ATE437956T1 - Verfahren zur herstellung von cytidin 5'- diphosphatcholin - Google Patents
Verfahren zur herstellung von cytidin 5'- diphosphatcholinInfo
- Publication number
- ATE437956T1 ATE437956T1 AT03728046T AT03728046T ATE437956T1 AT E437956 T1 ATE437956 T1 AT E437956T1 AT 03728046 T AT03728046 T AT 03728046T AT 03728046 T AT03728046 T AT 03728046T AT E437956 T1 ATE437956 T1 AT E437956T1
- Authority
- AT
- Austria
- Prior art keywords
- choline
- cdp
- diphosphatcholine
- aqueous medium
- producing
- Prior art date
Links
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 title 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 title 1
- UHDGCWIWMRVCDJ-XVFCMESISA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-XVFCMESISA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- RZZPDXZPRHQOCG-OJAKKHQRSA-M CDP-choline(1-) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-M 0.000 abstract 4
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 4
- 239000012736 aqueous medium Substances 0.000 abstract 3
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 abstract 2
- 229960001231 choline Drugs 0.000 abstract 2
- 229950004354 phosphorylcholine Drugs 0.000 abstract 2
- PYJNAPOPMIJKJZ-UHFFFAOYSA-N phosphorylcholine chloride Chemical compound [Cl-].C[N+](C)(C)CCOP(O)(O)=O PYJNAPOPMIJKJZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229940035893 uracil Drugs 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000011942 biocatalyst Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
Landscapes
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002132917 | 2002-05-08 | ||
| PCT/JP2003/005764 WO2003095660A1 (en) | 2002-05-08 | 2003-05-08 | Process for producing cytidine 5’-diphocphate choline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE437956T1 true ATE437956T1 (de) | 2009-08-15 |
Family
ID=29416654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03728046T ATE437956T1 (de) | 2002-05-08 | 2003-05-08 | Verfahren zur herstellung von cytidin 5'- diphosphatcholin |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050164359A1 (de) |
| EP (1) | EP1502956B1 (de) |
| JP (1) | JPWO2003095660A1 (de) |
| CN (1) | CN100513576C (de) |
| AT (1) | ATE437956T1 (de) |
| AU (1) | AU2003234789A1 (de) |
| DE (1) | DE60328595D1 (de) |
| ES (1) | ES2329566T3 (de) |
| PT (1) | PT1502956E (de) |
| WO (1) | WO2003095660A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4520219B2 (ja) * | 2004-05-28 | 2010-08-04 | 協和発酵バイオ株式会社 | ５−アミノレブリン酸の製造法 |
| TW200741005A (en) | 2005-08-10 | 2007-11-01 | Kyowa Hakko Kogyo Kk | A purification method of cytidine diphosphate |
| JP5112869B2 (ja) * | 2005-08-23 | 2013-01-09 | 協和発酵バイオ株式会社 | シチジンジリン酸コリンの製造法 |
| US8288437B2 (en) * | 2008-07-24 | 2012-10-16 | Valent Biosciences Corporation | Salts, aqueous liquid compositions containing salts of abscisic acid analogs and methods of their preparation |
| US9637746B2 (en) | 2008-12-15 | 2017-05-02 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways |
| EP2566953B1 (de) | 2010-05-07 | 2019-01-02 | Greenlight Biosciences, Inc. | Verfahren zur flusssteuerung bei stoffwechselwegen druch enzymumpositionierung |
| EP2611922A1 (de) | 2010-08-31 | 2013-07-10 | Greenlight Biosciences, Inc. | Verfahren zur flusssteuerung bei stoffwechselwegen durch proteasemanipulation |
| CN104093848A (zh) | 2011-09-09 | 2014-10-08 | 绿光生物科学公司 | 碳青霉烯(carbapenem)的无细胞制备 |
| AU2014306074B2 (en) | 2013-08-05 | 2018-08-30 | Greenlight Biosciences, Inc. | Engineered proteins with a protease cleavage site |
| BR112017020690A2 (pt) | 2015-03-30 | 2018-06-26 | Greenlight Biosciences Inc | produção livre de células de ácido ribonucleico |
| CA3020312A1 (en) | 2016-04-06 | 2017-10-12 | Greenlight Biosciences, Inc. | Cell-free production of ribonucleic acid |
| CN109207415B (zh) * | 2017-07-07 | 2022-09-16 | 苏州华赛生物工程技术有限公司 | 一种生产胞二磷胆碱的重组微生物及生产胞二磷胆碱的方法 |
| KR102894284B1 (ko) | 2017-10-11 | 2025-12-03 | 그린라이트 바이오사이언시스, 아이엔씨. | 뉴클레오시드 트리포스페이트 및 리보핵산 생산을 위한 방법 및 조성물 |
| CN107488603A (zh) * | 2017-10-19 | 2017-12-19 | 南通秋之友生物科技有限公司 | 一种过表达磷酸胆碱胞苷转移酶酿酒酵母基因工程菌及构建方法和应用 |
| CN108424859B (zh) * | 2017-11-23 | 2021-09-10 | 华东理工大学 | 生产胞磷胆碱的基因工程菌的构建与应用 |
| CA3231307A1 (en) | 2021-09-10 | 2023-03-16 | Kyowa Hakko Bio Co., Ltd. | Recombinant microorganism used for producing cdp-choline, and method for producing cdp-choline using said recombinant microorganism |
| CN116790466B (zh) * | 2023-07-19 | 2023-11-03 | 山东理工大学 | 一种工程改造枯草芽孢杆菌发酵生产胞磷胆碱的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4840758B1 (de) | 1969-03-24 | 1973-12-03 | ||
| JPS58110600A (ja) | 1981-12-25 | 1983-07-01 | Kyowa Hakko Kogyo Co Ltd | ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド |
| JPS60221091A (ja) | 1983-12-21 | 1985-11-05 | Kyowa Hakko Kogyo Co Ltd | 新規プロモ−タ− |
| JP2564268B2 (ja) | 1985-08-28 | 1996-12-18 | 協和醗酵工業株式会社 | 融合抗原ポリペプチド |
| JPH0710235B2 (ja) * | 1987-10-19 | 1995-02-08 | 協和醗酵工業株式会社 | 発酵法によるオロット酸の製造法 |
| JPH0322979A (ja) | 1989-06-19 | 1991-01-31 | Kyowa Hakko Kogyo Co Ltd | 新規プラスミノーゲン活性化因子 |
| KR0177841B1 (ko) * | 1992-01-30 | 1999-04-01 | 나까무라 간노스께 | 시티딘 디인산 콜린의 제조방법 |
| JP3369236B2 (ja) * | 1992-01-30 | 2003-01-20 | 協和醗酵工業株式会社 | シチジンジリン酸コリンの製造法 |
| WO1999049073A1 (fr) | 1998-03-20 | 1999-09-30 | Yamasa Corporation | Procede de production de cytidine 5'-diphosphate choline |
| JP3822006B2 (ja) | 1999-10-08 | 2006-09-13 | ヤマサ醤油株式会社 | シチジン５’−ジリン酸コリンの製造法 |
| JP2001238691A (ja) * | 2000-02-29 | 2001-09-04 | Kyowa Hakko Kogyo Co Ltd | ヌクレオシド５’−三リン酸の製造方法 |
| JP2002045185A (ja) * | 2000-08-02 | 2002-02-12 | Kyowa Hakko Kogyo Co Ltd | Ｆ０Ｆ１−ＡＴＰａｓｅおよび該酵素をコードするＤＮＡ |
-
2003
- 2003-05-08 US US10/513,718 patent/US20050164359A1/en not_active Abandoned
- 2003-05-08 WO PCT/JP2003/005764 patent/WO2003095660A1/ja not_active Ceased
- 2003-05-08 DE DE60328595T patent/DE60328595D1/de not_active Expired - Fee Related
- 2003-05-08 ES ES03728046T patent/ES2329566T3/es not_active Expired - Lifetime
- 2003-05-08 EP EP03728046A patent/EP1502956B1/de not_active Expired - Lifetime
- 2003-05-08 CN CNB038104350A patent/CN100513576C/zh not_active Expired - Fee Related
- 2003-05-08 AU AU2003234789A patent/AU2003234789A1/en not_active Abandoned
- 2003-05-08 PT PT03728046T patent/PT1502956E/pt unknown
- 2003-05-08 JP JP2004503650A patent/JPWO2003095660A1/ja active Pending
- 2003-05-08 AT AT03728046T patent/ATE437956T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1502956E (pt) | 2009-08-31 |
| CN1653188A (zh) | 2005-08-10 |
| JPWO2003095660A1 (ja) | 2005-09-15 |
| EP1502956A1 (de) | 2005-02-02 |
| WO2003095660A1 (en) | 2003-11-20 |
| US20050164359A1 (en) | 2005-07-28 |
| EP1502956A4 (de) | 2007-08-22 |
| CN100513576C (zh) | 2009-07-15 |
| AU2003234789A1 (en) | 2003-11-11 |
| ES2329566T3 (es) | 2009-11-27 |
| DE60328595D1 (de) | 2009-09-10 |
| EP1502956B1 (de) | 2009-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |