ATE442372T1 - Verfahren zur herstellung von cefoxitin - Google Patents

Verfahren zur herstellung von cefoxitin

Info

Publication number: ATE442372T1
Authority: AT; Austria
Prior art keywords: cefoxitin; producing; desacetylated; carbamoylated; cefalotin
Prior art date: 2005-07-27

Application number

AT06115844T

Other languages

English (en)

Inventor

Antonio Manca

Riccardo Monguzzi

Maurizio Zenoni

Leonardo Marsili

Original Assignee

Acs Dobfar Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-27

Filing date

2006-06-21

Publication date

2009-09-15

2006-06-21 Application filed by Acs Dobfar Spa filed Critical Acs Dobfar Spa

2009-09-15 Application granted granted Critical

2009-09-15 Publication of ATE442372T1 publication Critical patent/ATE442372T1/de

Links

229960002682 cefoxitin Drugs 0.000 title abstract 3
WZOZEZRFJCJXNZ-ZBFHGGJFSA-N cefoxitin Chemical compound N([C@]1(OC)C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)CC1=CC=CS1 WZOZEZRFJCJXNZ-ZBFHGGJFSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
GNWUOVJNSFPWDD-XMZRARIVSA-M Cefoxitin sodium Chemical compound [Na+].N([C@]1(OC)C(N2C(=C(COC(N)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)CC1=CC=CS1 GNWUOVJNSFPWDD-XMZRARIVSA-M 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
229960000603 cefalotin Drugs 0.000 abstract 1
VUFGUVLLDPOSBC-XRZFDKQNSA-M cephalothin sodium Chemical compound [Na+].N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C([O-])=O)C(=O)CC1=CC=CS1 VUFGUVLLDPOSBC-XRZFDKQNSA-M 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
239000003456 ion exchange resin Substances 0.000 abstract 1
229920003303 ion-exchange polymer Polymers 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
159000000000 sodium salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)

AT06115844T 2005-07-27 2006-06-21 Verfahren zur herstellung von cefoxitin ATE442372T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT001451A ITMI20051451A1 (it)	2005-07-27	2005-07-27	Procedimento per la preparazione di cefoxitin sodico

Publications (1)

Publication Number	Publication Date
ATE442372T1 true ATE442372T1 (de)	2009-09-15

Family

ID=37027871

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06115844T ATE442372T1 (de)	2005-07-27	2006-06-21	Verfahren zur herstellung von cefoxitin

Country Status (9)

Country	Link
US (1)	US7605256B2 (de)
EP (1)	EP1748049B1 (de)
KR (1)	KR101266018B1 (de)
CN (1)	CN1903861A (de)
AT (1)	ATE442372T1 (de)
DE (1)	DE602006009030D1 (de)
ES (1)	ES2332664T3 (de)
IT (1)	ITMI20051451A1 (de)
PT (1)	PT1748049E (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7662955B2 (en) *	2003-03-20	2010-02-16	Orchid Chemicals And Pharmaceuticals Ltd.	Process for the preparation of cefoxitin
ITMI20051991A1 (it) *	2005-10-20	2007-04-21	Acs Dobfar Spa	Purificazione di prodotti beta-lattamici
US8762056B2 (en) *	2007-06-28	2014-06-24	Apple Inc.	Route reference
ITMI20071951A1 (it)	2007-10-09	2008-01-08	Acs Dobfar Spa	Processo per la produzione di 7-metossi-3-desacetilcefalotina
CN101555252B (zh) *	2009-05-21	2011-05-11	苏州致君万庆药业有限公司	一种抗菌素头孢西丁的合成方法
CN102153567B (zh) *	2010-05-28	2013-08-14	重庆天地药业有限责任公司	一种制备头孢西丁酸的方法
CN102295654B (zh) *	2011-08-10	2012-07-04	江西新先锋医药有限公司	一种头孢西丁化合物及其组合物
CN102358744B (zh) *	2011-09-02	2013-11-06	山东罗欣药业股份有限公司	一种头孢西丁钠结晶化合物及其组合物粉针
CN102399234A (zh) *	2011-12-06	2012-04-04	苏州中联化学制药有限公司	头孢西丁钠的制备方法
CN104230956B (zh) *	2012-04-24	2016-07-06	齐鲁安替（临邑）制药有限公司	一种头孢西丁的制备方法
CN102633819A (zh) *	2012-04-24	2012-08-15	齐鲁安替（临邑）制药有限公司	一种头孢西丁的制备方法
CN103910748B (zh) *	2014-04-26	2016-05-25	济南康和医药科技有限公司	替莫西林钠的制备方法
CN104402908B (zh) *	2014-10-23	2017-10-27	胡梨芳	头孢西丁钠化合物实体及其组合物和用途
CN104402909B (zh) *	2014-11-12	2017-03-15	盐城开元医药化工有限公司	一种头孢西丁酸的合成方法
CN104890950A (zh) *	2015-04-27	2015-09-09	四川制药制剂有限公司	自动检验产品的注射用头孢西丁钠的制备工艺
CN109651403B (zh) *	2018-12-29	2022-01-07	上海上药新亚药业有限公司	一种头孢西丁钠的合成方法
CN111217836A (zh) *	2020-03-20	2020-06-02	侯二美	一种头孢西丁的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL156026B1 (pl)	1987-11-06	1992-01-31	Os Bad Rozwojowy Biotechnologi	Sposób wytwarzania półsyntetycznych cefaiosporyn
WO2004083217A1 (en)	2003-03-20	2004-09-30	Orchid Chemicals & Pharmaceuticals Ltd	An improved process for the preparation of cefoxitin
US7662955B2 (en) *	2003-03-20	2010-02-16	Orchid Chemicals And Pharmaceuticals Ltd.	Process for the preparation of cefoxitin
ITMI20071951A1 (it) *	2007-10-09	2008-01-08	Acs Dobfar Spa	Processo per la produzione di 7-metossi-3-desacetilcefalotina

2005
- 2005-07-27 IT IT001451A patent/ITMI20051451A1/it unknown
2006
- 2006-06-21 US US11/425,560 patent/US7605256B2/en not_active Expired - Fee Related
- 2006-06-21 ES ES06115844T patent/ES2332664T3/es active Active
- 2006-06-21 EP EP06115844A patent/EP1748049B1/de not_active Not-in-force
- 2006-06-21 DE DE602006009030T patent/DE602006009030D1/de active Active
- 2006-06-21 PT PT06115844T patent/PT1748049E/pt unknown
- 2006-06-21 AT AT06115844T patent/ATE442372T1/de active
- 2006-07-26 KR KR1020060070351A patent/KR101266018B1/ko not_active Expired - Fee Related
- 2006-07-26 CN CNA2006101080456A patent/CN1903861A/zh active Pending

Also Published As

Publication number	Publication date
CN1903861A (zh)	2007-01-31
KR20070014078A (ko)	2007-01-31
EP1748049A3 (de)	2007-06-06
EP1748049B1 (de)	2009-09-09
US20070027314A1 (en)	2007-02-01
US7605256B2 (en)	2009-10-20
EP1748049A2 (de)	2007-01-31
ITMI20051451A1 (it)	2007-01-28
DE602006009030D1 (de)	2009-10-22
ES2332664T3 (es)	2010-02-10
PT1748049E (pt)	2009-12-03
KR101266018B1 (ko)	2013-05-21

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2010-03-15

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