ATE420366T1 - ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN - Google Patents

ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN

Info

Publication number
ATE420366T1
ATE420366T1 AT01995216T AT01995216T ATE420366T1 AT E420366 T1 ATE420366 T1 AT E420366T1 AT 01995216 T AT01995216 T AT 01995216T AT 01995216 T AT01995216 T AT 01995216T AT E420366 T1 ATE420366 T1 AT E420366T1
Authority
AT
Austria
Prior art keywords
ßtethering
advanced
approach
quickly
finding ligands
Prior art date
Application number
AT01995216T
Other languages
English (en)
Inventor
Daniel Erlanson
Andrew Braisted
Robert Mcdowell
John Prescott
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE420366T1 publication Critical patent/ATE420366T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Structural Engineering (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Control And Safety Of Cranes (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
AT01995216T 2000-11-21 2001-11-20 ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN ATE420366T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25229400P 2000-11-21 2000-11-21

Publications (1)

Publication Number Publication Date
ATE420366T1 true ATE420366T1 (de) 2009-01-15

Family

ID=22955415

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01995216T ATE420366T1 (de) 2000-11-21 2001-11-20 ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN

Country Status (13)

Country Link
EP (2) EP1441228B1 (de)
JP (2) JP3836791B2 (de)
AT (1) ATE420366T1 (de)
AU (2) AU2573102A (de)
CA (1) CA2430234C (de)
DE (1) DE60137356D1 (de)
DK (1) DK1337853T3 (de)
ES (1) ES2322796T3 (de)
IL (2) IL155926A0 (de)
MX (1) MXPA03004435A (de)
NZ (1) NZ525861A (de)
WO (1) WO2002042773A2 (de)
ZA (1) ZA200303772B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214487B2 (en) * 1998-06-26 2007-05-08 Sunesis Pharmaceuticals, Inc. Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
MXPA04001074A (es) * 2001-08-07 2004-07-08 Sunesis Pharmaceuticals Inc Ligandos de bisulfuro y tiosulfonato y colecciones que comprenden estos ligandos.
NZ532579A (en) * 2001-11-21 2006-11-30 Sunesis Pharmaceuticals Inc Methods for ligand discovery based on tethering process
JP2005534286A (ja) 2002-03-21 2005-11-17 サネシス ファーマシューティカルズ, インコーポレイテッド キナーゼインヒビターの同定
CN1668918A (zh) 2002-07-24 2005-09-14 基德姆生物科学有限公司 药物发现的方法
US7149280B2 (en) 2002-12-23 2006-12-12 Astex Therapeutics Limited Synthesis and screening of ligands using X-ray crystallography
AU2003270848A1 (en) * 2003-09-17 2005-04-27 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors
JP5173193B2 (ja) * 2003-11-14 2013-03-27 スリーエム イノベイティブ プロパティズ カンパニー N−スルホニルアミノカルボニル含有化合物
US8053243B2 (en) 2004-04-12 2011-11-08 The University Of Vermont And State Agricultural College Detection of nitrosylated proteins
EP1824796A4 (de) * 2004-11-16 2010-02-17 Avidia Res Inst Proteingerüste und ihre verwendung
US20080070802A1 (en) * 2006-08-23 2008-03-20 Moerschell Richard P Directed heterobifunctional linkers
US8859731B2 (en) 2010-04-21 2014-10-14 Novo Nordisk A/S Selective modification of proteins
AP2013006706A0 (en) 2010-07-02 2013-02-28 Gilead Sciences Inc Napht-2-ylacetic acid derivatives to treat AIDS
PH12013500015A1 (en) 2010-07-02 2013-02-18 Gilead Sciences Inc 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds
UA111841C2 (uk) 2011-04-21 2016-06-24 Гіліад Сайєнсіз, Інк. Сполуки бензотіазолу та їх фармацевтичне застосування
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
US9096586B2 (en) 2012-04-20 2015-08-04 Gilead Sciences, Inc. Therapeutic compounds
US10782295B2 (en) * 2013-08-13 2020-09-22 The Scripps Research Institute Cysteine-reactive ligand discovery in proteomes
RU2685728C2 (ru) * 2014-01-29 2019-04-23 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Конъюгат лиганд - цитотоксическое лекарственное средство, способ его получения и его применения
AU2016218840A1 (en) * 2015-02-15 2017-08-31 Jiangsu Hengrui Medicine Co., Ltd. Ligand-cytotoxicity drug conjugate, preparing method therefor, and application thereof
JP6953400B2 (ja) * 2015-10-22 2021-10-27 ザ スクリプス リサーチ インスティテュート システイン反応性プローブとその使用
GB201614152D0 (en) 2016-08-18 2016-10-05 Imp Innovations Ltd Assay
WO2018136555A2 (en) 2017-01-18 2018-07-26 The Scripps Research Institute Photoreactive ligands and uses thereof
US20180372751A1 (en) * 2017-06-23 2018-12-27 The Scripps Research Institute Lysine reactive probes and uses thereof
JP7805983B2 (ja) 2022-03-22 2026-01-26 アッヴィ・インコーポレイテッド ブルトン型チロシンキナーゼを分解するためのピリミジン

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011436A1 (en) * 1996-09-13 1998-03-19 Whitehead Institute For Biomedical Research Non-specific affinity enhancement to identify combinatorial library members
US6344330B1 (en) * 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
US6335155B1 (en) * 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules

Also Published As

Publication number Publication date
IL155926A0 (en) 2003-12-23
EP1441228A1 (de) 2004-07-28
HK1063844A1 (en) 2005-01-14
DE60137356D1 (de) 2009-02-26
ZA200303772B (en) 2004-05-17
WO2002042773B1 (en) 2002-12-12
CA2430234C (en) 2008-02-12
JP3836791B2 (ja) 2006-10-25
DK1337853T3 (da) 2009-05-04
EP1337853B1 (de) 2009-01-07
EP1441228B1 (de) 2006-06-28
MXPA03004435A (es) 2005-01-25
AU2002225731B2 (en) 2005-04-14
WO2002042773A2 (en) 2002-05-30
JP2004514891A (ja) 2004-05-20
WO2002042773A3 (en) 2002-11-14
ES2322796T3 (es) 2009-06-29
JP2006113077A (ja) 2006-04-27
NZ525861A (en) 2004-09-24
CA2430234A1 (en) 2002-05-30
AU2573102A (en) 2002-06-03
IL155926A (en) 2009-06-15
EP1337853A2 (de) 2003-08-27

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