie-massenspektrometrie (lc-ms)
CN107782829A (zh) * 2017-11-01 2018-03-09 上海莱士血液制品股份有限公司 一种利用离子色谱法检测生物制品中三羟甲基氨基甲烷（Tris）的方法
US11393666B2 (en) 2019-12-19 2022-07-19 Thermo Finnigan Llc Automatic MS-N characterization of mass spectrometric “dark matter”
US11624734B2 (en) 2020-06-29 2023-04-11 Waters Technologies Corporation Chromatographic dimension selection in multidimensional liquid chromatography
JP7514789B2 (ja) * 2021-04-08 2024-07-11 日本電子株式会社 ウイルス由来タンパク質検出方法、マススペクトル処理装置及び質量分析システム
DE102024110223A1 (de) 2023-05-03 2024-11-07 Bruker Daltonics GmbH & Co. KG Verfahren zur bioanalytischen untersuchung unter verwendung von ionenspektrometrie, einschließlich massenanalyse

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2057826B (en) 1979-08-31 1983-01-12 Ibm Multibeam cathode ray tube apparatus
US6002127A (en) 1995-05-19 1999-12-14 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US5625184A (en) 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
GB9624927D0 (en) * 1996-11-29 1997-01-15 Oxford Glycosciences Uk Ltd Gels and their use
US6596529B1 (en) 1997-05-02 2003-07-22 Uab Research Foundation Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof
US6175112B1 (en) 1998-05-22 2001-01-16 Northeastern University On-line liquid sample deposition interface for matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy
US6348688B1 (en) 1998-02-06 2002-02-19 Perseptive Biosystems Tandem time-of-flight mass spectrometer with delayed extraction and method for use
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
CA2255122C (en) * 1998-12-04 2007-10-09 Mds Inc. Improvements in ms/ms methods for a quadrupole/time of flight tandem mass spectrometer
US6799121B2 (en) * 2000-03-30 2004-09-28 York University Sequencing of peptides by mass spectrometry
AU2001286059A1 (en) 2000-09-08 2002-03-22 Oxford Glycosciences (Uk) Ltd. Automated identification of peptides
WO2002061047A2 (en) * 2001-02-01 2002-08-08 Ciphergen Biosystems, Inc. Improved methods for protein identification, characterization and sequencing by tandem mass spectrometry
US6977732B2 (en) 2002-12-26 2005-12-20 National Taiwan University Miniature three-dimensional contour scanner

Also Published As

Publication number Publication date
US20040108452A1 (en) 2004-06-10
CA2495378A1 (en) 2004-03-04
AU2003262824B2 (en) 2007-08-23
EP1530721A2 (de) 2005-05-18
DE60325482D1 (de) 2009-02-05
EP1530721B1 (de) 2008-12-24
JP4160558B2 (ja) 2008-10-01
WO2004019035A9 (en) 2004-12-23
US6940065B2 (en) 2005-09-06
WO2004019035A2 (en) 2004-03-04
AU2003262824A1 (en) 2004-03-11
CA2495378C (en) 2011-03-01
WO2004019035A3 (en) 2005-02-17
JP2005536728A (ja) 2005-12-02

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