ATE42339T1 - Polypeptid- und proteinprodukte und verfahren zu deren herstellung und verwendung. - Google Patents

Polypeptid- und proteinprodukte und verfahren zu deren herstellung und verwendung.

Info

Publication number: ATE42339T1
Authority: AT; Austria
Prior art keywords: polypeptide; fusion protein; calcitonin; cat; manufacture
Prior art date: 1983-05-24

Application number

AT84303517T

Other languages

English (en)

Inventor

Alan David Bennett

Stephen Keith Rhind

Peter Anthony Lowe

Christopher Clive Ga Hentschel

Original Assignee

Celltech Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-24

Filing date

1984-05-24

Publication date

1989-05-15

1984-05-24 Application filed by Celltech Ltd filed Critical Celltech Ltd

1989-05-15 Application granted granted Critical

1989-05-15 Publication of ATE42339T1 publication Critical patent/ATE42339T1/de

Links

229920001184 polypeptide Polymers 0.000 title abstract 5
102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 title abstract 2
102000004169 proteins and genes Human genes 0.000 title abstract 2
108020001507 fusion proteins Proteins 0.000 abstract 4
102000037865 fusion proteins Human genes 0.000 abstract 4
108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 abstract 3
108090000746 Chymosin Proteins 0.000 abstract 2
230000000890 antigenic effect Effects 0.000 abstract 2
102000055006 Calcitonin Human genes 0.000 abstract 1
108060001064 Calcitonin Proteins 0.000 abstract 1
239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
241000710198 Foot-and-mouth disease virus Species 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
238000001042 affinity chromatography Methods 0.000 abstract 1
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
229960004015 calcitonin Drugs 0.000 abstract 1
229940080701 chymosin Drugs 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
229960000258 corticotropin Drugs 0.000 abstract 1
229940088598 enzyme Drugs 0.000 abstract 1
239000000122 growth hormone Substances 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
230000002163 immunogen Effects 0.000 abstract 1
239000004026 insulin derivative Substances 0.000 abstract 1
GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 abstract 1
108010064037 prorennin Proteins 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12N9/1033—Chloramphenicol O-acetyltransferase (2.3.1.28)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Toxicology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Endocrinology (AREA)
Immunology (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT84303517T 1983-05-24 1984-05-24 Polypeptid- und proteinprodukte und verfahren zu deren herstellung und verwendung. ATE42339T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB838314362A GB8314362D0 (en)	1983-05-24	1983-05-24	Polypeptide and protein products
EP84303517A EP0131363B1 (de)	1983-05-24	1984-05-24	Polypeptid- und Proteinprodukte und Verfahren zu deren Herstellung und Verwendung

Publications (1)

Publication Number	Publication Date
ATE42339T1 true ATE42339T1 (de)	1989-05-15

Family

ID=10543274

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT84303517T ATE42339T1 (de)	1983-05-24	1984-05-24	Polypeptid- und proteinprodukte und verfahren zu deren herstellung und verwendung.

Country Status (8)

Country	Link
US (1)	US5093241A (de)
EP (1)	EP0131363B1 (de)
JP (1)	JPH0638755B2 (de)
AT (1)	ATE42339T1 (de)
CA (1)	CA1306207C (de)
DE (1)	DE3477810D1 (de)
GB (1)	GB8314362D0 (de)
WO (1)	WO1984004756A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8412517D0 (en) *	1984-05-16	1984-06-20	Nagai K	Recombinant fusion proteins
US5342921A (en) *	1985-03-28	1994-08-30	Chiron Corporation	Superoxide dismutase fusion polypeptides for expression of mammalian proteins
US4751180A (en) *	1985-03-28	1988-06-14	Chiron Corporation	Expression using fused genes providing for protein product
CA1260858A (en) *	1985-03-28	1989-09-26	Lawrence S. Cousens	Expression using fused genes providing for protein product
DE3686365T3 (de)	1985-06-20	2000-07-27	Fujisawa Pharmaceutical Co., Ltd.	Herstellungsverfahren für humanes atriales natriuretisches Polypeptid.
WO1987002385A1 (en) *	1985-10-11	1987-04-23	Genetics Institute, Inc.	Method for producing heterologous proteins
EP0231883B1 (de) *	1986-01-31	1992-09-02	Sagami Chemical Research Center	Hybrides Plasminogenaktivatorähnliches Polypeptid
SE8601940D0 (sv) *	1986-04-25	1986-04-25	Kabigen Ab	Preparation of fused proteins, antibodies and processes therefor
US4859609A (en) *	1986-04-30	1989-08-22	Genentech, Inc.	Novel receptors for efficient determination of ligands and their antagonists or agonists
US5215896A (en) *	1987-03-20	1993-06-01	Creative Biomolecules, Inc.	Leader sequences for the production of recombinant proteins
US5013653A (en) *	1987-03-20	1991-05-07	Creative Biomolecules, Inc.	Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
FR2615528B1 (fr) *	1987-05-18	1991-05-24	Pasteur Institut	Procede de production d'un polypeptide ayant des proprietes choisies determinees, dans un organisme-hote transforme par un adn recombinant contenant des sequences nucleiques codant pour ce polypeptide et pour une proteine affine d'ose
DE3731875A1 (de) *	1987-09-18	1989-03-30	Schering Ag	Gentechnische herstellung von neukombinierten plasmiden fuer die produktion von humanem adrenocorticotropen horman (acth) und davon abgeleiteten derivaten durch enzymatische spaltung primaer synthetisierter fusionsproteine
JP2653820B2 (ja) *	1988-03-14	1997-09-17	壽之松尾	アミド化酵素及びその製造方法
WO1990001540A1 (en) *	1988-08-11	1990-02-22	California Biotechnology Inc.	Method for stabilizing heterologous protein expression and vectors for use therein
FI902151A7 (fi) *	1988-08-30	1990-04-27	Applied Res Systems Ars Holding	Yhdistelmä-DNA-fuusioproteiineja hormonierityksen muuttamiseksi
JP2852431B2 (ja) *	1988-12-07	1999-02-03	財団法人阪大微生物病研究会	レトロウイルスのプロテアーゼ、逆転写酵素及びエンドヌクレアーゼ、並びにこれ等の酵素の製法
AU5355790A (en) *	1989-04-19	1990-11-16	Cetus Corporation	Multifunctional m-csf proteins and genes encoding therefor
DE69032484D1 (de) *	1989-10-27	1998-08-20	Arch Dev Corp	Zusammensetzungen und deren verwendung zur förderung der immunopotentiation
EP0485611B1 (de) *	1990-05-28	1999-03-17	The Research Foundation For Microbial Diseases Of Osaka University	Herstellungsverfahren für ein plasmid mit fähigkeiten zu expression und prozessierung nach translation eines retroviralen gens, so erhaltenes plasmid und dessen expressionsprodukt
US5595887A (en) *	1990-07-16	1997-01-21	Bionebraska, Inc.	Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment
EP0645454A3 (de) *	1993-06-22	1997-01-15	Vladimir Glebovich Lunin	Chimäres Somatostatin enthaltendes Protein und kodierende DNA, Immunogen-Zusammensetzungen und Verfahren zur Erhöhung des Produktions von Farmtieren.
AU4415796A (en) *	1994-12-07	1996-06-26	Bionebraska, Inc.	Production of c-terminal amidated peptides from recombinant protein constructs
US5962270A (en)	1996-02-06	1999-10-05	Bionebraska, Inc.	Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs
EP1714972B1 (de) *	1998-07-10	2011-10-19	Scios, Inc.	Verfahren zur Herstellung eines Peptids mit einem pI grösser als 8 oder kleiner als 5
US20030190740A1 (en) *	1998-10-13	2003-10-09	The University Of Georgia Research Foundation, Inc	Stabilized bioactive peptides and methods of identification, synthesis, and use
KR20020002354A (ko)	1998-10-13	2002-01-09	추후제출	안정화된 생활성 펩티드 및 이들을 동정, 합성 및이용하는 방법
US6461834B1 (en)	1998-11-06	2002-10-08	Bionebraska, Inc.	Clostripain catalyzed amidation of peptides
DE60017211T2 (de)	1999-02-17	2005-06-02	Pfizer Products Inc., Groton	Fusionsproteine mit Trägern welche eine doppelte Immunantwort induzieren
WO2003099854A2 (en) *	2002-05-24	2003-12-04	Nps Allelix Corp.	Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
AR062711A1 (es) *	2006-09-08	2008-11-26	Wyeth Corp	Lavado de arginina en l a purificacion de proteinas usando cromatografia de afinidad
EP2164868B1 (de)	2007-05-04	2015-03-25	Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA	Gentechnisch gewonnene variable domänen von kaninchen-antikörpern und deren verwendung
CA2880764C (en)	2012-08-03	2022-08-30	Foundation Medicine, Inc.	Human papilloma virus as predictor of cancer prognosis
WO2014169274A2 (en)	2013-04-12	2014-10-16	Yale University	Modified proteins and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4411994A (en) *	1978-06-08	1983-10-25	The President And Fellows Of Harvard College	Protein synthesis
CA1200773A (en) *	1980-02-29	1986-02-18	William J. Rutter	Expression linkers
EP0070675A1 (de) *	1981-07-15	1983-01-26	Celltech Therapeutics Limited	Strukturiertes Gen für die Polyprotein-vorstufe des menschlichen Calcitonins

1983
- 1983-05-24 GB GB838314362A patent/GB8314362D0/en active Pending
1984
- 1984-05-24 WO PCT/GB1984/000179 patent/WO1984004756A1/en not_active Ceased
- 1984-05-24 JP JP50233884A patent/JPH0638755B2/ja not_active Expired - Lifetime
- 1984-05-24 EP EP84303517A patent/EP0131363B1/de not_active Expired
- 1984-05-24 AT AT84303517T patent/ATE42339T1/de not_active IP Right Cessation
- 1984-05-24 DE DE8484303517T patent/DE3477810D1/de not_active Expired
- 1984-05-24 CA CA000455032A patent/CA1306207C/en not_active Expired - Lifetime
1988
- 1988-09-23 US US07/250,962 patent/US5093241A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0131363B1 (de)	1989-04-19
US5093241A (en)	1992-03-03
GB8314362D0 (en)	1983-06-29
JPS60501391A (ja)	1985-08-29
DE3477810D1 (en)	1989-05-24
CA1306207C (en)	1992-08-11
EP0131363A1 (de)	1985-01-16
WO1984004756A1 (en)	1984-12-06
JPH0638755B2 (ja)	1994-05-25

Legal Events

Date	Code	Title	Description
1989-09-15	UEP	Publication of translation of european patent specification
1995-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3477810D1 (en)	1989-05-24	Polypeptide and protein products, and processes for their production and use
ATE123520T1 (de)	1995-06-15	Kex2-endoprotease und verfahren zu ihrer herstellung.
ATE124456T1 (de)	1995-07-15	Verfahren zur enzymatischen spaltung rekombinanter proteine unter verwendung von iga- proteasen.
ATE182173T1 (de)	1999-07-15	Hormon-rezeptor-verbindungen und methoden
DE3669175D1 (de)	1990-04-05	Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung.
FI880017A0 (fi)	1988-01-05	Menetelmä haiman erittämän trypsiini-inhibiittorivarianttien valmistamiseksi ja menetelmässä käytettävä DNA, vektori ja isäntäsolu
DK217985D0 (da)	1985-05-15	Rekombinant-fusionsproteiner
ATE364703T1 (de)	2007-07-15	Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
ATE30246T1 (de)	1987-10-15	Verfahren zur herstellung reifer proteine aus schmelzproteinen hergestellt in pro- oder eukaryotischen zellen.
ES2083352T3 (es)	1996-04-16	Produccion de proteinas activas que contienen residuos de cisteina.
EP0243333A3 (de)	1988-06-15	Herstellung von Fusionsproteinen, Antikörper und Verfahren dazu
FI830813A0 (fi)	1983-03-10	Foerfarande foer omvandling av pre-proinsulinanaloger till insulin
DK383984A (da)	1985-02-11	Fremgangsmaade til fremstilling af sekretin
FI885328A7 (fi)	1989-05-21	Menetelmä fuusioproteiinien selektiiviseksi lohkaisemiseksi
NO894362D0 (no)	1989-11-02	Fremgangsmaate for selektiv spaltning av fusjonsproteiner.
ATE110775T1 (de)	1994-09-15	Verfahren zur herstellung von hirudin.
KR100312455B1 (ko)	2001-11-03	공유적 결합을 이용한 고정화 유로키나제의 제조방법
KR100289500B1 (ko)	2001-05-02	반공유적 결합을 이용한 고정화 유로키나제의 제조방법
FI97239C (fi)	1996-11-11	Menetelmä fuusioproteiinin valmistamiseksi
JPS6091987A (ja)	1985-05-23	特定の蛋白質の過剰生産を指示する発現プラスミド
FI901219A0 (fi)	1990-03-12	Artificiell gen, som kodar foer autentiskt maenskligt serumalbumin, dess anvaendning och foerfarande foer framstaellning daerav.