ATE420161T1 - Monopropylenglykol als fermentationszusatz - Google Patents

Monopropylenglykol als fermentationszusatz

Info

Publication number
ATE420161T1
ATE420161T1 AT03761447T AT03761447T ATE420161T1 AT E420161 T1 ATE420161 T1 AT E420161T1 AT 03761447 T AT03761447 T AT 03761447T AT 03761447 T AT03761447 T AT 03761447T AT E420161 T1 ATE420161 T1 AT E420161T1
Authority
AT
Austria
Prior art keywords
sub
monopropylene glycol
fermentation additive
fermentation
additive
Prior art date
Application number
AT03761447T
Other languages
English (en)
Inventor
Svend Kaasgaard
Niels Banke
Kim Hansen
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE420161T1 publication Critical patent/ATE420161T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • C12N9/2408Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411Amylases
    • C12N9/2414Alpha-amylase (3.2.1.1.)
    • C12N9/2417Alpha-amylase (3.2.1.1.) from microbiological source
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Processing Of Solid Wastes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03761447T 2002-07-01 2003-07-01 Monopropylenglykol als fermentationszusatz ATE420161T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200201021 2002-07-01

Publications (1)

Publication Number Publication Date
ATE420161T1 true ATE420161T1 (de) 2009-01-15

Family

ID=29797022

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03761447T ATE420161T1 (de) 2002-07-01 2003-07-01 Monopropylenglykol als fermentationszusatz

Country Status (8)

Country Link
US (1) US20060127974A1 (de)
EP (1) EP1520012B1 (de)
CN (1) CN100529066C (de)
AT (1) ATE420161T1 (de)
AU (1) AU2003243925A1 (de)
DE (1) DE60325731D1 (de)
DK (1) DK1520012T3 (de)
WO (1) WO2004003187A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100173286A1 (en) * 2005-06-24 2010-07-08 Novozymes A/S Mutant Cells Suitable for Recombinant Polypeptide Production
CN100999742B (zh) * 2007-01-09 2011-05-11 清华大学 一种发酵生产1,3-丙二醇的高产工艺
EP2285823B2 (de) 2008-06-09 2024-03-06 Danisco US Inc. Rückgewinnung von unlöslichem enzym aus einer fermentationsbrühe und formulierung des unlöslichen enzyms
CN104480152B (zh) * 2014-11-20 2017-09-01 武汉华士特工业生物技术开发有限公司 一种提高裂殖壶菌油脂中二十二碳六烯酸含量的方法
CN111465680A (zh) * 2017-11-29 2020-07-28 巴斯夫欧洲公司 组合物、其制备和用途
US12146171B2 (en) 2019-06-13 2024-11-19 Basf Se Method of recovering a protein from fermentation broth using a divalent cation

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3111459A (en) * 1959-10-19 1963-11-19 Ajinomoto Kk Method for preparation of inosine
US3222257A (en) * 1961-04-19 1965-12-07 Ajinomoto Kk Process for producing nucleosides by microorganisms
GB1001173A (en) * 1962-10-22 1965-08-11 Miles Lab Process for the production of galactose oxidase
GB1296839A (de) 1969-05-29 1972-11-22
GB1372034A (en) 1970-12-31 1974-10-30 Unilever Ltd Detergent compositions
US3951937A (en) * 1973-12-20 1976-04-20 The Community Blood Council Of Greater New York, Inc. Large scale purification of hepatitis type B antigen using polyethylene glycol
DE2512735A1 (de) * 1975-03-22 1976-09-30 Henkel & Cie Gmbh Verfahren zur gewinnung von proteinen aus waessrigen protein- loesungen
US4069216A (en) * 1975-06-16 1978-01-17 Edward Shanbrom, Inc. Simplified methods for preparation of very high purity Factor VIII concentrate
JPS5953038B2 (ja) * 1979-04-07 1984-12-22 メルシャン株式会社 サイクロデキストリンの製造法
DD153495A3 (de) * 1979-07-03 1982-01-13 Petrolchemisches Kombinat Hilfsstoffkombination zur verbesserung mikrobiologischer verfahren
DK187280A (da) 1980-04-30 1981-10-31 Novo Industri As Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode
JPS6030682A (ja) * 1983-07-30 1985-02-16 Amano Pharmaceut Co Ltd β−アミラ−ゼの製造法
US4588691A (en) * 1984-02-29 1986-05-13 Johal Sarjit S Method for preparation of Fraction I protein and by-products thereof
US4673647A (en) * 1985-05-06 1987-06-16 Miles Laboratories, Inc. Process to solubilize enzymes and an enzyme liquid product produced thereby
JPH0697997B2 (ja) 1985-08-09 1994-12-07 ギスト ブロカデス ナ−ムロ−ゼ フエンノ−トチヤツプ 新規の酵素的洗浄剤添加物
US4728613A (en) * 1985-09-04 1988-03-01 Miles Laboratories, Inc. Method for the recovery of extracellular enzymes from whole fermentation beer
DE3750450T2 (de) 1986-08-29 1995-01-05 Novo Industri As Enzymhaltiger Reinigungsmittelzusatz.
NZ221627A (en) 1986-09-09 1993-04-28 Genencor Inc Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios
EP0305216B1 (de) 1987-08-28 1995-08-02 Novo Nordisk A/S Rekombinante Humicola-Lipase und Verfahren zur Herstellung von rekombinanten Humicola-Lipasen
JPS6474992A (en) 1987-09-16 1989-03-20 Fuji Oil Co Ltd Dna sequence, plasmid and production of lipase
DK6488D0 (da) 1988-01-07 1988-01-07 Novo Industri As Enzymer
DE68924654T2 (de) 1988-01-07 1996-04-04 Novonordisk As Spezifische Protease.
CH667673A5 (en) * 1988-01-22 1988-10-31 Eidgenoess Tech Hochschule Prodn. of fermentation broth with lignolytic activity - by growing fungi under nutrient limited conditions in stirred reactor and in presence of cell wall stabiliser
JP3079276B2 (ja) 1988-02-28 2000-08-21 天野製薬株式会社 組換え体dna、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法
US5648263A (en) 1988-03-24 1997-07-15 Novo Nordisk A/S Methods for reducing the harshness of a cotton-containing fabric
JP2728531B2 (ja) 1988-03-24 1998-03-18 ノボ ノルディスク アクティーゼルスカブ セルラーゼ調製品
US5260202A (en) * 1988-09-07 1993-11-09 Delta Biotechnology Limited Fermentation method
GB8915658D0 (en) 1989-07-07 1989-08-23 Unilever Plc Enzymes,their production and use
KR100236540B1 (ko) 1990-04-14 2000-01-15 레클로우크스 라우에르 알카리성 바실러스-리파제, 이를 코-딩하는 dna 서열 및 리파제를 생산하는 바실러스 균주
DK115890D0 (da) 1990-05-09 1990-05-09 Novo Nordisk As Enzym
DK0531372T4 (da) 1990-05-09 2004-08-09 Novozymes As Cellulasepræparat omfattende et endoglucanaseenzym
AU657278B2 (en) 1990-09-13 1995-03-09 Novo Nordisk A/S Lipase variants
ES2174820T3 (es) 1991-01-16 2002-11-16 Procter & Gamble Composiciones detergentes compactas con celulasa de alta actividad.
ES2121014T3 (es) 1991-05-01 1998-11-16 Novo Nordisk As Enzimas estabilizadas y composiciones detergentes.
US5371198A (en) * 1991-12-16 1994-12-06 Novo Nordisk A/S Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
EP0571014B1 (de) * 1992-05-18 2004-03-31 Genencor International, Inc. Alkalische Proteasen produzierende Bakterien, und Verfahren zur Herstellung dieser alkalischen Proteasen
DK88892D0 (da) 1992-07-06 1992-07-06 Novo Nordisk As Forbindelse
WO1994002597A1 (en) 1992-07-23 1994-02-03 Novo Nordisk A/S MUTANT α-AMYLASE, DETERGENT, DISH WASHING AGENT, AND LIQUEFACTION AGENT
JP3254457B2 (ja) * 1992-09-18 2002-02-04 株式会社日立製作所 無給油式スクリュー圧縮機のロータ形成方法およびそのロータを用いた無給油式スクリュー圧縮機
ATE262035T1 (de) 1992-10-06 2004-04-15 Novozymes As Zellulosevarianten
PT867504E (pt) 1993-02-11 2003-08-29 Genencor Int Alfa-amilase estavel a oxidacao
KR950702240A (ko) 1993-04-27 1995-06-19 한스 발터 라벤 세제로의 이용을 위한 새로운 리파제 변형체
DK52393D0 (de) 1993-05-05 1993-05-05 Novo Nordisk As
US5443981A (en) * 1993-06-09 1995-08-22 Rutgers, The State University Acremonium typhinum ATCC 74228 which exhibits endoproteolytic activity
JP2859520B2 (ja) 1993-08-30 1999-02-17 ノボ ノルディスク アクティーゼルスカブ リパーゼ及びそれを生産する微生物及びリパーゼ製造方法及びリパーゼ含有洗剤組成物
JPH07143883A (ja) 1993-11-24 1995-06-06 Showa Denko Kk リパーゼ遺伝子及び変異体リパーゼ
DE69527835T2 (de) 1994-02-22 2003-04-10 Novozymes A/S, Bagsvaerd Methode zur herstellung einer variante eines lipolytischen enzymes
DE69536145D1 (de) 1994-03-08 2011-04-07 Novozymes As Neuartige alkalische Zellulasen
US5824531A (en) 1994-03-29 1998-10-20 Novid Nordisk Alkaline bacilus amylase
WO1995030744A2 (en) 1994-05-04 1995-11-16 Genencor International Inc. Lipases with improved surfactant resistance
WO1995035381A1 (en) 1994-06-20 1995-12-28 Unilever N.V. Modified pseudomonas lipases and their use
AU2884695A (en) 1994-06-23 1996-01-19 Unilever Plc Modified pseudomonas lipases and their use
DE69535733T2 (de) 1994-10-06 2009-04-23 Novozymes A/S Ein enzympräparat mit endoglucanase aktivität
BE1008998A3 (fr) 1994-10-14 1996-10-01 Solvay Lipase, microorganisme la produisant, procede de preparation de cette lipase et utilisations de celle-ci.
US5827719A (en) 1994-10-26 1998-10-27 Novo Nordisk A/S Enzyme with lipolytic activity
AR000862A1 (es) 1995-02-03 1997-08-06 Novozymes As Variantes de una ó-amilasa madre, un metodo para producir la misma, una estructura de adn y un vector de expresion, una celula transformada por dichaestructura de adn y vector, un aditivo para detergente, composicion detergente, una composicion para lavado de ropa y una composicion para la eliminacion del
JPH08228778A (ja) 1995-02-27 1996-09-10 Showa Denko Kk 新規なリパーゼ遺伝子及びそれを用いたリパーゼの製造方法
CN102080070B (zh) 1995-03-17 2016-01-20 诺沃奇梅兹有限公司 新的内切葡聚糖酶
EP0839186B1 (de) 1995-07-14 2004-11-10 Novozymes A/S Modifiziertes enzym mit lipolytischer aktivität
AU6655196A (en) 1995-08-11 1997-03-12 Novo Nordisk A/S Novel lipolytic enzymes
US5763385A (en) 1996-05-14 1998-06-09 Genencor International, Inc. Modified α-amylases having altered calcium binding properties
US5616693A (en) * 1996-07-01 1997-04-01 Alpha Therapeutic Corporation Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste
AU3938997A (en) 1996-08-26 1998-03-19 Novo Nordisk A/S A novel endoglucanase
EP1726644A1 (de) 1996-09-17 2006-11-29 Novozymes A/S Zellulase Varianten
EP0932667B1 (de) 1996-11-04 2008-10-01 Novozymes A/S Subtilase varianten und verbindungen
JP4044143B2 (ja) 1996-11-04 2008-02-06 ノボザイムス アクティーゼルスカブ ズブチラーゼ変異体及び組成物
WO1998034946A1 (en) 1997-02-12 1998-08-13 Massachusetts Institute Of Technology Daxx, a novel fas-binding protein that activates jnk and apoptosis
CZ299290B6 (cs) 1997-02-20 2008-06-11 Dsm Ip Assets B.V. Zpusob výroby beta-laktamové slouceniny, zpusob prípravy a/nebo zlepšení vláknitého mikrobiálního kmene a použití chemicky definovaného fermentacníhomédia
EP1002061A1 (de) 1997-07-04 2000-05-24 Novo Nordisk A/S Varianten der 6 endo-1,4-beta-glukanase und diese enthaldende reinigungszusammensetzungen
JP5571274B2 (ja) 2000-03-08 2014-08-13 ノボザイムス アクティーゼルスカブ 改変された特性を有する変異体
WO2003014339A2 (en) * 2001-08-07 2003-02-20 Novozymes, A/S Carbohydrates and polyols for dissolving protein crystals

Also Published As

Publication number Publication date
US20060127974A1 (en) 2006-06-15
EP1520012A2 (de) 2005-04-06
DE60325731D1 (en) 2009-02-26
CN100529066C (zh) 2009-08-19
AU2003243925A8 (en) 2004-01-19
WO2004003187A2 (en) 2004-01-08
WO2004003187A3 (en) 2004-03-18
EP1520012B1 (de) 2009-01-07
CN1665923A (zh) 2005-09-07
DK1520012T3 (da) 2009-04-27
AU2003243925A1 (en) 2004-01-19

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