ATE447977T1 - Biotin-diamino-derivate und ihre konjugate mit makrocyclischen chelationsmitteln - Google Patents

Biotin-diamino-derivate und ihre konjugate mit makrocyclischen chelationsmitteln

Info

Publication number
ATE447977T1
ATE447977T1 AT06793583T AT06793583T ATE447977T1 AT E447977 T1 ATE447977 T1 AT E447977T1 AT 06793583 T AT06793583 T AT 06793583T AT 06793583 T AT06793583 T AT 06793583T AT E447977 T1 ATE447977 T1 AT E447977T1
Authority
AT
Austria
Prior art keywords
conjugates
biotin
chelating agents
macrocyclic chelating
diamino derivatives
Prior art date
Application number
AT06793583T
Other languages
English (en)
Inventor
Paolo Carminati
Mauro Ginanneschi
Giovanni Paganelli
Marco Chinol
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of ATE447977T1 publication Critical patent/ATE447977T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0495—Pretargeting

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AT06793583T 2005-09-27 2006-09-18 Biotin-diamino-derivate und ihre konjugate mit makrocyclischen chelationsmitteln ATE447977T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05021034 2005-09-27
PCT/EP2006/066440 WO2007039437A1 (en) 2005-09-27 2006-09-18 Biotin diaminoderivatives and their conjugates with macrocyclic chelating agents

Publications (1)

Publication Number Publication Date
ATE447977T1 true ATE447977T1 (de) 2009-11-15

Family

ID=35825361

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06793583T ATE447977T1 (de) 2005-09-27 2006-09-18 Biotin-diamino-derivate und ihre konjugate mit makrocyclischen chelationsmitteln

Country Status (23)

Country Link
US (1) US7816388B2 (de)
EP (1) EP1928508B1 (de)
JP (1) JP5207969B2 (de)
KR (1) KR101301549B1 (de)
CN (1) CN101272809B (de)
AR (1) AR056201A1 (de)
AT (1) ATE447977T1 (de)
AU (1) AU2006298827B2 (de)
BR (1) BRPI0616441B8 (de)
CA (1) CA2621960C (de)
CY (1) CY1109836T1 (de)
DE (1) DE602006010413D1 (de)
DK (1) DK1928508T3 (de)
EA (1) EA013130B1 (de)
ES (1) ES2335609T3 (de)
HR (1) HRP20100071T1 (de)
ME (1) ME01845B (de)
PL (1) PL1928508T3 (de)
PT (1) PT1928508E (de)
RS (1) RS51254B (de)
SI (1) SI1928508T1 (de)
TW (1) TWI381852B (de)
WO (1) WO2007039437A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100543342B1 (ko) * 2002-06-28 2006-01-20 한국 한의학 연구원 뇌신경세포의 손상을 치료하기 위한 한약재 조성물
JP5263805B2 (ja) * 2007-06-13 2013-08-14 国立大学法人群馬大学 両親媒性の高分子配位子によって安定化された高分子錯体および検査用組成物および医薬組成物
GB0922369D0 (en) * 2009-12-22 2010-02-03 Hammersmith Imanet Ltd Labelled biotin conjugates
US20140031302A1 (en) * 2010-10-22 2014-01-30 Universite De Strasbourg Pochoxime conjugates useful for the treatment of hsp90 related pathologies
CA3258344A1 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. CHELETARIANS AND BIFUNCTIONAL CONJUGATES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283342A (en) * 1992-06-09 1994-02-01 Neorx Corporation Biotinylated small molecules
EP0646019B9 (de) * 1992-06-09 2002-12-18 Neorx Corporation Biotin-DOTA Konjugate und deren Verwendung in "Pretargeting" Verfahren
US5911969A (en) * 1992-06-09 1999-06-15 Neorx Corporation Pretargeting protocols for enhanced localization of active agents to target sites
US6120768A (en) * 1993-05-17 2000-09-19 Immunomedics, Inc. Dota-biotin derivatives
US5955605A (en) * 1995-02-21 1999-09-21 Neorx Corporation Biotinidase resistant biotin-DOTA conjugates
ITRM20010079A1 (it) * 2001-02-16 2002-08-16 Sigma Tau Ind Farmaceuti Amminoderivati della biotina e loro coniugati con chelanti macrociclici.

Also Published As

Publication number Publication date
EA200800948A1 (ru) 2010-02-26
BRPI0616441A2 (pt) 2011-06-21
CN101272809B (zh) 2011-01-26
JP2009510009A (ja) 2009-03-12
JP5207969B2 (ja) 2013-06-12
ES2335609T3 (es) 2010-03-30
TW200744647A (en) 2007-12-16
BRPI0616441B1 (pt) 2019-07-02
CA2621960A1 (en) 2007-04-12
EP1928508B1 (de) 2009-11-11
TWI381852B (zh) 2013-01-11
EP1928508A1 (de) 2008-06-11
US20080249152A1 (en) 2008-10-09
ME01845B (me) 2010-12-31
WO2007039437A1 (en) 2007-04-12
KR101301549B1 (ko) 2013-09-04
PL1928508T3 (pl) 2010-04-30
AU2006298827A1 (en) 2007-04-12
CA2621960C (en) 2015-09-15
AR056201A1 (es) 2007-09-26
DK1928508T3 (da) 2010-03-29
US7816388B2 (en) 2010-10-19
SI1928508T1 (sl) 2010-03-31
HRP20100071T1 (hr) 2010-03-31
CN101272809A (zh) 2008-09-24
KR20080059159A (ko) 2008-06-26
EA013130B1 (ru) 2010-02-26
DE602006010413D1 (de) 2009-12-24
HK1125036A1 (en) 2009-07-31
CY1109836T1 (el) 2014-09-10
AU2006298827B2 (en) 2011-02-03
BRPI0616441B8 (pt) 2021-05-25
PT1928508E (pt) 2010-01-28
RS51254B (sr) 2010-12-31

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