ATE430166T1 - Diarylrest entfassende peptide als inhibitoren des ns-3 serinproteases von hepatitis c virus - Google Patents

Diarylrest entfassende peptide als inhibitoren des ns-3 serinproteases von hepatitis c virus

Info

Publication number
ATE430166T1
ATE430166T1 AT01986126T AT01986126T ATE430166T1 AT E430166 T1 ATE430166 T1 AT E430166T1 AT 01986126 T AT01986126 T AT 01986126T AT 01986126 T AT01986126 T AT 01986126T AT E430166 T1 ATE430166 T1 AT E430166T1
Authority
AT
Austria
Prior art keywords
diaryl
hepatitis
peptides
virus
inhibitors
Prior art date
Application number
AT01986126T
Other languages
English (en)
Inventor
Zhaoning Zhu
Zhong-Yue Sun
Srikanth Venkatraman
F George Njoroge
Ashok Arasappan
Bruce A Malcolm
Viyyoor M Girijavallabhan
Raymond G Lovey
Kevin X Chen
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE430166T1 publication Critical patent/ATE430166T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT01986126T 2000-12-12 2001-12-10 Diarylrest entfassende peptide als inhibitoren des ns-3 serinproteases von hepatitis c virus ATE430166T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25486900P 2000-12-12 2000-12-12
PCT/US2001/047383 WO2002048172A2 (en) 2000-12-12 2001-12-10 Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus

Publications (1)

Publication Number Publication Date
ATE430166T1 true ATE430166T1 (de) 2009-05-15

Family

ID=22965900

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01986126T ATE430166T1 (de) 2000-12-12 2001-12-10 Diarylrest entfassende peptide als inhibitoren des ns-3 serinproteases von hepatitis c virus

Country Status (18)

Country Link
US (1) US6911428B2 (de)
EP (1) EP1343807B1 (de)
JP (1) JP4368581B2 (de)
KR (1) KR20030091946A (de)
CN (1) CN1301994C (de)
AR (1) AR031905A1 (de)
AT (1) ATE430166T1 (de)
AU (2) AU2002236591B2 (de)
CA (1) CA2430458A1 (de)
DE (1) DE60138567D1 (de)
ES (1) ES2324594T3 (de)
HK (1) HK1054394B (de)
HU (1) HUP0303436A2 (de)
IL (1) IL155842A0 (de)
MX (1) MXPA03005219A (de)
PE (1) PE20020691A1 (de)
WO (1) WO2002048172A2 (de)
ZA (1) ZA200304382B (de)

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