MA27133A1 - Nouvelles formes polymorphes cristallines d'hydrochlorure de lercanidipine et procede de fabrication associe - Google Patents

Nouvelles formes polymorphes cristallines d'hydrochlorure de lercanidipine et procede de fabrication associe

Info

Publication number
MA27133A1
MA27133A1 MA27517A MA27517A MA27133A1 MA 27133 A1 MA27133 A1 MA 27133A1 MA 27517 A MA27517 A MA 27517A MA 27517 A MA27517 A MA 27517A MA 27133 A1 MA27133 A1 MA 27133A1
Authority
MA
Morocco
Prior art keywords
lercanidipine hydrochloride
manufacturing process
polymorphic forms
new crystalline
crystalline polymorphic
Prior art date
Application number
MA27517A
Other languages
English (en)
Inventor
Fausto Bonifacio
Francesco Campana
Iasi Gianluca De
Amedeo Leonardi
Original Assignee
Recordati Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11448245&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA27133(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd
Publication of MA27133A1 publication Critical patent/MA27133A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

NOUVELLES FORMES BRUTES ET CRISTALLINES DU CHLORHYDRATE DE LERCANIDIPINE L'invention décrit de nouvelles Formes brutes (A) et (B) de la lercanidipine, de nouvelles Formes cristallines (I) et (II) du chlorhydrate de lercanidipine obtenues à partir desdites Formes brutes, des compositions pharmaceutiques antihypertensives contenant en tant qu'un agent actif au 10 moins l'une des Formes cristallines (I) et (II) du chlorhydrate de lercanidipine, et des méthodes pour leur utilisation.
MA27517A 2001-08-06 2004-02-06 Nouvelles formes polymorphes cristallines d'hydrochlorure de lercanidipine et procede de fabrication associe MA27133A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2001MI001726A ITMI20011726A1 (it) 2001-08-06 2001-08-06 Forme polimorfe della lercanidipina cloridrato

Publications (1)

Publication Number Publication Date
MA27133A1 true MA27133A1 (fr) 2005-01-03

Family

ID=11448245

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27517A MA27133A1 (fr) 2001-08-06 2004-02-06 Nouvelles formes polymorphes cristallines d'hydrochlorure de lercanidipine et procede de fabrication associe

Country Status (35)

Country Link
EP (4) EP1432683B9 (fr)
JP (1) JP2005504045A (fr)
KR (3) KR100667687B1 (fr)
CN (2) CN101475524B (fr)
AP (1) AP1766A (fr)
AR (1) AR037139A1 (fr)
AT (2) ATE307114T1 (fr)
AU (1) AU2002327924C1 (fr)
BR (1) BR0211739A (fr)
CY (2) CY1109711T1 (fr)
DE (2) DE60206787T2 (fr)
DK (3) DK1600441T3 (fr)
EA (1) EA005673B1 (fr)
EC (1) ECSP044973A (fr)
ES (3) ES2555213T3 (fr)
HR (1) HRP20040156B1 (fr)
HU (1) HU229563B1 (fr)
IL (3) IL164648A0 (fr)
IT (1) ITMI20011726A1 (fr)
MA (1) MA27133A1 (fr)
ME (2) MEP2908A (fr)
MX (1) MXPA04001069A (fr)
NO (2) NO325541B1 (fr)
NZ (2) NZ531558A (fr)
OA (1) OA12648A (fr)
PE (1) PE20030328A1 (fr)
PL (1) PL216066B1 (fr)
PT (2) PT2157083E (fr)
RS (1) RS52161B (fr)
SI (3) SI1432683T1 (fr)
TN (1) TNSN04024A1 (fr)
UA (1) UA82988C2 (fr)
UY (1) UY27410A1 (fr)
WO (1) WO2003014084A1 (fr)
ZA (1) ZA200401806B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011726A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
AR043395A1 (es) * 2003-02-28 2005-07-27 Recordati Ireland Ltd Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii
EP1694305B1 (fr) * 2003-12-01 2019-10-16 Recordati Ireland Limited Compositions pharmaceutiques contenant de la lercanipidine
AR052918A1 (es) 2005-02-25 2007-04-11 Recordati Ireland Ltd Clorhidrato de lercanidipina amorfo
EP1940790B1 (fr) * 2005-09-16 2015-09-02 Glenmark Pharmaceuticals Limited Forme polymorphique d'hydrochlorure de lercanidipine et son procede de preparation
KR100821165B1 (ko) * 2006-03-10 2008-04-14 동우신테크 주식회사 레르카니디핀 염산염의 제조 방법
JP2010514753A (ja) * 2006-12-29 2010-05-06 ドンウ シンテック カンパニー リミテッド レルカニジピン塩酸塩の製造方法
CN101868442A (zh) * 2007-03-05 2010-10-20 阿克塔维什集团Ptc公司 盐酸乐卡地平多晶型物和1,1,n-三甲基-n-(3,3-二苯基丙基)-2-氨基乙酰醋酸乙酯的改进制法
WO2011161223A2 (fr) 2010-06-23 2011-12-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Formes pharmaceutiques à usage oral comprenant de la lercanidipine et de l'énalapril et leurs sels pharmaceutiquement acceptables
EP2444394A1 (fr) 2010-10-21 2012-04-25 Alembic Pharmaceuticals Limited Procédé de préparation de forme amorphe de lercanidipine HCI
SI2654729T1 (sl) 2010-12-24 2016-08-31 Krka, D.D., Novo Mesto Homogene farmacevtske oralne dozirne oblike, ki obsegajo lerkanidipin in enalapril ali njune farmacevtsko sprejemljive soli skupaj z organsko kislino
US20140031557A1 (en) * 2011-04-18 2014-01-30 Hefeibeinie Medical Technology Company, Ltd. Method for purification of calcium channel blockers of dihydorpyridine type and preparation of nanoparticles thereof
CN102531999B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 无定形盐酸乐卡地平及其制备方法
CN102558032B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 一种无定形盐酸乐卡地平及其制备方法
CN102584682A (zh) * 2011-12-31 2012-07-18 苏州二叶制药有限公司 盐酸乐卡地平的制备方法
CN103497075B (zh) * 2013-09-25 2016-03-23 山西北化关铝化工有限公司 水悬浮延期药造型粉
CN109232389B (zh) * 2018-05-15 2021-10-08 迪嘉药业集团有限公司 一种小粒度硝苯地平的结晶制备方法
CN115353485B (zh) * 2022-07-26 2024-04-19 山西双雁药业有限公司 从硝苯地平母液中回收硝苯地平的方法及应用
CN115671066B (zh) * 2022-11-21 2024-07-02 安徽宏业药业有限公司 一种盐酸乐卡地平片及其制备方法
CN117567358A (zh) * 2023-11-02 2024-02-20 成都地奥九泓制药厂 一种盐酸尼卡地平半乙酸乙酯合物晶体及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US596139A (en) * 1897-12-28 Process of generating acetylene gas
GB8403866D0 (en) 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
US5767136A (en) * 1995-05-12 1998-06-16 Recordati, S.A. Chemical And Pharmaceutical Company 1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls
IT1275532B (it) * 1995-07-14 1997-08-07 Recordati Chem Pharm Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa
IT1274480B (it) * 1995-05-12 1997-07-17 Recordati Chem Pharm Procedimento migliorato per la preparazione della lercanidipina cloridrato
US5696139A (en) 1995-05-12 1997-12-09 Recordati S.A., Chemical And Pharmaceutical Company Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure
ATE307121T1 (de) 2000-02-16 2005-11-15 Neurogen Corp Substituierte arylpyrazine
ITMI20011726A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
US20040198789A1 (en) 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations

Also Published As

Publication number Publication date
KR20040030903A (ko) 2004-04-09
ZA200401806B (en) 2005-06-29
UA82988C2 (uk) 2008-06-10
TNSN04024A1 (en) 2006-06-01
SI1432683T1 (sl) 2006-04-30
ES2555213T3 (es) 2015-12-29
IL164648A (en) 2007-02-11
EP1600441A3 (fr) 2005-12-07
EP2157083B1 (fr) 2015-09-30
EP1432683B1 (fr) 2005-10-19
AP2004002989A0 (en) 2004-03-31
SI2157083T1 (sl) 2016-01-29
KR20050111799A (ko) 2005-11-28
OA12648A (en) 2006-06-16
HRP20040156B1 (en) 2012-03-31
CN100448847C (zh) 2009-01-07
ES2212759T3 (es) 2006-04-16
KR100626819B1 (ko) 2006-09-20
ECSP044973A (es) 2004-06-28
EP2157083A2 (fr) 2010-02-24
DK1600441T3 (da) 2010-02-08
ATE453624T1 (de) 2010-01-15
HUP0401163A3 (en) 2009-04-28
NO325541B1 (no) 2008-06-16
PL216066B1 (pl) 2014-02-28
ES2212759T1 (es) 2004-08-01
NO20040266L (no) 2004-03-24
PL369522A1 (en) 2005-05-02
EP1600441B1 (fr) 2009-12-30
SI1600441T1 (sl) 2010-02-26
IL153917A0 (en) 2003-07-31
DE60234961D1 (de) 2010-02-11
CN101475524B (zh) 2012-08-29
ITMI20011726A0 (it) 2001-08-06
EP2157083A3 (fr) 2010-03-24
CN1538957A (zh) 2004-10-20
UY27410A1 (es) 2003-03-31
MXPA04001069A (es) 2005-02-17
EA005673B1 (ru) 2005-04-28
ES2334678T3 (es) 2010-03-15
HUP0401163A2 (hu) 2004-09-28
NO20082330L (no) 2004-03-24
EP1600441A2 (fr) 2005-11-30
PT1600441E (pt) 2010-01-20
HRP20040156A2 (en) 2004-08-31
JP2005504045A (ja) 2005-02-10
RS52161B (sr) 2012-08-31
CY1117051T1 (el) 2017-04-05
BR0211739A (pt) 2004-09-28
DK1432683T3 (da) 2006-03-06
ATE307114T1 (de) 2005-11-15
CY1109711T1 (el) 2014-08-13
EA200400280A1 (ru) 2004-08-26
HK1086263A1 (en) 2006-09-15
CN101475524A (zh) 2009-07-08
DE60206787D1 (de) 2006-03-02
HK1067123A1 (en) 2005-04-01
EP1432683B9 (fr) 2006-01-18
WO2003014084A1 (fr) 2003-02-20
AP1766A (en) 2007-08-10
IL164648A0 (en) 2005-12-18
HU229563B1 (en) 2014-02-28
PE20030328A1 (es) 2003-05-09
EP2036890A1 (fr) 2009-03-18
NO335651B1 (no) 2015-01-19
PT2157083E (pt) 2016-01-22
AR037139A1 (es) 2004-10-27
HK1140487A1 (en) 2010-10-15
NZ541341A (en) 2007-02-23
AU2002327924C1 (en) 2009-12-10
ME01525B (fr) 2011-02-10
DK2157083T3 (en) 2015-11-02
EP1432683A1 (fr) 2004-06-30
KR100667687B1 (ko) 2007-01-12
KR20050043992A (ko) 2005-05-11
DE60206787T2 (de) 2006-07-13
ITMI20011726A1 (it) 2003-02-06
IL153917A (en) 2005-11-20
RS11304A (sr) 2007-02-05
MEP2908A (en) 2010-10-10
NZ531558A (en) 2005-12-23
AU2002327924B2 (en) 2008-04-24

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