ATE453624T1 - Kristallform von lercanipidin-hydrochlorid zur verwendung als antihypertensives mittel - Google Patents

Kristallform von lercanipidin-hydrochlorid zur verwendung als antihypertensives mittel

Info

Publication number
ATE453624T1
ATE453624T1 AT05106264T AT05106264T ATE453624T1 AT E453624 T1 ATE453624 T1 AT E453624T1 AT 05106264 T AT05106264 T AT 05106264T AT 05106264 T AT05106264 T AT 05106264T AT E453624 T1 ATE453624 T1 AT E453624T1
Authority
AT
Austria
Prior art keywords
lercanipidine
hydrochloride
crystal form
antihypertensive agent
antihypertensive
Prior art date
Application number
AT05106264T
Other languages
English (en)
Inventor
Fausto Bonifacio
Francesco Campana
Iasi Gianluca De
Amedeo Leonardi
Original Assignee
Recordati Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11448245&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE453624(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd
Application granted granted Critical
Publication of ATE453624T1 publication Critical patent/ATE453624T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
AT05106264T 2001-08-06 2002-08-05 Kristallform von lercanipidin-hydrochlorid zur verwendung als antihypertensives mittel ATE453624T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001MI001726A ITMI20011726A1 (it) 2001-08-06 2001-08-06 Forme polimorfe della lercanidipina cloridrato

Publications (1)

Publication Number Publication Date
ATE453624T1 true ATE453624T1 (de) 2010-01-15

Family

ID=11448245

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02762428T ATE307114T1 (de) 2001-08-06 2002-08-05 Kristalline polymorphe formen von lercanidipin hydrochlorid und verfahren zu deren herstellung
AT05106264T ATE453624T1 (de) 2001-08-06 2002-08-05 Kristallform von lercanipidin-hydrochlorid zur verwendung als antihypertensives mittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT02762428T ATE307114T1 (de) 2001-08-06 2002-08-05 Kristalline polymorphe formen von lercanidipin hydrochlorid und verfahren zu deren herstellung

Country Status (35)

Country Link
EP (4) EP2157083B1 (de)
JP (1) JP2005504045A (de)
KR (3) KR100626819B1 (de)
CN (2) CN101475524B (de)
AP (1) AP1766A (de)
AR (1) AR037139A1 (de)
AT (2) ATE307114T1 (de)
AU (1) AU2002327924C1 (de)
BR (1) BR0211739A (de)
CY (2) CY1109711T1 (de)
DE (2) DE60234961D1 (de)
DK (3) DK1600441T3 (de)
EA (1) EA005673B1 (de)
EC (1) ECSP044973A (de)
ES (3) ES2212759T3 (de)
HR (1) HRP20040156B1 (de)
HU (1) HU229563B1 (de)
IL (3) IL153917A (de)
IT (1) ITMI20011726A1 (de)
MA (1) MA27133A1 (de)
ME (2) ME01525B (de)
MX (1) MXPA04001069A (de)
NO (2) NO325541B1 (de)
NZ (2) NZ541341A (de)
OA (1) OA12648A (de)
PE (1) PE20030328A1 (de)
PL (1) PL216066B1 (de)
PT (2) PT2157083E (de)
RS (1) RS52161B (de)
SI (3) SI1432683T1 (de)
TN (1) TNSN04024A1 (de)
UA (1) UA82988C2 (de)
UY (1) UY27410A1 (de)
WO (1) WO2003014084A1 (de)
ZA (1) ZA200401806B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011726A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
AR043395A1 (es) * 2003-02-28 2005-07-27 Recordati Ireland Ltd Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii
KR20060125824A (ko) * 2003-12-01 2006-12-06 라이프사이클 파마 에이/에스 레르카니디핀을 포함한 약학적 조성물
AR052918A1 (es) 2005-02-25 2007-04-11 Recordati Ireland Ltd Clorhidrato de lercanidipina amorfo
EP1940790B1 (de) 2005-09-16 2015-09-02 Glenmark Pharmaceuticals Limited Polymorphe form von lercanidipin-hydrochlorid und verfahren zu ihrer herstellung
KR100821165B1 (ko) * 2006-03-10 2008-04-14 동우신테크 주식회사 레르카니디핀 염산염의 제조 방법
JP2010514753A (ja) * 2006-12-29 2010-05-06 ドンウ シンテック カンパニー リミテッド レルカニジピン塩酸塩の製造方法
US20100104649A1 (en) * 2007-03-05 2010-04-29 Actavis Group Ptc Ehf Lercanidipine Hydrochloride Polymorphs and an Improved Process for Preparation of 1,1,N-Trimethyl-N-(3,3-Diphenylpropyl)-2-Aminoethyl Acetoacetate
EA027787B1 (ru) 2010-06-23 2017-09-29 Крка, Товарна Здравил, Д.Д., Ново Место Пероральные лекарственные формы, содержащие лерканидипин и эналаприл и их фармацевтически приемлемые соли
EP2444394A1 (de) 2010-10-21 2012-04-25 Alembic Pharmaceuticals Limited Verfahren zur Herstellung amorpher Formen von Lercanidipin HCl
WO2012085249A2 (en) 2010-12-24 2012-06-28 Krka, D.D., Novo Mesto Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts
US20140031557A1 (en) * 2011-04-18 2014-01-30 Hefeibeinie Medical Technology Company, Ltd. Method for purification of calcium channel blockers of dihydorpyridine type and preparation of nanoparticles thereof
CN102531999B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 无定形盐酸乐卡地平及其制备方法
CN102558032B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 一种无定形盐酸乐卡地平及其制备方法
CN102584682A (zh) * 2011-12-31 2012-07-18 苏州二叶制药有限公司 盐酸乐卡地平的制备方法
CN103497075B (zh) * 2013-09-25 2016-03-23 山西北化关铝化工有限公司 水悬浮延期药造型粉
CN109232389B (zh) * 2018-05-15 2021-10-08 迪嘉药业集团有限公司 一种小粒度硝苯地平的结晶制备方法
CN115353485B (zh) * 2022-07-26 2024-04-19 山西双雁药业有限公司 从硝苯地平母液中回收硝苯地平的方法及应用
CN115671066B (zh) * 2022-11-21 2024-07-02 安徽宏业药业有限公司 一种盐酸乐卡地平片及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US596139A (en) * 1897-12-28 Process of generating acetylene gas
GB8403866D0 (en) 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
IT1274480B (it) * 1995-05-12 1997-07-17 Recordati Chem Pharm Procedimento migliorato per la preparazione della lercanidipina cloridrato
US5767136A (en) * 1995-05-12 1998-06-16 Recordati, S.A. Chemical And Pharmaceutical Company 1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls
IT1275532B (it) * 1995-07-14 1997-08-07 Recordati Chem Pharm Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa
US5696139A (en) 1995-05-12 1997-12-09 Recordati S.A., Chemical And Pharmaceutical Company Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure
PL365238A1 (en) 2000-02-16 2004-12-27 Neurogen Corporation Substituted arylpyrazines
ITMI20011726A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
US20040198789A1 (en) 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations

Also Published As

Publication number Publication date
MXPA04001069A (es) 2005-02-17
PL216066B1 (pl) 2014-02-28
DK2157083T3 (en) 2015-11-02
RS11304A (sr) 2007-02-05
UA82988C2 (uk) 2008-06-10
EP2157083B1 (de) 2015-09-30
SI1432683T1 (sl) 2006-04-30
EA005673B1 (ru) 2005-04-28
KR20050043992A (ko) 2005-05-11
ATE307114T1 (de) 2005-11-15
IL153917A (en) 2005-11-20
AU2002327924C1 (en) 2009-12-10
ITMI20011726A1 (it) 2003-02-06
PT1600441E (pt) 2010-01-20
EP1600441A3 (de) 2005-12-07
ME01525B (de) 2011-02-10
CY1109711T1 (el) 2014-08-13
SI1600441T1 (sl) 2010-02-26
DE60234961D1 (de) 2010-02-11
DK1600441T3 (da) 2010-02-08
JP2005504045A (ja) 2005-02-10
WO2003014084A1 (en) 2003-02-20
KR100626819B1 (ko) 2006-09-20
IL164648A (en) 2007-02-11
EP1432683B1 (de) 2005-10-19
NO335651B1 (no) 2015-01-19
PT2157083E (pt) 2016-01-22
EP2036890A1 (de) 2009-03-18
CN100448847C (zh) 2009-01-07
HUP0401163A3 (en) 2009-04-28
EP2157083A2 (de) 2010-02-24
IL164648A0 (en) 2005-12-18
ES2555213T3 (es) 2015-12-29
NZ541341A (en) 2007-02-23
PE20030328A1 (es) 2003-05-09
CN101475524B (zh) 2012-08-29
MEP2908A (en) 2010-10-10
EP1432683B9 (de) 2006-01-18
CN1538957A (zh) 2004-10-20
RS52161B (sr) 2012-08-31
AR037139A1 (es) 2004-10-27
EA200400280A1 (ru) 2004-08-26
UY27410A1 (es) 2003-03-31
NZ531558A (en) 2005-12-23
DK1432683T3 (da) 2006-03-06
KR100667687B1 (ko) 2007-01-12
NO20040266L (no) 2004-03-24
CY1117051T1 (el) 2017-04-05
EP1600441B1 (de) 2009-12-30
HK1067123A1 (en) 2005-04-01
DE60206787T2 (de) 2006-07-13
ES2212759T3 (es) 2006-04-16
PL369522A1 (en) 2005-05-02
HK1140487A1 (en) 2010-10-15
HK1086263A1 (en) 2006-09-15
EP1600441A2 (de) 2005-11-30
TNSN04024A1 (en) 2006-06-01
KR20040030903A (ko) 2004-04-09
ZA200401806B (en) 2005-06-29
SI2157083T1 (sl) 2016-01-29
EP2157083A3 (de) 2010-03-24
AP1766A (en) 2007-08-10
CN101475524A (zh) 2009-07-08
HRP20040156B1 (en) 2012-03-31
AP2004002989A0 (en) 2004-03-31
NO325541B1 (no) 2008-06-16
ES2212759T1 (es) 2004-08-01
IL153917A0 (en) 2003-07-31
AU2002327924B2 (en) 2008-04-24
NO20082330L (no) 2004-03-24
HU229563B1 (en) 2014-02-28
ITMI20011726A0 (it) 2001-08-06
ECSP044973A (es) 2004-06-28
KR20050111799A (ko) 2005-11-28
ES2334678T3 (es) 2010-03-15
HUP0401163A2 (hu) 2004-09-28
DE60206787D1 (de) 2006-03-02
EP1432683A1 (de) 2004-06-30
OA12648A (en) 2006-06-16
BR0211739A (pt) 2004-09-28
MA27133A1 (fr) 2005-01-03
HRP20040156A2 (en) 2004-08-31

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