ATE444302T1 - Neue cholest-4-en-3-onoximderivate, pharmazeutische zusammensetzungen, die diese enthalten, und herstellungsverfahren - Google Patents

Neue cholest-4-en-3-onoximderivate, pharmazeutische zusammensetzungen, die diese enthalten, und herstellungsverfahren

Info

Publication number: ATE444302T1
Authority: AT; Austria
Prior art keywords: new; derivatives; onoxime; cholest; preparation
Prior art date: 2005-12-20

Application number

AT06841943T

Other languages

English (en)

Inventor

Cyrille Drouot

Delphine Maux

Original Assignee

Trophos

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-20

Filing date

2006-12-15

Publication date

2009-10-15

2006-12-15 Application filed by Trophos filed Critical Trophos

2009-10-15 Application granted granted Critical

2009-10-15 Publication of ATE444302T1 publication Critical patent/ATE444302T1/de

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 abstract 3
101150065749 Churc1 gene Proteins 0.000 abstract 3
102100038239 Protein Churchill Human genes 0.000 abstract 3
LVYGYHKQJHFGNS-LKGWFGLDSA-N (8s,9s,10r,13r,14s,17r)-3-hydroxyimino-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,7,8,9,11,12,14,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-6-one Chemical compound C1C(=O)C2=CC(=NO)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 LVYGYHKQJHFGNS-LKGWFGLDSA-N 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
QNTASHOAVRSLMD-GYKMGIIDSA-N n-[(8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]hydroxylamine Chemical class C1CC2=CC(=NO)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 QNTASHOAVRSLMD-GYKMGIIDSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
210000001185 bone marrow Anatomy 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
210000002161 motor neuron Anatomy 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
230000008092 positive effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000004083 survival effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Hematology (AREA)
Diabetes (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
AIDS & HIV (AREA)
Dermatology (AREA)
Cardiology (AREA)
Molecular Biology (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Tropical Medicine & Parasitology (AREA)

AT06841943T 2005-12-20 2006-12-15 Neue cholest-4-en-3-onoximderivate, pharmazeutische zusammensetzungen, die diese enthalten, und herstellungsverfahren ATE444302T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0512947A FR2894968B1 (fr)	2005-12-20	2005-12-20	Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
PCT/FR2006/002740 WO2007080270A2 (fr)	2005-12-20	2006-12-15	Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation

Publications (1)

Publication Number	Publication Date
ATE444302T1 true ATE444302T1 (de)	2009-10-15

Family

ID=37054406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06841943T ATE444302T1 (de)	2005-12-20	2006-12-15	Neue cholest-4-en-3-onoximderivate, pharmazeutische zusammensetzungen, die diese enthalten, und herstellungsverfahren

Country Status (17)

Country	Link
US (3)	US8481515B2 (de)
EP (1)	EP1963355B1 (de)
JP (1)	JP5452932B2 (de)
AT (1)	ATE444302T1 (de)
AU (1)	AU2006334608B2 (de)
BR (1)	BRPI0620133A2 (de)
CA (1)	CA2633633C (de)
CY (1)	CY1110592T1 (de)
DE (1)	DE602006009557D1 (de)
DK (1)	DK1963355T3 (de)
ES (1)	ES2331755T3 (de)
FR (1)	FR2894968B1 (de)
IL (1)	IL192258A (de)
PL (1)	PL1963355T3 (de)
PT (1)	PT1963355E (de)
SI (1)	SI1963355T1 (de)
WO (1)	WO2007080270A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2874923B1 (fr) *	2004-09-07	2006-10-27	Trophos Sa	Application a titre de medicaments de derives du 3, 5-seco-4-nor-cholestane, compositions pharmaceutiques les renfermant, nouveaux derives et leur procede de preparation
FR2894968B1 (fr) *	2005-12-20	2008-02-22	Trophos Sa	Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
FR2919180B1 (fr) *	2007-07-25	2009-11-27	Trophos	Utilisation d'au moins un derive oxime de la cholest-4-en-3-one comme antioxydants
WO2009092892A2 (fr) *	2007-10-30	2009-07-30	Trophos	Nouvelle composition pour traiter les effets secondaires des traitements anticancereux
FR2934596B1 (fr) *	2008-07-30	2015-04-10	Trophos	Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
WO2012069150A2 (en)	2010-11-22	2012-05-31	Powerpore Gmbh	Cytoprotectant agents for the prevention of drug-associated side-effects
FR2979239A1 (fr)	2011-08-25	2013-03-01	Trophos	Liposome comprenant au moins un derive de cholesterol
TWI637951B (zh)	2013-02-15	2018-10-11	英商葛蘭素史克智慧財產發展有限公司	作為激酶抑制劑之雜環醯胺類
BE1027157B9 (fr) *	2019-08-01	2020-11-03	Dendrogenix	Composition de dérivés de stérols pour son utilisationdans le traitement d’une pathologie neuronale liée à une hypoxie et/ou à une hypoglycémie et composition correspondante
CN115040524A (zh) *	2022-07-27	2022-09-13	深圳市中西医结合医院	4-胆甾烯-3-酮用于治疗多发性骨髓瘤骨病的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2401934A1 (fr) *	1977-08-31	1979-03-30	Roussel Uclaf	Nouveau procede de preparation d'oximes en 3 de derives steroides
JPH06172378A (ja) *	1992-12-03	1994-06-21	Taisho Pharmaceut Co Ltd	ステロイド化合物
ES2190348B1 (es) *	2001-07-19	2005-02-01	Universidade Da Coruña	Nuevos 6e-hidroximinoesteroides: su procdimiento de obtencion mediantesintesis a partir de esteroides comerciales, y su aplicacion como agentes citotoxicos.
FR2852246B1 (fr) *	2003-03-11	2005-07-08		Utilisation de l'oxime de cholest-4-en-3-one dans le traitement des affections du motoneurone
FR2860159B1 (fr) *	2003-09-26	2005-12-02	Trophos	Utilisation de l'oxime de cholest-4-en-3-one en tant que medicament neuroprotecteur
CA2517893C (fr) *	2003-03-11	2012-05-15	Trophos	Application a titre de medicaments de derives de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, nouveaux derives et leur procede de preparation
CN1450080A (zh) *	2003-05-22	2003-10-22	中国科学院广州化学研究所	一种新的甾体化合物及其提取方法
FR2894968B1 (fr) *	2005-12-20	2008-02-22	Trophos Sa	Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation

2005
- 2005-12-20 FR FR0512947A patent/FR2894968B1/fr not_active Expired - Fee Related
2006
- 2006-12-15 DK DK06841943T patent/DK1963355T3/da active
- 2006-12-15 BR BRPI0620133-4A patent/BRPI0620133A2/pt not_active IP Right Cessation
- 2006-12-15 JP JP2008546508A patent/JP5452932B2/ja not_active Expired - Fee Related
- 2006-12-15 WO PCT/FR2006/002740 patent/WO2007080270A2/fr not_active Ceased
- 2006-12-15 SI SI200630520T patent/SI1963355T1/sl unknown
- 2006-12-15 AT AT06841943T patent/ATE444302T1/de active
- 2006-12-15 AU AU2006334608A patent/AU2006334608B2/en not_active Ceased
- 2006-12-15 EP EP06841943A patent/EP1963355B1/de not_active Not-in-force
- 2006-12-15 US US12/158,640 patent/US8481515B2/en not_active Expired - Fee Related
- 2006-12-15 DE DE602006009557T patent/DE602006009557D1/de active Active
- 2006-12-15 ES ES06841943T patent/ES2331755T3/es active Active
- 2006-12-15 PT PT06841943T patent/PT1963355E/pt unknown
- 2006-12-15 PL PL06841943T patent/PL1963355T3/pl unknown
- 2006-12-15 CA CA2633633A patent/CA2633633C/fr not_active Expired - Fee Related
2008
- 2008-06-17 IL IL192258A patent/IL192258A/en not_active IP Right Cessation
2009
- 2009-12-29 CY CY20091101344T patent/CY1110592T1/el unknown
2012
- 2012-01-18 US US13/352,673 patent/US20120122827A1/en not_active Abandoned
2015
- 2015-04-27 US US14/696,933 patent/US20150225443A1/en not_active Abandoned

Also Published As

Publication number	Publication date
IL192258A0 (en)	2008-12-29
JP5452932B2 (ja)	2014-03-26
CY1110592T1 (el)	2015-04-29
CA2633633C (fr)	2015-11-17
US20120122827A1 (en)	2012-05-17
EP1963355A2 (de)	2008-09-03
DK1963355T3 (da)	2009-12-14
ES2331755T3 (es)	2010-01-14
CA2633633A1 (fr)	2007-07-19
PT1963355E (pt)	2009-11-19
AU2006334608B2 (en)	2012-05-03
WO2007080270A3 (fr)	2007-09-20
PL1963355T3 (pl)	2010-03-31
JP2009520006A (ja)	2009-05-21
FR2894968A1 (fr)	2007-06-22
FR2894968B1 (fr)	2008-02-22
IL192258A (en)	2013-01-31
BRPI0620133A2 (pt)	2011-11-01
US20090203662A1 (en)	2009-08-13
AU2006334608A1 (en)	2007-07-19
US20150225443A1 (en)	2015-08-13
US8481515B2 (en)	2013-07-09
SI1963355T1 (sl)	2010-02-26
WO2007080270A2 (fr)	2007-07-19
EP1963355B1 (de)	2009-09-30
DE602006009557D1 (de)	2009-11-12

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