ATE428721T1 - Verfahren zur herstellung von wachstumshormon und antagonisten davon mit geringeren konzentrationen an isoformen verunreinigungen davon - Google Patents

Verfahren zur herstellung von wachstumshormon und antagonisten davon mit geringeren konzentrationen an isoformen verunreinigungen davon

Info

Publication number: ATE428721T1
Authority: AT; Austria
Prior art keywords: growth hormone; isoform impurities; antagonists; impurities; isoform
Prior art date: 2002-08-28

Application number

AT03799266T

Other languages

English (en)

Inventor

Anurag Rathore

Stephen Lyle

David Steinmeyer

Scott Allen

John Meyer

Denis Boyle

John Buckley

Gary Johnson

Original Assignee

Pharmacia Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-28

Filing date

2003-08-26

Publication date

2009-05-15

2003-08-26 Application filed by Pharmacia Corp filed Critical Pharmacia Corp

2009-05-15 Application granted granted Critical

2009-05-15 Publication of ATE428721T1 publication Critical patent/ATE428721T1/de

Links

102000001708 Protein Isoforms Human genes 0.000 title abstract 6
108010029485 Protein Isoforms Proteins 0.000 title abstract 6
239000012535 impurity Substances 0.000 title abstract 6
108010051696 Growth Hormone Proteins 0.000 title abstract 3
102000018997 Growth Hormone Human genes 0.000 title abstract 3
239000000122 growth hormone Substances 0.000 title abstract 3
239000005557 antagonist Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000010188 recombinant method Methods 0.000 abstract 3
229940122853 Growth hormone antagonist Drugs 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
229920001184 polypeptide Polymers 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
230000003247 decreasing effect Effects 0.000 abstract 1
108700037519 pegvisomant Proteins 0.000 abstract 1
229960002995 pegvisomant Drugs 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Endocrinology (AREA)
Analytical Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT03799266T 2002-08-28 2003-08-26 Verfahren zur herstellung von wachstumshormon und antagonisten davon mit geringeren konzentrationen an isoformen verunreinigungen davon ATE428721T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US40655302P	2002-08-28	2002-08-28
US10/646,798 US20040048315A1 (en)	2002-08-28	2003-08-25	Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
PCT/US2003/026498 WO2004031213A1 (en)	2002-08-28	2003-08-26	Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof

Publications (1)

Publication Number	Publication Date
ATE428721T1 true ATE428721T1 (de)	2009-05-15

Family

ID=31997673

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03799266T ATE428721T1 (de)	2002-08-28	2003-08-26	Verfahren zur herstellung von wachstumshormon und antagonisten davon mit geringeren konzentrationen an isoformen verunreinigungen davon

Country Status (20)

Country	Link
US (2)	US20040048315A1 (de)
EP (1)	EP1546185B1 (de)
JP (1)	JP4312154B2 (de)
KR (1)	KR101176588B1 (de)
AT (1)	ATE428721T1 (de)
AU (1)	AU2003260045B2 (de)
BR (1)	BRPI0313829B1 (de)
CA (1)	CA2497146C (de)
CY (1)	CY1109167T1 (de)
DE (1)	DE60327228D1 (de)
DK (1)	DK1546185T3 (de)
ES (1)	ES2323586T3 (de)
IL (1)	IL167121A (de)
MX (1)	MXPA05002359A (de)
PL (1)	PL211502B1 (de)
PT (1)	PT1546185E (de)
RU (1)	RU2337920C2 (de)
SI (1)	SI1546185T1 (de)
TW (2)	TWI289603B (de)
WO (1)	WO2004031213A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040048315A1 (en)	2002-08-28	2004-03-11	Pharmacia Corporation	Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
ATE463503T1 (de) *	2004-12-29	2010-04-15	Novo Nordisk Healthcare Ag	Verfahren zur verhinderung der bildung von trisulfidderivaten von polypeptiden
EP2483289B2 (de)	2009-10-02	2025-03-26	Biogen MA Inc.	Verfahren zur vorbeugung und entfernung von trisulphid-bindungen
WO2011073235A1 (en) *	2009-12-18	2011-06-23	Csl Ltd.	Method of purifying polypeptides
WO2012158551A1 (en)	2011-05-13	2012-11-22	Biogen Idec Ma Inc.	Methods of preventing and removing trisulfide bonds
JP6116565B2 (ja) *	2011-08-25	2017-04-19	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	陽イオンおよび陰イオン交換クロマトグラフィー法
SG11201700365TA (en)	2014-07-24	2017-02-27	Genentech Inc	Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond
IL314040A (en) *	2016-05-10	2024-09-01	Genentech Inc	Methods of decreasing trisulfide bonds during recombinant production of polypeptides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5153265A (en)	1988-01-20	1992-10-06	Cetus Corporation	Conjugation of polymer to colony stimulating factor-1
US5969109A (en)	1990-02-28	1999-10-19	Bona; Constantin	Chimeric antibodies comprising antigen binding sites and B and T cell epitopes
DK44593D0 (da) *	1993-04-20	1993-04-20	Novo Nordisk As	Fremgangsmaade til fremstilling af et polypeptid
ZA955789B (en) *	1994-07-15	1996-03-11	Novo Nordisk As	A method of converting a hydrophobic derivative of a polypeptide into the native form
DK0851925T3 (da) *	1995-09-21	2005-11-28	Genentech Inc	Humane Væksthormonvarianter
SE9802454D0 (sv) *	1998-07-08	1998-07-08	Pharmacia & Upjohn Ab	Production of peptides
AR026743A1 (es) *	1999-12-09	2003-02-26	Pharmacia Ab	Produccion de peptidos
US7229789B1 (en)	2001-01-19	2007-06-12	N.V. Organon	Methods and compositions for extracting proteins from cells
US20040048315A1 (en)	2002-08-28	2004-03-11	Pharmacia Corporation	Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
US7470779B2 (en) *	2002-09-20	2008-12-30	Pfizer Inc.	Process for decreasing aggregate levels of pegylated protein

2003
- 2003-08-25 US US10/646,798 patent/US20040048315A1/en not_active Abandoned
- 2003-08-26 JP JP2004541486A patent/JP4312154B2/ja not_active Expired - Lifetime
- 2003-08-26 AU AU2003260045A patent/AU2003260045B2/en not_active Expired
- 2003-08-26 RU RU2005109388/13A patent/RU2337920C2/ru active
- 2003-08-26 PL PL374917A patent/PL211502B1/pl unknown
- 2003-08-26 CA CA2497146A patent/CA2497146C/en not_active Expired - Fee Related
- 2003-08-26 EP EP03799266A patent/EP1546185B1/de not_active Expired - Lifetime
- 2003-08-26 AT AT03799266T patent/ATE428721T1/de active
- 2003-08-26 PT PT03799266T patent/PT1546185E/pt unknown
- 2003-08-26 WO PCT/US2003/026498 patent/WO2004031213A1/en not_active Ceased
- 2003-08-26 DK DK03799266T patent/DK1546185T3/da active
- 2003-08-26 SI SI200331584T patent/SI1546185T1/sl unknown
- 2003-08-26 KR KR1020057003458A patent/KR101176588B1/ko not_active Expired - Fee Related
- 2003-08-26 BR BRPI0313829-1A patent/BRPI0313829B1/pt not_active IP Right Cessation
- 2003-08-26 DE DE60327228T patent/DE60327228D1/de not_active Expired - Lifetime
- 2003-08-26 ES ES03799266T patent/ES2323586T3/es not_active Expired - Lifetime
- 2003-08-26 MX MXPA05002359A patent/MXPA05002359A/es active IP Right Grant
- 2003-08-28 TW TW092123686A patent/TWI289603B/zh not_active IP Right Cessation
- 2003-08-28 TW TW095130368A patent/TW200700553A/zh unknown
2005
- 2005-02-27 IL IL167121A patent/IL167121A/en unknown
2009
- 2009-03-17 US US12/405,857 patent/US8148331B2/en not_active Expired - Fee Related
- 2009-06-24 CY CY20091100660T patent/CY1109167T1/el unknown

Also Published As

Publication number	Publication date
TW200407428A (en)	2004-05-16
TW200700553A (en)	2007-01-01
SI1546185T1 (sl)	2009-08-31
EP1546185A1 (de)	2005-06-29
RU2337920C2 (ru)	2008-11-10
US8148331B2 (en)	2012-04-03
CA2497146C (en)	2012-05-22
JP2006517091A (ja)	2006-07-20
KR20050059163A (ko)	2005-06-17
PL211502B1 (pl)	2012-05-31
PL374917A1 (en)	2005-11-14
RU2005109388A (ru)	2005-10-27
US20100021966A1 (en)	2010-01-28
CY1109167T1 (el)	2014-07-02
CA2497146A1 (en)	2004-04-15
ES2323586T3 (es)	2009-07-21
IL167121A (en)	2010-11-30
US20040048315A1 (en)	2004-03-11
JP4312154B2 (ja)	2009-08-12
HK1077074A1 (en)	2006-02-03
PT1546185E (pt)	2009-07-14
WO2004031213A1 (en)	2004-04-15
AU2003260045A1 (en)	2004-04-23
EP1546185B1 (de)	2009-04-15
BRPI0313829B1 (pt)	2021-10-26
BR0313829A (pt)	2005-07-26
DE60327228D1 (de)	2009-05-28
AU2003260045B2 (en)	2010-01-07
DK1546185T3 (da)	2009-06-22
TWI289603B (en)	2007-11-11
KR101176588B1 (ko)	2012-08-23
MXPA05002359A (es)	2005-07-15
EP1546185A4 (de)	2006-09-06

Legal Events

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Title

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2009-12-15

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Publication of translation of european patent specification

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Publication	Publication Date	Title
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