ES2477568T3 - Uso de uridina en combinación con colina para el tratamiento de trastornos de la memoria - Google Patents

Uso de uridina en combinación con colina para el tratamiento de trastornos de la memoria Download PDF

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Publication number
ES2477568T3
ES2477568T3 ES10075660.0T ES10075660T ES2477568T3 ES 2477568 T3 ES2477568 T3 ES 2477568T3 ES 10075660 T ES10075660 T ES 10075660T ES 2477568 T3 ES2477568 T3 ES 2477568T3
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Prior art keywords
choline
uridine
treatment
combination
memory disorders
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Expired - Lifetime
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ES10075660.0T
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English (en)
Inventor
Carol Watkins
Richard J. Wurtman
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Uso de (a) uridina o una fuente de uridina y (b) colina, un precursor de la colina, una sal o éster de colina o una mezcla de los mismos en la fabricación de una composición para tratar la disfunción cognitiva asociada con la edad y/o para ralentizar o revertir el envejecimiento cerebral.

Description

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Claims (1)

  1. imagen1
ES10075660.0T 1998-07-31 1999-07-30 Uso de uridina en combinación con colina para el tratamiento de trastornos de la memoria Expired - Lifetime ES2477568T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9500298P 1998-07-31 1998-07-31
US95002P 1998-07-31

Publications (1)

Publication Number Publication Date
ES2477568T3 true ES2477568T3 (es) 2014-07-17

Family

ID=22248474

Family Applications (5)

Application Number Title Priority Date Filing Date
ES99937631T Expired - Lifetime ES2294850T3 (es) 1998-07-31 1999-07-30 Tratamiento de la enfermedad de alzheimer mediante el aumento de los niveles de citidina in vivo.
ES10075661.8T Expired - Lifetime ES2478044T3 (es) 1998-07-31 1999-07-30 Uso de uridina en combinación con colina para el tratamiento de trastornos neurológicos
ES10075660.0T Expired - Lifetime ES2477568T3 (es) 1998-07-31 1999-07-30 Uso de uridina en combinación con colina para el tratamiento de trastornos de la memoria
ES09173495.4T Expired - Lifetime ES2476940T3 (es) 1998-07-31 1999-07-30 Uso de uridina en combinación con colina para el tratamiento de trastornos emocionales y del humor
ES07116909T Expired - Lifetime ES2332669T3 (es) 1998-07-31 1999-07-30 Uso de uridina en combinacion con colina para el tratamiento de trastornos de la memoria.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES99937631T Expired - Lifetime ES2294850T3 (es) 1998-07-31 1999-07-30 Tratamiento de la enfermedad de alzheimer mediante el aumento de los niveles de citidina in vivo.
ES10075661.8T Expired - Lifetime ES2478044T3 (es) 1998-07-31 1999-07-30 Uso de uridina en combinación con colina para el tratamiento de trastornos neurológicos

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES09173495.4T Expired - Lifetime ES2476940T3 (es) 1998-07-31 1999-07-30 Uso de uridina en combinación con colina para el tratamiento de trastornos emocionales y del humor
ES07116909T Expired - Lifetime ES2332669T3 (es) 1998-07-31 1999-07-30 Uso de uridina en combinacion con colina para el tratamiento de trastornos de la memoria.

Country Status (11)

Country Link
US (1) US6989376B2 (es)
EP (5) EP2145627B1 (es)
JP (1) JP2003517437A (es)
AT (2) ATE374029T1 (es)
CA (1) CA2339008C (es)
CY (1) CY1110570T1 (es)
DE (2) DE69941586D1 (es)
DK (5) DK1140104T3 (es)
ES (5) ES2294850T3 (es)
PT (5) PT1140104E (es)
WO (1) WO2000006174A1 (es)

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Also Published As

Publication number Publication date
EP1870103A3 (en) 2008-08-06
EP1870103B1 (en) 2009-10-21
EP1870103A2 (en) 2007-12-26
EP1140104A1 (en) 2001-10-10
DK2329829T3 (da) 2014-07-21
CA2339008A1 (en) 2000-02-10
PT2145627E (pt) 2014-07-24
EP2329829B1 (en) 2014-04-16
WO2000006174A1 (en) 2000-02-10
DK1140104T3 (da) 2008-01-21
DK1870103T3 (da) 2010-01-11
DK2322187T3 (da) 2014-07-21
EP2329829A2 (en) 2011-06-08
DK2145627T3 (da) 2014-07-21
EP2145627B1 (en) 2014-04-16
DE69941586D1 (de) 2009-12-03
PT2329829E (pt) 2014-07-24
CY1110570T1 (el) 2015-04-29
PT1870103E (pt) 2010-02-23
EP2329829A3 (en) 2011-07-20
US20020028787A1 (en) 2002-03-07
ATE374029T1 (de) 2007-10-15
PT1140104E (pt) 2007-12-26
ES2294850T3 (es) 2008-04-01
EP1140104B1 (en) 2007-09-26
EP1140104A4 (en) 2004-12-22
ES2478044T3 (es) 2014-07-18
PT2322187E (pt) 2014-07-24
EP2322187B1 (en) 2014-05-14
EP2322187A3 (en) 2011-07-20
US6989376B2 (en) 2006-01-24
DE69937198T2 (de) 2008-07-03
EP2322187A2 (en) 2011-05-18
ES2476940T3 (es) 2014-07-15
JP2003517437A (ja) 2003-05-27
DE69937198D1 (de) 2007-11-08
ES2332669T3 (es) 2010-02-10
ATE446097T1 (de) 2009-11-15
CA2339008C (en) 2009-12-15
EP2145627A1 (en) 2010-01-20

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