ATE443713T1 - Makrozyklische peptide mit wirkung gegen das hepatitis-c-virus - Google Patents
Makrozyklische peptide mit wirkung gegen das hepatitis-c-virusInfo
- Publication number
- ATE443713T1 ATE443713T1 AT03809217T AT03809217T ATE443713T1 AT E443713 T1 ATE443713 T1 AT E443713T1 AT 03809217 T AT03809217 T AT 03809217T AT 03809217 T AT03809217 T AT 03809217T AT E443713 T1 ATE443713 T1 AT E443713T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- virus
- active against
- against hepatitis
- macrocyclic peptides
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- -1 O-(C1-6)alkyl Chemical group 0.000 abstract 2
- 125000003368 amide group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 101800001838 Serine protease/helicase NS3 Proteins 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42141402P | 2002-10-25 | 2002-10-25 | |
| US43382002P | 2002-12-16 | 2002-12-16 | |
| US44276803P | 2003-01-27 | 2003-01-27 | |
| PCT/CA2003/001604 WO2004037855A1 (en) | 2002-10-25 | 2003-10-20 | Macrocyclic peptides active against the hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443713T1 true ATE443713T1 (de) | 2009-10-15 |
Family
ID=32180514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03809217T ATE443713T1 (de) | 2002-10-25 | 2003-10-20 | Makrozyklische peptide mit wirkung gegen das hepatitis-c-virus |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20050075279A1 (de) |
| EP (1) | EP1558632B1 (de) |
| JP (1) | JP4398424B2 (de) |
| AT (1) | ATE443713T1 (de) |
| AU (1) | AU2003275826A1 (de) |
| CA (1) | CA2498572C (de) |
| DE (1) | DE60329408D1 (de) |
| ES (1) | ES2330932T3 (de) |
| WO (1) | WO2004037855A1 (de) |
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| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
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| US7119072B2 (en) * | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
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| CA2541634A1 (en) * | 2003-10-10 | 2005-04-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
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| CA2547770A1 (en) * | 2003-12-08 | 2005-06-23 | Fabrice Gallou | Removal of ruthenium by-product by supercritical fluid processing |
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-
2003
- 2003-10-16 US US10/686,755 patent/US20050075279A1/en not_active Abandoned
- 2003-10-20 ES ES03809217T patent/ES2330932T3/es not_active Expired - Lifetime
- 2003-10-20 WO PCT/CA2003/001604 patent/WO2004037855A1/en not_active Ceased
- 2003-10-20 JP JP2005501488A patent/JP4398424B2/ja not_active Expired - Fee Related
- 2003-10-20 EP EP03809217A patent/EP1558632B1/de not_active Expired - Lifetime
- 2003-10-20 DE DE60329408T patent/DE60329408D1/de not_active Expired - Lifetime
- 2003-10-20 AT AT03809217T patent/ATE443713T1/de active
- 2003-10-20 AU AU2003275826A patent/AU2003275826A1/en not_active Abandoned
- 2003-10-20 CA CA2498572A patent/CA2498572C/en not_active Expired - Fee Related
-
2005
- 2005-12-10 US US11/298,443 patent/US7504378B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2330932T3 (es) | 2009-12-17 |
| DE60329408D1 (de) | 2009-11-05 |
| US20050075279A1 (en) | 2005-04-07 |
| AU2003275826A1 (en) | 2004-05-13 |
| JP2006517915A (ja) | 2006-08-03 |
| EP1558632B1 (de) | 2009-09-23 |
| EP1558632A1 (de) | 2005-08-03 |
| WO2004037855A1 (en) | 2004-05-06 |
| JP4398424B2 (ja) | 2010-01-13 |
| US20060089300A1 (en) | 2006-04-27 |
| US7504378B2 (en) | 2009-03-17 |
| CA2498572A1 (en) | 2004-05-06 |
| CA2498572C (en) | 2011-08-23 |
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