ATE443777T1 - Methoden und zusammensetzungen zur analyse von ribonukleinsäuren - Google Patents
Methoden und zusammensetzungen zur analyse von ribonukleinsäurenInfo
- Publication number
- ATE443777T1 ATE443777T1 AT05815286T AT05815286T ATE443777T1 AT E443777 T1 ATE443777 T1 AT E443777T1 AT 05815286 T AT05815286 T AT 05815286T AT 05815286 T AT05815286 T AT 05815286T AT E443777 T1 ATE443777 T1 AT E443777T1
- Authority
- AT
- Austria
- Prior art keywords
- probe
- compositions
- methods
- nucleic acid
- analyzing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229920002477 rna polymer Polymers 0.000 title 1
- 239000000523 sample Substances 0.000 abstract 7
- 150000007523 nucleic acids Chemical group 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 230000003321 amplification Effects 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 108091070501 miRNA Proteins 0.000 abstract 1
- 239000002679 microRNA Substances 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/963,415 US20060078894A1 (en) | 2004-10-12 | 2004-10-12 | Methods and compositions for analyzing nucleic acids |
| PCT/US2005/036799 WO2006042303A2 (en) | 2004-10-12 | 2005-10-12 | Methods and compositions for analyzing ribonucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443777T1 true ATE443777T1 (de) | 2009-10-15 |
Family
ID=36145799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05815286T ATE443777T1 (de) | 2004-10-12 | 2005-10-12 | Methoden und zusammensetzungen zur analyse von ribonukleinsäuren |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060078894A1 (de) |
| EP (1) | EP1812599B1 (de) |
| AT (1) | ATE443777T1 (de) |
| DE (1) | DE602005016828D1 (de) |
| WO (1) | WO2006042303A2 (de) |
Families Citing this family (82)
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| US20100022414A1 (en) | 2008-07-18 | 2010-01-28 | Raindance Technologies, Inc. | Droplet Libraries |
| EP2290072B1 (de) * | 2004-05-28 | 2014-12-17 | Asuragen, Inc. | Verfahren und Zusammensetzungen mit MicroRNA |
| ES2534304T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| EP1984738A2 (de) | 2006-01-11 | 2008-10-29 | Raindance Technologies, Inc. | Mikrofluidische vorrichtungen und verfahren zur verwendung bei der bildung und kontrolle von nanoreaktoren |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| EP4190448A3 (de) | 2006-05-11 | 2023-09-20 | Bio-Rad Laboratories, Inc. | Mikrofluidische vorrichtungen |
| US20090023221A1 (en) * | 2006-05-19 | 2009-01-22 | Exigon A/S | Oligonucleotide probes useful for detection and analysis of microrna precursors |
| EP2145001A2 (de) * | 2006-09-19 | 2010-01-20 | Asuragen, Inc. | Von mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulierte gene und stoffwechselwege als ziele für einen therapeutischen eingriff |
| WO2008052774A2 (en) * | 2006-10-31 | 2008-05-08 | Noxxon Pharma Ag | Methods for detection of a single- or double-stranded nucleic acid molecule |
| US20080131878A1 (en) * | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
| CN101622350A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为干预治疗靶标的miR-126调控基因和通路 |
| CA2671194A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-20 regulated genes and pathways as targets for therapeutic intervention |
| DK2104737T3 (da) * | 2006-12-08 | 2013-05-27 | Asuragen Inc | Funktioner og formål for let-7 mikro-RNAer |
| WO2008073920A2 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| US20090175827A1 (en) * | 2006-12-29 | 2009-07-09 | Byrom Mike W | miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US20080274458A1 (en) * | 2007-05-01 | 2008-11-06 | Latham Gary J | Nucleic acid quantitation methods |
| US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
| US20090227533A1 (en) * | 2007-06-08 | 2009-09-10 | Bader Andreas G | miR-34 Regulated Genes and Pathways as Targets for Therapeutic Intervention |
| US8008010B1 (en) | 2007-06-27 | 2011-08-30 | Applied Biosystems, Llc | Chimeric oligonucleotides for ligation-enhanced nucleic acid detection, methods and compositions therefor |
| WO2009014766A2 (en) * | 2007-07-26 | 2009-01-29 | The University Of Utah Research Foundation | Non-invasive recovery of rna and analysis of gene expression in skin |
| EP2198050A1 (de) * | 2007-09-14 | 2010-06-23 | Asuragen, INC. | Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon |
| US7993831B2 (en) * | 2007-09-14 | 2011-08-09 | Asuragen, Inc. | Methods of normalization in microRNA detection assays |
| WO2009052386A1 (en) * | 2007-10-18 | 2009-04-23 | Asuragen, Inc. | Micrornas differentially expressed in lung diseases and uses thereof |
| CA2706763C (en) * | 2007-11-27 | 2013-07-30 | Laboratory Corporation Of America Holdings | Enhanced method for detecting and/or quantifying an analyte in a sample |
| US8071562B2 (en) * | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
| US20090192114A1 (en) * | 2007-12-21 | 2009-07-30 | Dmitriy Ovcharenko | miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention |
| WO2009100430A2 (en) * | 2008-02-08 | 2009-08-13 | Asuragen, Inc | miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS |
| EP2271757A2 (de) * | 2008-03-26 | 2011-01-12 | Asuragen, INC. | Zusammensetzungen und verfahren in zusammenhang mit mir-16 und prostatakrebstherapie |
| WO2009126726A1 (en) * | 2008-04-08 | 2009-10-15 | Asuragen, Inc | Methods and compositions for diagnosing and modulating human papillomavirus (hpv) |
| US8258111B2 (en) * | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US20100179213A1 (en) * | 2008-11-11 | 2010-07-15 | Mirna Therapeutics, Inc. | Methods and Compositions Involving miRNAs In Cancer Stem Cells |
| US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| WO2010120803A2 (en) | 2009-04-13 | 2010-10-21 | Somagenics Inc. | Methods and compositions for detection of small rnas |
| AU2010242073C1 (en) | 2009-04-30 | 2015-12-24 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
| US12129514B2 (en) | 2009-04-30 | 2024-10-29 | Molecular Loop Biosolutions, Llc | Methods and compositions for evaluating genetic markers |
| AU2010249421A1 (en) | 2009-05-22 | 2011-12-08 | Asuragen, Inc. | miRNA biomarkers of prostate disease |
| EP2470897A4 (de) | 2009-08-28 | 2013-05-29 | Asuragen Inc | Mirna-biomarker für lungenerkrankungen |
| EP4435111A1 (de) | 2010-02-12 | 2024-09-25 | Bio-Rad Laboratories, Inc. | Digitale analytanalyse |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
| EP2675819B1 (de) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Zusammensetzungen und verfahren für molekulare etikettierung |
| WO2012167142A2 (en) | 2011-06-02 | 2012-12-06 | Raindance Technolgies, Inc. | Enzyme quantification |
| KR102082016B1 (ko) | 2011-06-27 | 2020-02-26 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 알츠하이머병을 나타내는 마이크로rna 바이오마커들 |
| EP2744916A4 (de) | 2011-07-13 | 2015-06-17 | Primeradx Inc | Multimodale verfahren zur simultanen erkennung und quantifizierung mehrerer nukleinsäuren in einer probe |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| US9644241B2 (en) | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
| AU2012316129B2 (en) * | 2011-09-28 | 2017-10-05 | Htg Molecular Diagnostics, Inc. | Methods of co-detecting mRNA and small non-coding RNA |
| CA2852665A1 (en) | 2011-10-17 | 2013-04-25 | Good Start Genetics, Inc. | Analysis methods |
| WO2013096839A1 (en) | 2011-12-22 | 2013-06-27 | Somagenics, Inc. | Methods of constructing small rna libraries and their use for expression profiling of target rnas |
| EP2823303A4 (de) * | 2012-02-10 | 2015-09-30 | Raindance Technologies Inc | Molekulardiagnostischer screeningtest |
| US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
| US8812422B2 (en) | 2012-04-09 | 2014-08-19 | Good Start Genetics, Inc. | Variant database |
| US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
| WO2014005038A1 (en) | 2012-06-29 | 2014-01-03 | Htg Molecular Diagnostics, Inc. | Nuclease protection methods for detection of nucleotide variants |
| US20140127688A1 (en) | 2012-11-07 | 2014-05-08 | Good Start Genetics, Inc. | Methods and systems for identifying contamination in samples |
| EP2971183A4 (de) | 2013-03-13 | 2016-10-26 | Meso Scale Technologies Llc | Verbesserte testverfahren |
| WO2014152421A1 (en) | 2013-03-14 | 2014-09-25 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
| EP3005200A2 (de) | 2013-06-03 | 2016-04-13 | Good Start Genetics, Inc. | Verfahren und systeme zur speicherung von sequenzlesedaten |
| EP3058096A1 (de) | 2013-10-18 | 2016-08-24 | Good Start Genetics, Inc. | Verfahren zur beurteilung eines genomischen bereichs einer person |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| EP3425066A1 (de) | 2014-01-05 | 2019-01-09 | Biomirna Holdings Ltd. | Lungenkrebsbestimmung mit mirna |
| WO2015120382A1 (en) | 2014-02-07 | 2015-08-13 | The Johns Hopkins University | Predicting response to epigenetic drug therapy |
| US11053548B2 (en) | 2014-05-12 | 2021-07-06 | Good Start Genetics, Inc. | Methods for detecting aneuploidy |
| KR20250011724A (ko) | 2014-05-15 | 2025-01-21 | 메소 스케일 테크놀러지즈, 엘엘시 | 개선된 분석 방법 |
| US20160048608A1 (en) | 2014-08-15 | 2016-02-18 | Good Start Genetics, Inc. | Systems and methods for genetic analysis |
| US11408024B2 (en) | 2014-09-10 | 2022-08-09 | Molecular Loop Biosciences, Inc. | Methods for selectively suppressing non-target sequences |
| EP3224595A4 (de) | 2014-09-24 | 2018-06-13 | Good Start Genetics, Inc. | Prozesssteuerung für erhöhte robustheit von genetischen assays |
| WO2016094330A2 (en) | 2014-12-08 | 2016-06-16 | 20/20 Genesystems, Inc | Methods and machine learning systems for predicting the liklihood or risk of having cancer |
| WO2016112073A1 (en) | 2015-01-06 | 2016-07-14 | Good Start Genetics, Inc. | Screening for structural variants |
| EP3292214A1 (de) | 2015-05-04 | 2018-03-14 | Academisch Medisch Centrum | Verfahren zur quantifizierung von mirnas mittels normalisierung |
| US11014957B2 (en) | 2015-12-21 | 2021-05-25 | Realseq Biosciences, Inc. | Methods of library construction for polynucleotide sequencing |
| HRP20230345T1 (hr) * | 2017-01-16 | 2023-06-09 | Spectrum Solutions L.L.C. | Otopina za očuvanje nukleinske kiseline i načini uporabe |
| US20200263233A1 (en) * | 2017-06-23 | 2020-08-20 | Eiken Kagaku Kabushiki Kaisha | Method For Nucleic Acid Detection, Primer For Nucleic Acid Detection, And Kit For Nucleic Acid Detection |
| EP3719144A1 (de) | 2019-04-05 | 2020-10-07 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung |
| EP3999664A1 (de) | 2019-07-19 | 2022-05-25 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Verfahren zur bestimmung des ansprechens auf die behandlung eines patienten mit nicht-kleinzelligem lungenkarzinom (nsclc) |
| WO2022051485A2 (en) * | 2020-09-02 | 2022-03-10 | Meso Scale Technologies,Llc. | Kits for detecting one or more target analytes in a sample and methods of making and using the same |
| KR102783485B1 (ko) | 2021-10-15 | 2025-03-20 | 아주대학교산학협력단 | miR-625-3p의 건선 중증도 진단용 바이오마커로서의 용도 |
| KR20240177780A (ko) | 2023-06-19 | 2024-12-30 | 재단법인 아산사회복지재단 | 맥락막 비후 질환의 진단 또는 예후 예측용 조성물, 키트 및 진단 또는 예후 예측을 위한 정보를 제공하는 방법 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4876187A (en) * | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
| US5011769A (en) * | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US4999290A (en) * | 1988-03-31 | 1991-03-12 | The Board Of Regents, The University Of Texas System | Detection of genomic abnormalities with unique aberrant gene transcripts |
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| WO1995014106A2 (en) * | 1993-11-17 | 1995-05-26 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
| US5801155A (en) * | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
| US6174670B1 (en) * | 1996-06-04 | 2001-01-16 | University Of Utah Research Foundation | Monitoring amplification of DNA during PCR |
| US6458533B1 (en) * | 1997-12-19 | 2002-10-01 | High Throughput Genomics, Inc. | High throughput assay system for monitoring ESTs |
| US6238869B1 (en) * | 1997-12-19 | 2001-05-29 | High Throughput Genomics, Inc. | High throughput assay system |
| US6232066B1 (en) * | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
| US5942398A (en) * | 1998-02-26 | 1999-08-24 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding glutx and uses thereof |
| GB9904991D0 (en) * | 1999-03-05 | 1999-04-28 | Univ Nottingham | Genetic screening |
| US7005261B1 (en) * | 1999-07-29 | 2006-02-28 | British Biocell International Limited | Method for detecting nucleic acid target sequences involving in vitro transcription from an RNA polymerase promoter |
| US7205105B2 (en) * | 1999-12-08 | 2007-04-17 | Epoch Biosciences, Inc. | Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis |
| EP1257664A4 (de) * | 2000-01-28 | 2006-04-05 | Althea Technologies Inc | Verfahren zur analyse der genexpression |
| US6573048B1 (en) * | 2000-04-18 | 2003-06-03 | Naxcor | Degradable nucleic acid probes and nucleic acid detection methods |
| US20030170623A1 (en) * | 2001-04-13 | 2003-09-11 | Jingwen Chen | Multiplexed gene analysis on a mobile solid support |
| CA2460639C (en) * | 2001-09-19 | 2013-07-16 | Alexion Pharmaceuticals, Inc. | Engineered templates and their use in single primer amplification |
-
2004
- 2004-10-12 US US10/963,415 patent/US20060078894A1/en not_active Abandoned
-
2005
- 2005-10-12 AT AT05815286T patent/ATE443777T1/de not_active IP Right Cessation
- 2005-10-12 DE DE602005016828T patent/DE602005016828D1/de not_active Expired - Lifetime
- 2005-10-12 WO PCT/US2005/036799 patent/WO2006042303A2/en not_active Ceased
- 2005-10-12 EP EP05815286A patent/EP1812599B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1812599A2 (de) | 2007-08-01 |
| US20060078894A1 (en) | 2006-04-13 |
| EP1812599B1 (de) | 2009-09-23 |
| DE602005016828D1 (de) | 2009-11-05 |
| WO2006042303A3 (en) | 2006-09-21 |
| WO2006042303A2 (en) | 2006-04-20 |
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