ATE447020T1 - Ligationscodierung unter verwendung von oligonukleotidbausteinen - Google Patents

Ligationscodierung unter verwendung von oligonukleotidbausteinen

Info

Publication number
ATE447020T1
ATE447020T1 AT05715120T AT05715120T ATE447020T1 AT E447020 T1 ATE447020 T1 AT E447020T1 AT 05715120 T AT05715120 T AT 05715120T AT 05715120 T AT05715120 T AT 05715120T AT E447020 T1 ATE447020 T1 AT E447020T1
Authority
AT
Austria
Prior art keywords
oligonucleotide
template
present
chemical entities
codon
Prior art date
Application number
AT05715120T
Other languages
English (en)
Inventor
Alex Gouliaev
Henrik Pedersen
Original Assignee
Nuevolution As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2004/000195 external-priority patent/WO2004083427A2/en
Application filed by Nuevolution As filed Critical Nuevolution As
Application granted granted Critical
Publication of ATE447020T1 publication Critical patent/ATE447020T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT05715120T 2004-03-22 2005-03-22 Ligationscodierung unter verwendung von oligonukleotidbausteinen ATE447020T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/DK2004/000195 WO2004083427A2 (en) 2003-03-20 2004-03-22 Ligational encoding of small molecules
US58500804P 2004-07-06 2004-07-06
DKPA200401067 2004-07-06
PCT/DK2005/000199 WO2005090566A2 (en) 2004-03-22 2005-03-22 Ligational encoding using building block oligonucleotides

Publications (1)

Publication Number Publication Date
ATE447020T1 true ATE447020T1 (de) 2009-11-15

Family

ID=40221922

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05715120T ATE447020T1 (de) 2004-03-22 2005-03-22 Ligationscodierung unter verwendung von oligonukleotidbausteinen

Country Status (6)

Country Link
US (1) US7704925B2 (de)
EP (1) EP1730277B1 (de)
AT (1) ATE447020T1 (de)
DE (1) DE602005017370D1 (de)
DK (1) DK1730277T3 (de)
WO (1) WO2005090566A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
DE60324778D1 (de) * 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004028682A2 (en) 2002-09-27 2004-04-08 Carlsberg A/S Spatially encoded polymer matrix
DK3299463T3 (da) 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
ATE450609T1 (de) 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
WO2005026387A1 (en) 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
RU2470077C2 (ru) 2003-12-17 2012-12-20 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Биологически активное соединение, содержащее кодирующий олигонуклеотид (варианты), способ его синтеза, библиотека соединений (варианты), способ ее синтеза и способ поиска соединения, связывающегося с биологической мишенью (варианты)
EP1723255B1 (de) * 2004-02-17 2010-12-29 Nuevolution A/S Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung
US7883848B2 (en) * 2005-07-08 2011-02-08 Olink Ab Regulation analysis by cis reactivity, RACR
EP1940755A2 (de) * 2005-10-28 2008-07-09 Praecis Pharmaceuticals Inc. Verfahren zur identifikation von verbindungen von interesse mithilfe kodierter bibliotheken
LT2336315T (lt) 2005-12-01 2017-11-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti efektyviai didelių bibliotekų sintezei
KR102231531B1 (ko) 2009-02-13 2021-03-23 엑스-켐, 인크. Ｄｎａ―코딩된 라이브러리의 생성 및 스크리닝 방법
CA2832672A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
ES2675111T3 (es) 2011-09-07 2018-07-06 X-Chem, Inc. Métodos para etiquetar bibliotecas con codificación de ADN
JP5820320B2 (ja) * 2012-03-27 2015-11-24 株式会社東芝 情報処理端末及び方法、並びに、情報管理装置及び方法
CN104685115A (zh) 2012-07-13 2015-06-03 X-化学有限公司 具有聚合酶不可读的编码性寡核苷酸连接的dna编码文库
US20180340174A1 (en) 2014-11-11 2018-11-29 Nanocore Aps Method for identification of molecules with desired characteristics
WO2016165621A1 (zh) * 2015-04-14 2016-10-20 成都先导药物开发有限公司 一种固相合成dna编码化合物库的方法
GB201603789D0 (en) 2016-03-04 2016-04-20 Apta Biosciences Ltd Oligonucleotides and methods for preparing
EP4299803A3 (de) 2016-05-02 2024-03-27 Encodia, Inc. Makromolekülanalyse mit verwendung von nukleinsäurecodierung
US11186836B2 (en) 2016-06-16 2021-11-30 Haystack Sciences Corporation Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
AU2018358057B2 (en) 2017-10-31 2023-03-02 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
SG11202003923PA (en) 2017-10-31 2020-05-28 Encodia Inc Methods and kits using nucleic acid encoding and/or label
US12203130B2 (en) 2018-12-20 2025-01-21 Krylov Sergey N Binder selection using capillary electrophoresis
CN114072499B (zh) 2019-04-30 2024-08-06 Encodia公司 用于制备分析物的方法和相关试剂盒
EP3885437A1 (de) * 2020-03-27 2021-09-29 Technische Universität Dortmund Dna-codierte chemische bibliothek, verwendung davon und verfahren zur synthese der bibliothek

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US5449602A (en) 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
WO1990005785A1 (en) 1988-11-18 1990-05-31 The Regents Of The University Of California Method for site-specifically incorporating unnatural amino acids into proteins
ES2118066T3 (es) 1989-10-05 1998-09-16 Optein Inc Sintesis y aislamiento, exentos de celulas, de nuevos genes y polipeptidos.
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
AU2313392A (en) 1991-08-01 1993-03-02 University Research Corporation Systematic polypeptide evolution by reverse translation
DK0604552T3 (da) * 1991-09-18 1997-08-04 Affymax Tech Nv Fremgangsmåde til syntese af forskellige samlinger af oligomerer
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
WO1994024143A1 (en) 1993-04-12 1994-10-27 Northwestern University Method of forming oligonucleotides
US5473060A (en) 1993-07-02 1995-12-05 Lynx Therapeutics, Inc. Oligonucleotide clamps having diagnostic applications
US5571903A (en) * 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
US6165778A (en) * 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
US5503805A (en) * 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
BR9407947A (pt) 1993-11-02 1996-11-26 Affymax Tech Nv Processo para sintetizar moléculas diversas em uma pluralidade de substratos e uma coleçao molecular etiquetade para realizaçao reaçoes de copulaçao em contas em paralelo para triar uma coleçao molecular etiquetada para detectar a presença de um ou mais diferentes etiquetas e para determinar a sequência de síntese aparelho para reaçoes de copulaçao paralelas em suportes sólidos bloco de alinhamento ótico para uso com um detector ótico sistemas de distribuiçao para distribuir reagentes dispositiv
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
JPH10507160A (ja) 1994-06-23 1998-07-14 アフィマックス テクノロジーズ エヌ．ブイ． 光活性化合物およびその使用方法
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5843650A (en) * 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US5830658A (en) * 1995-05-31 1998-11-03 Lynx Therapeutics, Inc. Convergent synthesis of branched and multiply connected macromolecular structures
US5780613A (en) * 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
DK0971946T3 (da) * 1997-01-21 2006-10-30 Gen Hospital Corp Selektion af proteiner ved anvendelse af RNA-protein-fusioner
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
ATE250668T1 (de) * 1997-05-28 2003-10-15 Discerna Ltd Ribosom-komplexe als selektionspartikel für die in vitro anzeige und evolution von proteinen
US6969584B2 (en) 1997-06-12 2005-11-29 Rigel Pharmaceuticals, Inc. Combinatorial enzymatic complexes
US20030004122A1 (en) * 1997-11-05 2003-01-02 Leonid Beigelman Nucleotide triphosphates and their incorporation into oligonucleotides
EP1068356B8 (de) 1998-04-03 2007-01-03 Adnexus Therapeutics, Inc. Adressierbare protein arrays
EP1073730A1 (de) * 1998-04-17 2001-02-07 Whitehead For Biomedical Research Verwendung von ribozym zum verbinden von nukleinsäuren mit polypeptiden
AU6295999A (en) 1998-10-09 2000-05-01 Pharmacopeia, Inc. Selecting codes to be used for encoding combinatorial libraries
AU1318400A (en) * 1998-10-19 2000-05-08 Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
PT1137812E (pt) 1998-12-02 2007-05-31 Adnexus Therapeutics Inc Fusões adn-proteína e suas utilizações
AU2951599A (en) * 1999-04-08 2000-11-14 Pavel Sergeev Synthesis of biologically active compounds in cells
EP1198591B1 (de) 1999-06-25 2011-03-16 Nanosphere, Inc. Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
IL147037A0 (en) * 1999-07-27 2002-08-14 Phylos Inc Peptide acceptor ligation methods
WO2001016151A1 (fr) * 1999-08-27 2001-03-08 Japan Science And Technology Corporation Acide nucleique a photocouplage reversible et phosphoroamidite
US7070928B2 (en) 2001-03-19 2006-07-04 President And Fellows Of Harvard College Evolving new molecular function
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
CN1539014A (zh) * 2001-06-20 2004-10-20 ŦΤ¬ɭ��˾ 模控分子和使用这种分子的方法
AU2002357770B2 (en) * 2001-11-30 2008-07-31 Biogen Ma Inc. Antibodies against monocyte chemotactic proteins
WO2003078445A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c=c double bond upon reaction
AU2003218630A1 (en) 2002-03-15 2003-09-29 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
US20050221318A1 (en) 2002-03-15 2005-10-06 Gouliaev Alex H Building block forming a c-c bond upon reaction
DE60324778D1 (de) * 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
US20050247001A1 (en) 2002-03-15 2005-11-10 Nuevolution A/S Building block forming a c-c or a c-hetero atom bond uponreaction
EP1488009A4 (de) 2002-03-22 2007-07-11 Univ Emory Schablonengesteuerte verfahren zur synthese von polymeren und mit solchen verfahren assoziierte komponenten
EP1520040A2 (de) 2002-06-20 2005-04-06 Nuevolution A/S Mikroarrays zur darstellung von kodierten molekülen
WO2004009814A1 (en) 2002-07-23 2004-01-29 Nuevolution A/S Gene shuffling by template switching
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
EP1539953A2 (de) 2002-09-12 2005-06-15 Nuevolution A/S Durch nähe unterstützte synthese von mit matrizen versehenen molekülen
DK3299463T3 (da) 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
ATE450609T1 (de) 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
EP1597394A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Eine methode zur erlangung struktureller information über ein kodiertes molekül
US7915201B2 (en) 2003-03-20 2011-03-29 Nuevolution A/S Ligational encoding of small molecules
WO2004099441A2 (en) 2003-05-09 2004-11-18 Hyscite Discovery As Selection and evolution of chemical libraries
WO2004110964A2 (en) 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
WO2005003778A2 (en) 2003-07-02 2005-01-13 Nuevolution A/S A method for identifying a synthetic molecule having affinity towards a target
EP1533385A1 (de) 2003-09-05 2005-05-25 Nuevolution A/S Matrizenabhängigen Verbindungen zur Herstellung von kodierten Molekülen und gesteuerten Verfahren unter Verwendung dieser Verbindungen
WO2005026387A1 (en) 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
CA2587010C (en) 2004-11-08 2017-08-15 Vipergen Aps Structural nucleic acid guided chemical synthesis
EP1828381B1 (de) 2004-11-22 2009-01-07 Peter Birk Rasmussen Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle

Also Published As

Publication number Publication date
WO2005090566A2 (en) 2005-09-29
US7704925B2 (en) 2010-04-27
EP1730277A2 (de) 2006-12-13
WO2005090566A3 (en) 2006-03-09
DK1730277T3 (da) 2010-03-01
US20090011957A1 (en) 2009-01-08
EP1730277B1 (de) 2009-10-28
DE602005017370D1 (de) 2009-12-10

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