ATE420366T1 - ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN - Google Patents

ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN

Info

Publication number
ATE420366T1
ATE420366T1 AT01995216T AT01995216T ATE420366T1 AT E420366 T1 ATE420366 T1 AT E420366T1 AT 01995216 T AT01995216 T AT 01995216T AT 01995216 T AT01995216 T AT 01995216T AT E420366 T1 ATE420366 T1 AT E420366T1
Authority
AT
Austria
Prior art keywords
ßtethering
advanced
approach
quickly
finding ligands
Prior art date
Application number
AT01995216T
Other languages
English (en)
Inventor
Daniel Erlanson
Andrew Braisted
Robert Mcdowell
John Prescott
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE420366T1 publication Critical patent/ATE420366T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Structural Engineering (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Control And Safety Of Cranes (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
AT01995216T 2000-11-21 2001-11-20 ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN ATE420366T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25229400P 2000-11-21 2000-11-21

Publications (1)

Publication Number Publication Date
ATE420366T1 true ATE420366T1 (de) 2009-01-15

Family

ID=22955415

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01995216T ATE420366T1 (de) 2000-11-21 2001-11-20 ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN

Country Status (13)

Country Link
EP (2) EP1441228B1 (de)
JP (2) JP3836791B2 (de)
AT (1) ATE420366T1 (de)
AU (2) AU2002225731B2 (de)
CA (1) CA2430234C (de)
DE (1) DE60137356D1 (de)
DK (1) DK1337853T3 (de)
ES (1) ES2322796T3 (de)
IL (2) IL155926A0 (de)
MX (1) MXPA03004435A (de)
NZ (1) NZ525861A (de)
WO (1) WO2002042773A2 (de)
ZA (1) ZA200303772B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US7214487B2 (en) 1998-06-26 2007-05-08 Sunesis Pharmaceuticals, Inc. Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates
IL159983A0 (en) * 2001-08-07 2004-06-20 Sunesis Pharmaceuticals Inc Disulfide and thiosulfonate ligands and libraries comprising these ligands
MXPA04004814A (es) * 2001-11-21 2004-08-11 Sunesis Pharmaceuticals Inc Metodos para descubrir ligandos.
WO2003081210A2 (en) 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors
US8019550B2 (en) 2002-07-24 2011-09-13 Keddem Bioscience Ltd. Drug discovery method
ATE354096T1 (de) 2002-12-23 2007-03-15 Astex Therapeutics Ltd Synthese und screening von liganden mit hilfe von röntgenkristallographie
EP1670422A4 (de) * 2003-09-17 2007-08-01 Sunesis Pharmaceuticals Inc Identifizierung von kinase-inhibitoren
WO2005049590A2 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company N-sulfonylaminocarbonyl containing compounds
WO2005101019A2 (en) * 2004-04-12 2005-10-27 University Of Vermont And State Agricultural College Detection of nitrosylated proteins
US20060234299A1 (en) * 2004-11-16 2006-10-19 Avidia Research Institute Protein scaffolds and uses thereof
US20080070802A1 (en) * 2006-08-23 2008-03-20 Moerschell Richard P Directed heterobifunctional linkers
CN102939110A (zh) 2010-04-21 2013-02-20 诺沃—诺迪斯克有限公司 蛋白质的选择性修饰
MX2012015097A (es) 2010-07-02 2013-05-28 Gilead Sciences Inc Derivados de acido naft-2-ilacetico para tratar sida.
EP2588455B1 (de) 2010-07-02 2018-04-04 Gilead Sciences, Inc. 2-quinolinyl-essigsäure derivate als hiv antivirale verbindungen
UA111841C2 (uk) 2011-04-21 2016-06-24 Гіліад Сайєнсіз, Інк. Сполуки бензотіазолу та їх фармацевтичне застосування
US9284323B2 (en) 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
UY34750A (es) 2012-04-20 2013-11-29 Gilead Sciences Inc ?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?.
US10782295B2 (en) 2013-08-13 2020-09-22 The Scripps Research Institute Cysteine-reactive ligand discovery in proteomes
US10562977B2 (en) * 2014-01-29 2020-02-18 Shanghai Hengrui Pharmaceutical Co., Ltd. Ligand-cytotoxic drug conjugate, preparation method thereof, and uses thereof
WO2016127790A1 (zh) * 2015-02-15 2016-08-18 江苏恒瑞医药股份有限公司 配体-细胞毒性药物偶联物、其制备方法及其应用
EP3365686A4 (de) * 2015-10-22 2019-03-27 The Scripps Research Institute Reaktive cysteinsonden und verwendungen davon
GB201614152D0 (en) 2016-08-18 2016-10-05 Imp Innovations Ltd Assay
US11535597B2 (en) 2017-01-18 2022-12-27 The Scripps Research Institute Photoreactive ligands and uses thereof
US20180372751A1 (en) * 2017-06-23 2018-12-27 The Scripps Research Institute Lysine reactive probes and uses thereof
JP7805983B2 (ja) 2022-03-22 2026-01-26 アッヴィ・インコーポレイテッド ブルトン型チロシンキナーゼを分解するためのピリミジン

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011436A1 (en) * 1996-09-13 1998-03-19 Whitehead Institute For Biomedical Research Non-specific affinity enhancement to identify combinatorial library members
US6344330B1 (en) * 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
US6335155B1 (en) * 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules

Also Published As

Publication number Publication date
NZ525861A (en) 2004-09-24
EP1441228B1 (de) 2006-06-28
EP1337853A2 (de) 2003-08-27
EP1441228A1 (de) 2004-07-28
JP2004514891A (ja) 2004-05-20
WO2002042773A2 (en) 2002-05-30
IL155926A (en) 2009-06-15
JP3836791B2 (ja) 2006-10-25
MXPA03004435A (es) 2005-01-25
WO2002042773B1 (en) 2002-12-12
JP2006113077A (ja) 2006-04-27
IL155926A0 (en) 2003-12-23
CA2430234A1 (en) 2002-05-30
HK1063844A1 (en) 2005-01-14
AU2573102A (en) 2002-06-03
WO2002042773A3 (en) 2002-11-14
ZA200303772B (en) 2004-05-17
DE60137356D1 (de) 2009-02-26
ES2322796T3 (es) 2009-06-29
AU2002225731B2 (en) 2005-04-14
CA2430234C (en) 2008-02-12
DK1337853T3 (da) 2009-05-04
EP1337853B1 (de) 2009-01-07

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