BRPI0411068B8 - análogos de colchicosídeos - Google Patents

análogos de colchicosídeos

Info

Publication number: BRPI0411068B8
Authority: BR; Brazil
Prior art keywords: colchicoside; analogues; colchicine; inflammatory; formula
Prior art date: 2003-06-06

Application number

BRPI0411068A

Other languages

English (en)

Portuguese (pt)

Inventor

Bombardelli Ezio

Fontana Gabriele

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-06

Filing date

2004-05-26

Publication date

2021-05-25

2004-05-26 Application filed by Indena Spa filed Critical Indena Spa

2006-08-01 Publication of BRPI0411068A publication Critical patent/BRPI0411068A/pt

2017-12-26 Publication of BRPI0411068B1 publication Critical patent/BRPI0411068B1/pt

2021-05-25 Publication of BRPI0411068B8 publication Critical patent/BRPI0411068B8/pt

Links

UXAFRQPVHYZDED-ZZEDUEFDSA-N Colchicoside Chemical class C1([C@@H](NC(C)=O)CCC2=C3)=CC(=O)C(OC)=CC=C1C2=C(OC)C(OC)=C3O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UXAFRQPVHYZDED-ZZEDUEFDSA-N 0.000 title abstract 2
230000003110 anti-inflammatory effect Effects 0.000 abstract 2
IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 abstract 1
UXAFRQPVHYZDED-UHFFFAOYSA-N Colchicoside Natural products C1=C2CCC(NC(C)=O)C3=CC(=O)C(OC)=CC=C3C2=C(OC)C(OC)=C1OC1OC(CO)C(O)C(O)C1O UXAFRQPVHYZDED-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
229940045695 antineooplastic colchicine derivative Drugs 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
JRRUSQGIRBEMRN-HNNXBMFYSA-N n-[(7s)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical group O=C1C(OC)=CC=C2C3=C(OC)C(OC)=C(O)C=C3CC[C@H](NC(C)=O)C2=C1 JRRUSQGIRBEMRN-HNNXBMFYSA-N 0.000 abstract 1
PKYOHQGXPPVIGD-HNNXBMFYSA-N n-[(7s)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical compound O=C1C(SC)=CC=C2C3=C(OC)C(OC)=C(O)C=C3CC[C@H](NC(C)=O)C2=C1 PKYOHQGXPPVIGD-HNNXBMFYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/248—Colchicine radicals, e.g. colchicosides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Physical Education & Sports Medicine (AREA)
Biochemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BRPI0411068A 2003-06-06 2004-05-26 análogos de colchicosídeos BRPI0411068B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT001144A ITMI20031144A1 (it)	2003-06-06	2003-06-06	Analoghi del colchicoside.
ITMI2003A001144		2003-06-06
PCT/EP2004/005645 WO2004111068A1 (en)	2003-06-06	2004-05-26	Colchicoside analogues

Publications (3)

Publication Number	Publication Date
BRPI0411068A BRPI0411068A (pt)	2006-08-01
BRPI0411068B1 BRPI0411068B1 (pt)	2017-12-26
BRPI0411068B8 true BRPI0411068B8 (pt)	2021-05-25

Family

ID=30131160

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0411068A BRPI0411068B8 (pt)	2003-06-06	2004-05-26	análogos de colchicosídeos

Country Status (23)

Country	Link
US (1)	US7683163B2 (de)
EP (1)	EP1631574B1 (de)
JP (1)	JP4718449B2 (de)
KR (1)	KR101121374B1 (de)
CN (1)	CN100348605C (de)
AT (1)	ATE425174T1 (de)
AU (1)	AU2004247346B2 (de)
BR (1)	BRPI0411068B8 (de)
CA (1)	CA2528223C (de)
CY (1)	CY1109019T1 (de)
DE (1)	DE602004019914D1 (de)
DK (1)	DK1631574T3 (de)
ES (1)	ES2321838T3 (de)
IL (1)	IL172358A (de)
IT (1)	ITMI20031144A1 (de)
MX (1)	MXPA05013161A (de)
NO (1)	NO330964B1 (de)
NZ (1)	NZ543943A (de)
PL (1)	PL1631574T3 (de)
PT (1)	PT1631574E (de)
RU (1)	RU2343157C2 (de)
SI (1)	SI1631574T1 (de)
WO (1)	WO2004111068A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20051418A1 (it) *	2005-07-22	2007-01-23	Indena Spa	Analoghi del tiocolchicoside ad attivita'miorilassante e antiinfiammatoria
EP2076525A2 (de)	2006-10-06	2009-07-08	Wisconsin Alumni Research Foundation	Colchicinneoglycoside und verfahren zu ihrer synthese und anwendung
PL2128170T3 (pl) *	2008-05-28	2011-05-31	Indena Spa	Sposób glikozydacji kolchicyny i tiokolchicyny
US8722205B2 (en)	2009-03-23	2014-05-13	Universal Display Corporation	Heteroleptic iridium complex
CN102448930A (zh) *	2009-05-27	2012-05-09	共有药物有限公司	硫代秋水仙碱衍生物、其制造方法和使用方法
EP2830606A4 (de) *	2012-03-30	2015-08-12	Takeda Pharmaceuticals Usa Inc	Colchizinformulierungen, verfahren zur herstellung und verfahren zur verwendung davon
WO2020000109A1 (en)	2018-06-29	2020-01-02	Alberta Health Services	Methods and uses of colchicine derivatives
IT202000014362A1 (it) *	2020-06-16	2021-12-16	Indena Spa	Processo semisintetico per la preparazione di colchicina

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH341831A (fr) *	1955-06-10	1959-10-31	Uclaf Societe Anonyme	Procédé de préparation de produits de condensation de saccharides sur l'azote des N-désacétyl-alcoylthiocolchicéines
GB773729A (en) *	1955-06-10	1957-05-01	Roussel Uclaf	New derivatives of n-deacetylalkylthiocolchiceines and process for their production
JPS5619357B2 (de) *	1972-05-02	1981-05-07
JP2894366B2 (ja) *	1990-12-25	1999-05-24	有限会社尾源研究所	デアセチルコルヒチンの製造方法
AU634921B2 (en) *	1990-12-25	1993-03-04	Ohgen Research Laboratories Ltd.	Deacetylcolchicine derivatives
IT1270124B (it) *	1994-10-05	1997-04-28	Indena Spa	Derivati della colchicina e loro impiego terapeutico
IT1276996B1 (it) *	1995-06-27	1997-11-04	Indena Spa	Derivati della colchicina, loro uso e formulazioni che li contengono
IT1282584B1 (it) *	1996-02-08	1998-03-31	Indena Spa	Processo di glicosidazione di derivati colchicinici e prodotti ottenuti
IT1285777B1 (it) *	1996-10-07	1998-06-18	Indena Spa	Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati
CN1208003A (zh) *	1997-08-08	1999-02-17	韩财元	摆翼式直升飞机
FR2779147B1 (fr) *	1998-05-27	2000-06-30	Synthelabo	Derive de thiocolchicoside sa preparation et son application en therapeutique

2003
- 2003-06-06 IT IT001144A patent/ITMI20031144A1/it unknown
2004
- 2004-05-26 JP JP2006508205A patent/JP4718449B2/ja not_active Expired - Fee Related
- 2004-05-26 AU AU2004247346A patent/AU2004247346B2/en not_active Ceased
- 2004-05-26 PT PT04739355T patent/PT1631574E/pt unknown
- 2004-05-26 ES ES04739355T patent/ES2321838T3/es not_active Expired - Lifetime
- 2004-05-26 BR BRPI0411068A patent/BRPI0411068B8/pt not_active IP Right Cessation
- 2004-05-26 CN CNB2004800156654A patent/CN100348605C/zh not_active Expired - Lifetime
- 2004-05-26 US US10/559,462 patent/US7683163B2/en not_active Expired - Lifetime
- 2004-05-26 SI SI200431102T patent/SI1631574T1/sl unknown
- 2004-05-26 CA CA2528223A patent/CA2528223C/en not_active Expired - Lifetime
- 2004-05-26 NZ NZ543943A patent/NZ543943A/en unknown
- 2004-05-26 EP EP04739355A patent/EP1631574B1/de not_active Expired - Lifetime
- 2004-05-26 DE DE602004019914T patent/DE602004019914D1/de not_active Expired - Lifetime
- 2004-05-26 WO PCT/EP2004/005645 patent/WO2004111068A1/en not_active Ceased
- 2004-05-26 DK DK04739355T patent/DK1631574T3/da active
- 2004-05-26 KR KR1020057023042A patent/KR101121374B1/ko not_active Expired - Fee Related
- 2004-05-26 MX MXPA05013161A patent/MXPA05013161A/es active IP Right Grant
- 2004-05-26 RU RU2005137870/04A patent/RU2343157C2/ru active
- 2004-05-26 AT AT04739355T patent/ATE425174T1/de active
- 2004-05-26 PL PL04739355T patent/PL1631574T3/pl unknown
2005
- 2005-12-05 NO NO20055754A patent/NO330964B1/no not_active IP Right Cessation
- 2005-12-05 IL IL172358A patent/IL172358A/en active IP Right Grant
2009
- 2009-05-05 CY CY20091100483T patent/CY1109019T1/el unknown

Also Published As

Publication number	Publication date
HK1090062A1 (zh)	2006-12-15
IL172358A (en)	2012-01-31
BRPI0411068B1 (pt)	2017-12-26
JP4718449B2 (ja)	2011-07-06
MXPA05013161A (es)	2006-03-17
EP1631574B1 (de)	2009-03-11
KR20060057536A (ko)	2006-05-26
CY1109019T1 (el)	2014-07-02
US20070129315A1 (en)	2007-06-07
IL172358A0 (en)	2009-02-11
ITMI20031144A1 (it)	2004-12-07
NO20055754L (no)	2005-12-05
CA2528223C (en)	2011-11-22
SI1631574T1 (sl)	2009-06-30
AU2004247346B2 (en)	2008-12-18
CA2528223A1 (en)	2004-12-23
WO2004111068A1 (en)	2004-12-23
ATE425174T1 (de)	2009-03-15
AU2004247346A1 (en)	2004-12-23
RU2343157C2 (ru)	2009-01-10
DE602004019914D1 (de)	2009-04-23
JP2006527173A (ja)	2006-11-30
DK1631574T3 (da)	2009-05-25
CN100348605C (zh)	2007-11-14
EP1631574A1 (de)	2006-03-08
NO330964B1 (no)	2011-08-29
ITMI20031144A0 (it)	2003-06-06
BRPI0411068A (pt)	2006-08-01
RU2005137870A (ru)	2006-06-10
PT1631574E (pt)	2009-05-05
NZ543943A (en)	2008-09-26
ES2321838T3 (es)	2009-06-12
CN1802383A (zh)	2006-07-12
KR101121374B1 (ko)	2012-03-09
US7683163B2 (en)	2010-03-23
PL1631574T3 (pl)	2009-07-31

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Legal Events

Date	Code	Title	Description
2012-07-03	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2015-12-29	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2017-04-11	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI
2017-05-23	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2017-10-10	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2017-12-26	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2017, OBSERVADAS AS CONDICOES LEGAIS.
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/05/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF
2024-03-19	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 20A ANUIDADE.
2024-07-09	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2776 DE 19-03-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.