ATE438740T1 - Verfahren und nukleinsäuren zur analyse von mit der prognose von störungen der proliferation von prostatazellen assoziierter genexpression - Google Patents

Verfahren und nukleinsäuren zur analyse von mit der prognose von störungen der proliferation von prostatazellen assoziierter genexpression

Info

Publication number
ATE438740T1
ATE438740T1 AT05853011T AT05853011T ATE438740T1 AT E438740 T1 ATE438740 T1 AT E438740T1 AT 05853011 T AT05853011 T AT 05853011T AT 05853011 T AT05853011 T AT 05853011T AT E438740 T1 ATE438740 T1 AT E438740T1
Authority
AT
Austria
Prior art keywords
nucleic acids
disorders
proliferation
prediction
gene expression
Prior art date
Application number
AT05853011T
Other languages
English (en)
Inventor
Susan Cottrell
Fabian Model
Carolina Haefliger
Gunter Weiss
Juergen Distler
Andrew Sledziewski
Xiaoling Song
Thomas Skillman
Jeffrey G Thomas
Original Assignee
Epigenomics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag filed Critical Epigenomics Ag
Application granted granted Critical
Publication of ATE438740T1 publication Critical patent/ATE438740T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT05853011T 2004-12-02 2005-12-02 Verfahren und nukleinsäuren zur analyse von mit der prognose von störungen der proliferation von prostatazellen assoziierter genexpression ATE438740T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US63325004P 2004-12-02 2004-12-02
US63242604P 2004-12-02 2004-12-02
US66222005P 2005-03-14 2005-03-14
US72305405P 2005-10-03 2005-10-03
US72312505P 2005-10-03 2005-10-03
US74073605P 2005-11-30 2005-11-30
PCT/US2005/043974 WO2006071466A2 (en) 2004-12-02 2005-12-02 Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders

Publications (1)

Publication Number Publication Date
ATE438740T1 true ATE438740T1 (de) 2009-08-15

Family

ID=39661458

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05853011T ATE438740T1 (de) 2004-12-02 2005-12-02 Verfahren und nukleinsäuren zur analyse von mit der prognose von störungen der proliferation von prostatazellen assoziierter genexpression

Country Status (9)

Country Link
US (2) US20090197250A1 (de)
EP (5) EP2284279A1 (de)
JP (2) JP5745202B2 (de)
AT (1) ATE438740T1 (de)
AU (1) AU2005322435B2 (de)
CA (1) CA2593546A1 (de)
DE (1) DE602005015893D1 (de)
ES (2) ES2534139T3 (de)
WO (1) WO2006071466A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331393B1 (en) 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
KR101708544B1 (ko) * 2005-04-15 2017-02-20 에피제노믹스 아게 세포 증식 질환을 분석하기 위한 방법 및 핵산
EP1945806B1 (de) * 2005-09-21 2013-02-27 Epigenomics AG Marker zur vorhersage des ausgangs einer anthracyclin-behandlung
WO2007039291A2 (en) * 2005-10-03 2007-04-12 Epigenomics Ag Methods, apparatus and nomograms to determine prostate cancer progression
US20080254470A1 (en) * 2005-10-03 2008-10-16 Epigenomics Ag Methods and Nucleic Acids For the Analysis of Gene Expression Associated With the Prognosis of Cell Proliferative Disorders
WO2007042041A1 (en) * 2005-10-12 2007-04-19 Scanvaegt International A/S Device for transfer of items
WO2007060671A2 (en) * 2005-11-27 2007-05-31 Compugen Ltd. Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
US20090062645A1 (en) * 2007-09-03 2009-03-05 Jens Fehre Method for diagnosis and treatment of prostate cancer
AU2008328222A1 (en) * 2007-11-23 2009-05-28 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
US20110003292A1 (en) * 2007-12-11 2011-01-06 Dimo Dietrich Methods and nucleic acids for analyses of cell proliferative disorders
JP5513375B2 (ja) * 2008-05-07 2014-06-04 北海道公立大学法人 札幌医科大学 癌の検出方法および検出用キット、ならびに癌治療剤
US9315802B2 (en) 2009-12-30 2016-04-19 Quest Diagnostics Investments Incorporated RNA isolation from soluble urine fractions
DE102010028105A1 (de) * 2010-04-22 2011-10-27 Siemens Aktiengesellschaft Verfahren, Vorrichtung und Gerätesystem für die Therapie von Prostatakrebs
US9663781B2 (en) 2010-12-30 2017-05-30 Quest Diagnostics Investments Incorporated Diagnosis of prostate cancer
EP2514836B1 (de) * 2011-04-19 2016-06-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Prostatakrebsmarker
US9598735B2 (en) * 2012-11-14 2017-03-21 JBS Science Inc. Detection of a panel of urine DNA markers for HCC screening and disease management
KR101467289B1 (ko) * 2013-01-22 2014-12-02 한국원자력의학원 Wdfy3를 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성물 및 이의 용도
US20150010518A1 (en) * 2013-07-03 2015-01-08 The University Of British Columbia Nr2e1 mini-promoters
WO2015023285A1 (en) * 2013-08-15 2015-02-19 Xia Xueliang James Biomarkers for use in colorectal cancer
JP6427750B2 (ja) * 2013-10-02 2018-11-28 コニカミノルタ株式会社 Cxcl1、ならびにsmoxおよび/またはid1の発現量に基づく肺癌患者の予後を判定するためのデータ収集方法およびキット
GB2524948A (en) * 2014-03-07 2015-10-14 Oxford Gene Technology Operations Ltd Detecting Increase or Decrease in the Amount of a Nucleic Acid having a Sequence of Interest
GB201404998D0 (en) * 2014-03-20 2014-05-07 Univ Birmingham Atrial fibrillation therapy
EP3037545A1 (de) * 2014-12-23 2016-06-29 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin DNS-Methylierungstest auf Prostatakrebs
EP3246415A1 (de) * 2016-05-18 2017-11-22 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Verfahren zur prognose von prostatakrebs
US20210318324A1 (en) * 2018-07-05 2021-10-14 The Board Of Regents Of The University Of Oklahoma Gene signatures for cancer characterization and methods of use
KR102637032B1 (ko) * 2020-01-28 2024-02-15 주식회사 젠큐릭스 특정 유전자의 CpG 메틸화 변화를 이용한 방광암 진단용 조성물 및 이의 용도
US11901083B1 (en) 2021-11-30 2024-02-13 Vignet Incorporated Using genetic and phenotypic data sets for drug discovery clinical trials
US11705230B1 (en) 2021-11-30 2023-07-18 Vignet Incorporated Assessing health risks using genetic, epigenetic, and phenotypic data sources
CN114015771A (zh) * 2022-01-05 2022-02-08 北京华诺奥美基因医学检验实验室有限公司 一种snrpn父源缺失的检测引物组、试剂盒及非诊断目的的检测方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585481A (en) * 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5457183A (en) * 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5245022A (en) * 1990-08-03 1993-09-14 Sterling Drug, Inc. Exonuclease resistant terminally substituted oligonucleotides
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5565552A (en) * 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5574142A (en) * 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
DE69417918T2 (de) 1993-11-30 2000-01-05 Mcgill University, Montreal Dna methyltransferase inhibierung
US5597696A (en) 1994-07-18 1997-01-28 Becton Dickinson And Company Covalent cyanine dye oligonucleotide conjugates
US5514758A (en) 1994-09-30 1996-05-07 The Goodyear Tire & Rubber Company Process for making latex for high performance masking tape
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
AU7829398A (en) 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US5958773A (en) * 1998-12-17 1999-09-28 Isis Pharmaceuticals Inc. Antisense modulation of AKT-1 expression
US6331393B1 (en) 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US6783933B1 (en) * 1999-09-15 2004-08-31 The Johns Hopkins University School Of Medicine CACNA1G polynucleotide, polypeptide and methods of use therefor
AU2002214576A1 (en) * 2000-10-13 2002-04-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Genes related to development of refractory prostate cancer
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes
EP1379694B1 (de) * 2001-03-01 2006-05-10 Epigenomics AG Verfahren und rechnerprogrammprodukte zur erfassung der biologischen wirkung und/oder aktivität von arzneimitteln, chemischen substanzen und/oder pharmazeuitschen verbindungen auf der basis ihrer effekte auf den methylierungszustand der dna
EP1410304A2 (de) * 2001-03-26 2004-04-21 Epigenomics AG Verfahren zur epigenetischen merkmalauswahl
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US20060024684A1 (en) * 2002-10-01 2006-02-02 Epigenomics Ag Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients
EP1554407B1 (de) * 2002-10-01 2009-07-29 Epigenomics AG Verfahren für die behandlung von proliferativen erkrankungen von brustzellen
SE524468C2 (sv) * 2002-12-09 2004-08-10 Axlon Int Ab Anordning och metod för sortering av mynt
US20040146868A1 (en) * 2003-01-24 2004-07-29 Epigenomics Ag Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the development of peripheral zone prostate cancer
CA2548528A1 (en) 2003-12-01 2005-06-16 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
JP2007513621A (ja) 2003-12-11 2007-05-31 エピゲノミクス アーゲー 乳房細胞増殖性障害の改良された処置のための方法および核酸
ATE508207T1 (de) * 2006-02-28 2011-05-15 Charite Universitaetsmedizin Nachweis und qualitätskontrolle von regulator-t- zellen mittels dna-methylierungsanalyse des foxp3-gens

Also Published As

Publication number Publication date
WO2006071466A2 (en) 2006-07-06
EP2311984A1 (de) 2011-04-20
AU2005322435B2 (en) 2012-02-23
EP2280084B1 (de) 2015-02-11
CA2593546A1 (en) 2006-07-06
ES2331146T3 (es) 2009-12-22
EP1831399B1 (de) 2009-08-05
US20160312287A1 (en) 2016-10-27
JP2012120538A (ja) 2012-06-28
DE602005015893D1 (de) 2009-09-17
ES2534139T3 (es) 2015-04-17
EP2213749A1 (de) 2010-08-04
EP2311984A8 (de) 2011-12-28
US20090197250A1 (en) 2009-08-06
AU2005322435A1 (en) 2006-07-06
JP2008522590A (ja) 2008-07-03
EP2284279A1 (de) 2011-02-16
JP5745202B2 (ja) 2015-07-08
EP2280084A1 (de) 2011-02-02
JP5883677B2 (ja) 2016-03-15
WO2006071466A8 (en) 2009-06-18
WO2006071466A3 (en) 2007-03-15
EP1831399A2 (de) 2007-09-12

Similar Documents

Publication Publication Date Title
DE602005015893D1 (de) Verfahren und nukleinsäuren zur analyse von mit der prognose von störungen der proliferation von prostatazellen assoziierter genexpression
DK2253718T3 (da) Fast overflade til biomolekylafgivelse og analyse med høj omsætning
AU2008222649A8 (en) Primers for melting analysis
DE602004024038D1 (de) Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotidbindungsproteinwechselwirkungen unter verwendung licht sammelnder multichromophoren
DE602006017527D1 (de) Verfahren und mittel zur entfernung einer ausgewählten dna-sequenz
ATE541054T1 (de) Bio-barcode erkennung für zielmoleküle
BRPI0519570A2 (pt) mÉtodo de determinaÇço de faixa de dose de uma warfarina para um indivÍduo, kit para determinaÇço da faixa de dose de uma warfarina, oligonucleotÍdeo ou complemento do mesmo, e, arranjo de oligonucleotÍdeos
WO2003072820A3 (en) Method and nucleic acids for the analysis of colon cell proliferative disorders
WO2005054517A3 (en) Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
DE602007009498D1 (de) Neue fluoreszenzproteine und verfahren zur verwendung davon
WO2005054270A3 (en) Identification and design of sirna molecules
DE602005025401D1 (de) Hes verfahren unter verwendung davon
ATE428771T1 (de) Antikörper gegen hundepankreaslipase
WO2003085083A3 (en) Liver necrosis predictive genes
WO2003095624A3 (en) Liver inflammation predictive genes
WO2009054474A1 (ja) アレル判定装置及び方法、ならびに、コンピュータプログラム
ATE415484T1 (de) Verfahren und zusammensetzungen zur charakterisierung eines redox-reagenz-system enzyms
GB2437460A (en) Method and apparatus for chromosome profiling
DE602004028924D1 (de) Polymorphismen des frzb gens und deren zusammenhang mit osteoporose
ATE394417T1 (de) Sonde zum nachweis von nukleinsäuren
ATE455867T1 (de) Echtzeit-pcr unter zusatz von pyrophosphatase
ATE498021T1 (de) Verwendung genetischer polymorphismen zur vorhersage arzneistoffinduzierter hepatotoxizität
ATE553221T1 (de) Verfahren zum nachweis von amplifikation oder deletion in einem genomischen dna-fragment
BRPI0507392A (pt) método e kit para determinar a possibilidade de metástase de cáncer em um indivìduo
WO2004061076A3 (en) Method and apparatus for determining gene expression levels

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties