ATE439451T1 - Verfahren und kit zur bestimmung von thymidinkinase-aktivität und verwendung davon - Google Patents

Verfahren und kit zur bestimmung von thymidinkinase-aktivität und verwendung davon

Info

Publication number: ATE439451T1
Authority: AT; Austria
Prior art keywords: biological sample; assay kit; activity; deoxy nucleoside; template
Prior art date: 2005-02-25

Application number

AT06716936T

Other languages

English (en)

Inventor

Simon Gronowitz

Original Assignee

Roennerbol Internat Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-02-25

Filing date

2006-02-24

Publication date

2009-08-15

2006-02-24 Application filed by Roennerbol Internat Ab filed Critical Roennerbol Internat Ab

2009-08-15 Application granted granted Critical

2009-08-15 Publication of ATE439451T1 publication Critical patent/ATE439451T1/de

Links

230000000694 effects Effects 0.000 title abstract 5
108091000080 Phosphotransferase Proteins 0.000 title abstract 3
102000020233 phosphotransferase Human genes 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
102000006601 Thymidine Kinase Human genes 0.000 abstract 4
108020004440 Thymidine kinase Proteins 0.000 abstract 4
238000003149 assay kit Methods 0.000 abstract 3
239000012472 biological sample Substances 0.000 abstract 3
239000002777 nucleoside Substances 0.000 abstract 3
150000003833 nucleoside derivatives Chemical class 0.000 abstract 3
229910019142 PO4 Inorganic materials 0.000 abstract 2
210000001175 cerebrospinal fluid Anatomy 0.000 abstract 2
-1 new drug candidates Chemical class 0.000 abstract 2
235000021317 phosphate Nutrition 0.000 abstract 2
239000007787 solid Substances 0.000 abstract 2
WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 abstract 1
206010003445 Ascites Diseases 0.000 abstract 1
WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 abstract 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 abstract 1
206010061818 Disease progression Diseases 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Natural products O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 abstract 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
229950004398 broxuridine Drugs 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
208000035269 cancer or benign tumor Diseases 0.000 abstract 1
229940041514 candida albicans extract Drugs 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
230000005750 disease progression Effects 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229940000406 drug candidate Drugs 0.000 abstract 1
230000009483 enzymatic pathway Effects 0.000 abstract 1
239000000284 extract Substances 0.000 abstract 1
ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 abstract 1
229960004716 idoxuridine Drugs 0.000 abstract 1
238000011534 incubation Methods 0.000 abstract 1
238000012544 monitoring process Methods 0.000 abstract 1
239000002547 new drug Substances 0.000 abstract 1
238000001668 nucleic acid synthesis Methods 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
210000002381 plasma Anatomy 0.000 abstract 1
210000004910 pleural fluid Anatomy 0.000 abstract 1
230000000379 polymerizing effect Effects 0.000 abstract 1
238000004393 prognosis Methods 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
229940104230 thymidine Drugs 0.000 abstract 1
210000001519 tissue Anatomy 0.000 abstract 1
239000012138 yeast extract Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Pathology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT06716936T 2005-02-25 2006-02-24 Verfahren und kit zur bestimmung von thymidinkinase-aktivität und verwendung davon ATE439451T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0500432		2005-02-25
PCT/SE2006/000246 WO2006091158A1 (en)	2005-02-25	2006-02-24	A method and kit for determination of thymidine kinase activity and use thereof

Publications (1)

Publication Number	Publication Date
ATE439451T1 true ATE439451T1 (de)	2009-08-15

Family

ID=36927697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06716936T ATE439451T1 (de)	2005-02-25	2006-02-24	Verfahren und kit zur bestimmung von thymidinkinase-aktivität und verwendung davon

Country Status (21)

Country	Link
US (2)	US8765378B2 (de)
EP (1)	EP1856275B1 (de)
JP (1)	JP5227034B2 (de)
KR (1)	KR101275585B1 (de)
CN (1)	CN101128600B (de)
AT (1)	ATE439451T1 (de)
AU (1)	AU2006217129B2 (de)
BR (1)	BRPI0609044B8 (de)
CA (1)	CA2598726C (de)
DE (1)	DE602006008435D1 (de)
DK (1)	DK1856275T3 (de)
EA (1)	EA012438B1 (de)
ES (1)	ES2330881T3 (de)
IL (1)	IL185425A (de)
MX (1)	MX2007010334A (de)
NO (1)	NO341196B1 (de)
NZ (1)	NZ556764A (de)
PL (1)	PL1856275T3 (de)
PT (1)	PT1856275E (de)
WO (1)	WO2006091158A1 (de)
ZA (1)	ZA200707334B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9429518B2 (en) *	2010-05-14	2016-08-30	Csens Ab	Kit and method
US8728751B2 (en) *	2011-04-12	2014-05-20	Veterinary Diagnostics Institute, Inc.	System and method for diagnosing lymphoma in cats
WO2013048952A1 (en) *	2011-09-28	2013-04-04	Biomed Valley Discoveries, Inc.	Methods and compositions for detecting infections
CN103728456B (zh) *	2013-09-16	2015-09-30	长沙赢润生物技术有限公司	胸腺嘧啶核苷激酶的elisa诊断试剂盒
CN106556592B (zh) *	2015-09-24	2019-05-21	深圳市安群生物工程有限公司	定量检测人tk1的化学发光试剂盒及其制备方法
ES2983797T3 (es) *	2018-08-31	2024-10-24	Hoffmann La Roche	Timidina cinasa (TK-1) en índices pronóstico para LDLBG

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE453514B (sv)	1982-05-14	1988-02-08	Gronowitz Jan Sim0N	Sett att bestemma deoxitymidinkinas-dtk-isoenzymnivaer i kroppsvetska eller cellprov och anvendningen av forfarandet for isoenzymtypning
SE462497B (sv) *	1988-11-30	1990-07-02	Clas Fredrik Runesson Kaelland	Saett foer att aktivitetsbestaemma polymeraser
KR100396548B1 (ko) *	2001-01-10	2003-09-03	삼성전자주식회사	프린팅 속도를 향상시키는 프린터 제어 장치 및 그 방법
DE60208787T2 (de) *	2001-06-14	2006-11-02	Cavidi Tech Ab	Verfahren zum messen der polymerisierung von dna und anwendungen des verfahrens
WO2004011627A2 (en) *	2002-07-25	2004-02-05	David-Nicolas Chaperon	A recombinant host cell line screening system for drugs with potential anti-cancer and anti-(retro-) viral activity
ATE352039T1 (de) *	2002-07-27	2007-02-15	Diasorin Ab	Verfahren zur bestimmung der aktivität von thymidinkinase-1 und dessen verwendung
DE602004029156D1 (de) *	2003-05-16	2010-10-28	Arocell Ab	Prognose des verlaufs einer krebserkrankung
DE102004032872A1 (de) *	2004-07-01	2006-01-19	Bayer Cropscience Ag	Verfahren zum Identifizieren von fungizid wirksamen Verbindungen basierend auf Thymidylat-Kinasen

2006
- 2006-02-24 CA CA2598726A patent/CA2598726C/en not_active Expired - Lifetime
- 2006-02-24 MX MX2007010334A patent/MX2007010334A/es active IP Right Grant
- 2006-02-24 PT PT06716936T patent/PT1856275E/pt unknown
- 2006-02-24 BR BRPI0609044A patent/BRPI0609044B8/pt not_active IP Right Cessation
- 2006-02-24 EP EP06716936A patent/EP1856275B1/de not_active Expired - Lifetime
- 2006-02-24 ZA ZA200707334A patent/ZA200707334B/xx unknown
- 2006-02-24 ES ES06716936T patent/ES2330881T3/es not_active Expired - Lifetime
- 2006-02-24 AT AT06716936T patent/ATE439451T1/de active
- 2006-02-24 PL PL06716936T patent/PL1856275T3/pl unknown
- 2006-02-24 AU AU2006217129A patent/AU2006217129B2/en not_active Ceased
- 2006-02-24 EA EA200701572A patent/EA012438B1/ru unknown
- 2006-02-24 US US11/883,187 patent/US8765378B2/en active Active
- 2006-02-24 DE DE602006008435T patent/DE602006008435D1/de not_active Expired - Lifetime
- 2006-02-24 JP JP2007556999A patent/JP5227034B2/ja not_active Expired - Fee Related
- 2006-02-24 KR KR1020077019117A patent/KR101275585B1/ko not_active Expired - Lifetime
- 2006-02-24 NZ NZ556764A patent/NZ556764A/en not_active IP Right Cessation
- 2006-02-24 CN CN200680005892.8A patent/CN101128600B/zh not_active Expired - Fee Related
- 2006-02-24 WO PCT/SE2006/000246 patent/WO2006091158A1/en not_active Ceased
- 2006-02-24 DK DK06716936T patent/DK1856275T3/da active
2007
- 2007-08-21 IL IL185425A patent/IL185425A/en active IP Right Grant
- 2007-09-25 NO NO20074882A patent/NO341196B1/no unknown
2014
- 2014-05-23 US US14/286,130 patent/US9376707B2/en active Active

Also Published As

Publication number	Publication date
US8765378B2 (en)	2014-07-01
AU2006217129A1 (en)	2006-08-31
ZA200707334B (en)	2009-02-25
AU2006217129B2 (en)	2011-06-30
IL185425A0 (en)	2008-01-06
US20140255949A1 (en)	2014-09-11
KR20070107055A (ko)	2007-11-06
US20080248472A1 (en)	2008-10-09
EP1856275A1 (de)	2007-11-21
DK1856275T3 (da)	2009-12-07
JP2008531012A (ja)	2008-08-14
US9376707B2 (en)	2016-06-28
BRPI0609044A8 (pt)	2017-02-14
BRPI0609044A2 (pt)	2011-08-30
DE602006008435D1 (de)	2009-09-24
CA2598726C (en)	2014-02-18
MX2007010334A (es)	2007-10-10
KR101275585B1 (ko)	2013-06-19
BRPI0609044B8 (pt)	2021-07-27
PT1856275E (pt)	2009-11-02
EA012438B1 (ru)	2009-10-30
NO341196B1 (no)	2017-09-11
JP5227034B2 (ja)	2013-07-03
CN101128600A (zh)	2008-02-20
EP1856275B1 (de)	2009-08-12
CN101128600B (zh)	2015-12-09
PL1856275T3 (pl)	2010-01-29
BRPI0609044B1 (pt)	2020-03-10
IL185425A (en)	2011-02-28
NO20074882L (no)	2007-11-22
WO2006091158A1 (en)	2006-08-31
NZ556764A (en)	2010-04-30
CA2598726A1 (en)	2006-08-31
EA200701572A1 (ru)	2008-02-28
ES2330881T3 (es)	2009-12-16
HK1117197A1 (zh)	2009-01-09

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2010-03-15

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