MA27441A1 - Composes d'imidazole nouveaux servant d'inhibiteurs du facteur de croissance transformant (tgf) - Google Patents

Composes d'imidazole nouveaux servant d'inhibiteurs du facteur de croissance transformant (tgf)

Info

Publication number
MA27441A1
MA27441A1 MA28155A MA28155A MA27441A1 MA 27441 A1 MA27441 A1 MA 27441A1 MA 28155 A MA28155 A MA 28155A MA 28155 A MA28155 A MA 28155A MA 27441 A1 MA27441 A1 MA 27441A1
Authority
MA
Morocco
Prior art keywords
tgf
growth factor
transforming growth
inhibitors
imidazole compounds
Prior art date
Application number
MA28155A
Other languages
English (en)
Inventor
Laura Cook Blumberg
Michael John Munchhof
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA27441A1 publication Critical patent/MA27441A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DEPOSANT Société dite : PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 18 Septembre 2002 60/411,894 US 2 Juillet 2003 60/484,522 Voir en annexe le titre de l'invention et le texte de l'abrégé Composés d'imidazole nouveaux servant d'inhibiteurs du facteur de croissance transformant (TGF) Des composés d'imidazole nouveaux, y compris leurs dérivés, des intermédiaires pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en médecine sont décrits. Les composés de la présente invention sont de puissants inhibiteurs de la voie de transmission de signal du facteur de croissance transformant ("TGF")-(bêta). Ils sont utiles dans le traitement de divers états pathologiques en rapport avec le TGF comprenant, par exemple, le cancer et des maladies fibrotiques.
MA28155A 2002-09-18 2005-03-18 Composes d'imidazole nouveaux servant d'inhibiteurs du facteur de croissance transformant (tgf) MA27441A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41189402P 2002-09-18 2002-09-18
US48452203P 2003-07-02 2003-07-02

Publications (1)

Publication Number Publication Date
MA27441A1 true MA27441A1 (fr) 2005-07-01

Family

ID=32033577

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28155A MA27441A1 (fr) 2002-09-18 2005-03-18 Composes d'imidazole nouveaux servant d'inhibiteurs du facteur de croissance transformant (tgf)

Country Status (28)

Country Link
US (2) US7153872B2 (fr)
EP (1) EP1542990B1 (fr)
JP (1) JP4547271B2 (fr)
KR (1) KR20050057392A (fr)
CN (1) CN1681805A (fr)
AP (1) AP2005003264A0 (fr)
AR (1) AR041274A1 (fr)
AT (1) ATE433968T1 (fr)
AU (1) AU2003263404A1 (fr)
BR (1) BR0314372A (fr)
CA (1) CA2498047C (fr)
CO (1) CO5550453A2 (fr)
DE (1) DE60328028D1 (fr)
EA (1) EA200500378A1 (fr)
EC (1) ECSP055680A (fr)
ES (1) ES2325687T3 (fr)
HR (1) HRP20050252A2 (fr)
IS (1) IS7712A (fr)
MA (1) MA27441A1 (fr)
MX (1) MXPA05002981A (fr)
NO (1) NO20051008L (fr)
OA (1) OA12928A (fr)
PA (1) PA8583301A1 (fr)
PE (1) PE20050072A1 (fr)
PL (1) PL375980A1 (fr)
TW (1) TW200404793A (fr)
UY (1) UY27982A1 (fr)
WO (1) WO2004026859A1 (fr)

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UA80295C2 (en) * 2002-09-06 2007-09-10 Biogen Inc Pyrazolopyridines and using the same
MXPA05002981A (es) * 2002-09-18 2005-06-22 Pfizer Prod Inc Nuevos compuestos de imidazol como inhibidores del factor de crecimiento transformante (tgf).
AU2003256003A1 (en) 2002-09-18 2004-04-08 Pfizer Products Inc. Novel oxazole and thiazole compounds as transforming growth factor (TGF) inhibitors
CA2496295C (fr) 2002-09-18 2010-11-23 Michael John Munchhof Nouveaux composes de pyrazole utilises comme inhibiteurs du facteur de croissance transformant (tgf)
PA8595001A1 (es) * 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
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US8394823B2 (en) 2008-04-11 2013-03-12 Bristol-Myers Squibb Company Triazolopyridine compounds useful as DGAT1 inhibitors
CN102131805A (zh) 2008-06-20 2011-07-20 百时美施贵宝公司 用作激酶抑制剂的咪唑并吡啶和咪唑并吡嗪化合物
WO2010149755A1 (fr) 2009-06-26 2010-12-29 Novartis Ag Dérivés d'imidazolidin-2-one 1,3-disubstitués en tant qu'inhibiteurs de cyp 17
DE102009043260A1 (de) 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
DE102009049679A1 (de) 2009-10-19 2011-04-21 Merck Patent Gmbh Pyrazolopyrimidinderivate
US8080568B1 (en) * 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
USRE47141E1 (en) 2010-06-29 2018-11-27 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
DE102010049595A1 (de) 2010-10-26 2012-04-26 Merck Patent Gmbh Chinazolinderivate
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
PL3089971T3 (pl) 2014-01-01 2021-01-25 Medivation Technologies Llc Związki i sposoby ich zastosowania
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
AU2017329090B9 (en) 2016-09-19 2019-09-05 Novartis Ag Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor
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KR102539660B1 (ko) 2020-08-20 2023-06-02 가천대학교 산학협력단 베타-폴리비닐리덴 플루오라이드 코팅층이 형성된 아연 음극 및 상기 음극을 포함하는 수계 아연 이온 전지
KR102733584B1 (ko) 2020-09-04 2024-11-21 고려대학교 세종산학협력단 전기화학적 및 광전기화학적 수소 생산용 황화니켈 나노결정 촉매 및 이의 제조방법
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Also Published As

Publication number Publication date
TW200404793A (en) 2004-04-01
PE20050072A1 (es) 2005-03-01
OA12928A (en) 2006-10-13
CA2498047A1 (fr) 2004-04-01
CO5550453A2 (es) 2005-08-31
HRP20050252A2 (en) 2005-10-31
CN1681805A (zh) 2005-10-12
US20070088037A1 (en) 2007-04-19
PA8583301A1 (es) 2004-09-16
DE60328028D1 (de) 2009-07-30
AU2003263404A1 (en) 2004-04-08
MXPA05002981A (es) 2005-06-22
BR0314372A (pt) 2005-07-19
CA2498047C (fr) 2009-05-19
ATE433968T1 (de) 2009-07-15
AR041274A1 (es) 2005-05-11
EP1542990A1 (fr) 2005-06-22
JP2006502237A (ja) 2006-01-19
ECSP055680A (es) 2005-05-30
KR20050057392A (ko) 2005-06-16
PL375980A1 (en) 2005-12-12
AP2005003264A0 (en) 2005-03-31
EP1542990B1 (fr) 2009-06-17
ES2325687T3 (es) 2009-09-14
JP4547271B2 (ja) 2010-09-22
US7153872B2 (en) 2006-12-26
IS7712A (is) 2005-02-24
US20040106608A1 (en) 2004-06-03
NO20051008L (no) 2005-06-07
US7635702B2 (en) 2009-12-22
UY27982A1 (es) 2004-04-30
WO2004026859A1 (fr) 2004-04-01
EA200500378A1 (ru) 2005-08-25

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