ATE426600T1 - 7-phenylpyrazolopyridinverbindungen - Google Patents

7-phenylpyrazolopyridinverbindungen

Info

Publication number: ATE426600T1
Authority: AT; Austria
Prior art keywords: phenylpyrazolopyridine; compounds; compound; äwherein; tetrahydropyranyl
Prior art date: 2002-10-22

Application number

AT03758781T

Other languages

English (en)

Inventor

Shigeki Hibi

Yorihisa Hoshino

Koichi Kikuchi

Kogyoku Shin

Yoshinori Takahashi

Masae Fujisawa

Hisashi Shibata

Mitsuhiro Ino

Original Assignee

Eisai R&D Man Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-22

Filing date

2003-10-22

Publication date

2009-04-15

2003-10-22 Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd

2009-04-15 Application granted granted Critical

2009-04-15 Publication of ATE426600T1 publication Critical patent/ATE426600T1/de

Links

FMVFEDWZIRSTGL-UHFFFAOYSA-N 7-phenyl-1h-pyrazolo[4,3-b]pyridine Chemical class C1=CN=C2C=NNC2=C1C1=CC=CC=C1 FMVFEDWZIRSTGL-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
-1 methoxy, methylthio, ethyl Chemical group 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 abstract 1
102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 abstract 1
230000008485 antagonism Effects 0.000 abstract 1
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Anesthesiology (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Plural Heterocyclic Compounds (AREA)

AT03758781T 2002-10-22 2003-10-22 7-phenylpyrazolopyridinverbindungen ATE426600T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2002306695		2002-10-22
US42107102P	2002-10-25	2002-10-25

Publications (1)

Publication Number	Publication Date
ATE426600T1 true ATE426600T1 (de)	2009-04-15

Family

ID=32179072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03758781T ATE426600T1 (de)	2002-10-22	2003-10-22	7-phenylpyrazolopyridinverbindungen

Country Status (21)

Country	Link
US (2)	US7323569B2 (de)
EP (1)	EP1555265B1 (de)
JP (1)	JP4322211B2 (de)
KR (1)	KR100984085B1 (de)
AT (1)	ATE426600T1 (de)
AU (1)	AU2003275589B2 (de)
BR (1)	BRPI0313976B8 (de)
CA (1)	CA2494574C (de)
CY (1)	CY1110319T1 (de)
DE (1)	DE60326869D1 (de)
DK (1)	DK1555265T3 (de)
ES (1)	ES2322143T3 (de)
MX (1)	MXPA05002185A (de)
NO (1)	NO331294B1 (de)
NZ (1)	NZ538860A (de)
PL (1)	PL213633B1 (de)
PT (1)	PT1555265E (de)
RU (1)	RU2327699C2 (de)
SI (1)	SI1555265T1 (de)
TW (1)	TWI283679B (de)
WO (1)	WO2004037822A1 (de)

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AU2003275589B2 (en) *	2002-10-22	2009-05-28	Eisai R & D Management Co., Ltd.	7-phenyl pyrazolopyridine compounds
AU2005233430B2 (en) *	2004-04-12	2010-11-25	Eisai R & D Management Co., Ltd.	Process for production of pyrazole-fused ring derivatives
MX335993B (es) *	2005-12-30	2016-01-07	Anacor Pharmaceuticals Inc	Moleculas pequeñas que contienen boro.
RU2357729C2 (ru) *	2007-05-21	2009-06-10	Эльвира Ивановна Белобородова	Способ лечения язвенной болезни двенадцатиперстной кишки, осложненной коморбидными тревожно-депрессивными расстройствами
WO2009051210A1 (ja)	2007-10-18	2009-04-23	Eisai R & D Management Co., Ltd.	ピラゾール縮合環誘導体の製造方法
MY152687A (en) *	2008-04-15	2014-10-31	Eisai R&D Man Co Ltd	3-phenylpyrazolo[5,1-b]thiazole compound
JPWO2011043387A1 (ja) *	2009-10-08	2013-03-04	エーザイ・アール・アンド・ディー・マネジメント株式会社	ピラゾロオキサゾール化合物
AR078521A1 (es)	2009-10-08	2011-11-16	Eisai R&D Man Co Ltd	Compuesto pirazolotiazol
AU2013289284B2 (en) *	2012-07-09	2017-03-30	Janssen Pharmaceutica Nv	Inhibitors of phosphodiesterase 10 enzyme
CN108218903B (zh) *	2015-08-14	2020-12-08	南京中硼联康医疗科技有限公司	L-bpa的制备方法

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JP3795305B2 (ja)	1999-07-19	2006-07-12	田辺製薬株式会社	医薬組成物
FR2801308B1 (fr)	1999-11-19	2003-05-09	Oreal	COMPOSITIONS DE TEINTURE DE FIBRES KERATINIQUES CONTENANT DE DES 3-AMINO PYRAZOLO-[1,(-a]-PYRIDINES, PROCEDE DE TEINTURE, NOUVELLES 3-AMINO PYRAZOLO-[1,5-a]-PYRIDINES
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MY129000A (en)	2000-08-31	2007-03-30	Tanabe Seiyaku Co	INHIBITORS OF a4 MEDIATED CELL ADHESION
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AU2003275589B2 (en) *	2002-10-22	2009-05-28	Eisai R & D Management Co., Ltd.	7-phenyl pyrazolopyridine compounds
US7176216B2 (en) *	2002-10-22	2007-02-13	Eisai Co., Ltd.	7-phenylpyrazolopyridine compounds

2003
- 2003-10-22 AU AU2003275589A patent/AU2003275589B2/en not_active Expired
- 2003-10-22 PL PL376132A patent/PL213633B1/pl unknown
- 2003-10-22 AT AT03758781T patent/ATE426600T1/de active
- 2003-10-22 TW TW092129327A patent/TWI283679B/zh not_active IP Right Cessation
- 2003-10-22 DK DK03758781T patent/DK1555265T3/da active
- 2003-10-22 DE DE60326869T patent/DE60326869D1/de not_active Expired - Lifetime
- 2003-10-22 JP JP2004546447A patent/JP4322211B2/ja not_active Expired - Lifetime
- 2003-10-22 SI SI200331567T patent/SI1555265T1/sl unknown
- 2003-10-22 EP EP03758781A patent/EP1555265B1/de not_active Expired - Lifetime
- 2003-10-22 NZ NZ538860A patent/NZ538860A/en not_active IP Right Cessation
- 2003-10-22 MX MXPA05002185A patent/MXPA05002185A/es active IP Right Grant
- 2003-10-22 BR BRPI0313976A patent/BRPI0313976B8/pt not_active IP Right Cessation
- 2003-10-22 KR KR1020057006800A patent/KR100984085B1/ko not_active Expired - Fee Related
- 2003-10-22 US US10/524,662 patent/US7323569B2/en not_active Expired - Lifetime
- 2003-10-22 RU RU2005115504/04A patent/RU2327699C2/ru active
- 2003-10-22 CA CA2494574A patent/CA2494574C/en not_active Expired - Lifetime
- 2003-10-22 PT PT03758781T patent/PT1555265E/pt unknown
- 2003-10-22 ES ES03758781T patent/ES2322143T3/es not_active Expired - Lifetime
- 2003-10-22 WO PCT/JP2003/013490 patent/WO2004037822A1/ja not_active Ceased
2005
- 2005-05-20 NO NO20052443A patent/NO331294B1/no not_active IP Right Cessation
2007
- 2007-09-20 US US11/858,160 patent/US20080076943A1/en not_active Abandoned
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Also Published As

Publication number	Publication date
MXPA05002185A (es)	2005-05-23
DK1555265T3 (da)	2009-06-22
PL213633B1 (pl)	2013-04-30
BRPI0313976B1 (pt)	2018-12-26
SI1555265T1 (sl)	2009-06-30
JPWO2004037822A1 (ja)	2006-02-23
EP1555265A4 (de)	2006-08-02
AU2003275589B2 (en)	2009-05-28
CA2494574A1 (en)	2004-05-06
KR100984085B1 (ko)	2010-09-30
BR0313976A (pt)	2005-07-19
EP1555265A1 (de)	2005-07-20
US20060235011A1 (en)	2006-10-19
HK1081536A1 (zh)	2006-05-19
US20080076943A1 (en)	2008-03-27
BRPI0313976B8 (pt)	2021-05-25
NZ538860A (en)	2006-07-28
JP4322211B2 (ja)	2009-08-26
KR20050070069A (ko)	2005-07-05
DE60326869D1 (de)	2009-05-07
AU2003275589A1 (en)	2004-05-13
RU2005115504A (ru)	2006-01-20
TW200427687A (en)	2004-12-16
US7323569B2 (en)	2008-01-29
NO331294B1 (no)	2011-11-21
RU2327699C2 (ru)	2008-06-27
WO2004037822A1 (ja)	2004-05-06
PT1555265E (pt)	2009-05-12
NO20052443L (no)	2005-07-22
EP1555265B1 (de)	2009-03-25
CA2494574C (en)	2011-05-17
ES2322143T3 (es)	2009-06-17
NO20052443D0 (no)	2005-05-20
CY1110319T1 (el)	2015-01-14
PL376132A1 (en)	2005-12-27
TWI283679B (en)	2007-07-11

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