ATE446097T1 - Verwendung von uridin in kombination mit cholin zur behandlung von gedächtnisstörungen - Google Patents

Verwendung von uridin in kombination mit cholin zur behandlung von gedächtnisstörungen

Info

Publication number
ATE446097T1
ATE446097T1 AT07116909T AT07116909T ATE446097T1 AT E446097 T1 ATE446097 T1 AT E446097T1 AT 07116909 T AT07116909 T AT 07116909T AT 07116909 T AT07116909 T AT 07116909T AT E446097 T1 ATE446097 T1 AT E446097T1
Authority
AT
Austria
Prior art keywords
choline
uridine
combination
memory disorders
treat memory
Prior art date
Application number
AT07116909T
Other languages
English (en)
Inventor
Carol Watkins
Richard Wurtman
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE446097T1 publication Critical patent/ATE446097T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT07116909T 1998-07-31 1999-07-30 Verwendung von uridin in kombination mit cholin zur behandlung von gedächtnisstörungen ATE446097T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9500298P 1998-07-31 1998-07-31

Publications (1)

Publication Number Publication Date
ATE446097T1 true ATE446097T1 (de) 2009-11-15

Family

ID=22248474

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07116909T ATE446097T1 (de) 1998-07-31 1999-07-30 Verwendung von uridin in kombination mit cholin zur behandlung von gedächtnisstörungen
AT99937631T ATE374029T1 (de) 1998-07-31 1999-07-30 Behandlung der alzheimer-krankheit durch erhöhung des cytidin-spiegels in vivo

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99937631T ATE374029T1 (de) 1998-07-31 1999-07-30 Behandlung der alzheimer-krankheit durch erhöhung des cytidin-spiegels in vivo

Country Status (11)

Country Link
US (1) US6989376B2 (de)
EP (5) EP1140104B1 (de)
JP (1) JP2003517437A (de)
AT (2) ATE446097T1 (de)
CA (1) CA2339008C (de)
CY (1) CY1110570T1 (de)
DE (2) DE69937198T2 (de)
DK (5) DK1870103T3 (de)
ES (5) ES2332669T3 (de)
PT (5) PT1140104E (de)
WO (1) WO2000006174A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060069061A1 (en) * 1998-07-31 2006-03-30 Dick Wurtman Compositions containing uridine and choline, and methods utilizing same
US8518882B2 (en) * 1998-07-31 2013-08-27 Massachusetts Institute Of Technology Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
US8143234B2 (en) * 1998-07-31 2012-03-27 Massachusetts Institute Of Technology Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
US20070004670A1 (en) * 1998-07-31 2007-01-04 Richard Wurtman Compositions containing citicoline, and methods of use thereof
US8314064B2 (en) * 1998-07-31 2012-11-20 Massachusetts Institute Of Technology Uridine administration stimulates membrane production
US20050203053A1 (en) * 1999-07-30 2005-09-15 Wurtman Richard J. Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
US7915233B1 (en) 1998-08-31 2011-03-29 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
US7807654B2 (en) 1998-08-31 2010-10-05 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
WO2001068104A1 (en) * 2000-03-16 2001-09-20 The Mclean Hospital Corporation Compounds for the treatment of psychiatric or substance abuse disorders
US6727231B1 (en) * 2000-10-12 2004-04-27 Repligen Corporation Uridine therapy for patients with elevated purine levels
NL1019368C2 (nl) * 2001-11-14 2003-05-20 Nutricia Nv Preparaat voor het verbeteren van receptorwerking.
CA2492725A1 (en) * 2002-07-11 2004-01-22 Yamasa Corporation Medicinal composition for drug-induced neuropathy
PT1565055E (pt) 2002-11-08 2013-09-16 Mclean Hospital Corp Compostos para o tratamento da dependência e da privação de tabaco
WO2004058160A2 (en) * 2002-12-20 2004-07-15 The Mclean Hospital Corporation Compounds for the normalization of the sleep/wake cycle
JP2007508315A (ja) * 2003-10-08 2007-04-05 ザ マクレーン ホスピタル コーポレーション ω−３脂肪酸を含む組み合わせを用いて、精神障害、物質乱用障害、および他の障害を治療する方法
WO2005034874A2 (en) * 2003-10-08 2005-04-21 The Mclean Hospital Corporation Enhanced efficacy of omega-3 fatty acid therapy in the treatment of psychiatric disorders and other indications
EP1750509A4 (de) * 2004-05-13 2010-03-24 Massachusetts Inst Technology Auswirkungen von uridin auf die dopaminfreisetzung
EP1765364A4 (de) * 2004-06-10 2010-09-22 Mclean Hospital Corp Pyrimidine, wie z:b: cytidin, bei der behandlung von patienten mit bipolaren störungen
WO2005122767A1 (en) * 2004-06-10 2005-12-29 Mclean Hospital Corporation Pyrimidines, such as uridine, in treatments for patients with bipolar disorder
US7947661B2 (en) * 2004-08-11 2011-05-24 The Mclean Hospital Corporation Compounds for the treatment of marihuana dependence, withdrawal, and usage
AU2005285090A1 (en) * 2004-09-15 2006-03-23 Massachusetts Institute Of Technology Compositions containing uridine, and methods utilizing same
AU2011253660B2 (en) * 2004-09-15 2013-12-19 Massachusetts Institute Of Technology Compositions containing uridine, and methods utilizing same
AU2012203650B2 (en) * 2005-05-23 2014-09-18 Massachusetts Institute Of Technology Compositions containing PUFA and methods of use thereof
CA2645645C (en) * 2005-05-23 2015-07-14 Massachusetts Institute Of Technology Compositions containing pufa and methods of use thereof
US20100048928A1 (en) * 2005-09-22 2010-02-25 Snow Brand Milk Products Co., Ltd Medicine, Food and Drink or Feed Containing Sphingomyelin
EP1951308B1 (de) * 2005-11-25 2013-02-20 Gisela Susilo Kombinationspräparate enthaltend physiologische zellmembran-bestandteile, einschliesslich phosphatidylserin, cholin und ein pyrimidinnukleos/tid
ATE509624T1 (de) 2005-12-23 2011-06-15 Nutricia Nv Zusammensetzung enthaltend mehrfach ungesättigte fettsäuren, proteine, mangan und/oder molybden und nukleotide/nukleoside, zur behandlung von demenz
JP5140584B2 (ja) * 2006-06-27 2013-02-06 ヤマサ醤油株式会社 抗心理社会的ストレス剤
US7972633B2 (en) * 2007-02-07 2011-07-05 Applied Cognitive Sciences, LLC Nutritional supplements for healthy memory and mental function
BRPI0817387A2 (pt) * 2007-11-02 2015-09-08 Massachusetts Inst Technology métodos de conformidade de suplementação dietária de uridina e uso dos mesmos
EP2303284A4 (de) * 2008-06-12 2013-04-24 Repligen Corp Verfahren zur behandlung von bipolaren störungen
US20100041621A1 (en) * 2008-08-15 2010-02-18 Perry Renshaw Methods and compositions for improving cognitive performance
JP6162125B2 (ja) 2011-09-30 2017-07-12 タフツ・ユニバーシティ 神経変性障害を処置するためのウリジン二リン酸誘導体、組成物および方法
WO2013066152A1 (en) 2011-10-31 2013-05-10 N.V. Nutricia Method for improving executive function
WO2014027882A1 (en) 2012-08-13 2014-02-20 N.V. Nutricia Product and method for supporting uridine homeostasis
US9163055B2 (en) 2012-09-28 2015-10-20 Tufts University Methods for treating glaucoma using uridine diphosphate derivatives
PL2968385T3 (pl) 2013-03-13 2019-05-31 Univ Tufts Pochodne nukleozydów urydynowych, kompozycje i sposoby zastosowania
US10138265B2 (en) 2013-03-13 2018-11-27 Tufts University Uridine nucleoside derivatives, compositions and methods of use
WO2015115885A1 (en) 2014-01-31 2015-08-06 N.V. Nutricia Method for reducing white matter lesions, white matter hyperintensities (wmh), leukoaraiosis or periventricular white matter disease in elderly
WO2016053085A1 (en) * 2014-09-30 2016-04-07 N.V. Nutricia Composition comprising a uridine source and butyrate producing fibres for preventing gastrointestinal disorders
WO2016072842A1 (en) * 2014-11-05 2016-05-12 N.V. Nutricia Method for preventing, reducing the risk of, or treating behavioral frontotemporal dementia
WO2017069613A1 (en) 2015-10-23 2017-04-27 N.V. Nutricia Method for improving recognition and/or working memory in hyperphenylalanimenia and phenylketonuria patients
EP3439647B1 (de) 2016-04-04 2023-03-22 N.V. Nutricia Zubereitung zur verminderung oder verhinderung von globaler entwicklungsverzögerung bei kindern
IL276236B2 (en) 2018-02-01 2025-12-01 Wellstat Therapeutics Corp Compositions and devices comprising uridine and the d enantiomer of beta-hydroxybutyrate and a cationic counterion
US11446303B2 (en) 2019-06-21 2022-09-20 Tosk, Inc. Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions
CN114990176A (zh) * 2022-05-26 2022-09-02 宁夏华吉生物有限公司 一种生产尿嘧啶核苷的方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508474A1 (de) * 1975-02-27 1976-09-02 Boehringer Mannheim Gmbh Infusions- und spuelfluessigkeiten zur behandlung von hirnoedemen
DE2629845A1 (de) * 1976-07-02 1978-01-05 Geb Graze Erika Graze Infusions- bzw. injektionsloesungen bzw. waessrige konzentrate zu deren bereitung zur therapeutischen restituion des zellulaeren energiestoffwechsels und der koerpereigenen regelfunktion
US4221784A (en) * 1979-04-05 1980-09-09 Massachusetts Institute Of Technology Process and composition for treating disorders by administering lecithin
IT1178044B (it) * 1984-10-09 1987-09-03 Polifarma Spa Agente attivo farmaceutico per il trattamento di patologie cerebrali a base di uridina
US4609647A (en) * 1985-05-28 1986-09-02 Massachusetts Institute Of Technology Cytidyl diphosphocholine-drug composition and process
ES2007350A6 (es) * 1987-05-29 1989-06-16 Ganadera Union Ind Agro Productos alimenticios enriquecidos con nucleosidos yno nucleotidos para la nutricion infantil y de adultos, y procedimiento para su preparacion.
EP0339075B1 (de) * 1987-10-28 1993-08-18 Pro-Neuron, Inc. Acylatiertes uridin und cytidin und deren verwendungen
US5470838A (en) 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
IT1219667B (it) 1988-06-21 1990-05-24 Polifarma Spa Impiego di uridina nel trattamento farmacologico di disturbi dovuti ad alterato equilibrio dopaminergico
RU2003332C1 (ru) 1989-06-09 1993-11-30 Борис Витальевич Страдомский Средство дл лечени депрессий
JPH0722495B2 (ja) * 1990-01-30 1995-03-15 美穂 田中 クロレラ含有油脂食品
US5141943A (en) 1990-04-12 1992-08-25 Brown University Research Foundation 5-benzyl barbiturate derivatives
US5567689A (en) * 1993-08-13 1996-10-22 The Uab Research Foundation Methods for increasing uridine levels with L-nucleosides
US5700590A (en) * 1994-01-10 1997-12-23 Abbott Laboratories Nutritional formula with ribo-nucleotides
JPH07215879A (ja) * 1994-02-02 1995-08-15 Otsuka Pharmaceut Factory Inc 抗ストレス組成物
DE9412374U1 (de) * 1994-08-01 1994-09-22 Rauch-Petz, Gisela G., Dr., 80803 München Nahrungsergänzungsmittel
JPH0930976A (ja) * 1995-07-17 1997-02-04 Otsuka Pharmaceut Factory Inc 記憶低下改善剤
US5843024A (en) * 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US5962459A (en) * 1996-05-28 1999-10-05 Polifarma S.P.A. Therapeutic active agent for treatment of neuron degenerative diseases
IT1290781B1 (it) * 1996-05-28 1998-12-10 Polifarma Spa Agente attivo terapeutico per il trattamento di malattie degenerative neuronali.
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
BR0008447A (pt) * 1999-02-23 2002-01-15 Univ California Métodos de tratamento de distúrbios mitocondriais
JP2001233776A (ja) * 2000-02-25 2001-08-28 Yamasa Shoyu Co Ltd 学習・記憶能低下改善剤およびその用途
US20030114415A1 (en) * 2001-12-14 2003-06-19 Wurtman Richard J. Compositions and methods for treating and preventing memory impairment using citicoline

Also Published As

Publication number Publication date
PT1140104E (pt) 2007-12-26
EP2322187A3 (de) 2011-07-20
CA2339008C (en) 2009-12-15
CA2339008A1 (en) 2000-02-10
EP1870103A3 (de) 2008-08-06
EP1870103B1 (de) 2009-10-21
ES2476940T3 (es) 2014-07-15
DK1140104T3 (da) 2008-01-21
EP2145627A1 (de) 2010-01-20
DE69941586D1 (de) 2009-12-03
PT2145627E (pt) 2014-07-24
ES2294850T3 (es) 2008-04-01
EP2329829B1 (de) 2014-04-16
EP2322187B1 (de) 2014-05-14
DE69937198D1 (de) 2007-11-08
ATE374029T1 (de) 2007-10-15
CY1110570T1 (el) 2015-04-29
EP1140104A1 (de) 2001-10-10
DK2329829T3 (da) 2014-07-21
EP2329829A2 (de) 2011-06-08
ES2478044T3 (es) 2014-07-18
PT2322187E (pt) 2014-07-24
JP2003517437A (ja) 2003-05-27
US20020028787A1 (en) 2002-03-07
ES2477568T3 (es) 2014-07-17
DE69937198T2 (de) 2008-07-03
EP1140104B1 (de) 2007-09-26
PT2329829E (pt) 2014-07-24
EP2329829A3 (de) 2011-07-20
US6989376B2 (en) 2006-01-24
ES2332669T3 (es) 2010-02-10
EP1870103A2 (de) 2007-12-26
WO2000006174A1 (en) 2000-02-10
EP2145627B1 (de) 2014-04-16
PT1870103E (pt) 2010-02-23
EP1140104A4 (de) 2004-12-22
DK1870103T3 (da) 2010-01-11
DK2145627T3 (da) 2014-07-21
EP2322187A2 (de) 2011-05-18
DK2322187T3 (da) 2014-07-21

Similar Documents

Publication Publication Date Title
DE69941586D1 (de) Verwendung von Uridin in Kombination mit Cholin zur Behandlung von Gedächtnisstörungen
DE60021266D1 (de) Verwendungen von zusammensetzungen zur behandlung oder vermeidung von schlafstörungen mit sehr niedrigdosierten cyclobenzaprine
DE69936335D1 (de) Verwendung von morpholinol zur behandlung von sexuellen funktionsstörungen
DE60031396D1 (de) Zubereitung zur behandlung von einer neurologischen erkrankung
ATA76995A (de) Stabiles präparat zur behandlung von blutgerinnungsstörungen
ATE247987T1 (de) Behandlung zur beseitigung von gerüchen
DE59107331D1 (de) Flupirtin in Kombination mit Antiparkinsonika zur Bekämpfung von Muskelverspannungen
DE69600635D1 (de) Zweikammerschrittmacher mit automatischer anpassung des av-escapeintervalls zur behandlung von cardiomyopathien
DE69925571D1 (de) Sulphonamid-derivate zur behandlung von störungen des zentralnervensystems
EP0709090A3 (de) Zusammensetzungen zur Behandlung von resistenten Tumoren
DE3884622D1 (de) Schmiermittelzubereitung zur behandlung von rheuma.
ATE207356T1 (de) Verwendung von tiagabin zur behandlung von schlafstörungen
DE69941154D1 (de) Verwendung von Hydroxamatverbindungen zur Behandlung von HER-2/neu positiven Karzinomen
DE3870508D1 (de) Zusammensetzung zur behandlung des haares.
DE69813839D1 (de) Verwendung von n,n-bis (phenylcarbamoylmethyl) dimethylammoniumchlorid und derivaten davon zur behandlung von chronischem schmerz
ATE137965T1 (de) Verwendung von tomoxetine zur behandlung von funktionsstörungen der niedrigen harnwege
ATE210447T1 (de) Verwendung von cck-b rezeptor antagonisten zur behandlung von schlafstörungen
DE69200684D1 (de) Vorrichtung zur thermischen Behandlung von laufenden Garnen.
DE69638281D1 (de) Anti-Interleukin-9 Antikörper oder Anti-Interleukin-9 Rezeptor Antikörper zur Behandlung von bronchialem Hyperreaktionsvermögen
DK1291018T3 (da) Phosphonatananaloger til mannose-6phosphat og deres anvendelse i behandlingen af sår og fibrotiske lidelser
DE69519602D1 (de) Kugelförmige Aktivkohle zur Behandlung von Hämorrhoiden
DE60117122D1 (de) Verwendung von mirtazapin zur behandlung von schlafstörungen
DE69518438D1 (de) Behandlung von übereregten nervenzellenfunktionen
DE69923464D1 (de) Benzenesulfonamide derivate in kombination mit beta-blockern zur behandlung von störungen des autonomen nervensystems
DK1100824T3 (da) Forbindelser med væksthormonfrigivende egenskaber

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1870103

Country of ref document: EP