ATE433968T1 - Imidazolverbindungen als inhibitoren des transformierenden wachstumsfaktors (twf) - Google Patents

Imidazolverbindungen als inhibitoren des transformierenden wachstumsfaktors (twf)

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Publication number
ATE433968T1
ATE433968T1 AT03797429T AT03797429T ATE433968T1 AT E433968 T1 ATE433968 T1 AT E433968T1 AT 03797429 T AT03797429 T AT 03797429T AT 03797429 T AT03797429 T AT 03797429T AT E433968 T1 ATE433968 T1 AT E433968T1
Authority
AT
Austria
Prior art keywords
twf
inhibitors
growth factor
transforming growth
imidazole compounds
Prior art date
Application number
AT03797429T
Other languages
English (en)
Inventor
L C Blumberg
M J Munchhof
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE433968T1 publication Critical patent/ATE433968T1/de

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT03797429T 2002-09-18 2003-09-08 Imidazolverbindungen als inhibitoren des transformierenden wachstumsfaktors (twf) ATE433968T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41189402P 2002-09-18 2002-09-18
US48452203P 2003-07-02 2003-07-02
PCT/IB2003/003833 WO2004026859A1 (en) 2002-09-18 2003-09-08 Novel imidazole compounds as transforming growth factor (tgf) inhibitors

Publications (1)

Publication Number Publication Date
ATE433968T1 true ATE433968T1 (de) 2009-07-15

Family

ID=32033577

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03797429T ATE433968T1 (de) 2002-09-18 2003-09-08 Imidazolverbindungen als inhibitoren des transformierenden wachstumsfaktors (twf)

Country Status (28)

Country Link
US (2) US7153872B2 (de)
EP (1) EP1542990B1 (de)
JP (1) JP4547271B2 (de)
KR (1) KR20050057392A (de)
CN (1) CN1681805A (de)
AP (1) AP2005003264A0 (de)
AR (1) AR041274A1 (de)
AT (1) ATE433968T1 (de)
AU (1) AU2003263404A1 (de)
BR (1) BR0314372A (de)
CA (1) CA2498047C (de)
CO (1) CO5550453A2 (de)
DE (1) DE60328028D1 (de)
EA (1) EA200500378A1 (de)
EC (1) ECSP055680A (de)
ES (1) ES2325687T3 (de)
HR (1) HRP20050252A2 (de)
IS (1) IS7712A (de)
MA (1) MA27441A1 (de)
MX (1) MXPA05002981A (de)
NO (1) NO20051008L (de)
OA (1) OA12928A (de)
PA (1) PA8583301A1 (de)
PE (1) PE20050072A1 (de)
PL (1) PL375980A1 (de)
TW (1) TW200404793A (de)
UY (1) UY27982A1 (de)
WO (1) WO2004026859A1 (de)

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CA2496295C (en) 2002-09-18 2010-11-23 Michael John Munchhof Novels pyrazole compounds as transforming growth factor (tgf) inhibitors
PA8595001A1 (es) * 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
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KR100749566B1 (ko) 2004-04-21 2007-08-16 이화여자대학교 산학협력단 Alk5 및/또는 alk4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체
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AU2005280168A1 (en) * 2004-08-31 2006-03-09 Biogen Idec Ma Inc. Pyrimidinylimidazoles as TGF-beta inhibitors
US20070275968A1 (en) * 2004-09-07 2007-11-29 Hitoshi Kurata Substituted Biphenyl Derivative
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WO2010149755A1 (en) 2009-06-26 2010-12-29 Novartis Ag 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
DE102009043260A1 (de) 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
DE102009049679A1 (de) 2009-10-19 2011-04-21 Merck Patent Gmbh Pyrazolopyrimidinderivate
US8080568B1 (en) * 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
USRE47141E1 (en) 2010-06-29 2018-11-27 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
DE102010049595A1 (de) 2010-10-26 2012-04-26 Merck Patent Gmbh Chinazolinderivate
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
PL3089971T3 (pl) 2014-01-01 2021-01-25 Medivation Technologies Llc Związki i sposoby ich zastosowania
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
AU2017329090B9 (en) 2016-09-19 2019-09-05 Novartis Ag Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor
WO2018132279A1 (en) * 2017-01-05 2018-07-19 Bristol-Myers Squibb Company Tgf beta receptor antagonists
CA3057969A1 (en) 2017-05-02 2018-11-08 Novartis Ag Combination therapy
BR112021011224A2 (pt) 2018-12-11 2021-08-24 Theravance Biopharma R&D Ip, Llc Inibidores de alk5
EP3969449B1 (de) 2019-05-13 2025-02-12 Novartis AG Neue kristalline formen von n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluormethyl)isonicotinamid als raf-inhibitoren zur behandlung von krebs
KR20220104208A (ko) * 2019-11-22 2022-07-26 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Alk5 억제제로서 치환된 1,5-나프티리딘 또는 퀴놀린
KR102539660B1 (ko) 2020-08-20 2023-06-02 가천대학교 산학협력단 베타-폴리비닐리덴 플루오라이드 코팅층이 형성된 아연 음극 및 상기 음극을 포함하는 수계 아연 이온 전지
KR102733584B1 (ko) 2020-09-04 2024-11-21 고려대학교 세종산학협력단 전기화학적 및 광전기화학적 수소 생산용 황화니켈 나노결정 촉매 및 이의 제조방법
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Also Published As

Publication number Publication date
TW200404793A (en) 2004-04-01
PE20050072A1 (es) 2005-03-01
MA27441A1 (fr) 2005-07-01
OA12928A (en) 2006-10-13
CA2498047A1 (en) 2004-04-01
CO5550453A2 (es) 2005-08-31
HRP20050252A2 (en) 2005-10-31
CN1681805A (zh) 2005-10-12
US20070088037A1 (en) 2007-04-19
PA8583301A1 (es) 2004-09-16
DE60328028D1 (de) 2009-07-30
AU2003263404A1 (en) 2004-04-08
MXPA05002981A (es) 2005-06-22
BR0314372A (pt) 2005-07-19
CA2498047C (en) 2009-05-19
AR041274A1 (es) 2005-05-11
EP1542990A1 (de) 2005-06-22
JP2006502237A (ja) 2006-01-19
ECSP055680A (es) 2005-05-30
KR20050057392A (ko) 2005-06-16
PL375980A1 (en) 2005-12-12
AP2005003264A0 (en) 2005-03-31
EP1542990B1 (de) 2009-06-17
ES2325687T3 (es) 2009-09-14
JP4547271B2 (ja) 2010-09-22
US7153872B2 (en) 2006-12-26
IS7712A (is) 2005-02-24
US20040106608A1 (en) 2004-06-03
NO20051008L (no) 2005-06-07
US7635702B2 (en) 2009-12-22
UY27982A1 (es) 2004-04-30
WO2004026859A1 (en) 2004-04-01
EA200500378A1 (ru) 2005-08-25

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