ATE480550T1 - Hybridisierungskettenreaktion - Google Patents

Hybridisierungskettenreaktion

Info

Publication number
ATE480550T1
ATE480550T1 AT05730392T AT05730392T ATE480550T1 AT E480550 T1 ATE480550 T1 AT E480550T1 AT 05730392 T AT05730392 T AT 05730392T AT 05730392 T AT05730392 T AT 05730392T AT E480550 T1 ATE480550 T1 AT E480550T1
Authority
AT
Austria
Prior art keywords
nucleic acid
chain reaction
initiator
hybridization chain
monomers
Prior art date
Application number
AT05730392T
Other languages
English (en)
Inventor
Robert Dirks
Niles Pierce
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Application granted granted Critical
Publication of ATE480550T1 publication Critical patent/ATE480550T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6823Release of bound markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Bipolar Transistors (AREA)
AT05730392T 2004-03-25 2005-03-22 Hybridisierungskettenreaktion ATE480550T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55614704P 2004-03-25 2004-03-25
PCT/US2005/009471 WO2005098049A2 (en) 2004-03-25 2005-03-22 Hybridization chain reaction

Publications (1)

Publication Number Publication Date
ATE480550T1 true ATE480550T1 (de) 2010-09-15

Family

ID=35125688

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05730392T ATE480550T1 (de) 2004-03-25 2005-03-22 Hybridisierungskettenreaktion

Country Status (5)

Country Link
US (2) US7632641B2 (de)
EP (1) EP1730161B1 (de)
AT (1) ATE480550T1 (de)
DE (1) DE602005023426D1 (de)
WO (1) WO2005098049A2 (de)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005098049A2 (en) * 2004-03-25 2005-10-20 California Institute Of Technology Hybridization chain reaction
US20060234261A1 (en) * 2005-03-08 2006-10-19 Pierce Niles A Colorimetric readout of hybridization chain reaction
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
EP1931806B1 (de) 2005-10-07 2011-10-05 California Institute Of Technology Pkr-aktivierung mittels hybridisierungskettenreaktion
WO2008106658A2 (en) 2007-03-01 2008-09-04 California Institute Of Technology TRIGGERED RNAi
US8043810B2 (en) * 2007-05-02 2011-10-25 Eagle Eye Research, Inc. Analyte detection using autocatalytic chain reactions
WO2008144562A1 (en) * 2007-05-16 2008-11-27 California Institute Of Technology A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
US8497364B2 (en) * 2008-02-27 2013-07-30 California Institute Of Technology Triggered RNAi
US20100021904A1 (en) * 2008-05-21 2010-01-28 Pierce Niles A Shielded cross-linking probes
US8241854B2 (en) * 2008-05-22 2012-08-14 California Institute Of Technology Triggered RNAi
US20100021901A1 (en) * 2008-05-22 2010-01-28 Peng Yin Compositions and methods for detecting analytes
WO2010046796A1 (en) * 2008-10-23 2010-04-29 Koninklijke Philips Electronics, N.V. Molecular imaging
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
US8962241B2 (en) 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
EP2444501A1 (de) * 2010-10-22 2012-04-25 Université de Fribourg Sensor
EP2633071B1 (de) * 2010-10-27 2016-10-12 President and Fellows of Harvard College Zusammensetzungen von "toehold" primer duplexen und deren anwendungen
CN102653789A (zh) * 2012-03-14 2012-09-05 河北大学 一种生物分子的定量检测方法
KR102148747B1 (ko) 2012-08-09 2020-08-27 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 현미경적 분석을 위한 생물학적 표본을 준비하기 위한 방법과 조성물
WO2014169206A2 (en) 2013-04-11 2014-10-16 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
US10221216B2 (en) 2013-04-11 2019-03-05 Carnegie Mellon University Template-directed γPNA synthesis process and γPNA targeting compounds
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
CN106103818A (zh) * 2013-12-16 2016-11-09 威廉马歇莱思大学 精细调节的超特异性核酸杂交探针
CN104726548A (zh) * 2013-12-20 2015-06-24 深圳先进技术研究院 一种基于杂交链式反应的dna、rna或蛋白质检测探针、检测方法及试剂盒
GB201401885D0 (en) 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
WO2015172058A1 (en) 2014-05-08 2015-11-12 Carnegie Mellon University Left-handed gamma-peptide nucleic acids, methods of synthesis and uses therefor
CA2983819A1 (en) 2015-04-24 2016-10-27 Atila Biosystems Incorporated Amplification with primers of limited nucleotide composition
CA3038658A1 (en) 2015-12-14 2017-06-22 The Penn State Research Foundation Polymer-based signal amplification for protein and cell detection
WO2017139501A1 (en) 2016-02-10 2017-08-17 The Board Of Trustees Of The Leland Stanford Junior University Rna fixation and detection in clarity-based hydrogel tissue
EP4613756A3 (de) 2016-04-25 2025-11-12 President And Fellows Of Harvard College Hybridisierungskettenreaktionsverfahren für den in-situ-molekularnachweis
IL290679B2 (en) 2016-07-05 2023-10-01 California Inst Of Techn Hybridization chain reaction based on a minimal initiator
IT201600073964A1 (it) 2016-07-14 2018-01-14 Ulisse Biomed S R L Nanointerruttore basato su nucleotidi e metodi per la rilevazione di anticorpi e altri analiti
CA3034617A1 (en) 2016-08-30 2018-03-08 California Institute Of Technology Immunohistochemistry via hybridization chain reaction
JP7573965B2 (ja) 2016-09-26 2024-10-28 カーネギー メロン ユニバーシティ 二価核酸塩基化合物およびそれらの使用
CN110799576B (zh) 2017-04-17 2023-02-17 南加利福尼亚大学 生成用于具有多模式标记和信号放大的分析物检测的生物相容的树枝状聚合物的方法
CN108624620A (zh) * 2018-04-02 2018-10-09 湖南大学 DNA纳米四分体实现对核酸高效输送及miRNA的超灵敏检测方法
CN120905352A (zh) 2018-04-02 2025-11-07 埃努梅拉分子股份有限公司 用于对核酸分子进行计数的方法、系统和组合物
US11414701B2 (en) 2018-05-24 2022-08-16 The Broad Institute, Inc. Multimodal readouts for quantifying and sequencing nucleic acids in single cells
GB201818742D0 (en) 2018-11-16 2019-01-02 Cartana Ab Method for detection of RNA
EP3947718A4 (de) 2019-04-02 2022-12-21 Enumera Molecular, Inc. Verfahren, systeme und zusammensetzungen zum zählen von nukleinsäuremolekülen
CN110257520B (zh) * 2019-07-04 2020-12-25 福州大学 一种利用短毛细管高速电泳检测肺癌细胞中miRNA的技术
WO2021034956A2 (en) * 2019-08-19 2021-02-25 Northwestern University Controlling the dna hybridization chain reaction
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
IL295981A (en) 2020-03-06 2022-10-01 California Inst Of Techn Analysis of target molecules within a sample using chain reaction hybridization
GB202100760D0 (en) * 2021-01-20 2021-03-03 Qbiotix Ltd Target-dependent polymerisation of oligonucleotides
WO2022164796A1 (en) 2021-01-26 2022-08-04 California Institute Of Technology Allosteric conditional guide rnas for cell-selective regulation of crispr/cas
US12275984B2 (en) 2021-03-02 2025-04-15 10X Genomics, Inc. Sequential hybridization and quenching
EP4301873A1 (de) 2021-03-03 2024-01-10 10X Genomics, Inc. In-situ-analytnachweis mit nukleinsäureorigami
WO2022256324A1 (en) 2021-06-01 2022-12-08 10X Genomics, Inc. Methods and compositions for analyte detection and probe resolution
WO2022256422A1 (en) 2021-06-02 2022-12-08 10X Genomics, Inc. Sample analysis using asymmetric circularizable probes
WO2023283442A1 (en) 2021-07-09 2023-01-12 10X Genomics, Inc. Methods for detecting analytes using sparse labelling
WO2023288225A1 (en) 2021-07-13 2023-01-19 10X Genomics, Inc. Methods for preparing polymerized matrix with controllable thickness
US12139751B2 (en) 2021-07-30 2024-11-12 10X Genomics, Inc. Circularizable probes for in situ analysis
AU2022317053B2 (en) 2021-07-30 2025-01-02 10X Genomics, Inc. Methods and compositions for synchronizing reactions in situ
US12391984B2 (en) 2021-08-03 2025-08-19 10X Genomics, Inc. Compositions and methods for rolling circle amplification
US12529096B2 (en) 2021-08-03 2026-01-20 10X Genomics, Inc. Stabilization and/or compaction of nucleic acid structures
EP4446426B1 (de) 2021-08-16 2026-03-04 10X Genomics, Inc. Sonden mit einem geteilten strichcodebereich und verfahren zur verwendung
JP2024538662A (ja) 2021-10-08 2024-10-23 ユニバーシティ オブ ロチェスター 液滴蒸発により増強される核酸ハイブリダイゼーションカスケード
CN114062672B (zh) * 2021-11-12 2023-04-25 福州大学 一种检测covid-19抗体的血糖生物传感器
EP4445377A2 (de) 2021-12-10 2024-10-16 10X Genomics, Inc. In-situ-decodierung mit mehreren auflösungen
CN114231632B (zh) * 2021-12-20 2023-09-22 深圳大学 一种可刺激性响应的dna水凝胶微针贴片及其制备方法与应用
EP4423296A2 (de) 2021-12-27 2024-09-04 10X Genomics, Inc. Verfahren und zusammensetzungen zur rolling-circle-amplifikation
EP4733410A2 (de) 2022-01-21 2026-04-29 10X Genomics, Inc. Mehrere auslesesignale zur analyse einer probe
EP4482982A1 (de) 2022-02-21 2025-01-01 Kanvas Biosciences, Inc Hochmultiplexierter nachweis von genexpression mit hybridisierungskettenreaktion
CN118974836A (zh) 2022-03-08 2024-11-15 10X基因组学有限公司 将光学拥挤最小化的原位代码设计方法
WO2023192302A1 (en) 2022-03-29 2023-10-05 10X Genomics, Inc. Spectral unmixing combined with decoding for super-multiplexed in situ analysis
EP4505177A1 (de) 2022-04-01 2025-02-12 10x Genomics, Inc. Zusammensetzungen und verfahren zur gezielten maskierung der autofluoreszenz
US20230323427A1 (en) 2022-04-06 2023-10-12 10X Genomics, Inc. Methods and compositions for multiplex cell analysis
EP4519674A1 (de) 2022-05-06 2025-03-12 10X Genomics, Inc. Analyse von antigen- und antigenrezeptorinteraktionen
US20240084378A1 (en) 2022-05-11 2024-03-14 10X Genomics, Inc. Compositions and methods for in situ sequencing
EP4540607A1 (de) 2022-06-17 2025-04-23 10X Genomics, Inc. Katalytische entvernetzung von proben zur in-situ-analyse
WO2024081869A1 (en) 2022-10-14 2024-04-18 10X Genomics, Inc. Methods for analysis of biological samples
EP4619736A1 (de) 2022-11-18 2025-09-24 10X Genomics, Inc. Systeme und verfahren zur aktiven abschwächung von schwingungen
EP4622746A1 (de) 2022-11-22 2025-10-01 10X Genomics, Inc. Systeme und verfahren zur schnittstellenbildung mit einer flasche
US12581050B2 (en) 2022-11-23 2026-03-17 10X Genomics, Inc. Optical assemblies for machine vision calibration
EP4638789A1 (de) 2022-12-21 2025-10-29 10X Genomics, Inc. Verfahren zur bindung von ribonukleinsäuren in biologischen proben
US20240336956A1 (en) 2023-04-04 2024-10-10 California Institute Of Technology Ultrasensitive molecular detection via hybridization chain reaction
EP4705515A1 (de) 2023-05-03 2026-03-11 10X Genomics, Inc. Verfahren und zusammensetzungen für räumliche tests
EP4461816A1 (de) 2023-05-10 2024-11-13 10X Genomics, Inc. Boronsäurezusammensetzungen und verfahren zur bindung von ribonukleinsäuren in biologischen proben
WO2025014758A1 (en) 2023-07-07 2025-01-16 10X Genomics, Inc. Systems and methods for tissue bounds detection
WO2025038914A1 (en) 2023-08-16 2025-02-20 10X Genomics, Inc. Systems and methods for image segmentation
WO2025076421A1 (en) 2023-10-06 2025-04-10 10X Genomics, Inc. Feature pyramiding for in situ data visualizations
WO2025111463A1 (en) 2023-11-22 2025-05-30 10X Genomics, Inc. Methods for processing ribonucleic acids in biological samples
WO2025122890A1 (en) 2023-12-07 2025-06-12 10X Genomics, Inc. Graphical user interface and method of estimating an instrument run completion time
US12406371B2 (en) 2024-01-25 2025-09-02 10X Genomics, Inc. Systems and methods for image segmentation using multiple stain indicators
US20250285229A1 (en) 2024-03-08 2025-09-11 10X Genomics, Inc. Multi-focus image fusion with background removal
US20250288988A1 (en) 2024-03-15 2025-09-18 10X Genomics, Inc. Systems and methods for covering and sealing an open well
WO2026076066A1 (en) 2024-10-01 2026-04-09 10X Genomics, Inc. Systems and methods for illumination of a sample

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4714680B1 (en) 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US4965204A (en) 1984-02-06 1990-10-23 The Johns Hopkins University Human stem cells and monoclonal antibodies
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
EP0273085A1 (de) 1986-12-29 1988-07-06 IntraCel Corporation Verfahren zur Einführung fremder Nukleinsäuren in eukaryotische Zellen
US5057410A (en) 1988-08-05 1991-10-15 Cetus Corporation Chimeric messenger RNA detection methods
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
PL172710B1 (pl) 1992-07-02 1997-11-28 Hybridon Inc Samostabilizujacy sie oligonukleotyd PL PL
US5677136A (en) 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
EP0871755A1 (de) 1995-03-23 1998-10-21 Cantab Pharmaceuticals Research Limited Vektoren zur verabreichung von genen
CA2224907A1 (en) 1995-07-25 1997-02-13 Introgene B.V. Methods and means for targeted gene delivery
US5579793A (en) 1995-11-15 1996-12-03 Rubbermaid Health Care Products, Inc. Foldable walker
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5928823A (en) * 1996-12-20 1999-07-27 Fuji Photo Film Co., Ltd. Method for preparation of waterless lithographic printing plate by electrophotographic process
US20020017295A1 (en) 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US6555367B1 (en) 1997-10-10 2003-04-29 The United States Of America As Represented By The Department Of Health And Human Services Complex of biotinylated viral vector and ligand for targeted gene delivery
GB9721909D0 (en) 1997-10-17 1997-12-17 Cantab Pharma Res Gene delivery vectors and their uses
US5989823A (en) * 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
AU3909199A (en) 1997-12-15 1999-07-05 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
US6242246B1 (en) * 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
AU3358999A (en) 1998-03-20 1999-10-11 Genzyme Corporation Chimeric adenoviral vectors for targeted gene delivery
AU762728B2 (en) 1998-07-02 2003-07-03 Gen-Probe Incorporated Molecular torches
DE19843415A1 (de) * 1998-09-22 2000-03-23 Philips Corp Intellectual Pty Induktives Bauelement mit einem Stabkern
US6899871B2 (en) 1998-10-01 2005-05-31 University Of Southern California Gene delivery system and methods of use
EP1059357A1 (de) 1999-06-09 2000-12-13 Universite Pierre Et Marie Curie Paris Vi Replizierende oder 'semi-replizierende' retrovirale Konstrukte, ihre Herstellung und Verwendungen für den Gentransfer
DE19937800B4 (de) 1999-08-10 2005-06-16 Gea Energietechnik Gmbh Anlage zur Kondensation von Dampf
ATE364722T1 (de) * 2000-06-02 2007-07-15 Bayer Corp Verfahren zum nachweis und zur lokalisierung von genen in situ durch hybridisierung einer verzweigten dna
US20040223953A1 (en) 2003-03-17 2004-11-11 Hsiang-Fu Kung Combined adeno-associated virus and adenovirus cocktail gene delivery system for high efficiency gene expression without eliciting immune response in immuno-competent subjects
WO2005098049A2 (en) 2004-03-25 2005-10-20 California Institute Of Technology Hybridization chain reaction
US7727721B2 (en) * 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
US20060234261A1 (en) * 2005-03-08 2006-10-19 Pierce Niles A Colorimetric readout of hybridization chain reaction
WO2007008276A2 (en) 2005-05-03 2007-01-18 Ensemble Discovery Corporation Turnover probes and use thereof for nucleic acid detection
EP1931806B1 (de) * 2005-10-07 2011-10-05 California Institute Of Technology Pkr-aktivierung mittels hybridisierungskettenreaktion
WO2008144562A1 (en) 2007-05-16 2008-11-27 California Institute Of Technology A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways

Also Published As

Publication number Publication date
US8105778B2 (en) 2012-01-31
EP1730161B1 (de) 2010-09-08
US20100047926A1 (en) 2010-02-25
DE602005023426D1 (de) 2010-10-21
EP1730161A2 (de) 2006-12-13
EP1730161A4 (de) 2008-05-21
US20050260635A1 (en) 2005-11-24
WO2005098049A3 (en) 2006-05-11
US7632641B2 (en) 2009-12-15
WO2005098049A2 (en) 2005-10-20

Similar Documents

Publication Publication Date Title
ATE480550T1 (de) Hybridisierungskettenreaktion
AU2018234832A1 (en) CRISPR effector system based diagnostics for virus detection
DE50312579D1 (de) Vorrichtung zur Detektion von Targetmolekülen
DE602006018477D1 (de) Dna und antikörpern sowie verwendungen davon
ATE534748T1 (de) Direkter snp-nachweis mit nichtamplifizierter dna
WO2002090572A3 (en) Nucleic acid detection in pooled samples
ATE450623T1 (de) Modifikatoren der lichtemission und ihre verwendungen zur detektion, amplifikation und analyse von nukleinsäuren
DK1381697T3 (da) Cirkulær probe-amplifikation (CPA) af ringformede nukleinsyremolekyler
ATE479780T1 (de) Qpcr unter verwendung eines ionen-sensitiven feldeffekt-transistors zur ph-messung
WO2006078289A3 (en) Bio-barcode based detection of target analytes
DK1788391T3 (da) Biosensorindretning og fremgangsmåder til brug deraf
ATE531820T1 (de) Gesundheitszustandstest
WO2005003394A3 (en) Bio-barcode based detection of target analytes
SE0301951D0 (sv) New method
WO2019113075A3 (en) Microbial-based biosensors
DK1649051T3 (da) Bestemmelse af sekvensen for et polynukleotid
TW200720441A (en) New labelling strategies for the sensitive detection of analytes
ATE298804T1 (de) Verfahren zur nachweis von nukleinsäuren
WO2007016275A3 (en) Methods and compositions for detecting bk virus
BRPI0513308A (pt) sistemas e métodos de análise de polìmeros de ácido nucléico e componentes relacionados
WO2002099381A3 (en) A single-cell biosensor for the measurement of gpcr ligands in a test sample
WO2007058629A3 (en) Influenza a virus detection method and kit therefor
WO2006119326A3 (en) Oligonucleotide probe/primer compositions and methods for polynucleotide detection
WO2007001310A3 (en) Methods and compositions for detecting rhinoviruses
ATE529746T1 (de) Zusammensetzung und verfahren zum nachweis von analyten über eine polymerisierungsbasierte signalverstärkung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties