ECSP055680A - Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf) - Google Patents

Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf)

Info

Publication number
ECSP055680A
ECSP055680A EC2005005680A ECSP055680A ECSP055680A EC SP055680 A ECSP055680 A EC SP055680A EC 2005005680 A EC2005005680 A EC 2005005680A EC SP055680 A ECSP055680 A EC SP055680A EC SP055680 A ECSP055680 A EC SP055680A
Authority
EC
Ecuador
Prior art keywords
tgf
growth factor
inhibitors
transforming growth
compounds
Prior art date
Application number
EC2005005680A
Other languages
English (en)
Inventor
Laura Cook Blumberg
Michael John Munchhof
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of ECSP055680A publication Critical patent/ECSP055680A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen nuevos compuestos de imidazol, incluyendo sus derivados, intermedios para su preparación, composiciones farmacéuticas que los contienen y su uso medicinal. Los compuestos de la presente invención son inhibidores potentes de la ruta se señalización del factor del crecimiento transformante ("TGF)-ß. Son de utilidad en el tratamiento de diversos estados de enfermedad relacionados con TGF incluyendo, por ejemplo cáncer y enfermedades fibróticas.
EC2005005680A 2002-09-18 2005-03-17 Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf) ECSP055680A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41189402P 2002-09-18 2002-09-18
US48452203P 2003-07-02 2003-07-02

Publications (1)

Publication Number Publication Date
ECSP055680A true ECSP055680A (es) 2005-05-30

Family

ID=32033577

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005680A ECSP055680A (es) 2002-09-18 2005-03-17 Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf)

Country Status (28)

Country Link
US (2) US7153872B2 (es)
EP (1) EP1542990B1 (es)
JP (1) JP4547271B2 (es)
KR (1) KR20050057392A (es)
CN (1) CN1681805A (es)
AP (1) AP2005003264A0 (es)
AR (1) AR041274A1 (es)
AT (1) ATE433968T1 (es)
AU (1) AU2003263404A1 (es)
BR (1) BR0314372A (es)
CA (1) CA2498047C (es)
CO (1) CO5550453A2 (es)
DE (1) DE60328028D1 (es)
EA (1) EA200500378A1 (es)
EC (1) ECSP055680A (es)
ES (1) ES2325687T3 (es)
HR (1) HRP20050252A2 (es)
IS (1) IS7712A (es)
MA (1) MA27441A1 (es)
MX (1) MXPA05002981A (es)
NO (1) NO20051008L (es)
OA (1) OA12928A (es)
PA (1) PA8583301A1 (es)
PE (1) PE20050072A1 (es)
PL (1) PL375980A1 (es)
TW (1) TW200404793A (es)
UY (1) UY27982A1 (es)
WO (1) WO2004026859A1 (es)

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CA2496295C (en) 2002-09-18 2010-11-23 Michael John Munchhof Novels pyrazole compounds as transforming growth factor (tgf) inhibitors
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WO2010149755A1 (en) 2009-06-26 2010-12-29 Novartis Ag 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
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DE102009049679A1 (de) 2009-10-19 2011-04-21 Merck Patent Gmbh Pyrazolopyrimidinderivate
US8080568B1 (en) * 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
USRE47141E1 (en) 2010-06-29 2018-11-27 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
DE102010049595A1 (de) 2010-10-26 2012-04-26 Merck Patent Gmbh Chinazolinderivate
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
PL3089971T3 (pl) 2014-01-01 2021-01-25 Medivation Technologies Llc Związki i sposoby ich zastosowania
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Also Published As

Publication number Publication date
TW200404793A (en) 2004-04-01
PE20050072A1 (es) 2005-03-01
MA27441A1 (fr) 2005-07-01
OA12928A (en) 2006-10-13
CA2498047A1 (en) 2004-04-01
CO5550453A2 (es) 2005-08-31
HRP20050252A2 (en) 2005-10-31
CN1681805A (zh) 2005-10-12
US20070088037A1 (en) 2007-04-19
PA8583301A1 (es) 2004-09-16
DE60328028D1 (de) 2009-07-30
AU2003263404A1 (en) 2004-04-08
MXPA05002981A (es) 2005-06-22
BR0314372A (pt) 2005-07-19
CA2498047C (en) 2009-05-19
ATE433968T1 (de) 2009-07-15
AR041274A1 (es) 2005-05-11
EP1542990A1 (en) 2005-06-22
JP2006502237A (ja) 2006-01-19
KR20050057392A (ko) 2005-06-16
PL375980A1 (en) 2005-12-12
AP2005003264A0 (en) 2005-03-31
EP1542990B1 (en) 2009-06-17
ES2325687T3 (es) 2009-09-14
JP4547271B2 (ja) 2010-09-22
US7153872B2 (en) 2006-12-26
IS7712A (is) 2005-02-24
US20040106608A1 (en) 2004-06-03
NO20051008L (no) 2005-06-07
US7635702B2 (en) 2009-12-22
UY27982A1 (es) 2004-04-30
WO2004026859A1 (en) 2004-04-01
EA200500378A1 (ru) 2005-08-25

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