ATE450623T1 - Modifikatoren der lichtemission und ihre verwendungen zur detektion, amplifikation und analyse von nukleinsäuren - Google Patents

Modifikatoren der lichtemission und ihre verwendungen zur detektion, amplifikation und analyse von nukleinsäuren

Info

Publication number
ATE450623T1
ATE450623T1 AT06013330T AT06013330T ATE450623T1 AT E450623 T1 ATE450623 T1 AT E450623T1 AT 06013330 T AT06013330 T AT 06013330T AT 06013330 T AT06013330 T AT 06013330T AT E450623 T1 ATE450623 T1 AT E450623T1
Authority
AT
Austria
Prior art keywords
analysis
nucleic acids
light emission
amplification
detection
Prior art date
Application number
AT06013330T
Other languages
English (en)
Inventor
Amar Gupta
Stephen Gordon Will
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE450623T1 publication Critical patent/ATE450623T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6823Release of bound markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6851Quantitative amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/706Specific hybridization probes for hepatitis
    • C12Q1/707Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT06013330T 2005-06-30 2006-06-28 Modifikatoren der lichtemission und ihre verwendungen zur detektion, amplifikation und analyse von nukleinsäuren ATE450623T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69625305P 2005-06-30 2005-06-30
US69629305P 2005-06-30 2005-06-30
US69630305P 2005-06-30 2005-06-30
US69599105P 2005-06-30 2005-06-30

Publications (1)

Publication Number Publication Date
ATE450623T1 true ATE450623T1 (de) 2009-12-15

Family

ID=37104934

Family Applications (2)

Application Number Title Priority Date Filing Date
AT09168656T ATE507311T1 (de) 2005-06-30 2006-06-28 Lichtemissionsmodifikatoren und ihre verwendung bei der nukleinsäureerkennung, -verstärkung und - analyse
AT06013330T ATE450623T1 (de) 2005-06-30 2006-06-28 Modifikatoren der lichtemission und ihre verwendungen zur detektion, amplifikation und analyse von nukleinsäuren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT09168656T ATE507311T1 (de) 2005-06-30 2006-06-28 Lichtemissionsmodifikatoren und ihre verwendung bei der nukleinsäureerkennung, -verstärkung und - analyse

Country Status (7)

Country Link
US (9) US7919242B2 (de)
EP (5) EP1746170B1 (de)
JP (6) JP4634340B2 (de)
AT (2) ATE507311T1 (de)
CA (5) CA2549671C (de)
DE (1) DE602006010764D1 (de)
ES (3) ES2336934T3 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080085515A1 (en) * 2000-03-24 2008-04-10 Eppendorf Array Technologies Sa (Eat) Identification of multiple biological (micro) organisms by detection of their nucleotide sequences on arrays
US7919242B2 (en) 2005-06-30 2011-04-05 Roche Molecular Systems, Inc. Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
US7972786B2 (en) * 2006-07-07 2011-07-05 Brandeis University Detection and analysis of influenza virus
JP5593582B2 (ja) * 2007-06-12 2014-09-24 東洋紡株式会社 核酸の迅速な検出方法
JP2009036687A (ja) * 2007-08-03 2009-02-19 Panasonic Corp 遺伝子検出方法
WO2009022939A1 (en) * 2007-08-09 2009-02-19 Uchrezhdenie Rossiiskoi Akademii Nauk Institut Molekulyarnoi Biologii Im. V.A. Engelgardta Ran (Imb Ran) Method for identifying the genotype and subtype of hepatitis c virus on a biological microchip
CN102007222A (zh) * 2007-08-13 2011-04-06 3M创新有限公司 用于检测耐药微生物的方法
US8767952B2 (en) * 2007-12-17 2014-07-01 Broadcom Corporation Method and system for utilizing a single connection for efficient delivery of power and multimedia information
EP2116614A1 (de) * 2008-05-06 2009-11-11 Qiagen GmbH Gleichzeitiger Nachweis mehrerer Nukleinsäuresequenzen in einer Reaktion
EP2402462A1 (de) * 2008-06-06 2012-01-04 F. Hoffmann-La Roche AG Intern gesteuerte Multiplex-Erkennung und Quantifizierung von mikrobiellen Nukleinsäuren
US8658366B2 (en) * 2008-09-18 2014-02-25 Roche Molecular Systems, Inc. Detection of target variants using a fluorescent label and a soluble quencher
US8606527B2 (en) 2009-02-27 2013-12-10 Bio-Rad Laboratories, Inc. SNP detection by melt curve clustering
US8039215B2 (en) 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
US8412466B2 (en) * 2009-04-13 2013-04-02 Canon U.S. Life Sciences, Inc. Rapid method of pattern recognition, machine learning, and automated genotype classification through correlation analysis of dynamic signals
CN102449166B (zh) 2009-05-26 2013-12-04 厦门大学 一种单管检测多个单核苷酸变异或单核苷酸多态性的方法
US8691504B2 (en) 2009-05-26 2014-04-08 Xiamen University Method for detecting variations in nucleic acid sequences
US8148515B1 (en) 2009-06-02 2012-04-03 Biotium, Inc. Detection using a dye and a dye modifier
JP2011062088A (ja) * 2009-09-15 2011-03-31 Ihi Corp レジオネラ菌検出方法
US12410463B2 (en) * 2009-09-18 2025-09-09 The Trustees Of The University Of Pennsylvania Molecular beacons
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
WO2011048529A1 (en) * 2009-10-21 2011-04-28 Koninklijke Philips Electronics N.V. Analyzing tool for amplification reactions
JP5623888B2 (ja) * 2009-12-10 2014-11-12 エフ.ホフマン−ラ ロシュアーゲーF.Hoffmann−La Roche Aktiengesellschaft 分析対象物を分離して検出する方法
SG184480A1 (en) 2010-04-09 2012-11-29 Life Technologies Corp VISUALIZATION TOOL FOR qPCR GENOTYPING DATA
WO2011160887A1 (en) * 2010-06-21 2011-12-29 Siemens Healthcare Diagnostics Inc. Soluble quencher to reduce background in qpcr assays
US9175332B2 (en) * 2010-07-29 2015-11-03 Roche Molecular Systems, Inc. Generic PCR
EP2614157A4 (de) * 2010-09-08 2014-03-26 Univ Brandeis Zusammensetzungen und verfahren für auf nukleinsäuren basierende diagnoseassays für ziele mit variabler sequenz
JP5722001B2 (ja) * 2010-11-10 2015-05-20 株式会社日立ハイテクノロジーズ 遺伝子検査方法及び検査装置
WO2012083235A1 (en) 2010-12-16 2012-06-21 Bio-Rad Laboratories, Inc. Universal reference dye for quantitative amplification
US20120164641A1 (en) * 2010-12-22 2012-06-28 Roche Molecular Systems, Inc. Methods and Compositions for Detecting Mutation in the Human Epidermal Growth Factor Receptor Gene
CN103620389B (zh) * 2011-04-18 2016-08-17 奥林巴斯株式会社 目标粒子的定量方法、光分析装置以及光分析用计算机程序
EP2700934B1 (de) * 2011-04-20 2016-12-14 Olympus Corporation Verfahren zur erkennung von einem nukleinsäuremolekül in einer biologischen probe
EP2725347B1 (de) * 2011-06-27 2018-09-26 Olympus Corporation Verfahren zum nachweis von zielpartikeln
WO2013040060A2 (en) * 2011-09-12 2013-03-21 Pathogenica, Inc. Nucleic acids for multiplex detection of hepatitis c virus
CN107326085B (zh) 2012-02-03 2022-05-03 加州理工学院 多路生化测定中信号的编码和解码
CN102766701B (zh) * 2012-07-04 2016-05-04 福州泰普生物科学有限公司 丙型肝炎病毒基因分型的试剂盒及方法
AU2013202808B2 (en) 2012-07-31 2014-11-13 Gen-Probe Incorporated System and method for performing multiplex thermal melt analysis
IN2015DN01609A (de) 2012-08-03 2015-07-03 California Inst Of Techn
ES2659747T3 (es) 2012-10-18 2018-03-19 F. Hoffmann-La Roche Ag Ensayo de doble sonda para la detección de poblaciones heterogéneas de amplicón
EP2722398B1 (de) * 2012-10-18 2017-07-12 F. Hoffmann-La Roche AG Test mit zwei Sonden zur Erkennung von HCV
EP2954301B1 (de) * 2013-02-05 2024-06-12 Tripath Imaging, Inc. Zytologische farbzusammensetzungen und verwendungen davon
EP3044337B1 (de) 2013-09-13 2020-03-18 Rutgers, the State University of New Jersey Diagnostischer multiplextest für die lyme-krankheit und andere erkrankungen aufgrund von zeckenbissen
GB201411567D0 (en) * 2014-06-30 2014-08-13 Epistem Ltd Quantification methods
CA3017265C (en) * 2016-03-11 2022-08-16 F. Hoffmann-La Roche Ag Compositions and methods for detection of zika virus
US10066263B2 (en) 2016-06-17 2018-09-04 California Institute Of Technology Nucleic acid reactions and related methods and compositions
CA3040907A1 (en) * 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
CN108546748A (zh) * 2017-04-05 2018-09-18 杭州丹威生物科技有限公司 一种检测核酸的方法和试剂盒
ES3035799T3 (en) 2017-10-03 2025-09-09 Abbott Molecular Inc Assay for detecting hepatitis c virus (hcv)
CN112424377A (zh) 2018-04-17 2021-02-26 克罗玛科德公司 用于多重分析的方法和系统
KR102063864B1 (ko) * 2018-05-16 2020-01-08 사회복지법인 삼성생명공익재단 표면-증강 라만 산란 기반의 감염 질환 진단용 마커 검출 방법
US12203129B2 (en) 2018-07-03 2025-01-21 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
CN112766296B (zh) * 2019-11-06 2023-04-07 济南信通达电气科技有限公司 输电线路安全隐患目标检测模型训练方法及装置
WO2021236116A1 (en) * 2020-05-20 2021-11-25 Delahoussaye Kevin Antiviral medicinal template
WO2022136477A1 (en) 2020-12-22 2022-06-30 F. Hoffmann-La Roche Ag Methods for performing multiplexed real-time pcr with the use of large stokes shift fluorescent dyes
KR102465706B1 (ko) * 2020-12-23 2022-11-09 건국대학교 산학협력단 Dna 주형 구리 나노입자 기반 fret 센서 및 이를 이용한 표적 핵산 분자의 검출 방법
KR102533568B1 (ko) * 2020-12-23 2023-05-16 건국대학교 산학협력단 라이트 업 RNA 앱타머를 사용한 형광 기반 다중 miRNA 검출 시스템
EP4700133A3 (de) * 2021-09-30 2026-04-29 Gen-Probe Incorporated Signalisierung einer temperaturwählbaren fret-kassette
CN114540526B (zh) * 2022-03-23 2023-10-31 福建医科大学孟超肝胆医院(福州市传染病医院) 对五种输入性疟原虫分型检测的引物、探针及方法

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE3529478A1 (de) 1985-08-16 1987-02-19 Boehringer Mannheim Gmbh 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
US6251581B1 (en) * 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
DE69223562T2 (de) 1991-08-27 1998-06-04 Hoffmann La Roche Verfahren und Reagenzien zum Nachweis von Hepatitis C
TW393513B (en) 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
EP1256589A3 (de) 1991-11-26 2003-09-17 Isis Pharmaceuticals, Inc. Oligomere, die modifizierte PyrimIdine enthalten
US5484908A (en) 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
ES2133529T3 (es) * 1992-11-27 1999-09-16 Innogenetics Nv Procedimiento para tipificar aislamientos de hcv.
ATE551423T1 (de) 1993-04-27 2012-04-15 Innogenetics Nv Sequenzen von hepatitis c virus-genotypen sowie ihre verwendungen als therapeutika und diagnostika
US5882852A (en) * 1993-06-29 1999-03-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
US5491063A (en) 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
DE69526973T3 (de) 1994-10-21 2010-01-07 Innogenetics N.V. Sequenzen von hepatitis-c-virus genotype 7, und deren verwendung als vorbeugende, therapeutische und diagnostische mittel
US5837442A (en) * 1995-11-29 1998-11-17 Roche Molecular Systems, Inc. Oligonucleotide primers for amplifying HCV nucleic acid
US5795729A (en) * 1996-02-05 1998-08-18 Biometric Imaging, Inc. Reductive, energy-transfer fluorogenic probes
DE69827060T2 (de) 1997-03-20 2005-03-24 F. Hoffmann-La Roche Ag Modifizierte Primer
WO1999011813A2 (en) 1997-09-04 1999-03-11 Bayer Corporation Oligonucleotide probes bearing quenchable fluorescent labels, and methods of use thereof
JPH11148521A (ja) 1997-11-13 1999-06-02 Nichias Corp 鳴き防止シム
GB9725197D0 (en) 1997-11-29 1998-01-28 Secr Defence Detection system
US6140054A (en) * 1998-09-30 2000-10-31 University Of Utah Research Foundation Multiplex genotyping using fluorescent hybridization probes
JP4975905B2 (ja) 1999-03-18 2012-07-11 エクシコン エ/エス 複合生物試料における核酸の単工程調製及び検出
DK1163250T3 (da) 1999-03-24 2006-11-13 Exiqon As Forbedret syntese af [2.2.1]bicyclonukleosider
US6734291B2 (en) 1999-03-24 2004-05-11 Exiqon A/S Synthesis of [2.2.1]bicyclo nucleosides
US6472156B1 (en) * 1999-08-30 2002-10-29 The University Of Utah Homogeneous multiplex hybridization analysis by color and Tm
DE69915468T2 (de) 1999-09-01 2005-01-20 Invitrogen Corp., Carlsbad Photon Dämpfer für Fluoreszenzassays
WO2001046469A1 (fr) 1999-12-22 2001-06-28 Otsuka Pharmaceutical Co., Ltd. Procede d'etude du genotype du virus de l'hepatite c
DE10027113A1 (de) 1999-12-23 2001-09-27 Andreas Hoeft Verfahren zur Bestimmung von mikrobieller DNS/RNS, Kit dafür und Verwendung des Verfahrens
CN1840522B (zh) 1999-12-27 2010-06-09 旭化成株式会社 生产甘氨酸的方法
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
JP2002345467A (ja) 2000-10-23 2002-12-03 Srl Inc C型肝炎ウイルスの型分類用プローブ及びそれを用いたc型肝炎ウイルスの型分類方法並びにそれを用いたインターフェロン投与の治療効果を予測する方法。
CN1322143C (zh) 2000-12-04 2007-06-20 普里马根公司 检测线粒体核酸与核基因核酸比率确定药物活性和/或副作用的方法
CN1366067A (zh) * 2001-01-15 2002-08-28 上海博华基因芯片技术有限公司 一种乙型、丙型肝炎双检基因芯片试剂盒及其制备和使用方法
EP1236804A1 (de) * 2001-03-02 2002-09-04 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Nukleinsäuren mittels einer Kontrolle
JP2002272475A (ja) 2001-03-22 2002-09-24 Eiken Chem Co Ltd 蛍光偏光法による核酸増幅産物の検出方法
WO2002083948A1 (en) 2001-04-12 2002-10-24 Biocore Co., Ltd. Oligonucleotide chip composition for analyzing hepatitis c virus (hcv) genotype and detecting method thereof
JP2003084002A (ja) 2001-06-27 2003-03-19 Fuji Photo Film Co Ltd 蛍光検出におけるバックグラウンドの低減方法
US6800765B2 (en) * 2001-08-02 2004-10-05 Molecular Devices Corporation Fluorescent pH indicators for intracellular assays
US7196183B2 (en) * 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US7393636B2 (en) 2001-11-08 2008-07-01 Sanko Junyaku Co., Ltd. Method for forming self-assembly substance using oligonucleotide synthesized by gene amplification reaction, self-assembly substance and method for detecting gene
WO2003057910A2 (en) 2002-01-08 2003-07-17 Roche Diagnostics Gmbh Use of silica material in an amplification reaction
US20030136921A1 (en) 2002-01-23 2003-07-24 Reel Richard T Methods for fluorescence detection that minimizes undesirable background fluorescence
EP1506000B9 (de) * 2002-05-20 2011-08-31 Bristol-Myers Squibb Company Heterocyclische sulfonamid-hepatitis-c-virus-hemmer
AU2003267960A1 (en) * 2002-05-22 2004-01-06 Marshall University Methods, probes, and accessory molecules for detecting single nucleotide polymorphisms
US7195885B2 (en) * 2002-08-12 2007-03-27 Bristol-Myers Squibb Company Hepatitis C virus assays
WO2004014852A2 (en) 2002-08-12 2004-02-19 Bristol-Myers Squibb Company Iminothiazolidinones as inhibitors of hcv replication
GB0223563D0 (en) 2002-10-10 2002-11-20 Secr Defence Detection system
JP2006506074A (ja) 2002-11-13 2006-02-23 ワシントン ユニヴァーシティー C型肝炎ウイルスの複製に対して高許容性である細胞系
JP4898119B2 (ja) 2002-11-22 2012-03-14 エフ.ホフマン−ラ ロシュ アーゲー 検出できるラベルされたヌクレオシド類似体及びその使用方法
EP1431398A1 (de) * 2002-12-20 2004-06-23 Evotec OAI AG Verfahren zum Nachweis die Menge eines Analyten in einer Mischung
WO2004074447A2 (en) 2003-02-18 2004-09-02 Applera Corporation Compositions and methods for multiplex analysis of polynucleotides
WO2005028650A2 (en) 2003-09-16 2005-03-31 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US7919242B2 (en) 2005-06-30 2011-04-05 Roche Molecular Systems, Inc. Light emission modifiers and their uses in nucleic acid detection, amplification and analysis

Also Published As

Publication number Publication date
US20100015629A1 (en) 2010-01-21
ES2630186T3 (es) 2017-08-18
US7919242B2 (en) 2011-04-05
US8222003B2 (en) 2012-07-17
JP2007006889A (ja) 2007-01-18
JP5155348B2 (ja) 2013-03-06
EP1746171A3 (de) 2007-06-20
EP1746170A3 (de) 2007-07-04
EP1746171B1 (de) 2017-05-17
CA2549671C (en) 2015-10-20
JP2007006890A (ja) 2007-01-18
US20070020664A1 (en) 2007-01-25
JP4634340B2 (ja) 2011-02-16
US8119346B2 (en) 2012-02-21
EP2128269A1 (de) 2009-12-02
US20100015598A1 (en) 2010-01-21
CA2895667A1 (en) 2006-12-30
EP1746171A2 (de) 2007-01-24
EP1746170B1 (de) 2017-05-03
US8114595B2 (en) 2012-02-14
DE602006010764D1 (de) 2010-01-14
US20070020665A1 (en) 2007-01-25
US20090098532A1 (en) 2009-04-16
US8067208B2 (en) 2011-11-29
US20070141560A1 (en) 2007-06-21
EP1746172A2 (de) 2007-01-24
EP1739190A1 (de) 2007-01-03
JP2007014333A (ja) 2007-01-25
JP4638388B2 (ja) 2011-02-23
US7465561B2 (en) 2008-12-16
JP4602945B2 (ja) 2010-12-22
CA2895667C (en) 2016-04-26
ES2336934T3 (es) 2010-04-19
CA2549754A1 (en) 2006-12-30
CA2549671A1 (en) 2006-12-30
JP6026977B2 (ja) 2016-11-16
EP1746172B1 (de) 2016-10-05
CA2549905C (en) 2016-10-18
JP2010162027A (ja) 2010-07-29
EP1746170A2 (de) 2007-01-24
ATE507311T1 (de) 2011-05-15
CA2549905A1 (en) 2006-12-30
US20100015630A1 (en) 2010-01-21
EP2128269B1 (de) 2011-04-27
JP2013255516A (ja) 2013-12-26
ES2605016T3 (es) 2017-03-10
JP5405715B2 (ja) 2014-02-05
US8163484B2 (en) 2012-04-24
EP1739190B1 (de) 2009-12-02
EP1746172A3 (de) 2007-03-28
CA2549754C (en) 2015-02-17
CA2549758C (en) 2017-03-07
US20120070820A1 (en) 2012-03-22
CA2549758A1 (en) 2006-12-30
US20070072211A1 (en) 2007-03-29
JP2007049985A (ja) 2007-03-01

Similar Documents

Publication Publication Date Title
DE602006010764D1 (de) Modifikatoren der Lichtemission und ihre Verwendungen zur Detektion, Amplifikation und Analyse von Nukleinsäuren
EP1468114A4 (de) Late-pcr
ATE443777T1 (de) Methoden und zusammensetzungen zur analyse von ribonukleinsäuren
ATE480550T1 (de) Hybridisierungskettenreaktion
WO2009117327A3 (en) Compositions and methods for analysis of nucleic acid molecules during amplification reactions
ATE534748T1 (de) Direkter snp-nachweis mit nichtamplifizierter dna
ATE515488T1 (de) Click-chemie zur herstellung von reportermolekülen
NO20072506L (no) Primaere, prober og fremgangsmater for nukelinsyreamplifikasjon
WO2006128138A3 (en) Biodetection by nucleic acid-templated chemistry
ATE480643T1 (de) Homogener nachweis von analyten
ATE373729T1 (de) Verfahren zur selektiven detektion einer zielnukleinsäure
ATE541054T1 (de) Bio-barcode erkennung für zielmoleküle
ATE428929T1 (de) Reagens, ausstattung und verfahren zur probenanalyse
ATE431854T1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
SE0301951D0 (sv) New method
RU2011107993A (ru) Алгоритм обнаружения для пцр-анализа
EP2295979A3 (de) Proteinnachweisreagentien und -verfahren mit Farbstoffen und Dextrinen
CN114341627A (zh) 核酸检测方法及装置
ATE546550T1 (de) Verfahren zum nachweis von hpv sowie sonden, primer und kits
CN111272723B (zh) 基于生物适配体的催化发夹自组装反应检测水环境中3,3′,4,4′-四氯联苯的方法
EP1610127A4 (de) N1,n12-diacetylspermin als tumormarker
ATE462803T1 (de) Kit und verfahren zum nachweis von urothelkarzinom
CY1114429T1 (el) Μεθοδος και διαταξη για την αναλυση αρκετων αναλυτων ταυτοχρονα με εναν εσωτερικο ελεγχο
Kim et al. The detection of a mismatched DNA by using hairpin DNA-templated silver nanoclusters
ATE340270T1 (de) Fluoreszenzmarkierten hybridisierungssonden mit reduzierter hintergrundfluoreszenz

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1739190

Country of ref document: EP