BRPI0410164A - composições e métodos para preparação de mutantes de glicosilação de hormÈnio do crescimento humano - Google Patents

composições e métodos para preparação de mutantes de glicosilação de hormÈnio do crescimento humano

Info

Publication number
BRPI0410164A
BRPI0410164A BRPI0410164-2A BRPI0410164A BRPI0410164A BR PI0410164 A BRPI0410164 A BR PI0410164A BR PI0410164 A BRPI0410164 A BR PI0410164A BR PI0410164 A BRPI0410164 A BR PI0410164A
Authority
BR
Brazil
Prior art keywords
mutants
human growth
methods
growth hormone
compositions
Prior art date
Application number
BRPI0410164-2A
Other languages
English (en)
Inventor
Shawn De Frees
Henrik Clausen
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Publication of BRPI0410164A publication Critical patent/BRPI0410164A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"COMPOSIçõES E MéTODOS PARA A PREPARAçãO DE MUTANTES DE GLICOSILAçãO DE HORMÈNIO DO CRESCIMENTO HUMANO". A presente invenção se relaciona a mutantes de hormónio do crescimento humano, que contêm sítios de glicosilação ligados a N ou ligado a O, recentemente introduzidos, de forma que esses polipeptídeos produzidos de forma recombinante têm padrões de glicosilação distintamente deferentes daqueles do hormónio do crescimento humano de ocorrência natural. As seqüências de codificação de polipeptídeos para os mutantes, cassetes de expressão compreendem as seqüências de codificação, células que expressam os mutantes e métodos para a produção dos mutantes também são revelados. Composições farmacêuticas que compreendem os mutantes e método para uso dos mutantes também são revelados.
BRPI0410164-2A 2003-05-09 2004-05-07 composições e métodos para preparação de mutantes de glicosilação de hormÈnio do crescimento humano BRPI0410164A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US46911403P 2003-05-09 2003-05-09
US49475103P 2003-08-13 2003-08-13
US49507603P 2003-08-14 2003-08-14
US53529004P 2004-01-08 2004-01-08
PCT/US2004/014254 WO2004103275A2 (en) 2003-05-09 2004-05-07 Compositions and methods for the preparation of human growth hormone glycosylation mutants

Publications (1)

Publication Number Publication Date
BRPI0410164A true BRPI0410164A (pt) 2006-05-16

Family

ID=33479814

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410164-2A BRPI0410164A (pt) 2003-05-09 2004-05-07 composições e métodos para preparação de mutantes de glicosilação de hormÈnio do crescimento humano

Country Status (11)

Country Link
US (1) US7932364B2 (pt)
EP (1) EP1624847B1 (pt)
JP (1) JP2007523630A (pt)
KR (1) KR20060030023A (pt)
AT (1) ATE540055T1 (pt)
AU (1) AU2004240553A1 (pt)
BR (1) BRPI0410164A (pt)
CA (1) CA2524936A1 (pt)
ES (1) ES2380093T3 (pt)
MX (1) MXPA05011832A (pt)
WO (1) WO2004103275A2 (pt)

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